LOCUS       NM_027994               8209 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus cullin associated and neddylation disassociated 1
            (Cand1), mRNA.
ACCESSION   NM_027994 XM_125901 XM_904108
VERSION     NM_027994.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8209)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8209)
  AUTHORS   Huang,X., Liu,X., Li,X., Zhang,Y., Gao,J., Yang,Y., Jiang,Y.,
            Gao,H., Sun,C., Xuan,L., Zhao,L., Song,J., Bao,H., Zhou,Z., Li,S.,
            Zhang,X., Lu,Y., Zhong,X., Yang,B. and Pan,Z.
  TITLE     Cullin-associated and neddylation-dissociated protein 1 (CAND1)
            alleviates NAFLD by reducing ubiquitinated degradation of ACAA2
  JOURNAL   Nat Commun 14 (1), 4620 (2023)
   PUBMED   37528093
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8209)
  AUTHORS   Li,X., Zhang,Y., Zhao,Y., Zhou,Y., Han,Q., Yang,Y., Zhang,L.,
            Shi,L., Jin,X., Zhang,R., Gao,H., Xue,G., Li,D., Zhang,Z.R., Lu,Y.,
            Yang,B. and Pan,Z.
  TITLE     Cullin-associated and neddylation-dissociated 1 protein (CAND1)
            governs cardiac hypertrophy and heart failure partially through
            regulating calcineurin degradation
  JOURNAL   Pharmacol Res 182, 106284 (2022)
   PUBMED   35661710
  REMARK    GeneRIF: Cullin-associated and neddylation-dissociated 1 protein
            (CAND1) governs cardiac hypertrophy and heart failure partially
            through regulating calcineurin degradation.
REFERENCE   4  (bases 1 to 8209)
  AUTHORS   Liu,X., Reitsma,J.M., Mamrosh,J.L., Zhang,Y., Straube,R. and
            Deshaies,R.J.
  TITLE     Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in
            F-Box Protein Expression
  JOURNAL   Mol Cell 69 (5), 773-786 (2018)
   PUBMED   29499133
  REMARK    GeneRIF: the adaptive exchange hypothesis, which posits that
            regulation of the koff of an FBP from SCF by the actions of
            substrate, Nedd8, and Cand1 molds the cellular repertoire of SCF
            complexes and that the plasticity afforded by this exchange
            mechanism may enable large variations in FBP expression during
            development and in FBP gene number during evolution.
REFERENCE   5  (bases 1 to 8209)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   6  (bases 1 to 8209)
  AUTHORS   Feng,S., Shen,Y., Sullivan,J.A., Rubio,V., Xiong,Y., Sun,T.P. and
            Deng,X.W.
  TITLE     Arabidopsis CAND1, an unmodified CUL1-interacting protein, is
            involved in multiple developmental pathways controlled by
            ubiquitin/proteasome-mediated protein Degradation
  JOURNAL   Plant Cell 16 (7), 1870-1882 (2004)
   PUBMED   15208391
REFERENCE   7  (bases 1 to 8209)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 8209)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 8209)
  AUTHORS   Aoki,T., Okada,N., Wakamatsu,T. and Tamura,T.A.
  TITLE     TBP-interacting protein 120B, which is induced in relation to
            myogenesis, binds to NOT3
  JOURNAL   Biochem Biophys Res Commun 296 (5), 1097-1103 (2002)
   PUBMED   12207886
REFERENCE   10 (bases 1 to 8209)
  AUTHORS   Aoki,T., Okada,N., Ishida,M., Yogosawa,S., Makino,Y. and
            Tamura,T.A.
  TITLE     TIP120B: a novel TIP120-family protein that is expressed
            specifically in muscle tissues
  JOURNAL   Biochem Biophys Res Commun 261 (3), 911-916 (1999)
   PUBMED   10441524
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160063.12.
            
            On or before Jun 6, 2008 this sequence version replaced
            XM_904108.3, XM_125901.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.182798.1,
                                           SRR1660815.13955.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               AC160063.12        3675-4089
            416-559             AC160063.12        16184-16327
            560-714             AC160063.12        23986-24140
            715-838             AC160063.12        25666-25789
            839-1095            AC160063.12        27023-27279
            1096-1201           AC160063.12        27482-27587
            1202-1347           AC160063.12        28383-28528
            1348-1640           AC160063.12        29891-30183
            1641-1782           AC160063.12        31149-31290
            1783-3276           AC160063.12        31582-33075
            3277-3372           AC160063.12        33661-33756
            3373-3542           AC160063.12        35288-35457
            3543-3707           AC160063.12        35539-35703
            3708-3815           AC160063.12        36907-37014
            3816-8209           AC160063.12        40525-44918
FEATURES             Location/Qualifiers
     source          1..8209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 67.08 cM"
     gene            1..8209
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /note="cullin associated and neddylation disassociated 1"
                     /db_xref="GeneID:71902"
                     /db_xref="MGI:MGI:1261820"
     exon            1..415
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            416..559
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            560..714
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            715..838
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1095
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1201
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1347
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1640
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1782
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..3276
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3372
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3542
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            3543..3707
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..3815
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..8209
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4357..4362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /note="hexamer: ATTAAA"
     polyA_site      4376
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /note="major polyA site"
     polyA_site      4436
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
     regulatory      4477..4482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /note="hexamer: CATAAA"
     polyA_site      4499
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
     regulatory      7738..7743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /note="hexamer: AATAAA"
     polyA_site      7771
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
     regulatory      8186..8191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
                     /note="hexamer: AATAAA"
     polyA_site      8207
                     /gene="Cand1"
                     /gene_synonym="2310038O07Rik; 6330512O03Rik; D10Ertd516e;
                     mKIAA0829; Tp120a"
ORIGIN      
        1 agcgagtgcg gagggagtgg gagcgaggcg gcccgaacgc aagtgtctgg cttcccggcg
       61 aggcccaagc cgtccgtccc gccgcccatg agctcggcgc cccgcgagca gcgccgtcgt
      121 taggccgtcc ccgtcactca ctctcggcct cccctacctc ccccccgggg cagccattcc
      181 cctccccatc cccgtctggc cggggactgg acgtcgcgtc ggagcgcctt ccccagtccg
      241 cgtcgcggtg cgaccctgga agcgggcgcc gccgccaagg agaggaggag ccccggccgc
      301 ggggcccagc agccactgag ccagcaggcg ggatcgaggc cggcaacatg gcgagcgctt
      361 cgtaccacat ctccaacttg ctggagaaaa tgacatccag cgacaaggac ttcaggttca
      421 tggcgaccaa cgacctgatg acagagctgc agaaagactc tatcaagctg gacgatgaca
      481 gcgagaggaa agttgtgaag atgattctca ggttgctgga ggataaaaat ggcgaagtgc
      541 agaacttagc tgtcaaatgc cttggccctt tggtgagtaa agtgaaagag taccaagtgg
      601 agacgatcgt ggacaccctc tgcaccaaca tgctttctga caaggagcag ctgcgagaca
      661 tttccagcat cggcctgaaa acagtaattg gagaacttcc gccagcttcc agtggctctg
      721 cattagctgc taatgtatgt aaaaagatta ctggacgcct taccagtgca atagcaaagc
      781 aggaagatgt ttctgttcag ctcgaagcct tggatatcat ggctgacatg ttgagcaggc
      841 aaggaggact gcttgttaat ttccaccctt caattctgac ctgtctgctt ccccagctga
      901 ccagccctag acttgcagtg aggaaaagaa caattattgc tcttggccac ctagttatga
      961 gctgcggaaa tatagttttt gtagacctta ttgaacatct gttgtcagag ttgtccaaaa
     1021 atgactccat gtcaacaaca aggacctaca tacagtgtat tgctgctatt agtaggcaag
     1081 ctggccatag aataggtgaa taccttgaaa agataattcc tttggtggta aaattttgta
     1141 atgtagatga tgatgaatta agagaatact gcattcaagc ttttgaatca tttgtgagaa
     1201 gatgccctaa agaagtttat cctcatgttt ctaccattat aaacatttgt ctaaaatacc
     1261 ttacctatga tccaaattac aattacgatg atgaagatga agatgagaat gctatggatg
     1321 ctgacggtgg ggacgacgat gaccaaggga gtgacgatga atatagtgac gatgacgaca
     1381 tgagttggaa agtgagacgc gcggctgcta agtgcctgga cgctgtagtt agcacacggc
     1441 atgagatgct cccggagttc tacaagactg tctctcctgc gctgatagcc agatttaaag
     1501 agcgggaaga aaatgtaaag gcagatgttt ttcatgcata cctgtctctt ctgaaacaaa
     1561 ctcgtccagt gcaaagttgg ctgtgtgacc ctgacgcaat ggagcaggga gacacgcccc
     1621 taacaatgct gcagagtcag gttcccaaca ttgttaaagc cctgcacaag cagatgaaag
     1681 agaagagtgt gaagacccga cagtgttgct ttaacatgtt aactgagctg gtaaatgtgc
     1741 tgccgggagc actaacccag cacattcctg tactggtacc aggaatcatt ttctcactga
     1801 atgataagtc cagctcatca aacctgaaga ttgatgcgct gtcgtgtctg tatgtcatcc
     1861 tctgtaacca ctctcctcaa gttttccatc ctcatgttca ggctctggtc cctccggtgg
     1921 tggcctgtgt gggagacccg ttttacaaga tcacttcaga agcccttctt gtcactcagc
     1981 agcttgtcaa agtgatccgt cctctagacc agccctcttc gttcgatgca acgccttaca
     2041 tcaaagatct cttcacctgc acaattaagc gcttaaaagc agctgacatt gatcaagaag
     2101 tcaaggaaag ggctatttcc tgtatgggac agattatttg caatcttgga gacaatttgg
     2161 gtcctgattt atcaaatacc ctacagattt tcttggagag actcaagaat gagattaccc
     2221 ggctaacgac cgtcaaagcg ctgaccctga ttgctgggtc acctttgaag atagatctga
     2281 ggcctgtgct gggagaggga gtccccatcc ttgcttcatt cctcaggaaa aatcagagag
     2341 ctttgaaact ggggaccctc tctgccctgg atattctcat taagaactac agtgacagcc
     2401 tgacggccgc catgattgac gcagttctgg atgagctccc ccccctcatc agcgagagcg
     2461 atatgcacgt gtcgcagatg gctatcagct tcctcaccac cctggccaag gtctatccct
     2521 cctccctgtc caagataagc ggatctatcc tcaatgaact gattggactt gtgagatcgc
     2581 ctctactgca gggaggagcg ctcagtgcca tgctagactt tttccaagct ctggttgtca
     2641 ctggaacaaa caatctaggg tacatggact tgctgcgcat gctaacgggt ccagtttatt
     2701 ctcagagcac tgctctcact cataagcagt cttattattc cattgccaaa tgtgtagctg
     2761 cccttactcg agcttgccct aaagagggac ccgccgtagt aggtcagttt attcaagatg
     2821 tcaagaactc aaggtctaca gattccattc gtctcttagc actcctttct cttggagaag
     2881 ttggacacca tattgactta agtgggcagt tggaattaaa atctgtaata ttagaggctt
     2941 tctcatcccc tagtgaagaa gtcaaatcag ctgcgtccta tgcattaggc agcattagtg
     3001 taggcaacct tcctgagtat ctgccctttg tactgcaaga aataaccagc cagcccaaaa
     3061 ggcagtatct tctgcttcac tctttgaagg agatcattag ctctgcatcg gtggcaggcc
     3121 ttaagccata tgttgagaac atctgggcct tgctgctaaa gcactgtgag tgtgcggagg
     3181 aaggcaccag gaatgtcgtg gctgaatgtc tagggaagct cactcttatt gatcctgaaa
     3241 ctctcctccc acggcttaaa gggtatttga tatcagggtc atcatatgcc aggagctcgg
     3301 tggttacagc tgtgaagttc acgatttctg atcatcctca gcctattgat ccactgttga
     3361 agaactgcat aggtgacttt ctaaaaactt tggaagaccc agatttgaac gtaagaagag
     3421 tggccttggt cacattcaat tctgcggccc ataacaagcc atcactgata cgggaccttc
     3481 tggactcagt tcttccacat ctttacaatg agacaaaagt taggaaggaa cttataagag
     3541 aggtagaaat gggtccattt aaacacacgg ttgatgacgg tctagacatt agaaaggcag
     3601 cttttgagtg tatgtataca cttctagaca gctgtcttga tagactggat atctttgaat
     3661 ttctaaatca tgttgaagat ggtttgaagg accattatga tattaagatg ctaacatttt
     3721 taatgttggt acgactgtct accctctgtc caagtgcagt actacaaagg ctggaccgac
     3781 ttgttgagcc actgcgtgct acgtgtacaa ctaaggtaaa ggcaaactct gtaaagcagg
     3841 agtttgaaaa gcaagatgag ctaaagcggt ctgccatgag ggcagtggcg gctttgttaa
     3901 ccattccaga ggcagagaag agccctctta tgagtgaatt ccagtcacag atcagctcca
     3961 acccggagct ggcagccatc tttgaaagta tccagaaaga ttcttcgtcc accaacttgg
     4021 aatcaatgga cacgagttag atgtgtgcgc cccgtgagga ccattccatg tgaccgcaca
     4081 atgcactgaa cgacaggttg accacagcca cgggagagaa gtgtccagag cttcacgatg
     4141 ttccacttta ctttccttcc cgggaagttt gtttggcttt cttccattgt tgtttttgta
     4201 gcttttactt cagaagtctg tatttccata agccagaggt tgtaaagcca ctgatgtttt
     4261 tagtggttag ggcaacattt gaaatgggaa cttaaagctt ggatttatga aatgtggaaa
     4321 tagggtccag tatctgtttg ccctgtaatg tgtaggatta aaatgttaaa actttatgac
     4381 catggatttc ttggttttgt aaattctctc atttaaaatc aattctgcaa cacgaagacc
     4441 atgtttcttt ccttgtacaa cctcttcttt cagcgacata aaatgatttt tacctggcag
     4501 atagagtatt catttaagat atgttatatt tcagagagat tggcatctta gccaagatgc
     4561 tgaagcacca cctaagtata cggcctaaca atatccctgt gcacactgac ttttgcatga
     4621 acaggtttac aactatgtct tgtctgtaac agcatgtaca gattcttcac aatacacatt
     4681 aaaataagca gtagtgcaat ttttcagata cttttgcaca ccaaatatta tctggtgaaa
     4741 gaggagttaa tgttgaatct ggttttctaa ctgccagtgt gaatttacgg atgtttccag
     4801 caaatcaagt cacagcaatt cgcaacttct tactattata aattacctca cacatttatg
     4861 gttttcctct gttccacagt gtccgtgcgt gttctcaaag ccagactgtt ttattcttgt
     4921 tgagtatctg cagttgttac tggaggacaa aaacctcacc tgtgcgttta agtttttgtt
     4981 tttaagaaat ttctcaagtt gctcatcact ggttttgtta gctaaagctt tcttagaatt
     5041 gagtcacagc tcacctcccc cagcccattg gcgagctaac ttacctattg tctttggtaa
     5101 gtgttgagta tttgctgggc cagcaaagct tttgcaattg tttcccttgt agttgaaatt
     5161 gtatccaaca ttctgtgagc tccttgcata ctgcctccat ctttgaggtg ttcctggaag
     5221 agctagctat tccaaaaata agagcactct tctttctgtg cacacaacgt agtttacatg
     5281 tattggaggg aggcagttgt taaattgagt ggtcggtttc aagaactcag cttgaaagct
     5341 gcaccgttgg actgccgtaa ggtcgaatgc acaattgctt gttccggtca gagcagactg
     5401 tggctgttgg ctttgattgt acagtgatgc caaccaaggg cattgactgg tgctggtgag
     5461 gctttggatt atgcactggc ttattctatg aaatcggtgc catggcaaaa taaggcaggt
     5521 gataatttta taccatagtt tgcacaaaac taataggaat ttattttagt atattctgca
     5581 ctatgcattg ctatggtata gatgtggata aagttcggct tggggttatg tgatgtgctc
     5641 tcacagtggt tacagcacaa gctctgggac tgaacagatt ttgacattgt tgtgttccat
     5701 gactgtctta gttaattacc tacagttaag cccctaaact ttcattggtt accccatggt
     5761 tacatgttac actttgtttt tctgagtctt gcaagtcaac tcattttcct acgtcactaa
     5821 attcttgtac gaagaaaatc ctgctttagt ggttaaagta tcacactacc tatacataca
     5881 gagccgagga actagacacg tctatacaca ggccatcaga agaaggctca ggggctccag
     5941 tgctgagcca cactgatgct gtggtgatgt ggtccacatc tggactggaa gcagcagacc
     6001 caccaccaca catgctagga aggtcgagct tctgcctgcc tgccagttct cccaggcggt
     6061 tcctagaagt cagtagtgcg agggagcaag ctggtggcga ttcttaggaa tgtgctgaga
     6121 ttactttaga actatatgga gtttttaaaa agaaagctca gtatacattg cgtttggggt
     6181 ttagactgtc ttattaaact tagacatgaa gaagtctaac ctaagaagtt atttataaag
     6241 ttagtaggat tgaatgcaac tattttaatt gtatatttta ttagtgatat ctaaaggctg
     6301 cttaactgct agcagttaga attcttaaaa gattggaata tgatggtttt gttaaatgtt
     6361 tgtatattta cataatttaa tcataattaa acaaccaaat gagtcctcct tagtctttac
     6421 attccttggg taaacaataa cacagggaaa taattctatg ggatgttttg atatttttgt
     6481 atctagctca gcctcagaca tgaagccatg attgaagttc aaaatattga agtatagaaa
     6541 accctcaact gctgaggtta tttaatttca cctaatttgt tcctatgtct tcagagccgt
     6601 gttagctaca tgataaagtg tataggaatg ctttgtaatt ggagtaatat tttctgccca
     6661 catcaaattt gactgctgct cttcaggaag ctgaggcagg agatgagttc aaggtcagct
     6721 tgaactgcat agcaagaccc tttctcaaaa tggcgtgttt gtgtgcatgt gtgtgagtct
     6781 aagttgtcca gagttacgtt tttgatattt ggatgcgaaa gttaaaagtt gcaacaagta
     6841 aaattgggat tgtagcgttt acttgatgtt tcatcttaac ttaagctatg gtctttaatc
     6901 tctgtggggc ggggaattga catttggtta taaaatggac cacagtggac cagtgccagc
     6961 agctgtccaa agctcaccag ataaagctgt tttttttttt tttttaggag gaacacaaaa
     7021 gtgaaaccac atatgcgtgt gagtagcttg gtttcctagt aataccagtg aagattctgg
     7081 gaagacctgt gccatgttgt ggggttttag taacatggtt ttgttctttg tatgttagaa
     7141 aggtggcttg gcttcccccg aaggatttgg ttttcttagg gcattttaat aaccagtgaa
     7201 ggtgctgttg ggcatcagtg agtcagagtc agattttatt tagtaggtta aggttctgtg
     7261 atggagtctt cggcccttta aattctagga acaaatctcg gggtggttcg gtaatgttat
     7321 tttgctcagg tcttcagaag agagagacaa ggaaaaactt acttgaaaca aaattctttt
     7381 ccctttacca atgaggcacc ggaagtgctg gaattagcct atctaggcac ttggtaacag
     7441 tgggtgctcc atgagggact tgggaatgct cacacatgtg aacgaaaagc tatagagctg
     7501 tactctgtat catacgatgg cggtcccgtg tcttactagt ctgtgataag ctattactct
     7561 ggaaagttac tttgcttgtt tcatagattt ttttttttca catttaaaca aaactgcaac
     7621 tgcttgctta gatgagggca gctaaatgtg tatgtacctg tactagtgtt aagacgtgta
     7681 tctgcttgca atcattgcca tatgtaaact aagcgaggct ttcttaagag atgtggaaat
     7741 aaactcctgg ttccttattc tagaaataaa atccatgttt tccttcagaa tttatactgc
     7801 agtaagtaaa aaatgttact ttagataagg attttggatg gcataagcag ctctgatcac
     7861 tcagttgcct tttgctcatt aatgagatca ataaggttaa tttttcagga ttttagccat
     7921 agatcggtga ctggccttgg taactttgaa cactttcttg cgtagtggtt ttctgctttt
     7981 aaaatctaca tgtagggctt ccagatagct cggcacttgc ccctccctcc caggactgct
     8041 tgaacccaag tttggtcttt gggatccaca tagtggaaag acacacaatt ctggcaggtt
     8101 gtcttctaat ctccacagga atactatcat agcatatcgt agtgttcgtg gcagccgcac
     8161 cccctaaata taaatacatt ttaaaaataa aatctacatt taaaccatg
//
