LOCUS       NM_001190385            1260 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus calcyon neuron-specific vesicular protein (Caly),
            transcript variant B, mRNA.
ACCESSION   NM_001190385
VERSION     NM_001190385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Elmarakby,A., Faulkner,J., Pati,P., Rudic,R.D. and Bergson,C.
  TITLE     Increased arterial pressure in mice with overexpression of the ADHD
            candidate gene calcyon in forebrain
  JOURNAL   PLoS One 14 (2), e0211903 (2019)
   PUBMED   30753204
  REMARK    GeneRIF: data suggest that upregulation of calcyon in forebrain
            could increase BP via alterations in noradrenergic transmission and
            increased oxidative stress during high salt challenge.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Shi,L., Muthusamy,N., Smith,D. and Bergson,C.
  TITLE     Dynein binds and stimulates axonal motility of the endosome adaptor
            and NEEP21 family member, calcyon
  JOURNAL   Int J Biochem Cell Biol 90, 93-102 (2017)
   PUBMED   28734834
  REMARK    GeneRIF: endocytic and cargo sorting functions of Caly in neurons
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Dillman,A.A., Hauser,D.N., Gibbs,J.R., Nalls,M.A., McCoy,M.K.,
            Rudenko,I.N., Galter,D. and Cookson,M.R.
  TITLE     mRNA expression, splicing and editing in the embryonic and adult
            mouse cerebral cortex
  JOURNAL   Nat Neurosci 16 (4), 499-506 (2013)
   PUBMED   23416452
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Muthusamy,N., Faundez,V. and Bergson,C.
  TITLE     Calcyon, a mammalian specific NEEP21 family member, interacts with
            adaptor protein complex 3 (AP-3) and regulates targeting of AP-3
            cargoes
  JOURNAL   J Neurochem 123 (1), 60-72 (2012)
   PUBMED   22650988
  REMARK    GeneRIF: The data of this study suggested that calcyon directly
            interacts with mu3A and mu3B, and regulates the subcellular
            distribution of AP-3 and the targeting of AP-3 cargoes.
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Vazdarjanova,A., Bunting,K., Muthusamy,N. and Bergson,C.
  TITLE     Calcyon upregulation in adolescence impairs response inhibition and
            working memory in adulthood
  JOURNAL   Mol Psychiatry 16 (6), 672-684 (2011)
   PUBMED   21403673
  REMARK    GeneRIF: The resultd of this study showed that with
            calcyon-overexpressing Cal(OE) transgenic mice that lifelong
            calcyon upregulation impairs executive functions including response
            inhibition and working memory.
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Davidson,H.T., Xiao,J., Dai,R. and Bergson,C.
  TITLE     Calcyon is necessary for activity-dependent AMPA receptor
            internalization and LTD in CA1 neurons of hippocampus
  JOURNAL   Eur J Neurosci 29 (1), 42-54 (2009)
   PUBMED   19120439
  REMARK    GeneRIF: Taken together, the present studies involving biochemical,
            immunological and electrophysiological analyses raise the
            possibility that calcyon plays a specialized role in regulating
            activity-dependent removal of synaptic AMPARs.
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Trantham-Davidson,H., Vazdarjanova,A., Dai,R., Terry,A. and
            Bergson,C.
  TITLE     Up-regulation of calcyon results in locomotor hyperactivity and
            reduced anxiety in mice
  JOURNAL   Behav Brain Res 189 (2), 244-249 (2008)
   PUBMED   18295356
  REMARK    GeneRIF: Transgenic mice display a range of abnormal behaviors
            including spontaneous hyperactivity, reduced anxiety, and/or
            impaired restraint (harm avoidance) that would indicate that
            calcyon up-regulation leads to deficits in control over behavioral
            output.
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Xiao,J., Dai,R., Negyessy,L. and Bergson,C.
  TITLE     Calcyon, a novel partner of clathrin light chain, stimulates
            clathrin-mediated endocytosis
  JOURNAL   J Biol Chem 281 (22), 15182-15193 (2006)
   PUBMED   16595675
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Dai,R. and Bergson,C.
  TITLE     Structure and expression of the murine calcyon gene
  JOURNAL   Gene 311, 111-117 (2003)
   PUBMED   12853145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003400.2 and AK002979.1.
            
            Transcript Variant: This variant (B) differs in the 3' UTR compared
            to variant A, and is also known as mcal-B. Variants A, B and C
            encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002979.1, BY703440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AK003400.2         2-6
            6-40                AK003400.2         8-42
            41-1260             AK002979.1         2-1221
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 85.07 cM"
     gene            1..1260
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /note="calcyon neuron-specific vesicular protein"
                     /db_xref="GeneID:68566"
                     /db_xref="MGI:MGI:1915816"
     exon            1..87
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     exon            88..247
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..793
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /note="calcyon; D1 dopamine receptor-interacting protein;
                     dopamine receptor D1 interacting protein"
                     /codon_start=1
                     /product="neuron-specific vesicular protein calcyon"
                     /protein_id="NP_001177314.1"
                     /db_xref="CCDS:CCDS21962.1"
                     /db_xref="GeneID:68566"
                     /db_xref="MGI:MGI:1915816"
                     /translation="MVKLGCSFSGKPGKEAGDQDGAAMDSVPLISPLDVSQLQPSFSD
                     QVVINTQTEYQLTSADQPKKFADLEGQRLACSHSEEGRRLPTARMIAFAMALLGCVLI
                     MYKAIWYDQFTCPDGFLLRHKICTPLTLEMYYTEMDPERHRSILAAIGAYPLSRKHGT
                     EMPAVWGNNYRTAKEEHKGTTPAAMAVSTAAAAAAAEGTEPSGKSLDTREKEDPQKAE
                     GVPSQPPK"
     exon            248..361
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     exon            362..475
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     exon            476..1260
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1238..1243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /note="hexamer: AGTAAA"
     polyA_site      1255
                     /gene="Caly"
                     /gene_synonym="0710001P07Rik; 1110004A22Rik; Calcyon;
                     Drd1ip"
                     /note="major polyA site"
ORIGIN      
        1 gcctggtggt gaagcgcctg gaactgcatc ctccgcatct acactgcatc cctgtcctcc
       61 cgcgactgcg tcctgcagca actgcctgct gggacgagga ccatcatcca ccatggtgaa
      121 gctaggctgc agcttctcag ggaagccagg caaggaagca ggagaccagg atggggctgc
      181 catggacagc gtccctctga tcagccccct ggatgtcagc cagcttcagc cgtcattctc
      241 agaccaggtg gtcatcaaca cacagacaga atatcaactt acctctgcag accagccaaa
      301 gaagtttgca gatttggagg gtcagaggct ggcttgcagt cactcagagg aaggacgcag
      361 actgcccacc gcaaggatga tcgcttttgc tatggcactt ctgggctgtg tgctgatcat
      421 gtacaaggcc atctggtatg accagtttac ctgcccagat ggcttcctac ttcggcacaa
      481 gatctgcacc ccactgaccc tggagatgta ctacaccgag atggaccccg aacgccaccg
      541 cagcatcctg gcagccatcg gggcctaccc actgagccgc aaacacggca ctgagatgcc
      601 cgctgtctgg ggaaacaact accggaccgc caaggaggag cataagggca ctacccctgc
      661 ggcgatggct gtgtccactg cagctgcagc tgcagcggca gagggcaccg agccgtcagg
      721 gaagtctttg gacacgagag agaaagaaga cccgcagaag gcggagggcg tgccatccca
      781 gccccccaag tgactgtctg ccccgtcccc gctccgcccg tgactggggt aagtgtgctc
      841 ggcctaaaca ggggctgact ggctcgcagg gtcacaggct tgcccagcct tgccttgccc
      901 tgtcttgccc tgccctttct cccgcccttt cctgtcccca cgaacctccc tccgtcccca
      961 cctccttcac ttccggtcag gcccagaaac ctacccagat gtccaccctc tctcaacgct
     1021 acctccgagt ctgcgcacgc ggcttgcctt cctgcccagg acaccagcct tctacccctt
     1081 tcaccttgac tcttgtatct tcacagcatc cctcaccagc tactttgaca tgcacactgc
     1141 ctgacgcttc tccacccagt gattgtgctc ctgtcccaaa gcaccccgct caagtctccc
     1201 acccctggtg gacctctgac tctgttgctt ttctttaagt aaagattcac atctatctgg
//
