LOCUS       NM_028420               1299 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase II
            inhibitor 2 (Camk2n2), mRNA.
ACCESSION   NM_028420 XM_914405 XM_990809
VERSION     NM_028420.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Nguyen,E.K., Koval,O.M., Noble,P., Broadhurst,K., Allamargot,C.,
            Wu,M., Strack,S., Thiel,W.H. and Grumbach,I.M.
  TITLE     CaMKII (Ca2+/Calmodulin-Dependent Kinase II) in Mitochondria of
            Smooth Muscle Cells Controls Mitochondrial Mobility, Migration, and
            Neointima Formation
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (6), 1333-1345 (2018)
   PUBMED   29599132
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Vigil,F.A., Mizuno,K., Lucchesi,W., Valls-Comamala,V. and
            Giese,K.P.
  TITLE     Prevention of long-term memory loss after retrieval by an
            endogenous CaMKII inhibitor
  JOURNAL   Sci Rep 7 (1), 4040 (2017)
   PUBMED   28642476
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1299)
  AUTHORS   Sebag,S.C., Koval,O.M., Paschke,J.D., Winters,C.J., Jaffer,O.A.,
            Dworski,R., Sutterwala,F.S., Anderson,M.E. and Grumbach,I.M.
  TITLE     Mitochondrial CaMKII inhibition in airway epithelium protects
            against allergic asthma
  JOURNAL   JCI Insight 2 (3), e88297 (2017)
   PUBMED   28194433
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1299)
  AUTHORS   Joiner,M.L., Koval,O.M., Li,J., He,B.J., Allamargot,C., Gao,Z.,
            Luczak,E.D., Hall,D.D., Fink,B.D., Chen,B., Yang,J., Moore,S.A.,
            Scholz,T.D., Strack,S., Mohler,P.J., Sivitz,W.I., Song,L.S. and
            Anderson,M.E.
  TITLE     CaMKII determines mitochondrial stress responses in heart
  JOURNAL   Nature 491 (7423), 269-273 (2012)
   PUBMED   23051746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX215091.1, BC157896.1 and AW120861.1.
            
            On Jun 17, 2008 this sequence version replaced NM_028420.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CX215091.1, AK013788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               CX215091.1         1-176
            177-1045            BC157896.1         154-1022
            1046-1299           AW120861.1         1-254               c
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.48 cM"
     gene            1..1299
                     /gene="Camk2n2"
                     /gene_synonym="2900075A18Rik"
                     /note="calcium/calmodulin-dependent protein kinase II
                     inhibitor 2"
                     /db_xref="GeneID:73047"
                     /db_xref="MGI:MGI:1920297"
     exon            1..253
                     /gene="Camk2n2"
                     /gene_synonym="2900075A18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..324
                     /gene="Camk2n2"
                     /gene_synonym="2900075A18Rik"
                     /note="caM-KIIN; caM-KII inhibitory protein"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase II
                     inhibitor 2"
                     /protein_id="NP_082696.1"
                     /db_xref="CCDS:CCDS49795.1"
                     /db_xref="GeneID:73047"
                     /db_xref="MGI:MGI:1920297"
                     /translation="MSEILPYGEDKMGRFGADPEGSDLSFSCRLQDTNSFFAGNQAKR
                     PPKLGQIGRAKRVVIEDDRIDDVLKGMGEKPPSGV"
     exon            254..1282
                     /gene="Camk2n2"
                     /gene_synonym="2900075A18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1253..1258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk2n2"
                     /gene_synonym="2900075A18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1277
                     /gene="Camk2n2"
                     /gene_synonym="2900075A18Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggctcccctg ctgagctagg gccggtccgg cagctagcct ctgcccgtgc cccgccgcag
       61 tccctagccc gcccggtgcc cgccatgtcc gagatcctac cctacggtga ggacaagatg
      121 ggccgcttcg gcgcagaccc cgaaggttcc gacctctctt tcagctgccg cctgcaggac
      181 accaactcct tcttcgctgg caaccaggcc aagcggcccc ccaagctggg ccagatcggc
      241 cgagccaaga gagtggtgat cgaggatgac cggatagacg acgtgctgaa ggggatgggg
      301 gagaagcctc cgtccggagt gtagacgcgc cggctctggc ggcgggctcc gggcccagcc
      361 ccgcagcggc caggagcacg ggccggcgat gcggctgccg gcgcaccccc gcccggggcc
      421 gaggtgccta cgggcggggg ctgcagggcc acgccgccac ggggtcagtg ttgctaccgc
      481 cgctgccagg cgctccggag ctgtccgctt cagcaccacg gcggcggcgg tagtggtggt
      541 gcggaccagc ccggagcccg ccgacgcact catgcacttt agaacctcgg gccgcagctc
      601 caccccgcac accggaaccg acacagagac ccacggcccc cagcccgccc cctcccgcac
      661 ggctcccctg ccccgcccct cctccgatca atctggtctg cagcccgggc agctgcggcg
      721 tcggactgcg cggccaggga ggtttggctg catatttgca tgagcttcct acccacctca
      781 gcctagccct ccgggcaatt cctcaactgt acccctgtct ggcgtgaccc cagcctcttt
      841 ctaagggact tcctcagcac atttgtattt ttatatccga ttctttgttt actggctccg
      901 ctcatggttt gtgcccttcc cccacagcct ccgccatgct cttctgcgcc tggcagatag
      961 aacaggtgtt gagactggga tgggacaagc ccccaacatg gtaactaacc acatggccag
     1021 tctgcccaat tctgacccca ggaggctcac tgggagactc ctccctccca aggtatcatc
     1081 ttttaagggc ccagatctga ttttaccttg gaccccttca tgctacccct gggaacccaa
     1141 atggggactg ctcagtacct ttggatgaca cctgtggacc ggaagatgtt ctcaacccag
     1201 ggttgtcctt tgtaaaaatg tttctccatc ctcaatgtaa caggagtgtg tgaataaaca
     1261 cagacctccg tgtgtgagtg tgaaaaaaaa aaaaaaaaa
//
