LOCUS       NM_001033226            1932 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus calreticulin 4 (Calr4), transcript variant 2, mRNA.
ACCESSION   NM_001033226 XM_205476 XM_897727 XM_897738 XM_916228
VERSION     NM_001033226.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1932)
  AUTHORS   Diaz Del Moral S, Barrena S, Hernandez-Torres F, Aranega A,
            Villaescusa JM, Gomez Doblas JJ, Franco D, Jimenez-Navarro M,
            Munoz-Chapuli R and Carmona R.
  TITLE     Deletion of the Wilms' Tumor Suppressor Gene in the Cardiac
            Troponin-T Lineage Reveals Novel Functions of WT1 in Heart
            Development
  JOURNAL   Front Cell Dev Biol 9, 683861 (2021)
   PUBMED   34368133
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1932)
  AUTHORS   Ansarullah, Jain C, Far FF, Homberg S, Wissmiller K, von Hahn FG,
            Raducanu A, Schirge S, Sterr M, Bilekova S, Siehler J, Wiener J,
            Oppenlander L, Morshedi A, Bastidas-Ponce A, Collden G, Irmler M,
            Beckers J, Feuchtinger A, Grzybek M, Ahlbrecht C, Feederle R,
            Plettenburg O, Muller TD, Meier M, Tschop MH, Coskun U and Lickert
            H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. PMID: 33712809]
REFERENCE   3  (bases 1 to 1932)
  AUTHORS   Dey S and Matsunami H.
  TITLE     Calreticulin chaperones regulate functional expression of
            vomeronasal type 2 pheromone receptors
  JOURNAL   Proc Natl Acad Sci U S A 108 (40), 16651-16656 (2011)
   PUBMED   21933956
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK163350.1, AK139540.1 and BG083829.2.
            
            On Oct 24, 2013 this sequence version replaced NM_001033226.3.
            
            Transcript Variant: This variant (2) has alternate 5' exon
            structure and it thus differs in the 5' UTR and 5' coding region,
            compared to variant 1. The encoded isoform (b) has a distinct and
            shorter N-terminus, compared to isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163350.1, SRR10662773.1061812.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1603              AK163350.1         2-1604
            1604-1912           AK139540.1         1583-1891
            1913-1932           BG083829.2         516-535
FEATURES             Location/Qualifiers
     source          1..1932
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 51.1 cM"
     gene            1..1932
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="calreticulin 4"
                     /db_xref="GeneID:108802"
                     /db_xref="MGI:MGI:2140435"
     exon            1..244
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1356
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="calreticulin 4 isoform b precursor"
                     /protein_id="NP_001028398.1"
                     /db_xref="CCDS:CCDS18461.1"
                     /db_xref="GeneID:108802"
                     /db_xref="MGI:MGI:2140435"
                     /translation="MCWFFFFSLSLSPFSTDGWTKRWVQSKHQSDYGQFQLASGKFYQ
                     DKERDKGLQTTEDAKFYALSTRFKPFSNENETLVVQFSVKHEQGIDCGGGYVKLFPAA
                     LNQEDMHSESQYYIMFGPDICGFGNNRLQVILSHKGKYHENNKTLKCRINKDTHLYTL
                     ILRPNATYEVKIDNQKVTSGGLEDDWDFLPPKKIKDPYARKPRKWDERQQIEDPDDKK
                     PEDWEDSEFIPDPDAKKPDDWNEAMDGVWEGPLIPNVKYMGEWKPRIIDNPNYQGEWI
                     HPEIDNPKYRPDPTIGHYHNISVLGLDLWQVKSGSIFDNFLLTNDEEFAEEVGNMTWG
                     LRKDVEQQWRELYEEMEKQKEAEETKKKREKERARQEDVWGLDEEDEEDAEEDDEEEA
                     EERLKQEGSAARASLDQKEAHLDQKDEL"
     exon            245..448
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            449..543
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..753
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            754..867
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1011
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1104
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1932
                     /gene="Calr4"
                     /gene_synonym="4933403L16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtaagcgtg atttcaggaa tattctgagt cacctgttac tttttccctc tgcccgtaga
       61 acttaattag caatggcaac ttgattcatt tgaatgtgtt ggtttttttt tttttctctc
      121 tctctctctc ctttctccac agatggatgg acaaaacggt gggtacaatc taaacatcag
      181 tcagattacg gccaattcca gctagcctcg ggaaaatttt atcaagataa agagagagat
      241 aaaggtctcc agaccacaga agatgccaag ttctacgccc tttccaccag gtttaagcca
      301 ttcagcaatg agaatgagac cttggtggtt cagttttcag taaaacacga gcaaggcatc
      361 gattgcggcg gtggctacgt gaaactcttt cctgccgcac tgaaccagga ggacatgcac
      421 tcagaatccc agtattacat catgttcggc ccggacatct gtggctttgg caacaacaga
      481 ctacaggtca tcctttctca caaagggaaa taccatgaga acaacaagac cctcaagtgc
      541 aggattaata aagacactca cctgtacact ctgatccttc gccctaatgc tacttatgag
      601 gttaaaattg acaaccagaa ggtgacaagt ggaggactgg aagatgactg ggacttcttg
      661 cctcccaaga aaataaaaga cccctacgcc aggaaaccaa ggaaatggga tgaacgacaa
      721 cagatagagg atcctgacga taagaaacct gaggactggg aggactctga attcatccca
      781 gacccggatg ccaagaagcc agatgactgg aatgaggcga tggatggagt gtgggaaggg
      841 cccttgatac caaacgtcaa gtacatggga gaatggaaac ctcggatcat tgacaacccc
      901 aattaccagg gcgagtggat tcacccagag atagacaacc ccaaatacag gcctgacccc
      961 accattggtc actatcacaa cattagtgtc cttggtctgg atctttggca ggtgaaatca
     1021 ggcagcatct ttgacaattt ccttctaaca aatgatgaag agtttgctga agaggttgga
     1081 aatatgacct ggggattaag aaaggatgtg gagcagcagt ggagagagct gtatgaggaa
     1141 atggagaaac agaaggaggc ggaggagacc aagaagaaga gggaaaagga gagagccagg
     1201 caagaggacg tctggggact agatgaggag gatgaggagg acgctgaaga ggacgacgag
     1261 gaggaagcag aggaaaggct caagcaggaa ggcagtgcag cgagggcgtc tctggaccag
     1321 aaggaagccc acttggatca gaaggatgaa ctgtaactgc acagacactg ggtgtggccg
     1381 aagtcagaga cggtgcttag agagggaaat gggccctcgc ttagcaaatt atgggaagta
     1441 aaacgactca ttctttttag ataaactttg gatttatagt tctactcccc ttccctgctc
     1501 tatttgctca ttggtagaaa gggaatgata attttatctc atgaaatggc ccttgggact
     1561 gaatgaggca atgcctgtaa catgcccaaa gtaaatactt gtaaaaaaaa tgtagtagtt
     1621 aaaactacta tcattatcat ggtgtttatg aaattaattg ttggtaaata agcttctata
     1681 taaacttggt tcttactttc aactggggtt tttcttttgt ttaaatatat gcaattctta
     1741 gtatttatgg agcagtgcta acagttgaac ccaatgtttc cttttttttt ttttttttta
     1801 aatgtattga gcacctaaag ccaaaagcag aacatccttt ggacgtttgg aaaaatactt
     1861 catgaaagtc accttgtttg cctgctgctc ttgccttatg tttaaacaat tgttacttgt
     1921 ttgcaagttt gc
//
