LOCUS       NM_028576               1522 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus calmodulin-lysine N-methyltransferase (Camkmt),
            transcript variant 1, mRNA.
ACCESSION   NM_028576 XM_355034 XM_899373 XM_899380 XM_899387 XM_899393
            XM_899398 XM_899405 XM_918109 XM_925497 XM_925501 XM_925503
            XM_925505 XM_925507 XM_989263 XM_989293 XM_989318 XM_989355
            XM_989382 XM_989412 XM_989447
VERSION     NM_028576.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Percival,C.J., Green,R., Roseman,C.C., Gatti,D.M., Morgan,J.L.,
            Murray,S.A., Donahue,L.R., Mayeux,J.M., Pollard,K.M., Hua,K.,
            Pomp,D., Marcucio,R. and Hallgrimsson,B.
  TITLE     Developmental constraint through negative pleiotropy in the
            zygomatic arch
  JOURNAL   Evodevo 9, 3 (2018)
   PUBMED   29423138
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1522)
  AUTHORS   Haziza,S., Magnani,R., Lan,D., Keinan,O., Saada,A., Hershkovitz,E.,
            Yanay,N., Cohen,Y., Nevo,Y., Houtz,R.L., Sheffield,V.C., Golan,H.
            and Parvari,R.
  TITLE     Calmodulin Methyltransferase Is Required for Growth, Muscle
            Strength, Somatosensory Development and Brain Function
  JOURNAL   PLoS Genet 11 (8), e1005388 (2015)
   PUBMED   26247364
  REMARK    GeneRIF: CaM methylation appears to have a role in growth, muscle
            strength, somatosensory development and brain function.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1522)
  AUTHORS   Chen,H., Palmer,J.S., Thiagarajan,R.D., Dinger,M.E., Lesieur,E.,
            Chiu,H., Schulz,A., Spiller,C., Grimmond,S.M., Little,M.H.,
            Koopman,P. and Wilhelm,D.
  TITLE     Identification of novel markers of mouse fetal ovary development
  JOURNAL   PLoS One 7 (7), e41683 (2012)
   PUBMED   22844512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113476.20, AC154475.2 and AC154217.2.
            
            On Jul 17, 2018 this sequence version replaced NM_028576.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155246.1, BC138272.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC113476.20        127897-128134
            239-411             AC113476.20        133761-133933
            412-476             AC113476.20        151054-151118
            477-537             AC154475.2         30594-30654         c
            538-592             AC154475.2         28715-28769         c
            593-656             AC154475.2         27562-27625         c
            657-723             AC154475.2         19735-19801         c
            724-798             AC154217.2         43776-43850
            799-862             AC154217.2         51832-51895
            863-994             AC154217.2         64501-64632
            995-1522            AC154217.2         70367-70894
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 55.2 cM"
     gene            1..1522
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /note="calmodulin-lysine N-methyltransferase"
                     /db_xref="GeneID:73582"
                     /db_xref="MGI:MGI:1920832"
     exon            1..238
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1072
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /EC_number="2.1.1.60"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="calmodulin-lysine N-methyltransferase isoform 1"
                     /protein_id="NP_082852.1"
                     /db_xref="CCDS:CCDS37712.1"
                     /db_xref="GeneID:73582"
                     /db_xref="MGI:MGI:1920832"
                     /translation="MESQVAAAGAAETEAEAGKRPAMGSASQGSLVSAPKGAVRWQLL
                     RQVLKQKQLDDHLRHVSVRRFESFNLFSVTEATKKGTEKEAGVWVQYTSIFYPKYSIS
                     VRHNSGSLNVEDVLTSFDNTGNVCIWPSEEVLAHYCLKHSHIFRDLAVCELGGGMTCL
                     AGLMVAISADVKEVLLTDGNEKAIRNVDSIIACNKKTGVFKTPKISSRVLRWDNETDV
                     SQLEGHFDIVMCADCLFLDQYRASLVDAIKRLLQPTGKAVVFAPRRGNTFNQFCNLAE
                     KAGFSLQRHENYDEPISNFHSKLKKEGSDIYEENLHYPLLLILTKTG"
     exon            239..411
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            412..476
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            477..537
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            538..592
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            593..656
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            657..723
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            724..798
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            799..862
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            863..994
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1522
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1491..1496
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /note="hexamer: AATAAA"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /note="hexamer: AACAAA"
     polyA_site      1516
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
     polyA_site      1522
                     /gene="Camkmt"
                     /gene_synonym="1700106N22Rik; CaM KMT; CLNMT"
                     /note="major polyA site"
ORIGIN      
        1 agaggccggg cgtcacaggt cctgacaggg aagaagttgg caggtcctga ctggggagag
       61 ccgtggcgga cgcaacctcc gggtccagtc agctctggag atggagtcgc aggtcgcggc
      121 cgctggggct gcagagactg aggcagaggc gggcaagcgt cccgcgatgg gcagtgccag
      181 ccagggctcg ctggtctcgg cgcccaaggg ggccgtccgg tggcagcttc tgcgacaggt
      241 tctgaagcag aaacagttgg atgatcatct gagacatgta tctgtgagaa gatttgaatc
      301 atttaatctg ttctcagtca cagaagccac aaaaaaggga actgaaaaag aggctggtgt
      361 gtgggtccag tacacaagca tcttttatcc caaatacagc atctccgtaa ggcataatag
      421 tggatccttg aatgtggaag acgtccttac cagctttgac aacacaggaa atgtttgcat
      481 ctggccatcc gaggaggtcc tggctcacta ctgcctcaag cacagtcata tattcaggga
      541 ccttgctgtg tgtgagctag ggggtggcat gacatgcttg gctgggctca tggttgctat
      601 ttctgcagat gtcaaagaag ttctgctaac tgatgggaat gaaaaggcca tcagaaatgt
      661 ggacagcatc atcgcatgca ataagaagac tggtgtgttt aagactccga aaatatcaag
      721 ccgcgtttta cgatgggata atgagacaga cgtctctcaa ctggaaggac attttgacat
      781 tgttatgtgt gctgactgcc tgtttctgga ccagtacaga gccagccttg ttgatgccat
      841 aaagagatta ctccagccca cagggaaagc ggtggtattt gccccacgcc gagggaatac
      901 tttcaaccag ttttgcaatc tagctgaaaa agctggtttc tctctccaaa gacatgaaaa
      961 ttacgatgag cccatttcaa acttccactc caagttgaaa aaagaagggt cagacatata
     1021 tgaagaaaac ctgcactacc cacttctgct tattttaacc aaaacgggat agaagaaaac
     1081 atcagatgca gagaaagatt tccacactat atgagaactc cgccacagcg cctctgggac
     1141 tcagggctcc acccactttc gaacattccg catcttggga ctccgcccat tactccggcc
     1201 ctcggcagct ctcccaccct ccgcagcgcg ctcgctccca ccagtccttt ttaaggaagc
     1261 ttgttgctct tccgtaccaa acctttgtgt gtttttctgt gtcagcagcc tgtcttagat
     1321 cagaatttga cttgtggagc aatctaaata gttttctctc taaagcacaa tttcttttga
     1381 tgatttccat ctgccgcccc ccctcctttt ttttaattgc ctttgttctt gtttggtaat
     1441 agtattcttt atccacaaac acagaaagca tcacccttct tttctggata aataaacaaa
     1501 ccttattttt ctgatatctc aa
//
