LOCUS       NM_009921                599 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus cathelicidin antimicrobial peptide (Camp), mRNA.
ACCESSION   NM_009921
VERSION     NM_009921.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 599)
  AUTHORS   Wang,Q., Wen,W., Zhou,L., Liu,F., Ren,X., Yu,L., Chen,H. and
            Jiang,Z.
  TITLE     LL-37 improves sepsis-induced acute lung injury by suppressing
            pyroptosis in alveolar epithelial cells
  JOURNAL   Int Immunopharmacol 129, 111580 (2024)
   PUBMED   38310763
  REMARK    GeneRIF: LL-37 improves sepsis-induced acute lung injury by
            suppressing pyroptosis in alveolar epithelial cells.
REFERENCE   2  (bases 1 to 599)
  AUTHORS   Hopfinger,A., Schmid,A., Karrasch,T., Pankuweit,S., Schaffler,A.
            and Grote,K.
  TITLE     Cathelicidin Antimicrobial Peptide Levels in Atherosclerosis and
            Myocardial Infarction in Mice and Human
  JOURNAL   Int J Mol Sci 25 (5), 2909 (2024)
   PUBMED   38474156
  REMARK    GeneRIF: Cathelicidin Antimicrobial Peptide Levels in
            Atherosclerosis and Myocardial Infarction in Mice and Human.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 599)
  AUTHORS   Nakamura,Y., Kulkarni,N.N., Takahashi,T., Alimohamadi,H.,
            Dokoshi,T., Liu,E., Shia,M., Numata,T., Luo,E.W., Gombart,A.F.,
            Yang,X., Secrest,P., Gordts,P.L., Tsimikas,S., Wong,G.C. and
            Gallo,R.L.
  TITLE     Increased LL37 in psoriasis and other inflammatory disorders
            promotes LDL uptake and atherosclerosis
  JOURNAL   J Clin Invest 134 (5), e172578 (2024)
   PUBMED   38194294
  REMARK    GeneRIF: Increased LL37 in psoriasis and other inflammatory
            disorders promotes LDL uptake and atherosclerosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 599)
  AUTHORS   Nakatsuji,T., Brinton,S.L., Cavagnero,K.J., O'Neill,A.M., Chen,Y.,
            Dokoshi,T., Butcher,A.M., Osuoji,O.C., Shafiq,F., Espinoza,J.L.,
            Dupont,C.L., Hata,T.R. and Gallo,R.L.
  TITLE     Competition between skin antimicrobial peptides and commensal
            bacteria in type 2 inflammation enables survival of S. aureus
  JOURNAL   Cell Rep 42 (5), 112494 (2023)
   PUBMED   37167061
REFERENCE   5  (bases 1 to 599)
  AUTHORS   Yang,Y., Huang,C., Hui,L., Song,Y., Fu,Y., Li,M., Yang,H., Wu,J.,
            Sun,J., Xu,W. and Wei,L.
  TITLE     Cathelicidins Target HSP60 To Restrict CVB3 Transmission via
            Disrupting the Exosome and Reducing Cardiomyocyte Apoptosis
  JOURNAL   J Virol 97 (3), e0143322 (2023)
   PUBMED   36916989
REFERENCE   6  (bases 1 to 599)
  AUTHORS   Yu,K., Park,K., Kang,S.W., Shin,S.Y., Hahm,K.S. and Kim,Y.
  TITLE     Solution structure of a cathelicidin-derived antimicrobial peptide,
            CRAMP as determined by NMR spectroscopy
  JOURNAL   J Pept Res 60 (1), 1-9 (2002)
   PUBMED   12081622
  REMARK    GeneRIF: solution structure in TFE/H2O solution determined by CD
            and NMR spectroscopy
REFERENCE   7  (bases 1 to 599)
  AUTHORS   Nizet,V., Ohtake,T., Lauth,X., Trowbridge,J., Rudisill,J.,
            Dorschner,R.A., Pestonjamasp,V., Piraino,J., Huttner,K. and
            Gallo,R.L.
  TITLE     Innate antimicrobial peptide protects the skin from invasive
            bacterial infection
  JOURNAL   Nature 414 (6862), 454-457 (2001)
   PUBMED   11719807
  REMARK    GeneRIF: an important native component of innate host defence in
            mice and provide protection against necrotic skin infection caused
            by Group A Streptococcus (GAS).
REFERENCE   8  (bases 1 to 599)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
REFERENCE   9  (bases 1 to 599)
  AUTHORS   Gallo,R.L., Kim,K.J., Bernfield,M., Kozak,C.A., Zanetti,M.,
            Merluzzi,L. and Gennaro,R.
  TITLE     Identification of CRAMP, a cathelin-related antimicrobial peptide
            expressed in the embryonic and adult mouse
  JOURNAL   J Biol Chem 272 (20), 13088-13093 (1997)
   PUBMED   9148921
REFERENCE   10 (bases 1 to 599)
  AUTHORS   Popsueva,A.E., Zinovjeva,M.V., Visser,J.W., Zijlmans,J.M.,
            Fibbe,W.E. and Belyavsky,A.V.
  TITLE     A novel murine cathelin-like protein expressed in bone marrow
  JOURNAL   FEBS Lett 391 (1-2), 5-8 (1996)
   PUBMED   8706928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC120754.1, U43409.1 and
            BY582734.1.
            
            On Apr 7, 2009 this sequence version replaced NM_009921.1.
            
            Summary: This gene encodes a member of the cathelicidin family of
            antimicrobial peptides that play an important role in the defense
            against microbial infection. The encoded preproprotein undergoes
            proteolytic processing to generate a mature polypeptide before
            secretion by host cells such as neutrophils, epithelial cells and
            macrophages. Mice lacking the encoded protein exhibit increased
            susceptibility to group A streptococcus and Escherichia coli
            infections. [provided by RefSeq, Oct 2015].
            
            CCDS Note: Owing to stop SNP rs48466509 in the reference strain,
            the CCDS translation is one amino-acid shorter than in the FVB and
            BALB/C strains. The UniProt translation for this locus, P51437, is
            derived from a BALB/C mRNA and is 173 amino-acids long, versus 172
            for the CCDS model.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120754.1, X94353.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               BC120754.1         1-534
            535-571             U43409.1           528-564
            572-599             BY582734.1         373-400
FEATURES             Location/Qualifiers
     source          1..599
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.8 cM"
     gene            1..599
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /note="cathelicidin antimicrobial peptide"
                     /db_xref="GeneID:12796"
                     /db_xref="MGI:MGI:108443"
     exon            1..214
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..541
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /note="cathelin-related antimicrobial peptide;
                     cathelin-like protein"
                     /codon_start=1
                     /product="cathelicidin antimicrobial peptide precursor"
                     /protein_id="NP_034051.2"
                     /db_xref="CCDS:CCDS52934.1"
                     /db_xref="GeneID:12796"
                     /db_xref="MGI:MGI:108443"
                     /translation="MQFQRDVPSLWLWRSLSLLLLLGLGFSQTPSYRDAVLRAVDDFN
                     QQSLDTNLYRLLDLDPEPQGDEDPDTPKSVRFRVKETVCGKAERQLPEQCAFKEQGVV
                     KQCMGAVTLNPAADSFDISCNEPGAQPFRFKKISRLAGLLRKGGEKIGEKLKKIGQKI
                     KNFFQKLVPQPE"
     exon            215..322
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /inference="alignment:Splign:2.1.0"
     exon            323..394
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /inference="alignment:Splign:2.1.0"
     exon            395..599
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      578..583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /note="hexamer: AATAAA"
     polyA_site      588
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /note="major polyA site"
     polyA_site      597
                     /gene="Camp"
                     /gene_synonym="CAP18; CLP; Cnlp; Cramp; FALL39; MCLP"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggca gtcttgggaa ccatgcagtt ccagagggac gtcccctccc tgtggctgtg
       61 gcggtcacta tcactgctgc tgctactggg cctggggttc tcccagaccc ccagctacag
      121 ggatgctgtg ctccgagctg tggatgactt caaccagcag tccctagaca ccaatctcta
      181 ccgtctcctg gacctggatc ctgagcccca aggggacgag gatccagata ctcccaagtc
      241 tgtgaggttc cgagtgaagg agactgtatg tggcaaggca gagcggcagc tacctgagca
      301 atgtgccttc aaggaacagg gggtggtgaa gcagtgtatg ggggcagtca ccctgaaccc
      361 ggccgctgat tcttttgaca tcagctgtaa cgagcctggt gcacagccct ttcggttcaa
      421 gaaaatttcc cggctggctg gacttctccg caaaggtggg gagaagattg gtgaaaagct
      481 taagaaaatt ggccagaaaa ttaagaattt ttttcagaaa cttgtacctc agccagagta
      541 gtaggcctgc cttggcctgt ttctggattc ctaaaataat aaacttggta aaagaaact
//
