LOCUS       NM_021371               2586 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus calneuron 1 (Caln1), transcript variant 2, mRNA.
ACCESSION   NM_021371
VERSION     NM_021371.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Andres-Alonso,M., Borgmeyer,M., Mirzapourdelavar,H., Lormann,J.,
            Klein,K., Schweizer,M., Hoffmeister-Ullerich,S., Oelschlegel,A.M.,
            Dityatev,A. and Kreutz,M.R.
  TITLE     Golgi satellites are essential for polysialylation of NCAM and
            expression of LTP at distal synapses
  JOURNAL   Cell Rep 42 (7), 112692 (2023)
   PUBMED   37355986
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Pereira,J.D., Sansom,S.N., Smith,J., Dobenecker,M.W.,
            Tarakhovsky,A. and Livesey,F.J.
  TITLE     Ezh2, the histone methyltransferase of PRC2, regulates the balance
            between self-renewal and differentiation in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 107 (36), 15957-15962 (2010)
   PUBMED   20798045
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   McCue,H.V., Burgoyne,R.D. and Haynes,L.P.
  TITLE     Membrane targeting of the EF-hand containing calcium-sensing
            proteins CaBP7 and CaBP8
  JOURNAL   Biochem Biophys Res Commun 380 (4), 825-831 (2009)
   PUBMED   19338761
REFERENCE   4  (bases 1 to 2586)
  AUTHORS   Haeseleer,F. and Palczewski,K.
  TITLE     Calmodulin and Ca2+-binding proteins (CaBPs): variations on a theme
  JOURNAL   Adv Exp Med Biol 514, 303-317 (2002)
   PUBMED   12596929
  REMARK    Review article
REFERENCE   5  (bases 1 to 2586)
  AUTHORS   Wu,Y.Q., Lin,X., Liu,C.M., Jamrich,M. and Shaffer,L.G.
  TITLE     Identification of a human brain-specific gene, calneuron 1, a new
            member of the calmodulin superfamily
  JOURNAL   Mol Genet Metab 72 (4), 343-350 (2001)
   PUBMED   11286509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY274079.1 and BC058963.1.
            
            On Sep 29, 2007 this sequence version replaced NM_021371.1.
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region, compared to
            variant 1. The resulting protein (isoform 2) has a shorter
            N-terminus when compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057129.1, AB041539.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY274079.1         1-21
            22-2125             BC058963.1         1-2104
            2126-2586           BC058963.1         2106-2566
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 69.29 cM"
     gene            1..2586
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /note="calneuron 1"
                     /db_xref="GeneID:140904"
                     /db_xref="MGI:MGI:2155987"
     exon            1..667
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /inference="alignment:Splign:2.1.0"
     exon            668..792
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /inference="alignment:Splign:2.1.0"
     CDS             675..1334
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /note="isoform b is encoded by transcript variant 2;
                     calcium-binding protein 8; calneuron I"
                     /codon_start=1
                     /product="calcium-binding protein 8 isoform b"
                     /protein_id="NP_067346.1"
                     /db_xref="CCDS:CCDS19714.1"
                     /db_xref="GeneID:140904"
                     /db_xref="MGI:MGI:2155987"
                     /translation="MPFHHVTAGLLYKGNYLNRSLSAGSDSEQLANISVEELDEIREA
                     FRVLDRDGNGFISKQELGMAMRSLGYMPSEVELAIIMQRLDMDGDGQVDFDEFMTILG
                     PKLVSSEGRDGFLGNTIDSIFWQFDMQRVTLEELKHILYHAFRDHLTMKDIENIIINE
                     EESLNETSGNCQTEFEGVHSQKQNRQTCVRKSLICAFAMAFIISVMLIAANQILRSGM
                     E"
     exon            793..936
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1049
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1206
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..2569
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1572..1577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /note="hexamer: AATAAA"
     polyA_site      1594
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /note="major polyA site"
     regulatory      2548..2553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
                     /note="hexamer: ATTAAA"
     polyA_site      2565
                     /gene="Caln1"
                     /gene_synonym="9630012C17Rik; Cabp8; MNCb-0849"
ORIGIN      
        1 ggtgggaggt ccccaatcct gggagaaaag agaagagaga ctggggtggc caagccagtc
       61 cagcaaccag gctccagcct cggtgggggg aagaagccaa gagtggtagg gggatctcct
      121 tgctagagac cgctaggctt cttcatctgg aggaaccggg gaggcactgg ggaggaggcc
      181 ggagctgcat ggagtttctg gggcgcgcaa ctccggcggg gcctcggcca ctgggctccc
      241 gggcgcagcg aggaggcagc cgcgcacatg ggctaagccc gcgcggccag cgggcgcggg
      301 aggggtagag gcgagagcgg tgcagggggt gcggggcgca cgttccccca gacgggaggc
      361 gaggacaagg acaggggaga aaggagcagc ctagatcatc gcgggctctg caaagcccag
      421 ctgtgagact caagggaaag gcaagactcg cgccgcgccg ggctcccggg tgccgctggg
      481 ttgggcaaag cggcctctca accagagtgg gggcacgccg tgggagccgg ctacggagag
      541 gaaggatgcc cgcgcgggga cgcgtgtgag cgccagcttg agcgctctgt ttcgcgtcgc
      601 cccctccctg cgggcctcgg aggaggtgcc tgggctgccg ggcagcggag ctccggctcc
      661 aggagaggga aaagatgccg ttccaccatg taaccgctgg cttgttgtac aaggggaatt
      721 acctcaaccg atctctgtct gcaggcagtg acagcgagca gttggctaat atctccgtgg
      781 aagaactgga tgaaatccga gaagccttcc gtgttctgga cagagatggc aacggcttca
      841 tctccaagca ggagctgggc atggccatgc gctccttggg gtacatgccg agcgaagtgg
      901 agctggctat catcatgcag cgtttggaca tggacggaga tgggcaggta gattttgatg
      961 aattcatgac gattcttggg cccaagctgg tgtcatcaga aggtcgggat ggttttcttg
     1021 gaaatacgat agacagtatc ttctggcagt tcgacatgca gagagtcacg ctggaagagc
     1081 tgaagcacat cctgtaccac gccttccggg atcacttaac gatgaaggac attgagaaca
     1141 ttatcatcaa cgaggaggag agtttgaacg agacctcggg gaactgccag acagagtttg
     1201 aaggagttca ttcgcagaaa cagaaccgac agacctgcgt ccgcaagagc ctcatatgcg
     1261 cctttgccat ggccttcatc ataagcgtca tgctgatcgc agccaaccag atcctgcgga
     1321 gcggcatgga gtaggatagc agccttccac cagccacacc gcgttgccag ctcactgcgc
     1381 atgtgcatgc cccgcgggca gactctgttc attcacacgg gagatctgga cctttatgga
     1441 tggatgcatt ggtacccttc agtaaagaac tcaagtttgc agtgcaaccg gggtcacgga
     1501 tcaactccat ctccttggca gggacacaaa agggctgtct tcaatgcttt catggttttg
     1561 tttcccaatg caataaatag ccaggagttc tcaattattg cttcaaccgc cagtagcaac
     1621 tctgaagtgg gggggaaaaa tactgctttc ttttcgtctt ggaattccag tagccatcca
     1681 gatagcatgg tggcctctga gagcgagaaa gaaaagacag gtataagcaa cagccacctc
     1741 tatccatgac ccaattcttt caacccaggg acccacggag actccctgct gaagttgact
     1801 tctgggttgc tacagaaaag gggactttcc atctcaccct ggcttccttc ctccacccag
     1861 tggagacccc ctcccaccaa ggcatggagg gggaaagcca ttaagcaggg tgcagctcct
     1921 tgcggtccct gctgttcttt atcgcctttt ctacaggaca cttgtcggta gagctggggc
     1981 actctcggtt ggtttccatg gctcttggct ttctgtttct gaagtccatc ccgcaccagc
     2041 atcttggaat ctgcagagag cctggctccc agctttcttg cctgtgctgc cattagagaa
     2101 aagaaaaaag aaaaaaaaaa aaaaagaaaa aatccataac ctgtgtctct ataacccaga
     2161 cacgtagaca gacaagagac ttttccacgc gtgatgctat tctccccaaa ttgcttactc
     2221 tggacgtgaa tctgttctct atctcacccc tatctgcttc tttagagcag agggggaagt
     2281 acctgggggt agggaaggat tgggtctggc ggcgaggagg cccacacccc aggcatccga
     2341 agtaacagag cccctctgag ccgccatatt tgacatctgt aagttaagat tggcccacat
     2401 ctaaccttcc cctcatcttg gactttatta gcaagccttt ccccagctaa gaaaaggaga
     2461 cctagaagct tgaagcagaa atatggaagg atcaaattgc tgtattttat ttaataactc
     2521 atgatattca ggttgtgcca atgactcatt aaaaaaaacc aaaaagacaa aaaaaaaaaa
     2581 aaaaaa
//
