LOCUS       NM_001174053            3910 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase II, beta
            (Camk2b), transcript variant 1, mRNA.
ACCESSION   NM_001174053
VERSION     NM_001174053.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Falcetta,D., Quirim,S., Cocchiararo,I., Chabry,F., Theodore,M.,
            Stiefvater,A., Lin,S., Tintignac,L., Ivanek,R., Kinter,J.,
            Ruegg,M.A., Sinnreich,M. and Castets,P.
  TITLE     CaMKIIbeta deregulation contributes to neuromuscular junction
            destabilization in Myotonic Dystrophy type I
  JOURNAL   Skelet Muscle 14 (1), 11 (2024)
   PUBMED   38769542
  REMARK    GeneRIF: CaMKIIbeta deregulation contributes to neuromuscular
            junction destabilization in Myotonic Dystrophy type I.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Ding,P., Liu,J., Meng,Y., Wang,H., Huang,Y., Su,G., Xia,C., Du,X.,
            Dong,N., Cui,T., Zhang,J. and Li,J.
  TITLE     MFG-E8 facilitates heart repair through M1/M2 polarization after
            myocardial infarction by inhibiting CaMKII
  JOURNAL   Int Immunopharmacol 126, 111216 (2024)
   PUBMED   37977072
  REMARK    GeneRIF: MFG-E8 facilitates heart repair through M1/M2 polarization
            after myocardial infarction by inhibiting CaMKII.
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Besio,R., Contento,B.M., Garibaldi,N., Filibian,M., Sonntag,S.,
            Shmerling,D., Tonelli,F., Biggiogera,M., Brini,M., Salmaso,A.,
            Jovanovic,M., Marini,J.C., Rossi,A. and Forlino,A.
  TITLE     CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD
            signaling in osteogenesis imperfecta
  JOURNAL   Matrix Biol 120, 43-59 (2023)
   PUBMED   37178987
  REMARK    GeneRIF: CaMKII inhibition due to TRIC-B loss-of-function
            dysregulates SMAD signaling in osteogenesis imperfecta.
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Mayford,M., Bach,M.E., Huang,Y.Y., Wang,L., Hawkins,R.D. and
            Kandel,E.R.
  TITLE     Control of memory formation through regulated expression of a
            CaMKII transgene
  JOURNAL   Science 274 (5293), 1678-1683 (1996)
   PUBMED   8939850
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Kozak,C.A., Danciger,M., Bowes,C., Adamson,M.C., Palczewski,K.,
            Polans,A.S. and Farber,D.B.
  TITLE     Localization of three genes expressed in retina on mouse chromosome
            11
  JOURNAL   Mamm Genome 6 (2), 142-144 (1995)
   PUBMED   7767000
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Suda,T., Oyanagi,M., Wakana,S., Takahashi,Y., Kanada,H.,
            Yonekawa,H., Miyashita,N., Shiroishi,T., Moriwaki,K. and
            Kominami,R.
  TITLE     Novel mouse microsatellites: primer sequences and chromosomal
            location
  JOURNAL   DNA Res 1 (4), 169-174 (1994)
   PUBMED   8535974
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Karls,U., Muller,U., Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and
            Harbers,K.
  TITLE     Structure, expression, and chromosome location of the gene for the
            beta subunit of brain-specific Ca2+/calmodulin-dependent protein
            kinase II identified by transgene integration in an embryonic
            lethal mouse mutant
  JOURNAL   Mol Cell Biol 12 (8), 3644-3652 (1992)
   PUBMED   1321343
REFERENCE   10 (bases 1 to 3910)
  AUTHORS   Danciger,M., Kozak,C.A., Adamson,M.C. and Farber,D.B.
  TITLE     Chromosomal localization of the murine genes for the alpha- and
            beta-subunits of calcium/calmodulin-dependent protein kinase II
  JOURNAL   Mamm Genome 3 (2), 122-125 (1992)
   PUBMED   1319776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL611926.12 and AL645469.18.
            
            On Mar 4, 2023 this sequence version replaced NM_001174053.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AL611926.12        7081-7231           c
            152-246             AL645469.18        140830-140924       c
            247-306             AL645469.18        127413-127472       c
            307-361             AL645469.18        113301-113355       c
            362-427             AL645469.18        109846-109911       c
            428-500             AL645469.18        104783-104855       c
            501-603             AL645469.18        102283-102385       c
            604-687             AL645469.18        102126-102209       c
            688-782             AL645469.18        101537-101631       c
            783-905             AL645469.18        101295-101417       c
            906-989             AL645469.18        100918-101001       c
            990-1032            AL645469.18        100064-100106       c
            1033-1070           AL645469.18        94684-94721         c
            1071-1142           AL645469.18        94464-94535         c
            1143-1191           AL645469.18        91636-91684         c
            1192-1320           AL645469.18        88728-88856         c
            1321-1396           AL645469.18        84776-84851         c
            1397-1491           AL645469.18        84595-84689         c
            1492-1725           AL645469.18        84180-84413         c
            1726-3910           AL645469.18        81605-83789         c
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.89 cM"
     gene            1..3910
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /note="calcium/calmodulin-dependent protein kinase II,
                     beta"
                     /db_xref="GeneID:12323"
                     /db_xref="MGI:MGI:88257"
     exon            1..151
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            152..246
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            247..306
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            307..361
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            362..427
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            428..500
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            501..603
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            604..687
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            688..782
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            783..905
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            906..989
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1032
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1070
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1142
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1191
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1320
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1396
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1491
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1725
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..3910
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1956..1961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /note="hexamer: AACAAA"
     polyA_site      1973
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /note="major polyA site"
     polyA_site      2025
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /note="major polyA site"
     polyA_site      2799
                     /gene="Camk2b"
                     /gene_synonym="CaMKII"
                     /note="major polyA site"
ORIGIN      
        1 gtgtcgccgc cgtgcccgcg agcgggagcc ggagtcgccg ccgcccgagc gcagccgagc
       61 gcacgccgag cccgatcgcc accgccatgg ccaccacggt gacctgcacc cgtttcaccg
      121 acgagtacca gctatacgag gatattggca agggggcttt ctctgtggtc cgacgctgtg
      181 tcaagctctg taccggccat gagtatgcag ccaagatcat taataccaag aagctgtcgg
      241 ccagagatca ccagaaactg gagagagaag ctcggatctg ccgcctgctg aagcattcca
      301 acattgtacg cctccatgac agcatctctg aagagggctt ccactacctg gtcttcgatc
      361 tggtcactgg tggggagctc tttgaagaca tcgtggcaag agagtactac agtgaagctg
      421 atgccagtca ctgcatccag cagatcctgg aagctgttct ccattgtcac caaatggggg
      481 tcgtccacag agacctcaag cctgagaacc tgcttctggc cagcaaatgc aaaggcgccg
      541 cagtgaagct ggcagacttc ggcctggcca tcgaggttca gggagaccag caggcatggt
      601 ttggatttgc gggaacgcca ggctacctgt ctcccgaggt ccttcggaag gaggcctacg
      661 gcaaacctgt ggacatctgg gcatgtgggg tgatcctgta tatcctgctg gtgggctacc
      721 cacctttctg ggatgaggac caacacaagc tgtaccagca gatcaaggct ggggcgtatg
      781 atttcccatc ccctgagtgg gacaccgtta ctcctgaagc caaaaacctc atcaaccaga
      841 tgctgaccat caaccctgcc aagcgcatca cggcccatga ggccctgaag cacccatggg
      901 tctgccaacg ttccaccgtg gcctctatga tgcacagaca ggagactgtg gaatgtctga
      961 agaagttcaa tgcaaggagg aagctcaagg gagccatcct caccactatg ctggccacac
     1021 ggaatttctc agccaagagt ttactcaaca agaaagcaga tggagtcaag ccccagacaa
     1081 acagcaccaa aaacagctcg gccatcacca gccccaaagg atctctccct cctgctgccc
     1141 tggaatcttc cgacagcacc aacacaacca tagaggatga agatgccaaa gcccccagga
     1201 tctctgacat cctcaactca gtgaggcggg gctcagggac cccagaagct gagggcctcc
     1261 caccagtggg ccccccaccc tgcccatctc cgactctccc tggccccttg cccaccccat
     1321 cccggaagca ggaaatcatc aagaccacag agcagctcat tgaggccgtc aacaatgggg
     1381 actttgaggc ctatgcgaaa atctgtgacc caggcctgac ctcatttgag cctgaagctc
     1441 tgggcaacct ggtcgaaggg atggatttcc acagattcta ctttgagaac ctgctggcca
     1501 agaacagcaa gccgatccac accaccatcc tgaacccgca cgtgcacgtc attggcgagg
     1561 atgcggcatg catcgcctac atccgcctca cacagtacat cgatggccag ggcagacccc
     1621 gtaccagcca gtccgaagag acccgtgtgt ggcaccgccg cgacggcaag tggcagaatg
     1681 tacatttcca ctgctcgggc gctccagtgg ccccgctgca gtgagagctg cgcctggttt
     1741 cgccggacag agttggtgtt tggagcccag ccgccctcgg gcgcacggcc tgcctgtcgc
     1801 atgtttgtgt ctgcctcgtc ccctcccctg gtgcctgtgt ctgcagaaaa acaagaccag
     1861 atgtgatttg tttttaaaaa taagatgatg acaacgacaa ccacacgcaa accaacaaac
     1921 aaaattttgg catcggatga aatggaaaac aagcaaacaa acaaaaacct aaagaaagga
     1981 aaaagctgta aaaatctggc atttgtgggg ccaccccacc cccaagctcc actgtgtctg
     2041 ttgtgctcct ggctttgggg accctcaggg cgtgaatgtg cccatgccga ccgtgttagt
     2101 ctgtaggtac cgcactcacc ccataccttg ggcgtctgca tcctccctcc catgcatggg
     2161 ccccacgtgc taacctggct gttgtggtgt caggtgtctt gggaagggct gggggctgcc
     2221 tcctttcctg ctagttgtgc ctgagagttg ctgctgctcc tgctttcccc tacctgtccc
     2281 ttgtcccgtc ctgtgaaggg ctgggagggt gctcctctag ccaaggacct acctttgccc
     2341 catggagtgt gtagaagctt gtccccgagg tcatcagaaa agaacctggg ctctcagccc
     2401 cggttctttg gggagtgagg tatggaggta cggatcttgc ctccagacct cctgcctggc
     2461 aggggttggt taagaaggcc tgctggctgc agtgcctacc catgtagcta tgaagagagg
     2521 actgggcaga ggatggcctc cttcctgttt ggggtacttg tcccttccct gccaccagca
     2581 gctgagcaac agtggcccac ccctggcctg ggaagttcct ctctgaagtt ggcagcagac
     2641 cctaatgaag atggagaacc tgagatactg gacggatact gggaacaggc caggctgcgt
     2701 ctagggtgtt tgtccactca gcttggagcc tgggtgttcg agacttggtt aaatgttgca
     2761 gaatgtggta aagaggggcc agaagttggg ttctagactt ctgggcaatg caggtccata
     2821 caagtgtttg atgaaatggg agtgctttct tgacctgggc ctagagaaga gcatatgcca
     2881 cctagaggca tgtggaaggc caaaattggt tagggctgta ttgtgtgggg ctcttccagg
     2941 taggccagag acacagctta gagagaaggc aggctggggg cagagatata tggctgtggg
     3001 gcctggatac cagtgggtgg gtggagggcc catcaggaca gtgtggcacc tccaagggcc
     3061 cagtggtgct cctaggtgcc ggctgcctgg actcgttgtg ggtggccctg gcccttggtg
     3121 actgagggaa tcattaaggc tggacatgtt acaaagtcag gctagggaga tataggtctg
     3181 aagccgggtt gggtgggggt ggtcagaggc tttgactgca gaggttcatg ggcctccacc
     3241 ccaacgctga ccactttaaa ttcatgtcat tttcaaccag gattttcttt atcttttact
     3301 acaaatcaag ccaagggagg ggcacgaagt ggggaacggg acacaggatc ctaaactcca
     3361 aggggactgt ccacctacag acactcagtg gataccacct ttcatccaca ctgtgcccag
     3421 gacagctgtt ccctacccat ggacacaggg taaacatctg ccacccatgg acacagggta
     3481 aacatctgag tggcccaagg ccatggaaca gtggcagggc ttgccatgga cagtgtgagg
     3541 ccctgtggcc tgccaccctg gcatcctggg gtctcctttc ctctcccacc caccttgtta
     3601 tctccacaaa gctgcctgtc tgggataatt tggggatttt ttttttctgg gggacaattc
     3661 ttttgcatga ccctctaaag agcaggacac tcctgctcta actggctagg tgttcgcagg
     3721 tggtggcgtc gaccgctggc cagtgctgta gtgtgttact gcctgcagta ctggtggccc
     3781 tcctctcttc tctctttttg ctgagttcca ctgtcttttc tttctgagcc ttgtaggtgt
     3841 acaaaactta ttcttatttt gttctgtctc gggaaactgc aaataaaaaa aaaaaaaaaa
     3901 aaaaaaaaag
//
