LOCUS       NM_177407               4966 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase II alpha
            (Camk2a), transcript variant 2, mRNA.
ACCESSION   NM_177407
VERSION     NM_177407.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4966)
  AUTHORS   Chang,E.E., Liu,H., Choi,Z.Y., Malki,Y., Zhang,S.X., Pang,S.Y.,
            Kung,M.H., Ramsden,D.B., Ho,S.L. and Ho,P.W.
  TITLE     Loss of mitochondrial Ca2+ response and CaMKII/ERK activation by
            LRRK2R1441G mutation correlate with impaired depolarization-induced
            mitophagy
  JOURNAL   Cell Commun Signal 22 (1), 485 (2024)
   PUBMED   39390438
  REMARK    GeneRIF: Loss of mitochondrial Ca[2+] response and CaMKII/ERK
            activation by LRRK2[R1441G] mutation correlate with impaired
            depolarization-induced mitophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4966)
  AUTHORS   Li,J., Zhang,J., Zhong,Y., Xie,D., Han,H., Zhang,Z., Liu,Y. and
            Li,S.
  TITLE     TRPC6 regulates necroptosis in myocardial ischemia/reperfusion
            injury via Ca2+/CaMKII signaling pathway
  JOURNAL   Cell Signal 122, 111344 (2024)
   PUBMED   39134250
  REMARK    GeneRIF: TRPC6 regulates necroptosis in myocardial
            ischemia/reperfusion injury via Ca[2+]/CaMKII signaling pathway.
REFERENCE   3  (bases 1 to 4966)
  AUTHORS   Lin,J., Xia,H., Yu,J., Wang,Y., Wang,H., Xie,D., Cheng,C., Lu,L.,
            Bian,T., Wu,Y. and Liu,Q.
  TITLE     circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced
            emphysema through driving M2 macrophage polarization
  JOURNAL   Environ Int 190, 108832 (2024)
   PUBMED   38936066
  REMARK    GeneRIF: circADAMTS6 via stabilizing CAMK2A is involved in
            smoking-induced emphysema through driving M2 macrophage
            polarization.
REFERENCE   4  (bases 1 to 4966)
  AUTHORS   Anjum,R., Clarke,V.R.J., Nagasawa,Y., Murakoshi,H. and Paradis,S.
  TITLE     Rem2 interacts with CaMKII at synapses and restricts long-term
            potentiation in hippocampus
  JOURNAL   PLoS One 19 (7), e0301063 (2024)
   PUBMED   38995900
  REMARK    GeneRIF: Rem2 interacts with CaMKII at synapses and restricts
            long-term potentiation in hippocampus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4966)
  AUTHORS   Naillat,F., Deshar,G., Hankkila,A., Rak-Raszewska,A., Sharma,A.,
            Prunskaite-Hyyrylainen,R., Railo,A., Shan,J. and Vainio,S.J.
  TITLE     Calcium signaling induces partial EMT and renal fibrosis in a
            Wnt4mCherry knock-in mouse model
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (5), 167180 (2024)
   PUBMED   38653356
REFERENCE   6  (bases 1 to 4966)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (bases 1 to 4966)
  AUTHORS   Silva,A.J., Stevens,C.F., Tonegawa,S. and Wang,Y.
  TITLE     Deficient hippocampal long-term potentiation in
            alpha-calcium-calmodulin kinase II mutant mice
  JOURNAL   Science 257 (5067), 201-206 (1992)
   PUBMED   1378648
REFERENCE   8  (bases 1 to 4966)
  AUTHORS   Silva,A.J., Paylor,R., Wehner,J.M. and Tonegawa,S.
  TITLE     Impaired spatial learning in alpha-calcium-calmodulin kinase II
            mutant mice
  JOURNAL   Science 257 (5067), 206-211 (1992)
   PUBMED   1321493
REFERENCE   9  (bases 1 to 4966)
  AUTHORS   Silva,A.J., Wang,Y., Paylor,R., Wehner,J.M., Stevens,C.F. and
            Tonegawa,S.
  TITLE     Alpha calcium/calmodulin kinase II mutant mice: deficient long-term
            potentiation and impaired spatial learning
  JOURNAL   Cold Spring Harb Symp Quant Biol 57, 527-539 (1992)
   PUBMED   1339689
REFERENCE   10 (bases 1 to 4966)
  AUTHORS   Danciger,M., Kozak,C.A., Adamson,M.C. and Farber,D.B.
  TITLE     Chromosomal localization of the murine genes for the alpha- and
            beta-subunits of calcium/calmodulin-dependent protein kinase II
  JOURNAL   Mamm Genome 3 (2), 122-125 (1992)
   PUBMED   1319776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083245.1, BC031745.1 and AW490258.1.
            
            On Nov 27, 2007 this sequence version replaced NM_177407.3.
            
            Transcript Variant: This variant (2) is the longest transcript and
            encodes the longest isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083245.1, AK122410.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AK083245.1         2-20
            20-3215             BC031745.1         1-3196
            3216-3669           AK083245.1         3216-3669
            3670-4948           AK083245.1         3671-4949
            4949-4966           AW490258.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..4966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 34.41 cM"
     gene            1..4966
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /note="calcium/calmodulin-dependent protein kinase II
                     alpha"
                     /db_xref="GeneID:12322"
                     /db_xref="MGI:MGI:88256"
     exon            1..209
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            210..304
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            305..364
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            365..419
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            420..485
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            486..558
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            559..661
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            662..745
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            746..840
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            841..963
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1047
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1090
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1131
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1180
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1256
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1351
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1580
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..4956
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4779..4784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /note="hexamer: AATAAA"
     polyA_site      4798
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /note="major polyA site"
     regulatory      4928..4933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
                     /note="hexamer: AATAAA"
     polyA_site      4956
                     /gene="Camk2a"
                     /gene_synonym="CaMKII; mKIAA0968"
ORIGIN      
        1 agaagcccca agctcgtcag tcaagccggt tctccgtttg cactcaggag cacgggcagg
       61 cgagtggccc ctagttctgg gggcagcgct tcagcatccc agccctagtt cccagcctaa
      121 agcctcgcct gcctgcccag tgccaggatg gctaccatca cctgcacccg attcacagaa
      181 gagtaccagc tctttgagga actgggaaag ggagccttct ctgtggtgcg caggtgtgtg
      241 aaggtgctgg ctggtcagga gtatgctgcc aagattatca acaccaagaa gctttcagcc
      301 agagatcacc agaagctgga gcgtgaggcc cgcatctgcc gcttgttgaa gcaccccaat
      361 atcgtccgac tccatgacag catctccgag gaggggcacc actaccttat cttcgatctg
      421 gttactggtg gggaactgtt tgaagacatt gtggcccggg agtattacag tgaagctgat
      481 gccagccact gtatccagca gatcttggag gctgtgctac actgtcacca gatgggggtg
      541 gtgcatcgtg acctgaagcc tgagaatctg ttgctggcct cgaagctcaa gggcgctgct
      601 gtgaagctgg cagactttgg cctggccata gaggtggagg gggagcagca ggcatggttt
      661 gggttcgcag ggacacctgg atacctctcc ccagaagtgc tgaggaagga cccgtacggg
      721 aagcccgtgg acctgtgggc ctgtggcgtc atcctgtata tcttgctggt tgggtatccc
      781 ccgttctggg atgaagacca gcatcgcctg taccagcaga tcaaagctgg tgcctatgat
      841 ttcccatcac cagaatggga caccgtcacc ccagaagcca aggatctgat caataagatg
      901 ctgaccatca acccgtccaa acgcatcacg gccgctgagg ctctcaagca cccatggatc
      961 tcgcaccgct ccaccgtggc ctcctgcatg cacagacagg agaccgtgga ctgcctgaag
     1021 aagttcaatg ccaggaggaa actgaaggga gccatcctca ccactatgct ggccaccagg
     1081 aacttctccg gagggaagag cggaggaaac aagaagaacg atggtgtgaa ggaatcttct
     1141 gagagcacca acaccaccat tgaggacgaa gacaccaaag tgcgcaaaca ggaaattatc
     1201 aaagtgacag agcagctgat cgaagccata agcaatggag actttgagtc ctacacgaag
     1261 atgtgcgacc ctggaatgac agcctttgaa ccagaggccc tggggaacct ggtggagggc
     1321 ctggactttc atcgattcta ttttgaaaac ctgtggtccc ggaacagcaa gcccgtgcac
     1381 accaccatcc tgaaccctca catccacctg atgggtgacg agtcagcctg catcgcctat
     1441 atccgcatca ctcagtacct ggatgcaggc ggcatacccc gcacggccca gtcagaggag
     1501 acccgcgtct ggcaccgcag ggacggcaaa tggcagatcg tccacttcca cagatctggg
     1561 gcgccctccg tcctgccgca ttgaaggacc aggccagggt ccctgcgtcc ttgcttcgca
     1621 gagatccgct ctttgtccgt ggaatgtggc tgctggttct cctttggatt ttgctggaat
     1681 tctccctgtc agatcaccct accattgcca cctatgtact cgcgtcacga aaacctgctt
     1741 gttcacagaa gtcgccacga catcacagtg aacagccagc tctccccagc tccgttgccc
     1801 aagctcttcc tgccagtggg gaccttcttc cggcttaagt acccagggtg ctggccccag
     1861 gaacccccac cccctaccca ctgttgttgg cctagcctag ctttagctat agatggggcc
     1921 tcagctgtgc aattggcagg aagtgaggaa gaggcaggca agctgtgttg agggcacctc
     1981 tcatcgattc cttctttcct ggggttcccc ggggaagctc acacgaggcc ctcagtctcc
     2041 aagccaaccc cttatgaggg agagtgagag aggagccaac gccagtgagc caggaactgc
     2101 tgctctcatc tgctctcctc tgtgttggcc ttgcctttga ccagaccatc cgctacgagg
     2161 ggtgggctct accgcccagg tgccccactc actctgcctc agtcctcctg tgaagtttgc
     2221 ctccagtgtt gacccaccca ccctgccctt caacgtcctt ggagaattcc agcttcatct
     2281 gtctgagagg agattggaag gtgtttcagg ggcaaagcaa gcaacattta ggtatcactt
     2341 ctacttggac gcatgccttt ttacagccaa acttccgtgt atttcgtaaa tggattttgc
     2401 gttaacggac atctatgtga taactagacc tctcaagttt actgtaaaga agagtcggat
     2461 gggttgggaa gtgggtggga agaggagtga gaggaagttt taaccccatt ccagagggtc
     2521 ttttttttgg ggggtgtccc ttctggggga gggtgctttc tgaggtggcc tcacccccca
     2581 gggagcatgg tttccttcca ttatggtccc caaagtcagc tgacaagatt tcttccagag
     2641 ccagcatgac taacacacag tgagtcaggt caggggaggc tatcaggaag gggttatcta
     2701 gacttggcat ctctggaact ggagacctca ctaccctact tcccaggaaa tctttcccgt
     2761 atccttgtgc tatctctcct cagcccagcc cccactcacc accttctagg cacattattc
     2821 tcatcacctc tctcaacttg gccaagcaag agtgccagaa acttattttc ctacttcatg
     2881 ctgaacttgg cctggtgtgc gctctattgt gcttgcctgc ctccctggcc ttcctcgact
     2941 cccctgcccc gacatacaca cacacacaca cacacacaca cacacgcaca cgcacacgcg
     3001 cgcacacaca cacatgcaca cgcacatgca cacactcaca ccacttcctt ccaccacttc
     3061 cttcctcccc cctctccctc cctttctctt tctcttctct ccctcttcct gggtttggct
     3121 cttgtatgga atgctgtatc tcattcacgg ggatctcctg tctgcactgt tttctttgca
     3181 tgactttata tgcagtaagt atgttgaaaa acaaacaaaa aacaaaaaag gagaaaaaca
     3241 ctcaacaaaa tcaaacgaca cgtttttttt tggacaaaaa ataataacat tcaaggtaat
     3301 agtctcagtg tccaacttgg acttacgttg ctgcctctcc gtgcttttgg tctctctgtg
     3361 gctatgtttt gccagcatga gaccctgttc cctctggaag ttgctagggg aggaagagcc
     3421 atgcgtccag gggtttggag acagctttat cctctcggct tttctgaggg tcgatgggag
     3481 cagaagtgga agggatgttt aatccagaac tttctggtat tcccctttcg cctacatgtg
     3541 agctatatcc cgggctcttc tctcaaatcc tgctgcccag ggacaagtac agggtagaag
     3601 agtggctctc ttgtctaagc cgctccactg tagcctctgc ccttggtaga gacactgcta
     3661 cccaggccca agaatgggcc cttgtcctgc cccagaacca ggcttcttca taaggctcag
     3721 caaacccatt gtccccagcc actccccaga taaaggtaaa ggagggtgtg gcctttacca
     3781 ggggacactg caatctccat gcaggatcta caatcccttc ttcaagcctc agtttctcca
     3841 tcaatgttcc tacccagact gatggagggt cagagtaaaa gatgtcacaa gcacccacca
     3901 cctctgagag cttgttgggt ttgtcactgg ctggccctct tatgcaccag gtctggccaa
     3961 cccccaccct ttcctctgtg tgcccctcat tttactattt ggtgccagtc cgttgatgac
     4021 cagcaatgga ctgcagggga aagaagtgtt tgggggctct gatcccgggt tctgaccaga
     4081 tccgggtttt gtgtagcttt gggtaaatcc tttgccctct tcaggcttta gtttcgccaa
     4141 ccagaagatg cctatgccct gccttccgtt ggctaacatg cccctgtcca ctatgtgctt
     4201 gttcacgtgt gggagaagtg gaggcaagtc cctgccccag tctgagacgg ccccctctgc
     4261 agaggccgct cctgtgggtg ggcagccaac taatgaagac cttgggacac tacgatggcc
     4321 ccaaggtgac aggcagggga acaggcagaa aaactgtcca gagcccaccc tcatctgaca
     4381 agctccatgc tccgtccaaa taccctccag atgaaaaaaa aaagagagag agagagaaag
     4441 aaacaaagag tcaaatcaca tttataggaa aagcgtctcc agctctatgc accatagctc
     4501 aaatcctgcc ccatggcttc cccacccccc ttcaaaggga gagccttggg ggaatgcgtt
     4561 tgccaggccc cgtgctggct tctttgttac tatttgttta gggttttgtt ctagttctct
     4621 ctctctctct ctctctctct ctctctctct ctctctctct ctctttcttt tttaatctgt
     4681 ggctgtgaac ttgaatgacc actgctcaaa ctttctgcta ctgggggggt gggggagggg
     4741 agaagagatg tctggtttat tcttggcgtt ttcagtggaa taaatagcta caaatttatg
     4801 tgagtccgtg tcttcctgaa ttggtcaagg cacagagccc caggaactgg cattttgctt
     4861 tggcttgttt tttgggtttt ttgtttgttt gtttgttttt gtttgtttca aatctcccct
     4921 gttgcaaaat aaaagtcctg gtcctatgga ttggaaaaaa aaaaaa
//
