LOCUS       NM_025451               3613 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase II
            inhibitor 1 (Camk2n1), mRNA.
ACCESSION   NM_025451 XM_890229 XM_979631
VERSION     NM_025451.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3613)
  AUTHORS   Zhang,X., Tian,L., Li,Z., Liu,R., Yu,J. and Liu,B.
  TITLE     CAMK2N1 has a cancer-suppressive function in colorectal carcinoma
            via effects on the Wnt/beta-catenin pathway
  JOURNAL   Biochem Biophys Res Commun 626, 220-228 (2022)
   PUBMED   35998547
  REMARK    GeneRIF: CAMK2N1 has a cancer-suppressive function in colorectal
            carcinoma via effects on the Wnt/beta-catenin pathway.
REFERENCE   2  (bases 1 to 3613)
  AUTHORS   Wei,Z., Fei,Y., Wang,Q., Hou,J., Cai,X., Yang,Y., Chen,T., Xu,Q.,
            Wang,Y. and Li,Y.G.
  TITLE     Loss of Camk2n1 aggravates cardiac remodeling and malignant
            ventricular arrhythmia after myocardial infarction in mice via
            NLRP3 inflammasome activation
  JOURNAL   Free Radic Biol Med 167, 243-257 (2021)
   PUBMED   33746041
  REMARK    GeneRIF: Loss of Camk2n1 aggravates cardiac remodeling and
            malignant ventricular arrhythmia after myocardial infarction in
            mice via NLRP3 inflammasome activation.
REFERENCE   3  (bases 1 to 3613)
  AUTHORS   Wang,Q., Yin,P., Yu,B., Zhao,Z., Richter-Levin,G., Yu,L. and Cao,X.
  TITLE     Down-regulation of dorsal striatal alphaCaMKII causes
            striatum-related cognitive and synaptic disorders
  JOURNAL   Exp Neurol 298 (Pt A), 112-121 (2017)
   PUBMED   28890075
  REMARK    GeneRIF: Camk2n1 down-regulation caused dorsal striatum-related
            cognitive disorders by inhibiting synaptic plasticity.
REFERENCE   4  (bases 1 to 3613)
  AUTHORS   Vigil,F.A., Mizuno,K., Lucchesi,W., Valls-Comamala,V. and
            Giese,K.P.
  TITLE     Prevention of long-term memory loss after retrieval by an
            endogenous CaMKII inhibitor
  JOURNAL   Sci Rep 7 (1), 4040 (2017)
   PUBMED   28642476
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3613)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   6  (bases 1 to 3613)
  AUTHORS   Ling,K.H., Hewitt,C.A., Beissbarth,T., Hyde,L., Cheah,P.S.,
            Smyth,G.K., Tan,S.S., Hahn,C.N., Thomas,T., Thomas,P.Q. and
            Scott,H.S.
  TITLE     Spatiotemporal regulation of multiple overlapping sense and novel
            natural antisense transcripts at the Nrgn and Camk2n1 gene loci
            during mouse cerebral corticogenesis
  JOURNAL   Cereb Cortex 21 (3), 683-697 (2011)
   PUBMED   20693275
  REMARK    GeneRIF: We propose that the differential regulation of multiple
            sense and novel overlapping natural antisense transcripts at the
            Nrgn and Camk2n1 loci will increase the diversity of
            posttranscriptional regulation
REFERENCE   7  (bases 1 to 3613)
  AUTHORS   Ling,K.H., Hewitt,C.A., Beissbarth,T., Hyde,L., Banerjee,K.,
            Cheah,P.S., Cannon,P.Z., Hahn,C.N., Thomas,P.Q., Smyth,G.K.,
            Tan,S.S., Thomas,T. and Scott,H.S.
  TITLE     Molecular networks involved in mouse cerebral corticogenesis and
            spatio-temporal regulation of Sox4 and Sox11 novel antisense
            transcripts revealed by transcriptome profiling
  JOURNAL   Genome Biol 10 (10), R104 (2009)
   PUBMED   19799774
REFERENCE   8  (bases 1 to 3613)
  AUTHORS   Saha,S., Datta,K. and Rangarajan,P.
  TITLE     Characterization of mouse neuronal Ca2+/calmodulin kinase II
            inhibitor alpha
  JOURNAL   Brain Res 1148, 38-42 (2007)
   PUBMED   17350603
  REMARK    GeneRIF: Camk2n1 was shown to be a 37 kDa protein localized in the
            post synaptic density (PSD) of mouse brain
REFERENCE   9  (bases 1 to 3613)
  AUTHORS   Saha,S., Ramanathan,A. and Rangarajan,P.N.
  TITLE     Regulation of Ca2+/calmodulin kinase II inhibitor alpha
            (CaMKIINalpha) in virus-infected mouse brain
  JOURNAL   Biochem Biophys Res Commun 350 (2), 444-449 (2006)
   PUBMED   17010311
  REMARK    GeneRIF: The mouse Ca2+/calmodulin kinase II inhibitor alpha
            (CaMKIINalpha) gene encodes a 2.9kb brain-specific transcript whose
            expression is downregulated in mouse brain during Japanese
            encephalitis virus and rabies virus infection.
            GeneRIF: Camk2n1 mRNA expression is down regulated in mouse brain
            during virus infection
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807249.8.
            
            On Jun 5, 2008 this sequence version replaced NM_025451.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY523601.1, SRR1660819.212366.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AL807249.8         239677-239880
            205-3613            AL807249.8         241247-244655
FEATURES             Location/Qualifiers
     source          1..3613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.3 cM"
     gene            1..3613
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
                     /note="calcium/calmodulin-dependent protein kinase II
                     inhibitor 1"
                     /db_xref="GeneID:66259"
                     /db_xref="MGI:MGI:1913509"
     exon            1..204
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..275
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
                     /note="CaMKII inhibitor protein alpha; CaMKIIN-alpha;
                     mCaMKIINalpha; calcium/calmodulin-dependent protein kinase
                     II inhibitor alpha; CaMKIINalpha"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase II
                     inhibitor 1"
                     /protein_id="NP_079727.1"
                     /db_xref="CCDS:CCDS38930.1"
                     /db_xref="GeneID:66259"
                     /db_xref="MGI:MGI:1913509"
                     /translation="MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQSKRP
                     PKLGQIGRSKRVVIEDDRIDDVLKTMTDKAPPGV"
     exon            205..3613
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1608..1613
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1631
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
                     /note="major polyA site"
     regulatory      3592..3597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3610
                     /gene="Camk2n1"
                     /gene_synonym="1810006K23Rik"
ORIGIN      
        1 gcggaggagg tgccgcctcg gagcccccgg acgcgaccat gtcggaggtg ctgccctacg
       61 gcgacgagaa gctgagcccc tacggcgacg gcggcgacgt gggccagatc ttctcgtgcc
      121 gcctgcagga caccaacaac ttcttcgggg ctgggcagag caagcggcct cccaagctgg
      181 gccagatcgg ccggagcaag cgcgttgtta ttgaagatga taggattgat gacgtgctga
      241 aaaccatgac cgacaaggca ccccctggtg tctaactgcc ccaaagacaa tgtgttgagg
      301 gaaagaataa gaagagtggc gggctgtgac agttactgac aaaaagcacg aggaggagga
      361 ggagggagaa agcactttga aatttattaa tagcttgcta cctgcgatga aatcgacaac
      421 ttgtgtctca agtcaggccg ggagacagat gaggtggaga ggaggaggag gaggaagagg
      481 aggaggtgga ggtggtggag gtggtggtgg tggtggtagc agcggtagcg gtggctctgg
      541 gctcctctac aaaaacaaaa gttaaaaaaa aacacacaaa aagtaaaaaa ataaaataaa
      601 aaaaataaaa atcactatat acacacatat aaaagaaaaa agtctcagtt gcagctattt
      661 gtcaagatta atacctgttt ctttttatat atggtaaata ttgtgcaatt atagctctgg
      721 agtttgaacc acttcccgaa agcagcaccg accacgtgaa ggtgcttgcc ttctctgctg
      781 atttggctgt tcccaatgtt tacataattt catctgtgca cttggatgtg acatgcggtc
      841 tagtccagtt tttttttttt aatgttgttt attcttggat gtacaaaaga aaattggggg
      901 caggggaatg acctctgtag atactgttgt acttgggtca tctttgaatg aaccccattt
      961 taaagcagaa agtaactttt ctacggactg atgctttggg aaggcccctt cctggtcttg
     1021 ttttcgagag acaactgaaa agcttgcgct tctttgttgc agtacagctc tttgcccagg
     1081 ttaacaccaa cagtgggttt tatatgtcag aaagaagaag aagaaaaaca aagacaaact
     1141 tgcttgagct ttttctagcc tccctggggg ctctgttgag tgaacccctc tttcttcttc
     1201 aatattgtgt cactttatcc attctcttta atggactgta aaaaaaaaac aaaaacaaac
     1261 aacaaatgta atcacaagag tgccaaatat cttgaaccgc caaaaggcat tttggtttcc
     1321 ttttgtcccc tgtgctctga gtcctgtgtg ggaacacttg gagagtcttt tctgttattt
     1381 ataggggttc tcttaaggct cgccagctgc ctgttttgca tggtatttgc aaaaaaatgc
     1441 ctcttgcgtg aggaatcttt tacctttttt tttttgttct tttaaattat ttgtttgcaa
     1501 ctttggacct caagaggtcc ccacccctcc cagttccttc ttttcttaat tctctattct
     1561 gtatgttgca ccttgaacca gcacacaggg ctatttctcc agtgtacaat aaagaactct
     1621 tcctgtgtct actctttcgt tagccttgtt tctcagggac tggaatacag agatggtggc
     1681 tttggcctgt aggatgaaac agtttgtgtg cgttgttggg gggttatcag ccagtgggct
     1741 ggatgggtca ggctatcccc taagaatggc agagtcagtg gactttgaat tttgcaaatg
     1801 gctccttctg gattccctga ggcttgcttg ggccatcctg ttgggttggg aggccgccag
     1861 tcctgtggag actgaagctg ggagactgga cttgggttca ggttctagct ctgactgcct
     1921 tactctcgga actggaactt ctgtaaacat cacctgcctg atctgcagag accgatgaac
     1981 tcagctgctg cctcttaggg tcaagaagag gagtatcaat cctcggcaca ccagaacctt
     2041 ccacattggg ccgccgctag catccactaa acatccaacc cgagacccag ttatggacat
     2101 acgtgtctct accactagag cctactgtta catgcttgag gatgagtctg ttctctgggg
     2161 atgcatgggg ggggggggaa gtcccaaaag tttccaagca cctgctgtac ctgcctctaa
     2221 tcacccatta ggaaaagtct gttgggcagg gtggggaggt agctccagtt ctctttaaac
     2281 tggaggcagt gatgaggggt tcaggttctg tagggagagg acttgggagg aggggttttg
     2341 gctcaaggaa gaggtcctgt gtccccacct ccttgcctcc tacccctccc ccaacccttg
     2401 ggatgttttg catgtagaaa ccccactgcc tggagctttt aatgtgtttg ttttaaagct
     2461 gtcagccagg gagtcacaac acagctcaca gtgacaggag cttgagtatg actcagacat
     2521 caggtaagag tccccacggg gtggggtggg gggactgcag aagaggagct ccagggggcc
     2581 ccagggaaag gagggcaaat gtcttatccc ccttcttaag tctgacagcc tcagcaggtc
     2641 ccagcctggg gttcttcatc ctgtggtcat tactgggact gatgggggag ctggaactgg
     2701 cagtgcccag cctgcggatg caagcggatg ccaacttcat ttccccaggc gcacagtcct
     2761 cttcttgaat ctggctgtct tccctcttga ccccaggcac tcccttttgg acttgaaggt
     2821 ctataggctc cattagagcc aagaaatgca atgtactgct cccctcccca gaaggccgag
     2881 ggggttactg ggggaaagga ttagagctag ggcctgcttt ttgttcaaat aataatctgc
     2941 cgagagggac agaggccagg caagaaggta gctttaggga tgtggtttct ggtactgtag
     3001 tcactgagta ccatctcatg tggttgtctc agcacttcta gaaacccagt gacattcact
     3061 taccagttac caaagaagct gaggtctcag ggaagcaaga aagctttccc tgaacaccag
     3121 actcacaaca gcccagaaga atgggtggtg ttacctggct gcacagtaga tagcgtgtct
     3181 cagagagggt aattcctgcc aagcgcctca gtttgatagc tgcagaggca ggattggaac
     3241 ccagagccca ccatctggga tgaagatgca gacagactgg ctctgttccg gcttcaacgg
     3301 ttgtccttca gcctttaaaa gtccttgtgt tggtgtgtct tccgcaagct ctgcccatct
     3361 ccatcatcct gcacaacttg agactgcatc aggggtcaga aggaggcagt gtgtggatgt
     3421 ggtcagccag ctcctggagc tgccccgcgc cctgggccaa ggctgaaggt ccattttaat
     3481 aagtgatgta ttaaaacgtt cctgctggag gccactgggc agcaaaggca gtgcctgcct
     3541 cagcctggaa tgagtctgcc tttctagaga cctccattca gtagcaagga aaataaatct
     3601 cttaaatata cta
//
