LOCUS       NM_001199676            4903 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase kinase 2,
            beta (Camkk2), transcript variant 1, mRNA.
ACCESSION   NM_001199676
VERSION     NM_001199676.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4903)
  AUTHORS   Mattingly,B.T., Kambrath,A.V., Ding,X., Thompson,W.R. and Sankar,U.
  TITLE     Conditional loss of CaMKK2 in Osterix-positive osteoprogenitors
            enhances osteoblast function in a sex-divergent manner
  JOURNAL   Bone 184, 117113 (2024)
   PUBMED   38703937
  REMARK    GeneRIF: Conditional loss of CaMKK2 in Osterix-positive
            osteoprogenitors enhances osteoblast function in a sex-divergent
            manner.
REFERENCE   2  (bases 1 to 4903)
  AUTHORS   Han,F., Wu,S., Dong,Y., Liu,Y., Sun,B. and Chen,L.
  TITLE     Aberrant expression of NEDD4L disrupts mitochondrial homeostasis by
            downregulating CaMKKbeta in diabetic kidney disease
  JOURNAL   J Transl Med 22 (1), 465 (2024)
   PUBMED   38755664
  REMARK    GeneRIF: Aberrant expression of NEDD4L disrupts mitochondrial
            homeostasis by downregulating CaMKKbeta in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4903)
  AUTHORS   Virga,D.M., Hamilton,S., Osei,B., Morgan,A., Kneis,P., Zamponi,E.,
            Park,N.J., Hewitt,V.L., Zhang,D., Gonzalez,K.C., Russell,F.M.,
            Grahame Hardie,D., Prudent,J., Bloss,E., Losonczy,A., Polleux,F.
            and Lewis,T.L. Jr.
  TITLE     Activity-dependent compartmentalization of dendritic mitochondria
            morphology through local regulation of fusion-fission balance in
            neurons in vivo
  JOURNAL   Nat Commun 15 (1), 2142 (2024)
   PUBMED   38459070
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4903)
  AUTHORS   Chen,M., Zhu,J.Y., Mu,W.J., Luo,H.Y., Li,Y., Li,S., Yan,L.J.,
            Li,R.Y. and Guo,L.
  TITLE     Cdo1-Camkk2-AMPK axis confers the protective effects of exercise
            against NAFLD in mice
  JOURNAL   Nat Commun 14 (1), 8391 (2023)
   PUBMED   38110408
  REMARK    GeneRIF: Cdo1-Camkk2-AMPK axis confers the protective effects of
            exercise against NAFLD in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4903)
  AUTHORS   Negoita,F., Addinsall,A.B., Hellberg,K., Bringas,C.F., Hafen,P.S.,
            Sermersheim,T.J., Agerholm,M., Lewis,C.T.A., Ahwazi,D.,
            Ling,N.X.Y., Larsen,J.K., Deshmukh,A.S., Hossain,M.A.,
            Oakhill,J.S., Ochala,J., Brault,J.J., Sankar,U., Drewry,D.H.,
            Scott,J.W., Witczak,C.A. and Sakamoto,K.
  TITLE     CaMKK2 is not involved in contraction-stimulated AMPK activation
            and glucose uptake in skeletal muscle
  JOURNAL   Mol Metab 75, 101761 (2023)
   PUBMED   37380024
  REMARK    GeneRIF: CaMKK2 is not involved in contraction-stimulated AMPK
            activation and glucose uptake in skeletal muscle.
REFERENCE   6  (bases 1 to 4903)
  AUTHORS   Peters,M., Mizuno,K., Ris,L., Angelo,M., Godaux,E. and Giese,K.P.
  TITLE     Loss of Ca2+/calmodulin kinase kinase beta affects the formation of
            some, but not all, types of hippocampus-dependent long-term memory
  JOURNAL   J Neurosci 23 (30), 9752-9760 (2003)
   PUBMED   14586002
  REMARK    GeneRIF: findings suggest CaM kinase kinase beta isoforms are
            required for the formation of hippocampal long-term memory[LTM],
            but not needed for contextual, trace fear, and passive avoidance
            LTM
REFERENCE   7  (bases 1 to 4903)
  AUTHORS   Vinet,J., Carra,S., Blom,J.M., Harvey,M., Brunello,N., Barden,N.
            and Tascedda,F.
  TITLE     Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase
            beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha
            distribution in the adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 111 (1-2), 216-221 (2003)
   PUBMED   12654522
REFERENCE   8  (bases 1 to 4903)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 4903)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4903)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042935.1, AK031399.1, AK032070.1, AC115728.11 and AW045178.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032070.1, SRR7974084.24911.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AK042935.1         2-99
            99-1086             AK031399.1         24-1011
            1087-2375           AK032070.1         1060-2348
            2376-4734           AC115728.11        130576-132934
            4735-4903           AW045178.1         1-169               c
FEATURES             Location/Qualifiers
     source          1..4903
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 62.55 cM"
     gene            1..4903
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /note="calcium/calmodulin-dependent protein kinase kinase
                     2, beta"
                     /db_xref="GeneID:207565"
                     /db_xref="MGI:MGI:2444812"
     exon            1..159
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            160..688
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1984
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /EC_number="2.7.11.17"
                     /note="isoform 1 is encoded by transcript variant 1; caMKK
                     2; caM-KK 2; caMKK beta; caM-KK beta; caM-kinase kinase 2;
                     caM-kinase kinase beta; calcium/calmodulin-dependent
                     protein kinase kinase beta"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 2 isoform 1"
                     /protein_id="NP_001186605.1"
                     /db_xref="CCDS:CCDS80395.1"
                     /db_xref="GeneID:207565"
                     /db_xref="MGI:MGI:2444812"
                     /translation="MSSCVSSQPTSDRVAPQDELGSGGGSREGQKPCEALRGLSSLSI
                     HLGMESFIVVTECEPGRGVDLNLARDQPPEADGQELPLEASDPESRSPLSGRKMSLQE
                     PSQGGPASSSNSLDMNGRCICPSLSYSPASSPQSSPRMPRRPTVESHHVSITGLQDCV
                     QLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGARP
                     APGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVM
                     EVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS
                     NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMD
                     ERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHG
                     AEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREER
                     SLSAPGNLLTKKPTREWEPLSEPKEARQRRQPPGPRAGPCGGGGSALVKGGPCVESWG
                     APAPGSPPRMPPLQPEEVMEPE"
     exon            689..736
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            737..790
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            791..842
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            843..976
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1013
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1035
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1124
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1324
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1378
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1452
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1540
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1669
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1770
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1813
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..4889
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4863..4868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /note="hexamer: AATAAA"
     polyA_site      4889
                     /gene="Camkk2"
                     /gene_synonym="6330570N16Rik; mKIAA0787"
                     /note="major polyA site"
ORIGIN      
        1 caatcagcaa ggagcccgag gcgccgccgc gccgcgcgcg agccgaagcc cgggcggctc
       61 ctcccgtgga gagccgaacc ggaccgagcc gagccgagcc aagccgagcc aagccgagcc
      121 gggggcgcag agcgcgggag gcggcggcgc ggagcccagg cagctctgct gctgatggga
      181 gcgcccccgc ctggctgatg aggttggtac acacaccatg tcatcatgtg tctctagcca
      241 gcccaccagc gaccgggtgg ccccccagga tgagctggga agtgggggtg gcagccggga
      301 aggccagaag ccctgtgagg cactgcgggg actctcatcc ttaagtatcc acttgggcat
      361 ggaatccttc atcgtggtca ccgagtgtga gccaggccgg ggtgtggacc tcaacctggc
      421 cagagaccag cctccggagg ccgatggcca ggaactcccc ctcgaagcct cggaccctga
      481 gtcccggtcc ccgctttctg gtcgcaagat gtccctgcag gagccgtccc agggcgggcc
      541 ggcatccagc agcaacagcc tggacatgaa tggacgctgc atctgcccat ccctgtccta
      601 ctcaccagcc agctccccac agtcctctcc ccggatgccc cggcggccca cagtagagtc
      661 acaccacgtc tccattaccg gtttgcagga ctgcgtgcag ctgaatcagt acaccctgaa
      721 ggatgaaatt ggaaagggct cctatggtgt tgtcaagctg gcctacaatg aaaatgacaa
      781 tacttattac gcaatgaaag tgctgtccaa aaagaagctg atccgacagg ctggcttccc
      841 acgtcgcccc ccaccacgag gagctcgccc agccccaggg ggctgcatcc agcccagggg
      901 ccccatcgag caagtgtacc aggagattgc tatcctcaaa aagctggatc atcccaacgt
      961 ggtgaagctg gtagaggtcc tggatgaccc taatgaggac catctgtaca tggtgtttga
     1021 gttggtgaac caagggcctg taatggaagt gcccaccctc aagccactgt ccgaagacca
     1081 ggcccgcttc tacttccagg atctgatcaa aggcatagag tacttgcatt accagaagat
     1141 catccatcgg gacatcaaac cttccaacct cctggtgggg gaagacgggc acatcaagat
     1201 tgccgacttc ggtgtaagca acgagttcaa gggcagcgac gccttgctgt ctaacaccgt
     1261 gggcacacct gccttcatgg cacccgagtc gctctcagag acccgcaaga tcttctccgg
     1321 aaaggcgttg gatgtttggg ccatgggtgt gacgctgtac tgctttgtct ttggccagtg
     1381 ccctttcatg gatgaacgaa tcatgtgttt gcacagtaag atcaagagtc aggccctgga
     1441 gtttcccgac cagcccgata tagccgaaga cttgaaagat ctgatcactc ggatgttgga
     1501 caaaaatcca gagtccagga ttgtggtgcc tgaaatcaag ctgcaccctt gggttacgag
     1561 gcacggggcc gagccattgc cgtcggagga cgagaactgc acactggtcg aggtgaccga
     1621 agaggaggtc gagaattcag tcaaacacat tcccagcctg gcaactgtga tcctggtaaa
     1681 gaccatgatt cgaaagcgct cattcgggaa cccgttcgaa ggtagccgcc gggaggaacg
     1741 ttccctgtca gcgcctggaa acctgctcac caaaaaacca accagggagt gggagccctt
     1801 gtctgagccc aaggaagcaa ggcagcgaag acagcccccg gggcccagag ccggcccctg
     1861 tgggggagga ggaagtgctc ttgtgaaagg tggtccctgc gtggaaagtt ggggggctcc
     1921 ggcccctggc tccccaccac gcatgcctcc actgcagccc gaggaggtga tggagccgga
     1981 gtagctgcgt ggaccacctg acctcgcatg cctggctgtg tggccctgca cggggctgct
     2041 gcaccctgcg tttccatagc agcatgtcct acggaaacca agcacgtgtg tagagccttg
     2101 actgtcgtct ctggttatct gttttttttg tttttgtttt ttttgttgtt gttgctgttg
     2161 tttttcttgt ggtttttctt tttctttttt ttctttccct ttgttgtcta aggggacaaa
     2221 gaaaaaaaaa aggacttgac tccatgtcgt cgactttggc cgctggctgg ccggaccggc
     2281 gggtgtgagg agttgcaaac cgaaaccaac atgcattttg ggacaattgc tttttaaaat
     2341 gtttttaatg ccaaaaacaa acaaacaaac aaaaacccgc cccctccatt gtgaattcag
     2401 aaccatgtca gatgtaccag gtgaatgtgt gtggggtttg agctgcgtgg agaatcacgt
     2461 ggggcgagtc ctgccggctg gggctacact gggggggggg gggcggatta gaaggatcgg
     2521 tgtgacccac gtacaaaccc catgcctggg cgccttccag gatcatggaa agacagggct
     2581 agccctcagt agctgcaggg aacttccatg tcatttattt gtaatgagga ctttttaagt
     2641 gtgtgtgtgt gtttttttta atgggtataa ttatagtcag gaaaactaca agggcttgca
     2701 gttgaaatgc tcgaggggta ctttgcaccc ctgaatgcga gcattcctca gctgtggtgg
     2761 tagaggtctg tctggaggct gaacacactt catgttagct gctccaactg ggtttctgag
     2821 attgtcagct aagctaattc tctttgtaaa ttggcaaaaa aaaaaaaaaa aaaaacaacc
     2881 aaaaacaaaa aaaaaaaaaa cccaacaact tcaggttgga atctgctctt tcatgtacat
     2941 tacatggctt acagctcaag agatgtttcc aagtctctga ctagccagaa ctccggagag
     3001 gttcacaagt tccaaaggtt ggagcttcca ggatgggtgt ccctctgtgc ggctgtgtga
     3061 cagggaccga gagccggtga gacctgtgcc tgtatattag cagctgcgtt tgtttattgc
     3121 ctgtgtattc tagagactgt aaactttctt tccttttcca gaatgtctgg tcggtacaat
     3181 gaaacatcag tttccctgtg ggccacttag gcaagacttg tcactcagct taggagcaaa
     3241 gctgtagtgt gatatcagtg acatcagggt gccattgtag agcaaagtgt caaaccccag
     3301 agtgttcctc agggcaaagg gctttcgggt ttttttttgt tgttgttgtt gttttttgtt
     3361 tttttcctgt agccagaaac ctagagagcc aataggaacc tttttgactt tcaaccaata
     3421 ttggaagttt ggttgaagtt tgggtgtgat gacccaggga cacagaagca aacaggaagt
     3481 taaagggggg cttccagact ggtttccagt gctttggtag tggctgtctt gccagtcagt
     3541 catggggccc agacaaccga cttctggcct gtgcggaggc caggccctcc tggcttcctt
     3601 ccgtatggtt tgttaagctc tttactgtgg tctagccgct atccctgctg tcacataagc
     3661 agttaggatc caggtacaga ctgcagtgtg gggagggtct gtgtgaccaa ggacttcctg
     3721 tcacttttcc ctttttaaaa ttgaaggaga aacagcccag tagctccacc ctttctggcc
     3781 acagatggca ttccgttagt ttgcaatagc caccttatgg ttaaagccaa caggtcatac
     3841 agcttggtcc cagctcgtct gcctggacgc tgagcggcct gcccgagtag ggtaggcgtg
     3901 atacagagct ctgcagaatt cttgtgttta cacaacccct ctgggcaatg ccgtggtttc
     3961 tctcgacagg atgtcttaag attgtcggca atcacgcagc caccagctgc tcaggaagaa
     4021 ggaatcgaga ggtctgcatg ggtaactttt tttcttaaag aaacaccaaa gaaagctgtg
     4081 gaaaggagtg actccccccc cccccgtccc cctcccccca cccccatcct gcccagctgc
     4141 cgtggaaagt gtaagaggtc cagccataac tagagcatta gagcacaaat aattgttttt
     4201 caaaagtatc attagtgagg agaggagccg ggcagagtgg cttttctctg tgggcagatg
     4261 ggctgcccac aattccttcc atggctggtt cacccgtgat tcgcgtgtaa gcagcttggc
     4321 cttgaaagca caagcctcgt tcctctcttt ctgtctttat tgcctccccc catgcgtctc
     4381 ataggctccc agaacacctt acagagcccc ttgttctccc ttggggctgc ataggccacc
     4441 tcccagggtc tggcctttcc aggggacaga atccttatcc ttgaaccttt ctaggcgcag
     4501 gataacatct gtgcaagttg acaccaggtt aggcctgcaa ctctcgccca tcctccaggg
     4561 ggcgcacttt acattgccaa ccacagcctc cattggctcc caaggtgcta gggaagattg
     4621 ttggtttctg tcttctccag ctctgtgggt tcgagtttcg tgggacttgg gacttttata
     4681 tttggtgacc agtgccctcc gcttctgttt gactccccgt gacctctcta ctatgcattt
     4741 ccctttttat caggtgtata aagttaaata ctgtgtattt atcacttaca agaacatgaa
     4801 cttaaaaaag atgagctttc ggttgttttt ccacaggtga tcaagcttct gtgtaaactt
     4861 gaaataaaca gacagcaaaa tggtgcaaaa aaaaaaaaaa aaa
//
