LOCUS       NM_007594               3229 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calumenin (Calu), transcript variant 1, mRNA.
ACCESSION   NM_007594
VERSION     NM_007594.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3229)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3229)
  AUTHORS   Wang,Q., Shen,B., Chen,L., Zheng,P., Feng,H., Hao,Q., Liu,X.,
            Liu,L., Xu,S., Chen,J. and Teng,J.
  TITLE     Extracellular calumenin suppresses ERK1/2 signaling and cell
            migration by protecting fibulin-1 from MMP-13-mediated proteolysis
  JOURNAL   Oncogene 34 (8), 1006-1018 (2015)
   PUBMED   24632605
  REMARK    GeneRIF: Extracellular calumenin regulates fibulin-1 to have
            crucial roles in ERK1/2 signaling and cell migration.
REFERENCE   3  (bases 1 to 3229)
  AUTHORS   Vasiljevic,M., Heisler,F.F., Hausrat,T.J., Fehr,S., Milenkovic,I.,
            Kneussel,M. and Sieghart,W.
  TITLE     Spatio-temporal expression analysis of the calcium-binding protein
            calumenin in the rodent brain
  JOURNAL   Neuroscience 202, 29-41 (2012)
   PUBMED   22178608
  REMARK    GeneRIF: This study points to a possible important role of
            calumenin in migration and differentiation of neurons
REFERENCE   4  (bases 1 to 3229)
  AUTHORS   Sahoo,S.K., Kim,T., Kang,G.B., Lee,J.G., Eom,S.H. and Kim,D.H.
  TITLE     Characterization of calumenin-SERCA2 interaction in mouse cardiac
            sarcoplasmic reticulum
  JOURNAL   J Biol Chem 284 (45), 31109-31121 (2009)
   PUBMED   19740751
  REMARK    GeneRIF: Regions of 132-222 amino acids of calumenin and 853-892
            amino acids of SERCA2 are the major binding partners.
REFERENCE   5  (bases 1 to 3229)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   6  (bases 1 to 3229)
  AUTHORS   Lee,Y.J., Park,C.W., Hahn,Y., Park,J., Lee,J., Yun,J.H., Hyun,B.
            and Chung,J.H.
  TITLE     Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely
            linked to Peg1/Mest(1)
  JOURNAL   FEBS Lett 472 (2-3), 230-234 (2000)
   PUBMED   10788617
REFERENCE   7  (bases 1 to 3229)
  AUTHORS   Nakamura,T., Yabe,D., Kanazawa,N., Tashiro,K., Sasayama,S. and
            Honjo,T.
  TITLE     Molecular cloning, characterization, and chromosomal localization
            of FKBP23, a novel FK506-binding protein with Ca2+-binding ability
  JOURNAL   Genomics 54 (1), 89-98 (1998)
   PUBMED   9806833
REFERENCE   8  (bases 1 to 3229)
  AUTHORS   Yabe,D., Taniwaki,M., Nakamura,T., Kanazawa,N., Tashiro,K. and
            Honjo,T.
  TITLE     Human calumenin gene (CALU): cDNA isolation and chromosomal mapping
            to 7q32
  JOURNAL   Genomics 49 (2), 331-333 (1998)
   PUBMED   9598325
REFERENCE   9  (bases 1 to 3229)
  AUTHORS   Yabe,D., Nakamura,T., Kanazawa,N., Tashiro,K. and Honjo,T.
  TITLE     Calumenin, a Ca2+-binding protein retained in the endoplasmic
            reticulum with a novel carboxyl-terminal sequence, HDEF
  JOURNAL   J Biol Chem 272 (29), 18232-18239 (1997)
   PUBMED   9218460
REFERENCE   10 (bases 1 to 3229)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ084197.1, AK163674.1, AK135295.1 and AK148178.1.
            
            On Oct 18, 2013 this sequence version replaced NM_007594.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148178.1, BC051423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CJ084197.1         3-15
            14-850              AK163674.1         2-838
            851-3221            AK135295.1         776-3146
            3222-3229           AK148178.1         3174-3181
FEATURES             Location/Qualifiers
     source          1..3229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.36 cM"
     gene            1..3229
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /note="calumenin"
                     /db_xref="GeneID:12321"
                     /db_xref="MGI:MGI:1097158"
     exon            1..103
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            104..330
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            331..524
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            525..691
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            692..752
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            753..952
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            953..3229
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1472..1477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      1500
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /note="major polyA site"
     regulatory      3203..3208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3228
                     /gene="Calu"
                     /gene_synonym="9530075H20Rik"
ORIGIN      
        1 ggggccatta accacttccg gttgggcggt gcttgtgcgc gggagctcac tccctgggtg
       61 agccgcagcc acggtatcct gcggcgtgga gctcccggga aaggttatca tggacctgcg
      121 tcagtttctt atgtgcctgt ccctgtgcac agcctttgct ttgagcaagc ctacagaaaa
      181 gaaggaccga gtacaccatg agcctcagct cagcgataaa gttcacaatg atgctcagaa
      241 ttttgactat gaccatgatg ccttcttggg tgcagaagag gcaaagagtt ttgatcagct
      301 gacaccagaa gagagcaagg aaaggcttgg aaagattgta agtaaaatag atgacgacaa
      361 ggatgggttt gtcactgtgg atgaactcaa aggctggatt aagtttgcac aaaagcgctg
      421 gattcacgag gatgtagagc ggcaatggaa ggggcacgac ctcaatgagg atggcctcgt
      481 ttcctgggag gagtataaaa atgccaccta cggctacgtt ttagatgatc cagatcctga
      541 tgatggattt aattataaac agatgatggt cagagatgag cggaggttta aaatggcaga
      601 caaggatgga gacctaattg ccacaaagga agagttcaca gctttcctgc accctgagga
      661 atatgactac atgaaagaca tagtcgtgca ggaaaccatg gaggatatag acaagaatgc
      721 tgatgggttc attgatctag aggagtacat tggtgacatg tacagtcatg atgggaatgc
      781 tgatgagcca gagtgggtga agacagagcg agaacagttc gtggagtttc gagataagaa
      841 ccgggatggg aagatggaca aggaagagac caaagactgg atcctcccct cagactatga
      901 ccatgcagag gcagaagcca ggcatctggt ctatgagtca gaccaaaaca aggatggcaa
      961 gctcaccaag gaggagattg tcgacaagta tgatttattt gtgggcagcc aggccacaga
     1021 tttcggggag gccttagtac gacatgatga gttctgagct gcagacagag gaacctacat
     1081 ttcttcaaaa gtaatttatt tttacagctc tggtttcaca taaaattgcg ctactgagac
     1141 tgttattaca aactttttaa gacgtgaaaa ggcatattga gatagtgaaa tcacccgtcc
     1201 ccactcctcc tccctctgag gggctggagg gaacccgagc ttccgaggaa caactctgat
     1261 tagtacactt gtgtctgtag gtttacactt tgtataatgt ataacatggt gtgtttattt
     1321 ttgtattgtt ctctagttgg ggctatacta tgaaggatcg agatcctcca cccacacttg
     1381 taggcagata ttagcattta cacgtcctca atcctttacc atagttttta taattctcac
     1441 ttaactaatt tttttaaagc ctgagatcaa taagaaatgt tcaggagaga aaaagcaaaa
     1501 ggaaaaccat gtgtgtcagg atcgatgctt agaggagaat gctttctctt gcctgttgaa
     1561 aagtctcatt gcatgagttg ctgctcggtt gtcataggcc cagccactga gcctgccatt
     1621 gtctgggcaa cgatagagtc ctgtgctgta agacagcttg acacaactcg atgtcattct
     1681 ttttcccctt taggactagc tgttttctaa ttttgtcaga cacagctgtg ctaggaagaa
     1741 ttagggccag tgtcttgaaa aatcaatcaa gtagtgtgta tgatgtcttc acggggctat
     1801 ttctagctct ttatagagct gtttccaact agaaacagct ggaaaacaag aagaacaaag
     1861 tgtatgcagg gcatgcatct tactcttact tgaaatcact gtaaggcccc atccagcccc
     1921 tttctaagaa ttaaccttgg ttttactgca gttaaagttg attcttttcc aatcatgaca
     1981 ttgaaagtgc ctttaacagg aaaaatgatc actgaatggg aattggacta agataaacaa
     2041 tttgggcacc ttccatgaaa gcattgaact tcctgataca gtggggtttc cccctttttc
     2101 tcttgagaac aggagctaaa tagcagtatt cattacaagc ttgcttgcag tgttcttacc
     2161 ttgtgggctg gttcctaaac ctcaccctgc tgattggacc agggatcctc atacctcaga
     2221 aggcaaacca ctcttctccc aggcctctgc tcaccagggc ttgagctttg cctcaaggat
     2281 agaaggatgt acagaggggg ctcttggttt gaggaccact tgagccgttt tctcatctcc
     2341 ctttctctct gacacaaaaa ggtggggttg taggagggtt gtagatcatc atgttgccat
     2401 ccttattaaa aataatcatc atcatcatct gttgccaact ccattcacct gttttggtct
     2461 cgagttgatg ggcctcttaa gaattattgt accccaagtc tttaaccctc aggttactaa
     2521 gatgaataca catctgtata atctttatta cttcctatat ctctgaacaa cacattcagg
     2581 tggtgctggg tgatggccat atctgaacct agacttccct ttggtcttcc ccaatccagt
     2641 tgaggtgggc ggcctggtgt ggtaaaagcc cagttgtggt gtgacttcac cttagccatt
     2701 gcatcaagct cttgatagca gatacactct tacgtttcta accccagtct aggagtaatg
     2761 aacatcactg ccttccaggc cctcaactgt attgttaagg agaccagaga taatgaatgc
     2821 caccaaccct ggcttagaaa gggcaggtca cacactgtgt ggcaagaggg cattacagct
     2881 cattaggtgc acagagccta atgctagcgt gaaagtcaca cacttatcca gcaagctgag
     2941 tctgctagga tggcatcttc tggacctggg tgctcagcag caaaaactgt gctctaatgt
     3001 ctatgagccc ctcatagtgt tggggtttgg gtgtgggttt ctggtttaaa tcaagtctga
     3061 ggcagtgagc agtggtctca tgtctataga gtgtgccctg tgaatgctaa gctctcttga
     3121 atttgagtat tggttctttt ttttatagag tgtaaaccaa gttttatatt ctgtaatgca
     3181 aacaggtacc tatctgtttc tgaataaaac tgtttacatt catcaaggg
//
