LOCUS       NM_177343               7226 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calcium/calmodulin-dependent protein kinase ID
            (Camk1d), transcript variant 1, mRNA.
ACCESSION   NM_177343 NM_198036
VERSION     NM_177343.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7226)
  AUTHORS   Akizuki,K., Ono,A., Xue,H., Kameshita,I., Ishida,A. and Sueyoshi,N.
  TITLE     Biochemical characterization of four splice variants of mouse
            Ca2+/calmodulin-dependent protein kinase Idelta
  JOURNAL   J Biochem 169 (4), 445-458 (2021)
   PUBMED   33417706
  REMARK    GeneRIF: Biochemical characterization of four splice variants of
            mouse Ca2+/calmodulin-dependent protein kinase Idelta.
REFERENCE   3  (bases 1 to 7226)
  AUTHORS   Li,L., Ruan,X., Wen,C., Chen,P., Liu,W., Zhu,L., Xiang,P.,
            Zhang,X., Wei,Q., Hou,L., Yin,B., Yuan,J., Qiang,B., Shu,P. and
            Peng,X.
  TITLE     The COMPASS Family Protein ASH2L Mediates Corticogenesis via
            Transcriptional Regulation of Wnt Signaling
  JOURNAL   Cell Rep 28 (3), 698-711 (2019)
   PUBMED   31315048
REFERENCE   4  (bases 1 to 7226)
  AUTHORS   Akizuki,K., Kinumi,T., Ono,A., Senga,Y., Osawa,J., Shigeri,Y.,
            Ishida,A., Kameshita,I. and Sueyoshi,N.
  TITLE     Autoactivation of C-terminally truncated Ca2+/calmodulin-dependent
            protein kinase (CaMK) Idelta via CaMK kinase-independent
            autophosphorylation
  JOURNAL   Arch Biochem Biophys 668, 29-38 (2019)
   PUBMED   31071303
  REMARK    GeneRIF: CaMK1d is activated through CaMKK-independent
            phosphorylation at serine(296).
REFERENCE   5  (bases 1 to 7226)
  AUTHORS   Senga,Y., Ishida,A., Shigeri,Y., Kameshita,I. and Sueyoshi,N.
  TITLE     The Phosphatase-Resistant Isoform of CaMKI,
            Ca(2)/Calmodulin-Dependent Protein Kinase Idelta (CaMKIdelta),
            Remains in Its 'Primed' Form without Ca(2) Stimulation
  JOURNAL   Biochemistry 54 (23), 3617-3630 (2015)
   PUBMED   25994484
  REMARK    GeneRIF: Data suggest that, under cell signaling conditions in
            which Camk1a is significantly dephosphorylated by phosphoprotein
            phosphatase activity, little Camk1d dephosphorylated is observed.
REFERENCE   6  (bases 1 to 7226)
  AUTHORS   Kamata,A., Sakagami,H., Tokumitsu,H., Owada,Y., Fukunaga,K. and
            Kondo,H.
  TITLE     Spatiotemporal expression of four isoforms of
            Ca2+/calmodulin-dependent protein kinase I in brain and its
            possible roles in hippocampal dendritic growth
  JOURNAL   Neurosci Res 57 (1), 86-97 (2007)
   PUBMED   17056143
REFERENCE   7  (bases 1 to 7226)
  AUTHORS   Sakagami,H., Kamata,A., Nishimura,H., Kasahara,J., Owada,Y.,
            Takeuchi,Y., Watanabe,M., Fukunaga,K. and Kondo,H.
  TITLE     Prominent expression and activity-dependent nuclear translocation
            of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal
            neurons
  JOURNAL   Eur J Neurosci 22 (11), 2697-2707 (2005)
   PUBMED   16324104
  REMARK    GeneRIF: CaMKIdelta is involved in nuclear functions through its
            nuclear translocation in response to stimuli that trigger
            intracellular Ca2+ influx--Ca2+/calmodulin-dependent protein kinase
            Idelta.
REFERENCE   8  (bases 1 to 7226)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 7226)
  AUTHORS   Yamada,T., Suzuki,M., Satoh,H., Kihara-Negishi,F., Nakano,H. and
            Oikawa,T.
  TITLE     Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase
            I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells
  JOURNAL   Exp Cell Res 294 (1), 39-50 (2004)
   PUBMED   14980499
  REMARK    GeneRIF: CKLiK is up-regulated by the PU.1 transcription factor in
            murine erythroleukemia cells and is involved in apoptosis of these
            cells.
REFERENCE   10 (bases 1 to 7226)
  AUTHORS   Maxwell,K.N., Soccio,R.E., Duncan,E.M., Sehayek,E. and Breslow,J.L.
  TITLE     Novel putative SREBP and LXR target genes identified by microarray
            analysis in liver of cholesterol-fed mice
  JOURNAL   J Lipid Res 44 (11), 2109-2119 (2003)
   PUBMED   12897189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147616.1, BC141414.1 and BF460707.1.
            
            On Mar 13, 2014 this sequence version replaced NM_177343.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147616.1, BC141414.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1894              AK147616.1         2-1895
            1895-5375           BC141414.1         1395-4875
            5376-7202           AK147616.1         5374-7200
            7203-7226           BF460707.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..7226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.39 cM"
     gene            1..7226
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /note="calcium/calmodulin-dependent protein kinase ID"
                     /db_xref="GeneID:227541"
                     /db_xref="MGI:MGI:2442190"
     exon            1..617
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..1683
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /EC_number="2.7.11.17"
                     /note="isoform a is encoded by transcript variant 1;
                     calcium/calmodulin-dependent protein kinase type 1D;
                     calcium/calmodulin-dependent protein kinase 1D; caMKI
                     delta; caM-KI delta; caM kinase ID; caM kinase I delta;
                     camKI-like protein kinase"
                     /codon_start=1
                     /product="calcium/calmodulin-dependent protein kinase type
                     1D isoform a"
                     /protein_id="NP_796317.2"
                     /db_xref="CCDS:CCDS15665.1"
                     /db_xref="GeneID:227541"
                     /db_xref="MGI:MGI:2442190"
                     /translation="MARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKA
                     TGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVS
                     GGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESK
                     IMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGY
                     PPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARH
                     PWIAGDTALSKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRRLQLGSSLDSSNAS
                     VSSNLSLASQKDCLAPSTLCSFLSSSSGVAGVGAERRPRPTTVTTGHTGSK"
     exon            618..749
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            750..824
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            825..963
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1090
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1166
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1279
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1358
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1446
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1564
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..7209
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7184..7189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /note="hexamer: AATAAA"
     polyA_site      7203
                     /gene="Camk1d"
                     /gene_synonym="A630059D12Rik; CaMKIdelta; CKLiK;
                     E030025C11Rik; mCKLiK"
                     /note="major polyA site"
ORIGIN      
        1 acccgccctc gcccggggac ccagggtgcg cggacggcct gggagcgtgc gtggctccgt
       61 ggtcaagtgc tgcatcccgg cgcccaagca cggagctcct ggggagggga gggggagcgg
      121 gacatccccg aaggccgcct cgcgggaggc ggggaggctg ccgggtgcac tgggagggcg
      181 gggagcccgc gggaggaggc gggctggggg agtggggcgg gcggcgggga gggagcagga
      241 gccaggcaag aaagtagcag aaagtgaggc tggcaggcgg cggcagaggc aggaagtctt
      301 tgccggagag cagtagaaat tagagccagg gagggaccgc ggcggcagca gccaaggcga
      361 aagaggaaac tgccgaagag gaagctctgc ggcagcccga gcctccctgc gctccgcatc
      421 ctcccgctcc gcatcccggc gccgggcatc ccccggagcc cgcgccgcgc ctccggcgcc
      481 ccttccccag cgcaaccctc ggccgcccta cagcattagt ctgccatggc ccgggagaac
      541 ggcgagagca gctcctcctg gaaaaagcaa gcagaagaca ttaagaagat cttcgagttc
      601 aaggagaccc tcggaactgg ggccttttct gaagttgttt tagccgagga gaaagctact
      661 gggaagctct tcgcagtgaa gtgcatcccg aagaaggcgc tgaagggcaa ggagagcagc
      721 atcgagaacg agattgccgt gcttagaaag attaagcatg aaaacattgt tgccttggaa
      781 gatatttatg aaagcccaaa tcacctctac ctggtcatgc aacttgtgtc tggtggagaa
      841 ctcttcgatc ggatagtgga gaaggggttt tacacagaga aagatgccag cactctcatc
      901 cgccaggtcc tggatgccgt atactatctc cacagaatgg gcattgtcca cagggacctc
      961 aagccggaga atctcttata ctacagtcaa gacgaggagt ccaaaataat gatcagtgac
     1021 tttggcttgt cgaaaatgga gggcaaagga gatgtgatgt ccacggcctg cgggacccca
     1081 ggctatgttg ctccggaagt tctcgcccag aaaccgtaca gcaaagctgt ggactgctgg
     1141 tccatcgggg tgatcgccta tatcttgctc tgtggttacc ctccttttta tgatgaaaat
     1201 gactcgaagc tgtttgaaca gatcctcaag gcagaatatg agtttgattc cccctactgg
     1261 gatgacatct ccgactctgc caaagacttc attcggaatc tgatggagaa agacccaaat
     1321 aaaagataca cttgtgagca ggcagctcga cacccatgga ttgctggtga cacagccctt
     1381 agcaaaaaca ttcacgaatc tgtcagtgcc cagatccgga agaattttgc aaagagcaaa
     1441 tggagacaag cgtttaacgc cacggcagtc gtgagacata tgcggaggct ccagcttggc
     1501 agcagcctgg acagttcaaa tgcaagtgtc tcaagcaacc tcagtttggc cagccaaaaa
     1561 gattgtctgg caccttccac gctctgtagt ttcctttctt cttcgtcggg ggtcgcagga
     1621 gtcggagctg agaggagacc caggcccacc actgtgacaa cagggcacac tggaagcaag
     1681 tgacccggct ctggaggtgg aacccagggg gcagggccgg ggaaggagaa gcccctggcc
     1741 ggagcagctc ctgcatcaga aaccccaccc accctgcatg gtgcacctgc ataggactgg
     1801 aagatagaag gttttttatg gccatatttt atactgcaat tctgatgtgt tcatttctca
     1861 caaactgtac tgactgactc aaggggagct ggcgtcacgg gatctggtgc tgtatataag
     1921 aatcttgcaa agctctaact gaatggacct tcttgctccc ctcccccaac tccaccactt
     1981 ccgctctctc agtgtaggca gccgtctagg gtgtattttt ttcatggaaa aaaaaatcaa
     2041 ggtttcaact ggattattta aatattggta catgttgtgc attaggaatt attttttttc
     2101 ttttgagatg tgtccttttg atctctgtta gttacatgac ctctatcatt tgctctttaa
     2161 tattagtttt acgttaacct ttaagagatt tttttcccct cccagaaggg ttaaagggta
     2221 ttttttacga attctaagag gatcaagaat ctgtgtccac ttctaagagt gcacttgtta
     2281 cttgtgttcc attgctccca gtcccttctt ccagaggtca ccccaacagc tgtgccgggc
     2341 tggcttctcg cagggtggct tttggcaggg aaccagcaga aaccgtacag gcagcttccc
     2401 ctgagaactg cttaccaacc acagaagata gaagcttgtt tcctccactc tgaacttcag
     2461 gctccacatt acaggtgaac cgcactccgg gaacgggatt ccccacagtg ccaagagtta
     2521 ggagcctccc ttgaagaagg gacggacgga ctgccatctt gttttttaaa tgaaccacac
     2581 gcagccctca attctcatgg gggatgatag atgaaactct gttctcagct atgcactttt
     2641 aaaacgaatc tctttatcta ttttaatttt ttaaaattca tttctaatag tacccttcaa
     2701 atggcctata ccacacactt tctccccaac atttttaccc tgttctctca tgagcattac
     2761 ccgagagagg ggacagaaat gaccttgaag aagaaacctt ttattttagg tggaaaggaa
     2821 aatcgcatca aatgagcaga atactgccca tcccagagat ggctaactca gcaagatcca
     2881 gctggttggt gcacaagcct tcccttacat cggaggaatc taaaactgac gggacctgtg
     2941 gtagtcaggc tattgtgcat cctggtttaa cagggactga aggattttcc aggaagtgga
     3001 acttgaaggc taaagtcagg aatgtccatc tcattgaccc acatgcacag agggtagata
     3061 tggaggaaga gcaggcccaa gcatagtcca gggcaaacat tctccacgga ggctcttgga
     3121 gagcaaggca ggtcgttcaa aggcagtttt gccaacggtt cccttcagct ctcatgtctg
     3181 tctaaagcct gagcctcatc tgcagtcaac tgtagcctgc caagatggac tgtgacaggt
     3241 ctccctcatg actcaggggc tgtcatctca ggctgttgtc ctcatgccct ttttatgtac
     3301 ttgccagcca tagaaattcc tgctggacga gtaagtcatt cttgtcaccc ctacactttg
     3361 ctcccagccc tctcccatgc gtgtacatac acacacacac acacacacac acacacacac
     3421 acacacactg tcactagaca ggcaactctg caaaggacac tgtacaagat atataagagc
     3481 gatttcaaac tcagacatct ggtataccct gttctcatgt gtatcaaata aatacagacc
     3541 aggtaaagag aaagccctag tacaggtacc ttgcaatcaa ccatgcttgg ttcaaccttg
     3601 acacatcagg tctccatgta cttgtataag gcagtgatgg ccagtgccag cccagtagta
     3661 ggcaagattg aacatgctgt caggaagccc gtgcatgaca tcatttccta ctgtttcaag
     3721 aagggtgaaa ataaatgcca ctggaaagag tcttctaaga gtcatcgtgg tcgaaagcta
     3781 aagtttcgct tccacttgat agtattataa aataatatat gagaacacag aatggactta
     3841 gtcttaagac ctggaagtgg gggtgacaaa gtcttagctc ccccactctt ctcagagtct
     3901 ggagacgtaa gcggagaagt gcaggaccag tgtaatgaat gaacatacca gtgtgcttgg
     3961 cagcaccgtg tggccataca ggcccccctc tcagactggg ttgctaacac cagtctctcc
     4021 ccacacctcc attatattgc cttttcacat ttgctaggca agtgggcatg catatcctta
     4081 cttggttatg aaatattgaa atacttccag gagagtctct ccctctgctt cctgcctgtc
     4141 ctccccccaa ggtcctgccc tttacctata cttgaggcag aaagagcagc taatactcat
     4201 ccaagaccaa ccgtgagtgg acgctctcac tacgtctcca cagagccaac agcttctcat
     4261 tctaaagcaa gggatcccta gagtttggag cttcatgttg gggttaggaa gtgacagagg
     4321 cagtgggagg ctagaggggc agggaatgcc acagaatccc tgagggcatg gagactagag
     4381 tgactgagat aacaatccca gtgttgtagg tagcctttgt aacaagcccc agcaaggttt
     4441 taccccttcc cactgcctct aacccaaaag aggctctgac gccaaaagat cagctgacat
     4501 tcatatttct gtgtgaaaga aaaggactat ggagaaggta tttcgacaaa ccagaaggta
     4561 tggattcctg ccctccacct tgattctggg tcacttctca acactacctt gagtctccag
     4621 ccgtaccact ttgattgtga cagatatcaa tgaagattcc tccttttaaa aaaaaaaaat
     4681 agccacctcc acttgcacac caactggtag tctagagaca ctacctctct ttaggtatcc
     4741 ctaagtgtgg tatctggaaa cacaggagtt ggctcagtga atcccagact ctatttacct
     4801 atttatgctt tttgtttcta tacttcagta ctggatagct tgtcgatggc agagagaatt
     4861 ggcctttaca ccacaggcca agtacaacat ggacacagga gatgaaacca attggtcctc
     4921 tcaagagttt tgacccccct cctataggat gcaaaacttg atatggtcag agttcctggg
     4981 tttgatgatt tttagcatgt ttaaacatgt ctaaagaaca ggaccctgcc tcaaaaaaca
     5041 aaaaaacaaa acaaaataaa aaagagcagg aaaagcccac ccagtggaaa tgactatgga
     5101 ttttagagct ttaggctact cagaactgtg accaaagctg acttttcaca ctgaggagac
     5161 caaacaggtg ccaacactcc aggctgcagg caggaagctt aggggcagaa cctctctgcc
     5221 ttgaagggtt tgtgaaaatg ctgtgctggg tttttctggg ccatgaggaa tgaaagtgaa
     5281 gataggtgaa ggacagcccc ttccatgtct tataaccaga aatcactttc cccagggttg
     5341 cataaccact tacttccagc aagtgagatg tggggccccc cttgcatgtc ctccaaaacc
     5401 agtgcccatc ccttctcaca ctctgacaac ttccctttcc cttaaccaca ttccagacca
     5461 aacactgttc agtttgtttc caaaattaaa aaccaatgta tatatctgta tgtactccac
     5521 tgctctgtag ggggtttcct ggtcctaggg tggggctgca ggcagaaaag gtattccaat
     5581 cctttggttt tcagaattga acgttttgaa gtgatttgct tggttggttg gggttttttt
     5641 aattttgttt ttcaagctaa gctgggaaag tagattttga aaggcaaact tccttcctgg
     5701 aaactccaca aacatttctg tgcggaagag ttagtttgaa atcttcaact ctgggaggta
     5761 ggcaagtcta aaagacaagg aagaagagga aaagccacat cccatctacc aggtcccttc
     5821 ttggtggtct caatgcatga acgtctgtct gcagctctgg tgtgtgcaca ggaacctagc
     5881 cccactgtga agacagccct gcatgctggc cacagcctgg cctgccttct cccagcagaa
     5941 tcttcataat catcagggag gccttcgccc tgcgcagact tccctgtgaa ctccagtggg
     6001 agcagctcag cttgtggctt tatgggttct acttctgcaa acccaaaggc tgtgcatttg
     6061 gaagccaaat attcagttca gcatgtggct gccaagtctg gttttgtgga caaagcaaac
     6121 tgtgcaatgg cttctctgtg tctgtatttt tctaagccaa agggacgaac tattgcattg
     6181 acatcctgcc ccctgtacta aagctgcttc cgcagtctcc atgaccattc ttaacctttt
     6241 ttgtctctgg ggggatttgt catataatta ctatgtcctc tgatgtttta ccaaactgtg
     6301 ttgcttatag gtgattttat tttccttatg gatgggaaaa acagaaaatg agagacatct
     6361 ttgaggcttt agtcaaagac atcactcaaa agttccaaac actagttaac ttgtttctca
     6421 ataggaaaaa aatcttagtt tggatagaca atgattctga ggccctcctg aataaccctg
     6481 cactttagaa gacaacaccc tggggcagag ctggcagtga ggctacaaaa gagggggtgg
     6541 tggtgaggaa gggactagaa catcatctcg gatgtttgtc ccacactaca ggagctgcag
     6601 ctcttcttga caggcacttg gccatttcag ggcaacgtaa ggctctgtcc agtgttacag
     6661 cagcagggct gcatgtttca gagaacattt atcttagccc acatttgggt gagaagacac
     6721 caaaggtata ttctgcccag aatattggaa taatgtctaa attggcttct gtagctattt
     6781 atacatgata taatttgtct ccattcagct ctctcccaat gatgggcatg ttttcccaac
     6841 agtttccatc aagtccagga ttggcccact cattattacc aggcttgcga ttggtttggt
     6901 tttggttttt ggttttttgg gtttttttta aattattatt aaaaacatgc ttatccaaaa
     6961 aataaaaaaa taaagtaaaa aaaaaaaaag taaaagaagg gaaactgtgc atttatccca
     7021 tgcatgtagt aaactctgca agaagtttaa cccccataag tttgcggcac tgcaaaattg
     7081 ttcatgggtc tatgtagcaa atgattctct gccttgacaa tcatgtatac atatcgattt
     7141 ctatcataat gataatgaga ttggtgactt cttgttttcc tccaataaag agaattaatc
     7201 acctttggaa aaaaaaaaaa aaaaaa
//
