LOCUS       NM_018883               3486 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase kinase 1,
            alpha (Camkk1), transcript variant 1, mRNA.
ACCESSION   NM_018883 XM_488602
VERSION     NM_018883.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3486)
  AUTHORS   Urbanek,M.E. and Zuo,J.
  TITLE     Genetic predisposition to tinnitus in the UK Biobank population
  JOURNAL   Sci Rep 11 (1), 18150 (2021)
   PUBMED   34518561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3486)
  AUTHORS   Horigane,S., Ageta-Ishihara,N., Kamijo,S., Fujii,H., Okamura,M.,
            Kinoshita,M., Takemoto-Kimura,S. and Bito,H.
  TITLE     Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIalpha pathway
            during neuronal polarization
  JOURNAL   Mol Brain 9, 8 (2016)
   PUBMED   26772170
  REMARK    GeneRIF: the CaMKK-CaMKIalpha cascade is required for the axonal
            growth effect of Wnt5a during neuronal polarization.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3486)
  AUTHORS   Ferey,J.L., Brault,J.J., Smith,C.A. and Witczak,C.A.
  TITLE     Constitutive activation of CaMKKalpha signaling is sufficient but
            not necessary for mTORC1 activation and growth in mouse skeletal
            muscle
  JOURNAL   Am J Physiol Endocrinol Metab 307 (8), E686-E694 (2014)
   PUBMED   25159322
  REMARK    GeneRIF: Data (including data from knockout mice) suggest that
            up-regulation of Camkk1 and calcium signaling stimulates muscle
            growth via up-regulation of mTORC1 (mammalian target of rapamycin
            complex 1) signaling and muscle protein biosynthesis.
REFERENCE   4  (bases 1 to 3486)
  AUTHORS   Hinkley,J.M., Ferey,J.L., Brault,J.J., Smith,C.A., Gilliam,L.A. and
            Witczak,C.A.
  TITLE     Constitutively active CaMKKalpha stimulates skeletal muscle glucose
            uptake in insulin-resistant mice in vivo
  JOURNAL   Diabetes 63 (1), 142-151 (2014)
   PUBMED   24101676
  REMARK    GeneRIF: caCaMKKalpha stimulates glucose uptake additively with
            insulin, and in insulin-resistant muscle, and alters the
            phosphorylation of TBC1D1/TBC1D4.
REFERENCE   5  (bases 1 to 3486)
  AUTHORS   Racioppi,L., Noeldner,P.K., Lin,F., Arvai,S. and Means,A.R.
  TITLE     Calcium/calmodulin-dependent protein kinase kinase 2 regulates
            macrophage-mediated inflammatory responses
  JOURNAL   J Biol Chem 287 (14), 11579-11591 (2012)
   PUBMED   22334678
REFERENCE   6  (bases 1 to 3486)
  AUTHORS   Blaeser,F., Sanders,M.J., Truong,N., Ko,S., Wu,L.J., Wozniak,D.F.,
            Fanselow,M.S., Zhuo,M. and Chatila,T.A.
  TITLE     Long-term memory deficits in Pavlovian fear conditioning in
            Ca2+/calmodulin kinase kinase alpha-deficient mice
  JOURNAL   Mol Cell Biol 26 (23), 9105-9115 (2006)
   PUBMED   17015467
REFERENCE   7  (bases 1 to 3486)
  AUTHORS   Schmitt,J.M., Wayman,G.A., Nozaki,N. and Soderling,T.R.
  TITLE     Calcium activation of ERK mediated by calmodulin kinase I
  JOURNAL   J Biol Chem 279 (23), 24064-24072 (2004)
   PUBMED   15150258
  REMARK    GeneRIF: ERK activation and neurite outgrowth in response to
            depolarization are mediated by CaMKK activation of CaMKI
REFERENCE   8  (bases 1 to 3486)
  AUTHORS   Takemoto-Kimura,S., Terai,H., Takamoto,M., Ohmae,S., Kikumura,S.,
            Segi,E., Arakawa,Y., Furuyashiki,T., Narumiya,S. and Bito,H.
  TITLE     Molecular cloning and characterization of CLICK-III/CaMKIgamma, a
            novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein
            kinase (CaMK)
  JOURNAL   J Biol Chem 278 (20), 18597-18605 (2003)
   PUBMED   12637513
REFERENCE   9  (bases 1 to 3486)
  AUTHORS   Vinet,J., Carra,S., Blom,J.M., Harvey,M., Brunello,N., Barden,N.
            and Tascedda,F.
  TITLE     Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase
            beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha
            distribution in the adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 111 (1-2), 216-221 (2003)
   PUBMED   12654522
REFERENCE   10 (bases 1 to 3486)
  AUTHORS   Lawson,N.D., Zain,M., Zibello,T., Picciotto,M.R., Nairn,A.C. and
            Berliner,N.
  TITLE     Modulation of a calcium/calmodulin-dependent protein kinase cascade
            by retinoic acid during neutrophil maturation
  JOURNAL   Exp Hematol 27 (11), 1682-1690 (1999)
   PUBMED   10560916
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670399.4, AK144483.1 and AI846603.1.
            
            On May 1, 2018 this sequence version replaced NM_018883.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017529.1, AF117384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL670399.4         42849-42868
            21-1305             AK144483.1         2-1286
            1306-3357           AK144483.1         1556-3607
            3358-3486           AI846603.1         1-129               c
FEATURES             Location/Qualifiers
     source          1..3486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.12 cM"
     gene            1..3486
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /note="calcium/calmodulin-dependent protein kinase kinase
                     1, alpha"
                     /db_xref="GeneID:55984"
                     /db_xref="MGI:MGI:1891766"
     exon            1..140
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            141..541
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1699
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /EC_number="2.7.11.17"
                     /note="calcium calmodulin dependent protein kinase kinase
                     alpha; caM-kinase kinase 1; caM-kinase IV kinase;
                     caM-kinase kinase alpha"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase
                     kinase 1"
                     /protein_id="NP_061371.2"
                     /db_xref="CCDS:CCDS24993.1"
                     /db_xref="GeneID:55984"
                     /db_xref="MGI:MGI:1891766"
                     /translation="MESGPAVCCQDPRAELVDRVAAINVAHLEEADEGPEPARNGVDP
                     PPRARAASVIPGSASRPTPVRPSLSARKFSLQERPAGSCLGAQVGPYSTGPASHISPR
                     SWRRPTIESHRVAISDTEDCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLS
                     KKKLLKQYGFPRRPPPRGSQATQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVL
                     DDPAEDNLYLVFDLLRKGPVMEVPCDKPFPEEQARLYLRDIILGLEYLHCQKIVHRDI
                     KPSNLLLGDDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKAL
                     DVWATGVTLYCFVYGKCPFIDDYILTLHRKIKNEAVVFPEEPEVSEDLKDLILRMLDK
                     NPETRIGVSDIKLHPWVTKHGEEPLPSEEEHCSVVEVTEEEVKNSVRLIPSWTTVILV
                     KSMLRKRSFGNPFEPQARREERSMSAPGSLLMKEGCGEGCKSPELPGVQEDEAAS"
     exon            542..589
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            590..643
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            644..695
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            696..829
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            830..866
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            867..888
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            889..977
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1177
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1231
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1305
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1393
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1522
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1626
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..3479
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3410..3415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /note="hexamer: TATAAA"
     polyA_site      3434
                     /gene="Camkk1"
                     /gene_synonym="caM-KK 1; caM-KK alpha; Camkk; caMKK 1;
                     caMKK alpha; CaMKKalpha"
                     /note="major polyA site"
ORIGIN      
        1 ggggggagcg agcgcagcct ggagctgcgg cgccagcggg ttgagccggg cgatcctagc
       61 ccggcaaggc gggcagggcg gggcgcgcac agcgggagcg agcctggtgc ccaccgcaga
      121 gactgtcgcc aggtgcctag gttcccaaca aggttctaca gactgtctgc tgactggagt
      181 gatggagagt ggcccagccg tctgctgcca agaccctcgt gcagagctgg tggatcgggt
      241 ggcggccatc aatgtggccc acttggaaga agcagatgag ggtccagagc ctgccaggaa
      301 tggtgtggat cctccacccc gggccagagc tgcctccgtg atccctggca gtgcttcaag
      361 acccactcca gtgcgcccca gcctctcggc tagaaagttc tccctgcagg aacgaccagc
      421 tggaagctgt ctgggggctc aagttgggcc ttactctaca ggacctgcca gtcacatctc
      481 tcctcggtcc tggcggagac ccaccatcga gtcccaccgt gtggccatct cagacacaga
      541 ggactgtgtg caactgaacc agtacaagct gcagagtgag attggcaagg gtgcctatgg
      601 tgtggtgagg ctggcctaca acgaaagtga agacagacac tatgcaatga aagttctttc
      661 caaaaagaag ttactgaagc agtatggctt tcctcgccgt cctcccccca gagggtccca
      721 agctacccag ggagggccag ccaaacagct gctgcccctg gagcgtgtgt atcaggagat
      781 tgccattcta aagaagctgg accacgtgaa tgtagtcaaa ttgatcgagg tcctggatga
      841 tcccgctgaa gacaacctct atttggtgtt cgacctcctg agaaaagggc cagtcatgga
      901 agtgccctgc gacaagccct tcccagagga gcaagctcgc ctctacctcc gggacatcat
      961 cctgggcctc gagtacttgc actgccagaa gattgtccac agggacatca agccatctaa
     1021 cctactcctt ggggacgacg ggcatgtgaa gatcgccgac tttggtgtca gtaaccagtt
     1081 tgaggggaat gatgctcagc tgtccagtac ggcagggacc ccggcattca tggccccgga
     1141 ggccatttct gattccggcc agagcttcag tgggaaggcc ttggatgtat gggccactgg
     1201 ggtcacgcta tattgctttg tctatgggaa gtgcccgttc attgatgact acatcctgac
     1261 cctgcaccgt aagatcaaga atgaggccgt ggtgttccct gaggagccag aggtcagcga
     1321 ggacctcaaa gacctgatcc tgaggatgct agacaagaat cctgagacaa gaattggggt
     1381 gtcagatatc aagttacacc cttgggtgac caagcatgga gaggagcccc tcccttcaga
     1441 ggaggagcac tgcagtgtgg tggaggtgac cgaggaagag gtgaagaact cagtcaggct
     1501 catccccagc tggaccactg tgatcctggt caagtctatg ctgagaaagc gttcctttgg
     1561 aaacccattc gagccccaag cacgcaggga agaaagatcc atgtctgcac caggaagctt
     1621 actgatgaaa gaaggatgcg gagaagggtg caaaagccca gagcttcccg gagtccagga
     1681 ggatgaggct gcgtcctgag tccctgcatg tgcccagggc cgtcggcagc atgctcattc
     1741 cgcacctcca gaggcccacc gccctcatgc aatagtcgcc cctgcaggca gggggctggg
     1801 gaccgcagcc cctctcctgg cccccctcac ccattgtgct gcatgacctg cgcacaggca
     1861 catccaggga caggattgga atgtgtgtca tctggggctt gggggtccca gttggtcctc
     1921 tctgttctga atcatcttgc agggaatatt agaaacccta cctgactggc tggtgaggcc
     1981 caggggagaa ggcaagagat caaaatggca ggtagagacc tggtgggctg cttcttagag
     2041 aacgcccata gggattggtg gcccgcccag ctggtgcaca caaggagggc gattgcctca
     2101 cctctgtgtg gaaggtgctg agtgctggcg tactcagatc tctagcgtgg atgctacgga
     2161 taatggcacg tgcctgggag cagactcacc ttggagaatc cagattcctc tttcattgtc
     2221 ttttacctga gggctggggt gggagcagct gtcgtgggga gcatcttcct ctggcttcag
     2281 gtagtccctg gcacactgtt tggcagtcat ctggacttga cattcatgga ctgtgtttta
     2341 tactctgcac ttgccggaga aagggctgaa gtggatgcag ctcagagcat aggccagagc
     2401 ccagagcagt gtactttgcc tgtcagcctc ccttcctgtc ttatggatct ccggaatgaa
     2461 gggtacagaa taccagcagt gacaaggagg gtcatgactc tcagaactgt ggccccgcag
     2521 atgtggaagt aactgggatc caggctctga gccgacgctg gcttactcac cacatgccta
     2581 tgatgaagga taaactgccc gggtgggagg caggtggccc ttctgccagt tgcttcagtt
     2641 aagggcatca gacggtcagc cacacaggtc agagctgcac acaattggga cacccatgga
     2701 caatgccctt ccagaacaga tgtcagctct ctggattctg tggtcatctg gctattctaa
     2761 tgtttacgaa taatgctcat agggattggt ccccaaaggg agatgagcag gactcaggta
     2821 gccctctctg aaagcctccc ggaagagatc ctggctgccc acttgggttt cagaatgcag
     2881 gaaggctgga ctagaaaaga ggccgggtag gagcactggt tcccactgta tctctgtgcc
     2941 catgggtgta cattgctcct tcatgtgcac atgcgtgtgc gtgcccatct gctgtataca
     3001 gcacacttgc atgtctcata ctggcacatg catctgtaat atagtttcta catcaactta
     3061 tgcctaggag cagcaggtag cccactgtca aagggctccc atttcaaccc aattcctctg
     3121 cactaaggca gccaatggaa cccagggctt gaaaacaaac catctaatcc tatctctaag
     3181 aatactttta tagagtgact gggaggcaag ctaaatacca accagtaaat aacaaggagt
     3241 cagggagctt cgtggatggg acccacatgg gagaagctgt cagttgggtg gctggcctca
     3301 ttgaccccag tggagccagg aagtcatgct cactgttgcc tgttgctgag agctttggtt
     3361 ggctttggtt gtgattgtag cacaagtgaa caaactccat aagagtgttt ataaaactta
     3421 acttcttagg aagtgaatta caaacaataa aaagcccttt gttgagttta aaaaaaaaaa
     3481 aaaaaa
//
