LOCUS       NM_009793              12331 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase IV
            (Camk4), mRNA.
ACCESSION   NM_009793
VERSION     NM_009793.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 12331)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 12331)
  AUTHORS   Xu,M., Ito-Kureha,T., Kang,H.S., Chernev,A., Raj,T., Hoefig,K.P.,
            Hohn,C., Giesert,F., Wang,Y., Pan,W., Zietara,N., Straub,T.,
            Feederle,R., Daniel,C., Adler,B., Konig,J., Feske,S., Tsokos,G.C.,
            Wurst,W., Urlaub,H., Sattler,M., Kisielow,J., Wulczyn,F.G.,
            Lyszkiewicz,M. and Heissmeyer,V.
  TITLE     The thymocyte-specific RNA-binding protein Arpp21 provides TCR
            repertoire diversity by binding to the 3'-UTR and promoting Rag1
            mRNA expression
  JOURNAL   Nat Commun 15 (1), 2194 (2024)
   PUBMED   38467629
  REMARK    Erratum:[Nat Commun. 2024 Aug 5;15(1):6632. doi:
            10.1038/s41467-024-50610-8.. PMID: 39103338]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12331)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 12331)
  AUTHORS   Scherlinger,M., Li,H., Pan,W., Li,W., Karino,K., Vichos,T.,
            Boulougoura,A., Yoshida,N., Tsokos,M.G. and Tsokos,G.C.
  TITLE     CaMK4 controls follicular helper T cell expansion and function
            during normal and autoimmune T-dependent B cell responses
  JOURNAL   Nat Commun 15 (1), 840 (2024)
   PUBMED   38287012
  REMARK    GeneRIF: CaMK4 controls follicular helper T cell expansion and
            function during normal and autoimmune T-dependent B cell responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12331)
  AUTHORS   Li,L., Li,L., Shao,Y., Du,R., Li,L., Shi,X. and Bai,Y.
  TITLE     Calcium/calmodulin dependent protein kinase IV in trophoblast cells
            under insulin resistance: functional and metabolomic analyses
  JOURNAL   Mol Med 29 (1), 82 (2023)
   PUBMED   37386367
  REMARK    GeneRIF: Calcium/calmodulin dependent protein kinase IV in
            trophoblast cells under insulin resistance: functional and
            metabolomic analyses.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 12331)
  AUTHORS   Mock,B.A., Contente,S., Kenyon,K., Friedman,R.M. and Kozak,C.A.
  TITLE     The gene for lysyl oxidase maps to mouse chromosome 18
  JOURNAL   Genomics 14 (3), 822-823 (1992)
   PUBMED   1358813
REFERENCE   7  (bases 1 to 12331)
  AUTHORS   Danciger,M., Kozak,C.A., Adamson,M.C. and Farber,D.B.
  TITLE     Chromosomal localization of the murine genes for the alpha- and
            beta-subunits of calcium/calmodulin-dependent protein kinase II
  JOURNAL   Mamm Genome 3 (2), 122-125 (1992)
   PUBMED   1319776
REFERENCE   8  (bases 1 to 12331)
  AUTHORS   Jones,D.A., Glod,J., Wilson-Shaw,D., Hahn,W.E. and Sikela,J.M.
  TITLE     cDNA sequence and differential expression of the mouse
            Ca2+/calmodulin-dependent protein kinase IV gene
  JOURNAL   FEBS Lett 289 (1), 105-109 (1991)
   PUBMED   1893997
REFERENCE   9  (bases 1 to 12331)
  AUTHORS   Sikela,J.M., Adamson,M.C., Wilson-Shaw,D. and Kozak,C.A.
  TITLE     Genetic mapping of the gene for Ca2+/calmodulin-dependent protein
            kinase IV (Camk-4) to mouse chromosome 18
  JOURNAL   Genomics 8 (3), 579-582 (1990)
   PUBMED   1981056
REFERENCE   10 (bases 1 to 12331)
  AUTHORS   Sikela,J.M., Law,M.L., Kao,F.T., Hartz,J.A., Wei,Q. and Hahn,W.E.
  TITLE     Chromosomal localization of the human gene for brain
            Ca2+/calmodulin-dependent protein kinase type IV
  JOURNAL   Genomics 4 (1), 21-27 (1989)
   PUBMED   2536634
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ104330.1, BC070420.1 and AC114919.5.
            
            On Nov 27, 2007 this sequence version replaced NM_009793.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.110308.1,
                                           SRR1660819.96063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               CJ104330.1         2-120
            120-1907            BC070420.1         1-1788
            1908-12331          AC114919.5         112317-122740
FEATURES             Location/Qualifiers
     source          1..12331
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.15 cM"
     gene            1..12331
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /note="calcium/calmodulin-dependent protein kinase IV"
                     /db_xref="GeneID:12326"
                     /db_xref="MGI:MGI:88258"
     exon            1..504
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1765
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /EC_number="2.7.11.17"
                     /note="caMK IV; CAM kinase-GR; Ca2+/calmodulin-dependent
                     protein kinase type IV/Gr"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     IV"
                     /protein_id="NP_033923.2"
                     /db_xref="CCDS:CCDS29122.1"
                     /db_xref="GeneID:12326"
                     /db_xref="MGI:MGI:88258"
                     /translation="MLKVTVPSCPSSPCSSVTASTENLVPDYWIDGSNRDPLGDFFEV
                     ESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKE
                     IFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRD
                     LKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEV
                     DMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKL
                     IVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSR
                     LGSASSSHTSIQENHKASSDPPSTQDAKDSTDLLGKKMQEEDQEEDQVEAEASADEMR
                     KLQSEEVEKDAGVKEEETSSMVPQDPEDELETDDPEMKRDSEEKLKSVEEEMDPMTEE
                     EAPDAGLGVPQQDAIQPEY"
     exon            505..583
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            584..646
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            647..729
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            730..802
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            803..893
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            894..968
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1044
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1171
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1324
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..12331
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1907
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
     regulatory      12308..12313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /note="hexamer: AATAAA"
     polyA_site      12328
                     /gene="Camk4"
                     /gene_synonym="A430110E23Rik; CaMKIV; CaMKIV/Gr;
                     D18Bwg0362e"
                     /note="major polyA site"
ORIGIN      
        1 tggccctgcg gcagcctcag cctggaaggg agagcacagg gagggggctg gcagggcagg
       61 cgggagggag gcacggaggt ggggcggcgg gagcgagggg gagggcgcct gagctctgcg
      121 gttccctgcc tggtctctgc cggctggcgg tggctccggg ttcccctgcg ccggtgctcg
      181 cggtctcggg catctccgcc cgccctcgct cccgagcgcg gaggcgagcc gcagcccagc
      241 gcggcggtgg gcgtgtgcgc gctgaaggac gcctcctctc gctcccgtgt tgcaggcggc
      301 ggccggcggc tcgagctccg gcagcggcgg cgtcttccgg agtcccgcgg cgaagatgct
      361 caaagtcacg gtgccctcct gtccctcctc gccctgctcc tcggtcaccg ccagtactga
      421 gaacctcgtc ccggattact ggatcgacgg ctctaaccga gatcctctgg gcgatttctt
      481 cgaggtggag tcagagctgg gacggggtgc tacatccatt gtgtacagat gcaaacagaa
      541 ggggacccag aagccctatg ctctcaaagt gttaaagaaa acagtggaca agaagattgt
      601 gagaacagaa ataggagttc tcctgcgtct ctcacacccg aacatcataa aactcaagga
      661 aatattcgaa acccccacag aaatcagcct ggtccttgag ctggtcacag gaggagaact
      721 gtttgacagg attgtggaga agggatacta cagtgagcgc gatgcggctg acgcggtgaa
      781 gcagatcctg gaggccgttg cttacctgca tgaaaatggg attgtccatc gtgacctcaa
      841 accagagaat cttctttatg caactccagc ccctgatgca cccctcaaaa ttgctgattt
      901 tggactttca aaaattgtgg aacatcaagt gctcatgaag acagtgtgtg gaaccccggg
      961 gtactgcgca cctgagattc tccgaggctg tgcctacgga cctgaggtgg acatgtggtc
     1021 tgtaggaata atcacctaca tcctactttg tggatttgaa ccattctatg acgagcgagg
     1081 tgatcagttc atgttcagga gaattctgaa ttgtgaatat tactttatct ccccctggtg
     1141 ggatgaagtg tctttaaatg ccaaggactt ggtcaaaaag ctcattgttt tggatcccaa
     1201 gaaacggctg actacatttc aagccctcca acacccatgg gtcacaggta aagcggccaa
     1261 ctttgttcac atggacactg ctcagaagaa acttcaagaa ttcaatgctc ggcgcaagct
     1321 taaggcagcg gtgaaggctg tggtggcctc ttctcggctg ggaagtgcca gcagtagcca
     1381 caccagcatc caagagaacc acaaggccag ctcggatcca ccttcaaccc aagatgccaa
     1441 ggacagcaca gatcttctgg gaaagaaaat gcaagaggag gaccaagagg aggaccaagt
     1501 ggaggccgag gcttcagccg atgagatgag gaagctgcag tccgaggagg tggagaaaga
     1561 tgcaggtgta aaagaggagg agacctccag tatggtgcct caggatccag aggatgagct
     1621 ggaaacagat gacccagaga tgaagaggga ttcagaggag aagctgaaga gtgtggagga
     1681 agaaatggac cccatgactg aggaggaagc ccctgacgcg ggacttgggg ttccacagca
     1741 ggatgcgatt cagccagagt actaagctgg cttcctttag gtcagggcca accccagcat
     1801 tttatgcact ctgtccctca gcaaggcggg gaagcatgat atgcactata gtgattctgt
     1861 tttgaggtgc aaaaaaaaaa cccatatata ccagttggta accctaatgt cagtgcatgt
     1921 gtttgcttta tgaaataatg acattttcta tggcatgtaa tggataccta atactgatga
     1981 gttaaatttg aaatttctag caaacaacgc aacacttaaa cattctcagc ctttggtggc
     2041 acatattgaa gtgaaatggc aaacagactt tgaaagctta ggcatcctac acccactaga
     2101 agtcttcaaa gagggcaatt cctttgaact cagctaaaac cagctggagg tagaggacac
     2161 actcccatga cttttcaaat acttgcagtg ggaagggccg agtaggccgt tttaaaagta
     2221 ggctgaagat ggttataaaa gataacctgt agaacgtgca aaaacatcca tgtacagtgt
     2281 tgagaagttg agtcattctt acaaggctct gagtccacag tcctcttaag tgtatgcaga
     2341 gaatgtctta tttttcttta gtatactcta taagaatacc caaaatgttc agtataaaat
     2401 tctgccagtt tacaattctt gggaaattaa tttttaaact gtgccgctac ttttcctcta
     2461 cctgcctttc aaataaaata ccccgcagag tatacagcct aggaaagagg aaatttaact
     2521 aaaatgagat agaattaggc tttggatgta ccaagattaa ctccttttca tttctcacaa
     2581 aaatttgcat ttgtgagctt atatgatatt ttgcatatca gaacattttt atggatacac
     2641 tctgcaagta gcaagtttca agttttggaa aagcccattg tacaagtcga ggccaaaatg
     2701 tctgaatctt ataacaatac attcaatggt tagattactt agtactgagg ttgttagagt
     2761 aaggaaatgt tagcacagga tattcccctc cacctatgta tacatactgt tcattaaaat
     2821 tcactatgag agctaggagc ttttccaatg gaggggttta cacattttat aatgttgaaa
     2881 tatgttgaat atatgccaag aaatttagca tagtgtgaac tttttttttt tttgccttaa
     2941 aaataagcaa aaccaaaaat aaaataaaaa cacatcttga actagacctc ggagagggca
     3001 cagcattaga tcttagttag catgattttc ttcttagaat aattgggggg gggggtatac
     3061 gaaatccaat acctcaaatt ttgtgtttga gtgaaaatga gcactttatc aaaatagctg
     3121 tttaatattt tgtgtggatt ttcttgactt aaaaaaaagt attactttta aagtccaaaa
     3181 tgggggcagg aaaaatgaat agcacagaat ttttttttca ttaaactaat aatttgttct
     3241 gacgcgttca gtcacactgg gaactgacgt tctatcagag gtttctccag gctgttagag
     3301 tgtcagcact tcagcaggtc aagcacaaac ctctgacagc ttttggggaa ggagacagtg
     3361 tggtgctttg agcattttgt gaatgggtcc ttgacaggca gctgactagg agggcatcat
     3421 ctgacgaggg tgattctttt cctgttgact tccattcaca gtgtttatgc tcctcctcct
     3481 gtttgaattc ttccctcttg gaagacctca ttctgagggt cataaagggc tccctagttt
     3541 taacttttaa gagtgctttg ttacgatttc catttaggaa gagcaattcc ctggtgtaat
     3601 tttcctcatc aaacttacca tatgtatggt gagtttccca tatttggaaa gagtagagaa
     3661 gactaggggg tcttgttaga agatggcatc taaatatcag aacatatcat tgctcaaacc
     3721 cagcccaggc ctttcttcat cccagcatat gctgaatgcc tcgaatgacc ctgtaggcta
     3781 taggaagagc attataaatg ccaaggcctc tcggatctca gaatcagttg cttaaatgat
     3841 tgtatctcat cccttcttgg tggaactcaa gagttctagc acaattccct ccctctcttt
     3901 cataacctac acatttcact agctaaacat catgagtagg tttcatttgt aactggtaca
     3961 ctaaagatta agtcctacta atacttacaa cctttcgctc aaatcattca gagattccat
     4021 ctaagaataa ttattttacc cacttaaaag aacaatcaac atttatattg cttgttaaaa
     4081 ttatattatc tatttcaaag attatgtaaa ctgaaggaag acagtcttaa tttgaaagaa
     4141 tacgttctaa tattactctt aattgttaat tgtctttgtt agggttttac tcctctgaag
     4201 agacaccatg accaaagcaa ctcttgtcat ggaaaacact taattggggg ctggcttaca
     4261 gttttagagg ttcaatccat tatcatcatg gcaggaagca gggcagcatc caggccaata
     4321 tagtgctgga gaagagacag agttctacat cttaattcaa aggtagcagc aggagactct
     4381 ggatcacact gaccagattt aagcatatat ataagcggga catcaaagcc ctgcctccac
     4441 actgactacc ttcccctaac aaggccacac ctcctccagt aaggccacac cccctaaata
     4501 atgccacttc ccatgggaca agcacattca aaccaccaca gtaatacagt cacaaagcaa
     4561 aacaaaattt taaatttcag caaatagcaa atatgcattc caaggtggtg ggaggcagag
     4621 gcagacggat ctctgagtcc caaggacagc ctgcctggtc tacagagtaa gttccaagac
     4681 atccagggct gcaaagagaa accctgtatc aacaaaaagc caaagccaaa gagcaacaga
     4741 aaagttacat tcattattgg tttttatttc aagatcagac atatagctta acggggttct
     4801 ttcaccacag aggacagtct gcaaattttt ttctcctatt tagaaagtcc acctgtgctt
     4861 acagtggttt ctcaaactgt tagccctctt gccacaacag cacataaatg agagattaga
     4921 atagaatggt tacaaagtta tcttctgaaa taagtgttta tattaaaaag tataataagg
     4981 tacacatgta aaaacaattc tcagacaagg ttttattatg aattgcaggc tggccttgaa
     5041 ttcactttgt aatctaggct gacctcagac tcacacagtg atcttcctgc ctcatctttc
     5101 cctggatctg gggttataag catatgccac cactcccata accatgcatg tatctttaga
     5161 ttttctatta gctacattct aaaaagaaaa tatggaatta atactatatt ttaatccagt
     5221 atacacatat tattacatca aaattaaaat taataagata atttgaatct attttatact
     5281 gtttctaaat taacagttta agcatgttta catcgggcgg tcatgagcca cattaagcca
     5341 gtggttccta tggtagacat gctagtctag cctagagcac ttttcttcgg agcagagtaa
     5401 gacttgagtt tctatggtca gatctgagct gacttagttt tccacattgg tgagttggtg
     5461 agcagctaag atgcaaatgt tataggtgta gatgcataaa tcctggctac ccctggacat
     5521 gcattttctt aaataaaaaa aagtgatctg tgttatcaca tcaaagtaac acttccttac
     5581 acattgtcaa agtgtatgta ctggtcagag tccagcttat ccccatttgg ctctggaaac
     5641 ctgactgtac cccagtttcc tgagtactgc caaagagcca acagaattcc cacttagcag
     5701 aaattattgt gggcccaccg cgtgtcacca ctgagcagcc tatatacaga gtccattctc
     5761 tagacactga actcagctgg acatcatcct catgtatgca ggcaatcttt ccagaagcct
     5821 cctggaaaat acagttgcat ggtggatatg ttagttgaag gtggtgatat ggcagatacc
     5881 cacaaaatgg aaatgccatc atgtctggca tttgtgaagc ctcatagaag gaactggtca
     5941 acactgacac tgacagattt tttaaaaaag acttttggaa atttttacat actgatttta
     6001 gaataatatc ctaatcgttt tattggcaaa tttatagaga aagagcagct tgccttttaa
     6061 agggaccttg attgcatgcc atttgatatt ttgtaatgta gaatgttcag cattttttta
     6121 attggctatt tccagtataa cacaaggttg ctaattgtga gctgcctgca ggttgaagct
     6181 tgaaagagcc attgtatttc atggttcagt ttttattaca cagaaacagc tggttgcatt
     6241 tcaaattgga aaaagaaaaa caatgccaga aaagacaaca cacttctact ttggaattgt
     6301 tcttatgaag ccaaattaaa aataatttta aaagaggtca tcagcgtgaa ttagcacaga
     6361 acagtcaatt tcgggattat gatgccactg tgtgattgcg aagcactcgt ctggctgtcg
     6421 aggtttattt gagagagcac aaagtttcca gacattactt atgcaatgag atttgtaata
     6481 gctttgtaat tactgtccat taggtcacac cccaatttcc ttaatgtttt ccactgatac
     6541 attaccaatc agcatcatgg ctgacatctg aacaaattcc agttgaacac tgcggaaggt
     6601 tagatcagtg tctgcagtgt ttgttttaat atgcaaatag agtcctatgt tggtgtttat
     6661 agccacacgg atgaaaacgt acaaaatttt ctacctaaaa attttaagac acttaacttt
     6721 cttataaaaa ggtggctctc tagtttcttg aaagtgaagg taggatagaa gagggagaag
     6781 agaggaggga ggagggtaaa agagagagag ggaaggggta gggatacata gattagtaac
     6841 acactcagtg ctgcactgat caggaggttc acatttcttg tttgcattca aagataagct
     6901 tctgtcattt ctctttggga atatcacctg aggtcaaata acatagactc agtccaatcg
     6961 tttttcactt accttggaag gcagtagcaa acaatttatg attggctaaa atcaattttc
     7021 ataaatgatc tgcgacagat tcagaaaggc ttgacactat ctgttcccag gcatctggtc
     7081 cagaagtcca ggtcaaaacc ttgtcataaa accagactgc ctggcattat tgcaggaatc
     7141 agctttaaag atccccagca tctgacctag ttagactcaa gtacagaccc tccatgctct
     7201 gaaggactgt ctctttaaat ccttcactgt tcttgaccaa atgacaagaa aagggaattc
     7261 tgtcaatcac gtttctttgt gtgtcccagt cggggtattg ttttatccat ccagacatca
     7321 gcctcacttt ggaaatgtga agtcctttaa tttctggtag gagcattcta cactaactag
     7381 aggaacaggt tttaggcctc aggttgacac actgatgagg aattctaaga ctgcaaaatc
     7441 acactgctca taattatctt ccttgttttg tgaagattga cttgaaagac ccatagatat
     7501 agatacttac gtccaattta ataattactt tgattcattg tattgaaaat gacgaatatt
     7561 taatcttcag tcaaattaaa taatcttatt ttccacctaa aaggttactt caagataata
     7621 ctcgctgggc agtggtggcg cacgccttta cttccagcac ttgggaggca gaggcaggtg
     7681 gatttctgag tttgaggcca gcctggtcta tagagtgagt tccaggacag ccagggttcc
     7741 agggttccac agagaaaccc tgtctcagaa aaaaaaaaaa aaaaaaaaaa aaaaagataa
     7801 tactcaaaga ggcttcacct ctttgaaact gcttattgaa gctatctcca aatcctgata
     7861 gttatggatg ataaaaatct tctagatgtg cgcttccttt gtcctgtctt tgaaacatgg
     7921 ataacaatat attttgtata tgacacaaat atgaccataa tttgaaaatt atcattgcat
     7981 aatgcctact tttaacctga cctgtttggt atgtctgctt aactaactgt atattatgta
     8041 actaataggc aattgttctg attactaaat agcatattca tgattgatat ctctcctggc
     8101 catggcattc ttggtctcag taatatttta tgaccatcta taaacccaaa gagattttct
     8161 aaattttaag ttctttggtt gaaatggcac agaacttttg tcattctatg tccaacacat
     8221 attgcttttc cccttaaagt ctataaacat ctcatgagtt tggtggctgg gaacagtgac
     8281 ttgagtacag ataaatctaa tgaatgaaag ttacaaacaa atgggctatt agggtgatgt
     8341 tttaagttaa taatcatacc atttgtattc caataatttt tatatcttgt cattgagata
     8401 gatatattct ctagtttctt tgatgtgata aacaccagga ccaaaaacaa ggtagaagag
     8461 gaaaagttct attttatctt agatgctcca gtctaccatg agggaaagct acatcaggac
     8521 cttatggtag gcacctggag gcagaatgta gcacagaaag catgaggaac actgtttcct
     8581 ggcttgctca gctcttacac agcccagggc ccctgcctat ggatggtact gcccacagtg
     8641 ggccaggccc tcacatcagt tagttatcaa ggaaatgcca aacagcaaag ctcaaacgtc
     8701 agtctgatca aggcagtctc taatccagac tccctcatac catttgggga catgtccagc
     8761 tgacagctga agctaactag agcatataaa agtacataca tgtaaaaact tttcccatag
     8821 ggttctccaa agaactaaat ttaaatcccc acaaaacagt tttcagaact taggcaaact
     8881 atagtttaaa gagcaaattt taattaagga cttagattgt aattaattca aacaaatttt
     8941 attataatgg tcagattcat tttatgggtt tttttttttg tctatttgca aattactaga
     9001 atagcatgat tccgtctttt tctgattttt cagcagaaga ccatacaatc tacattacct
     9061 aaaatgtcta tctggccctt tataggaaaa acaaaactca gtttttctct acccgtcatg
     9121 ctctgcgatg accttaggaa tcccttttcc acactgtagc ttctttttgc cttagttaga
     9181 ttctctcatt tgcttcttag aagttaggtg atctttgttt catgttgcaa atggtctcac
     9241 aactgcgtag gaggcaaaaa ttaaaatttc catgtagaac agaaaatgta aagtcacatt
     9301 agttatttct taagaaggaa attgtgtgac ttgagttaaa agtgcgtgtt cagattcttc
     9361 attgttgaac aggttttaga aactttaaag acacgtggat taaacagaaa accataacca
     9421 acactgcctc gtgtcatcgt catgccctat tgcttaacaa gcttcagatg agcactcatt
     9481 ggctccaaac ctcaaatgca atgaaatgat ttctagcaat tcgattttca caaacattta
     9541 ggaagtggtg tgttgttcta tgaaaatgac ttgcttgcca gcagttcagg gaatacagcc
     9601 accttcattt ttaaagttat tttcctttac ccacatgtgt ttctctgagt gttgtacttc
     9661 tcatgtgaaa ggagccgtta gtacatagtt ttctagcaaa tttagaaacc ctctagtcta
     9721 tttctcccct gacaaattac cattccaaaa tatctgcctt aagggaacca agtagcccag
     9781 ttatcaaggg aactttagac atttgtgact ttcctttcag tttgactgtc aactttgtaa
     9841 ccacaaaggt cacaaaagat atactgagta ggagaccttt attcgaccta ccactgggaa
     9901 tagttacaat aaccggcata ttcttttctt taaacagttg cagcaatcag taagatgtta
     9961 tagccactgg gatgttacag aatatgggaa cagcagggca gtggtggcac atgcctttaa
    10021 tcccagcact tgggaggcag aggcaggcag atttctgagt tcaaggccag cctggtctac
    10081 agagtgagtt ccaggacagc cagggctaca cagagaaacc ctgtctcacc gccccccaac
    10141 cacccccccc aaaaaaaaca aacaacaaca aaaaccaaaa aacagaatat gggaacaaat
    10201 gacagagtca ttctctgagc cccggtggtt aacaagggta ggaggcagac tgctggaaca
    10261 agagagggaa aggtcactta atattaggat tccacattct tatctgccag tcttctaggg
    10321 tggctcagag tttgagggca gttattgata tacttcaaac cttaaaatga gttggtgaaa
    10381 attaatatct aattttcctt tcagaaatta tatagtatag cttagaggat atctggccta
    10441 catggaaagc cacggttaag ggcatgactc actaccagca aaacccttcc cagaaataga
    10501 ccattccagg aactctactt cccatagtaa atgttcactg atgagccctt acttgcaata
    10561 caggagtcag aaatgaatta agcacagtgc tgcccttcag ggggagcctt tttagttggg
    10621 aagaaaaggc aggtaaccac acatagcctg tgctgagtac ctacagatgg taagctctcc
    10681 ggggtgggaa aagggaaaat ggtctcacac caaaaatgtg caaggcaagc ttcatgggaa
    10741 cacagctaat attgaaggat gtaccagtcc ctaaggtgga gaaaagggac atgtttgatt
    10801 aaggaatggc cagaccaggg tggagatgca cacttcaagg aggagattaa cgtgggatga
    10861 ggaaggctga gatacccagt gaagtgctat ccagtgtgga gcagtctcag atctcatctg
    10921 agttccttgc tttcttactc tggacagatg ccggtgaagc tcttctgcag agcacctacc
    10981 cctacgactt ggctagcctc ctggtacata gctaacagga taaaaatcac ccaagatatc
    11041 gaagacatgt ttgcaactcc acagctaatc ttcaaacctc aagctggtcc tgccaggttt
    11101 ttaattcttc agtcttctct ccagtgtata taatctatac atttataact ataaattata
    11161 taaaatctaa ggaatttatt atatctctta ttggaggcac tatttttcca ttcatcttca
    11221 agacaccttt ttaaaattac ccattagaat tagattaccc tgtgactact ctggcttgta
    11281 catcttcact tatttctcgt gatatttgtg gatagtagat ggctacattc ctccaggata
    11341 aataaaatga ggagaggtag agacaaagac tgtatctcag ttgaagggga aagatgctaa
    11401 gaaataaaga tgctgtgggg acacagacca ggttagtgga cactaagaaa ggaacacttg
    11461 ctaggagggg gtttctggct aagatggcat tatctgagac actcttgttg atagtttgtc
    11521 agatatgaaa aatacactga tggctgttga aagccttttg gattaatggg acataagtag
    11581 cttcaacaac aacatggaag aatacagaat accaccatat gaaagaaaca cagatttcca
    11641 atagtctgga tcacaactca ttgacccaaa gcaagagctc atatgacttg gaggagaaag
    11701 tctaagtacc ttagtttaca cagctaagac tatggttggc tttttcactt tctaacacaa
    11761 agtcctaaga gggagctgta aacatttcat tttctaaatg tgtcaaaatg gtgctattga
    11821 ttccttaata caaagataga attataatat ttttaggtgt gttaagccca gcttggctat
    11881 aaatgtaaat acataaaatg tttgcaaagc cttcaacaaa aacatgtcca tttgctaaca
    11941 gttgaggtac tgtgttcttc agtgtgggtg actgacctga gtttgcattt tctgttaaag
    12001 gaacaggaca gccactggct ctctctcaac tgccaaaaat ctccgacatt tgcagctcac
    12061 taagttctcc ttggatgcag gttggacaat ccaagtcaag gattaagtat gctcatttgg
    12121 tgatagtggg ggtgttggcc aagaacttgg gggatgtgtg ctgtgagcaa aaccagtgct
    12181 gccagactaa actttagtga ggtccagtgt aactgagttc acccagactg tcagaacatg
    12241 ccaaaggaag ctacccagta ccttgcaact ggtcaacctg tgaaagaatc tgcatgtaca
    12301 atgtgacaat aaatcatcta agagcccacc a
//
