LOCUS       NM_007591               1943 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus calreticulin (Calr), mRNA.
ACCESSION   NM_007591
VERSION     NM_007591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1943)
  AUTHORS   Chen,C.C., Hsu,L.W., Chen,K.D., Chiu,K.W., Kung,C.P., Li,S.R.,
            Chen,C.L. and Huang,K.T.
  TITLE     Calreticulin regulates hepatic stellate cell activation through
            modulating TGF-beta-induced Smad signaling
  JOURNAL   Cell Calcium 121, 102895 (2024)
   PUBMED   38703416
  REMARK    GeneRIF: Calreticulin regulates hepatic stellate cell activation
            through modulating TGF-beta-induced Smad signaling.
REFERENCE   2  (bases 1 to 1943)
  AUTHORS   Haage,T.R., Charakopoulos,E., Bhuria,V., Baldauf,C.K., Korthals,M.,
            Handschuh,J., Muller,P., Li,J., Harit,K., Nishanth,G., Frey,S.,
            Bottcher,M., Fischer,K.D., Dudeck,J., Dudeck,A., Lipka,D.B.,
            Schraven,B., Green,A.R., Muller,A.J., Mougiakakos,D. and Fischer,T.
  TITLE     Neutrophil-specific expression of JAK2-V617F or CALRmut induces
            distinct inflammatory profiles in myeloproliferative neoplasia
  JOURNAL   J Hematol Oncol 17 (1), 43 (2024)
   PUBMED   38853260
  REMARK    GeneRIF: Neutrophil-specific expression of JAK2-V617F or CALRmut
            induces distinct inflammatory profiles in myeloproliferative
            neoplasia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1943)
  AUTHORS   Holl,K., Chatain,N., Krapp,S., Baumeister,J., Maie,T., Schmitz,S.,
            Scheufen,A., Brock,N., Koschmieder,S. and Moreno-Andres,D.
  TITLE     Calreticulin and JAK2V617F driver mutations induce distinct mitotic
            defects in myeloproliferative neoplasms
  JOURNAL   Sci Rep 14 (1), 2810 (2024)
   PUBMED   38308077
  REMARK    GeneRIF: Calreticulin and JAK2V617F driver mutations induce
            distinct mitotic defects in myeloproliferative neoplasms.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1943)
  AUTHORS   Melnikova,A., Ishii,H., Tamatani,T., Hattori,T., Takarada-Iemata,M.
            and Hori,O.
  TITLE     Neuroprotective role of calreticulin after spinal cord injury in
            mice
  JOURNAL   Neurosci Res 195, 29-36 (2023)
   PUBMED   37295503
  REMARK    GeneRIF: Neuroprotective role of calreticulin after spinal cord
            injury in mice.
REFERENCE   5  (bases 1 to 1943)
  AUTHORS   Grockowiak,E., Korn,C., Rak,J., Lysenko,V., Hallou,A.,
            Panvini,F.M., Williams,M., Fielding,C., Fang,Z.,
            Khatib-Massalha,E., Garcia-Garcia,A., Li,J., Khorshed,R.A.,
            Gonzalez-Anton,S., Baxter,E.J., Kusumbe,A., Wilkins,B.S., Green,A.,
            Simons,B.D., Harrison,C.N., Green,A.R., Lo Celso,C.,
            Theocharides,A.P.A. and Mendez-Ferrer,S.
  TITLE     Different niches for stem cells carrying the same oncogenic driver
            affect pathogenesis and therapy response in myeloproliferative
            neoplasms
  JOURNAL   Nat Cancer 4 (8), 1193-1209 (2023)
   PUBMED   37550517
REFERENCE   6  (bases 1 to 1943)
  AUTHORS   Mazzarella,R.A., Gold,P., Cunningham,M. and Green,M.
  TITLE     Determination of the sequence of an expressible cDNA clone encoding
            ERp60/calregulin by the use of a novel nested set method
  JOURNAL   Gene 120 (2), 217-225 (1992)
   PUBMED   1398135
REFERENCE   7  (bases 1 to 1943)
  AUTHORS   Michalak,M., Milner,R.E., Burns,K. and Opas,M.
  TITLE     Calreticulin
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 681-692 (1992)
   PUBMED   1497605
  REMARK    Review article
REFERENCE   8  (bases 1 to 1943)
  AUTHORS   Abe,H., Watanabe,M., Goto,K., Sakagami,H. and Kondo,H.
  TITLE     Localization of gene expression of calreticulin in the brain of
            adult mouse
  JOURNAL   Brain Res Mol Brain Res 14 (4), 337-343 (1992)
   PUBMED   1326696
REFERENCE   9  (bases 1 to 1943)
  AUTHORS   Smith,M.J. and Koch,G.L.
  TITLE     Multiple zones in the sequence of calreticulin (CRP55, calregulin,
            HACBP), a major calcium binding ER/SR protein
  JOURNAL   EMBO J 8 (12), 3581-3586 (1989)
   PUBMED   2583110
REFERENCE   10 (bases 1 to 1943)
  AUTHORS   Tuan,R.S. and Kirwin,J.J.
  TITLE     Mouse placental 57-kDa calcium-binding protein: I. Cloning of cDNA
            and characterization of developmental expression
  JOURNAL   Differentiation 37 (2), 98-103 (1988)
   PUBMED   2456241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291864.1, AK075605.1, AK160197.1 and BB727203.1.
            
            On Oct 31, 2006 this sequence version replaced NM_007591.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075605.1, X14926.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY291864.1         1-62
            63-1557             AK075605.1         2-1496
            1558-1940           AK160197.1         1494-1876
            1941-1943           BB727203.1         446-448
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.21 cM"
     gene            1..1943
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /note="calreticulin"
                     /db_xref="GeneID:12317"
                     /db_xref="MGI:MGI:88252"
     exon            1..224
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1384
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /note="CRP55; ERp60; HACBP; endoplasmic reticulum resident
                     protein 60"
                     /codon_start=1
                     /product="calreticulin precursor"
                     /protein_id="NP_031617.1"
                     /db_xref="CCDS:CCDS22479.1"
                     /db_xref="GeneID:12317"
                     /db_xref="MGI:MGI:88252"
                     /translation="MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKS
                     DFGKFVLSSGKFYGDLEKDKGLQTSQDARFYALSAKFEPFSNKGQTLVVQFTVKHEQN
                     IDCGGGYVKLFPSGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKD
                     IRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPED
                     WDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWK
                     PRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITN
                     DEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDDDDRD
                     EDEDEEDEKEEDEEESPGQAKDEL"
     exon            225..326
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     exon            327..530
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     exon            531..625
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     exon            626..835
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     exon            836..949
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1093
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1186
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1943
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /note="hexamer: ATTAAA"
     polyA_site      1940
                     /gene="Calr"
                     /gene_synonym="Calregulin; CRT"
                     /note="major polyA site"
ORIGIN      
        1 ggctgtgtca ggttcgggtg agaggtaggt gaatataaat tgaagcggcg gtggccgcgt
       61 ccgtcaatac cgcagagccg ctgcctgaag atcgtcttaa aaggcctgtg tgccgccgcc
      121 ccctcggccc gccatgctcc tttcggtgcc gctcctgctt ggcctcctcg gcctggccgc
      181 cgcagaccct gccatctatt tcaaagagca gttcttggac ggagatgcct ggaccaaccg
      241 ctgggtcgaa tccaaacata agtccgattt tggcaaattt gtcctcagtt ctggcaaatt
      301 ttacggggac ctggagaagg ataaagggct gcagacaagc caagatgccc gattttacgc
      361 actgtccgcc aaattcgaac ccttcagcaa taagggccag acactggtgg tacagttcac
      421 ggtgaagcat gagcagaata tcgactgtgg gggcggctac gtgaagctgt ttccgagtgg
      481 tttggaccag aaggacatgc atggagactc agaatataac atcatgtttg gtccggacat
      541 ctgcggtcct ggcaccaaga aggttcatgt catctttaac tacaagggca agaatgtgct
      601 gatcaacaag gatatccggt gtaaggatga tgaattcaca cacctataca cactgattgt
      661 gcggccagac aacacctatg aggtgaaaat tgacaacagc caggtggagt caggctcctt
      721 ggaggatgat tgggactttc tgccacccaa gaagataaag gaccctgatg ctgccaagcc
      781 ggaagactgg gatgaacgag ccaagatcga tgaccccaca gattccaagc ctgaggactg
      841 ggacaagcca gagcacatcc ctgaccctga tgctaagaag cctgaggact gggatgaaga
      901 gatggatgga gagtgggaac caccagtgat tcaaaatcct gaatacaagg gcgagtggaa
      961 accacgtcaa attgacaacc cagattacaa gggtacctgg atacacccag aaattgacaa
     1021 ccctgaatac tcccccgatg caaatatcta tgcctatgat agttttgctg tactgggcct
     1081 agatctctgg caggtcaagt ccgggacaat ctttgacaat ttcctcatca ccaatgatga
     1141 ggcctatgca gaggagtttg gcaatgagac gtggggtgtt accaaggctg cagagaagca
     1201 gatgaaggac aagcaggatg aggagcagag gcttaaggaa gaagaagagg acaagaagcg
     1261 taaagaggaa gaagaagctg aggataaaga ggatgatgat gacagagatg aagatgagga
     1321 cgaagaagat gagaaggagg aagatgagga agaatcccct ggccaagcca aggatgagct
     1381 gtagaggcca caccacctgc cttcagggct ggactgaggc ctgaacaccc tgccgcagag
     1441 ctggctgctc ccaataatgt ctctatgaga ctcaagaact tttcattttt tccaggcagg
     1501 ttcagatctg gggtagattc tgattttgtt cccctgcctc ccccattacc cccccccctt
     1561 ttttttttta ctggtgtttg tctttaattc tccttcagcc ctcatctggt ttctcatttt
     1621 tgaatcaaca tcttttcctt ctgtccctcc ctttctccat cttttggtca ctaccctcca
     1681 actctaggaa caggggtgta gaggagaagc cctaggcttg agatttcatc tgctctcctt
     1741 cctgcatctc agaggagggc aggagaaggg ggtggtgttt tccctccccc cgcactgagg
     1801 aagaatgggg ctcttctcat cccctttctc ccttgccccc aggactgggc cacttgtggg
     1861 gcagccagtt ctagcacagc tcacactgag agtgtaagaa ctacaaacaa aatttctatt
     1921 aaattaagtt ttgtgtcttc cct
//
