LOCUS       NM_027171               4303 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calmodulin regulated spectrin-associated protein
            family, member 3 (Camsap3), transcript variant 2, mRNA.
ACCESSION   NM_027171 XM_133997
VERSION     NM_027171.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4303)
  AUTHORS   Flinois,A., Mean,I., Mutero-Maeda,A., Guillemot,L. and Citi,S.
  TITLE     Paracingulin recruits CAMSAP3 to tight junctions and regulates
            microtubule and polarized epithelial cell organization
  JOURNAL   J Cell Sci 137 (5) (2024)
   PUBMED   37013686
  REMARK    GeneRIF: Paracingulin recruits CAMSAP3 to tight junctions and
            regulates microtubule and polarized epithelial cell organization.
REFERENCE   2  (bases 1 to 4303)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4303)
  AUTHORS   O'Donnell,J. and Zheng,J.
  TITLE     Vestibular Hair Cells Require CAMSAP3, a Microtubule Minus-End
            Regulator, for Formation of Normal Kinocilia
  JOURNAL   Front Cell Neurosci 16, 876805 (2022)
   PUBMED   35783105
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4303)
  AUTHORS   Liu,H., Zheng,J., Zhu,L., Xie,L., Chen,Y., Zhang,Y., Zhang,W.,
            Yin,Y., Peng,C., Zhou,J., Zhu,X. and Yan,X.
  TITLE     Wdr47, Camsaps, and Katanin cooperate to generate ciliary central
            microtubules
  JOURNAL   Nat Commun 12 (1), 5796 (2021)
   PUBMED   34608154
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4303)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4303)
  AUTHORS   Kurita,S., Yamada,T., Rikitsu,E., Ikeda,W. and Takai,Y.
  TITLE     Binding between the junctional proteins afadin and PLEKHA7 and
            implication in the formation of adherens junction in epithelial
            cells
  JOURNAL   J Biol Chem 288 (41), 29356-29368 (2013)
   PUBMED   23990464
REFERENCE   7  (bases 1 to 4303)
  AUTHORS   Nagae,S., Meng,W. and Takeichi,M.
  TITLE     Non-centrosomal microtubules regulate F-actin organization through
            the suppression of GEF-H1 activity
  JOURNAL   Genes Cells 18 (5), 387-396 (2013)
   PUBMED   23432781
REFERENCE   8  (bases 1 to 4303)
  AUTHORS   Tanaka,N., Meng,W., Nagae,S. and Takeichi,M.
  TITLE     Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific
            organization of noncentrosomal microtubules
  JOURNAL   Proc Natl Acad Sci U S A 109 (49), 20029-20034 (2012)
   PUBMED   23169647
  REMARK    GeneRIF: CAMSAP2 and -3 work together to maintain noncentrosomal
            microtubules in epithelial cells, suppressing the
            microtubule-organizing ability of the centrosome.
REFERENCE   9  (bases 1 to 4303)
  AUTHORS   Meng,W., Mushika,Y., Ichii,T. and Takeichi,M.
  TITLE     Anchorage of microtubule minus ends to adherens junctions regulates
            epithelial cell-cell contacts
  JOURNAL   Cell 135 (5), 948-959 (2008)
   PUBMED   19041755
REFERENCE   10 (bases 1 to 4303)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD349198.1, AK081728.1, BC043081.1 and CO042496.1.
            
            On Aug 4, 2009 this sequence version replaced NM_027171.2.
            
            Transcript Variant: This variant (2) lacks two exons in the 5'
            coding region compared to variant 3. The encoded isoform (2) is
            shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048787.1, AK081728.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-226               CD349198.1         1-226
            227-1981            AK081728.1         2-1756
            1982-4266           BC043081.1         1641-3925
            4267-4303           CO042496.1         8-44                c
FEATURES             Location/Qualifiers
     source          1..4303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 1.92 cM"
     gene            1..4303
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /note="calmodulin regulated spectrin-associated protein
                     family, member 3"
                     /db_xref="GeneID:69697"
                     /db_xref="MGI:MGI:1916947"
     exon            1..510
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            511..764
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            765..887
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            888..983
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1122
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1262
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1356
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1411
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1485
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1555
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..3026
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3166
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            3167..3483
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3583
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3696
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3815
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..4293
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4240..4245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /note="hexamer: AATAAA"
     polyA_site      4251
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /note="major polyA site"
     polyA_site      4256
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
                     /note="major polyA site"
     polyA_site      4293
                     /gene="Camsap3"
                     /gene_synonym="2310057J16Rik; Kiaa1543; Nezha"
ORIGIN      
        1 gcgttcttct gcagcccttc cctcatccgc catcactgcc gccctttgca gcaggaggac
       61 ctatggaagc tttaatgtca gtggggaccc atgtggaccc aggagccaga gagaactgag
      121 tccaatctgg gggcggggcg cacctgggtt ccgccttggg gcggggtcga cgccgcgtcg
      181 ccagcgcgct cgaccgcacc tggttcagcg gcgcctcagc agctttatta gtaacagcag
      241 cagccgcggc ggcaacccga ttcggggtgg cggaggctcg gcagcagcgc agcgcagcgc
      301 agcgcacgca gcccagccca tcagagcgcg cggacccggg cggccgtaac cccggcgtcg
      361 ccatggtgga agcggcgccc gcagggtccg ggccactgcg gaggactttc ctggtccccg
      421 agatcaagtc tttggaccag tacgatttct ctcgagccaa ggcggcggcg agtctggcgt
      481 gggtgctgcg ggccgcattc gggggagcag agcatgtgcc tccggagctg tgggaaccct
      541 tctacaccga tcagtacgca caggagcacg tgaagccccc agtgacgcgg ctgctgctct
      601 ctgcggaact atactgtcgg gcctggcgcc aggcactgcc acagctcgag ccatccccca
      661 gtccctctgc tctgttggcc ttgctggcga ggaggggcac ggtgccttca ctgcctgagc
      721 acccagtgcg cgaggctgac ctgaaacacc agccaattct catgggagcc cacctagctg
      781 tcatcgatgc tctcatggtt gccttctcat ttgagtggac aaagacacta cctggtccct
      841 tggctctgag cagcttggag cacaaactcc ttttctgggt agacacaact gttcggcggc
      901 tgcaggagaa gacagaacaa gaagcagccc agcgtgcatc tcctgcagcc cctctggatg
      961 gggcctctcc tgcccagccc tcgattcgat atcgcaagga ccgtgccatt gcccgaaggg
     1021 ctccctgctt tccaaatgtg actacccttc aggacctggc cagtggggca gcactggctg
     1081 ccaccatcca ctgctattgt ccccagctat tacgacttga ggaggtgtgc ctcaaggacc
     1141 ccatgtctgt ggcagacagt ctatacaacc tccagctggt gcaagacttc tgtgcctccc
     1201 atcttcctcg aggctgcccc ctgtcccttg aagacttgct gtatgtccca ccacccctca
     1261 aggtcaacct ggtggtgctg ttggctgaga tgtatatgtg ctttgaggtt ctgaagcctg
     1321 attttgtgca ggccaaagac ttgcctgatg gacatgctgt ctccccccgg aatacagaga
     1381 ctgttccatc tcagaacaac agtggcagca gttctcctgt cttcaacttc cgtcacccac
     1441 ttctgtcacc tggtggtccc cagtctccac tccgaggatc cacaggctcc ctgaagtcct
     1501 ctccatcaat gtctcacatg gaggctcttg gcaaagcctg gaaccgtcag cttagccgtc
     1561 ccctctccca ggctgtgtcg ttcagcactc cctttggcct ggacagcgat gtggatgtcg
     1621 tcatgggaga tcctgtcctg ctccgctccg tcagctcaga cagtctgggt cctccacgtc
     1681 ctgtgtcaac atcatcccgg aattctgctc agccagcccc agaatctgga gacctaccca
     1741 cgattgaaga ggccctgcag atcattcaca gtgctgagcc ccgactgctc cctgatgggg
     1801 ctgctgatgg cagtttctac ctccattctc ctgagggtct ctccaaacca ccactctccc
     1861 cctaccctcc cgaaggagcc tcaaagccgc tgtctgatag gctcaacaag gcgcctatct
     1921 atatatcaca ccctgagaac ccttcaaaat catctccctg ctcaacagga gagatactga
     1981 aaccaccacc cccatccgag ggttccccca aagctgtggc ttcatcccca gcagccaaca
     2041 actccgaagt gaagatgacc agttttgctg aacgcaagaa acagctggtg aaggctgagg
     2101 ctgagtcagg attggggtct ccaacatcca cccccgtagc acctgaggcc ttgagctcag
     2161 agatgagtga gctgggagcc aggctggagg agaagcgccg agccatagag gcacagaaac
     2221 gacgcattga ggcaatcttt gccaagcata ggcagaggct gggcaagagc gctttcctgc
     2281 aggtgcagcc tcgggaggct gcaggggagg ccgaggagga agctgagctg ggctcagttc
     2341 ctggtgggga acggccagca ggtgagggcc agggtgagcc gtccttacgg cacaagtcag
     2401 ttaccttctc tccagacctg ggcccagtgc ccccagaggg acttggggat tacaatagag
     2461 cagtcagtaa gctgagtgcc gctctgagct ctctgcagcg ggacatgcag aggctcacag
     2521 accagcaaca gcggcttcta gcccctccag aagctcctgg acctgcccca ccacctgcag
     2581 cctgggtcat tcctggaccc gccactgggc ctaaagcagc atcccccagc cctgcccgtc
     2641 gtgccccagc tgcccgacgc agccctgggc caggccccag cccaacaccc cgtagtccaa
     2701 aacatgcaag gccggcagag ctgaagcttg cacctttgac aagggtactc acaccacccc
     2761 atgatgtaga cagcctccct cacctacgca agttttcacc cagccaggtg cctgtacaga
     2821 ctcgctcctc tatcctcctg tcggagggga cacctcccga ggagcccacc accaagcctg
     2881 ccctcattga gatccctcta gccagcctgg gggagcctgc tgctgatgag gaaggagatg
     2941 ggagcccccc tggggctgag gattccttag aggaagaggc atcttctgag ggagagcccc
     3001 gatcagggct tggattcttt tataaggacg aagacaagcc tgaggatgag atggctcaga
     3061 agcgagctag cctgctggag cgtcagcaga ggcgggtaga ggaagcccgg cggcgcaaac
     3121 agtggcagga ggcagagaag gagcagaaac gggaggaggc cgccaggctg gctcaggagg
     3181 ctccaggctt ggcctttaca actcctgttg tagcctctgc ggctccagtg gccaccttgg
     3241 ctcctactac cagagccatg gccccagctg aggaggaggt gggcccccgg cggggggact
     3301 tcacaagact tgagtatgaa cgccgggcac aactgaaact gatggatgac cttgataagg
     3361 tgctacggcc ccgggcctca gggaccgggg gaccagggcg gggcgggcgc agggccaccc
     3421 ggccacgctc tggttgctgt gatgactcgg ccttggcacg aagcccagcc cgcggcctgc
     3481 tgggttcacg gctcagcaag gtctattccc agtccacgct gtccctatct acggtggcca
     3541 acgaggctcc caataacctt ggtgtgaaga ggcccacctc tcgggcccct tctccatcag
     3601 gcctcatgtc tccaagccgc ctgcctggca gtcgagaacg tgactgggag aatggaagca
     3661 atgcatcctc cccagcatca gtgcctgagt acacaggtcc ccggctatac aaggaaccca
     3721 gcgccaagtc taacaagttt atcatccaca atgccttgtc acactgctgc ctggcaggca
     3781 aggtgaatga gccccagaag aacagaattc tagaggaaat cgagaaaagc aaggccaacc
     3841 acttcctgat tctctttcgg gactcaagct gccagttccg ggccctctac actctgtctg
     3901 gggagacaga ggagctatcg aggctggcag gctatgggcc tcggaccgtc actcctgcca
     3961 tggtcgaagg catctataag tacaactcgg atcgcaaacg gttcacccag atccctgcta
     4021 aaaccatgtc tatgagtgta gacgccttca ctatccaggg acacctttgg caaagcaaga
     4081 agcccaccac gcccaagaag ggtggcggta cccccaaata gtgcccacct tgggcagtgc
     4141 actcctgggt cctgtctggt catgctgtgg ggggctgagc tgggagcttc agtgactcag
     4201 ggctcagctc agtccccttg tctgtcctcc actttcttga ataaaataac tgaaaagaga
     4261 agctgagaca cggtgtctcc tccctaagcc tgaaaaaaaa aaa
//
