LOCUS       NM_020036                936 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus calmodulin 4 (Calm4), mRNA.
ACCESSION   NM_020036 XM_904572 XM_918900
VERSION     NM_020036.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 936)
  AUTHORS   Zhang,J., Li,Y., Chen,Y., Yu,X., Wang,S., Sun,H., Zheng,X.,
            Zhang,L., Wang,Y. and Zhu,D.
  TITLE     Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle
            autophagy by binding Purb
  JOURNAL   J Mol Cell Cardiol 176, 41-54 (2023)
   PUBMED   36716953
  REMARK    GeneRIF: Circ-calm4 regulates hypoxia-induced pulmonary artery
            smooth muscle autophagy by binding Purb.
REFERENCE   2  (bases 1 to 936)
  AUTHORS   Jiang,Y., Liu,H., Yu,H., Zhou,Y., Zhang,J., Xin,W., Li,Y., He,S.,
            Ma,C., Zheng,X., Zhang,L., Zhao,X., Wu,B., Jiang,C. and Zhu,D.
  TITLE     Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial
            Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6
            Axis
  JOURNAL   Arterioscler Thromb Vasc Biol 41 (5), 1675-1693 (2021)
   PUBMED   33657879
  REMARK    GeneRIF: Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary
            Arterial Smooth Muscle Cells Pyroptosis via the
            Circ-Calm4/miR-124-3p/PDCD6 Axis.
REFERENCE   3  (bases 1 to 936)
  AUTHORS   Lessard,J.C., Kalinin,A., Bible,P.W. and Morasso,M.I.
  TITLE     Calmodulin 4 is dispensable for epidermal barrier formation and
            wound healing in mice
  JOURNAL   Exp Dermatol 24 (1), 55-57 (2015)
   PUBMED   25316000
  REMARK    GeneRIF: Calm4 is dispensable for epidermal barrier formation,
            maintenance and repair
REFERENCE   4  (bases 1 to 936)
  AUTHORS   Chen,H., Li,J., Li,H., Hu,Y., Tevebaugh,W., Yamamoto,M., Que,J. and
            Chen,X.
  TITLE     Transcript profiling identifies dynamic gene expression patterns
            and an important role for Nrf2/Keap1 pathway in the developing
            mouse esophagus
  JOURNAL   PLoS One 7 (5), e36504 (2012)
   PUBMED   22567161
  REMARK    Erratum:[PLoS One. 2012;7(5):
            doi/10.1371/annotation/b2554ac2-5eec-4fc1-b625-c79f0cc064ed]
REFERENCE   5  (bases 1 to 936)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   6  (bases 1 to 936)
  AUTHORS   Hwang,J., Kalinin,A., Hwang,M., Anderson,D.E., Kim,M.J.,
            Stojadinovic,O., Tomic-Canic,M., Lee,S.H. and Morasso,M.I.
  TITLE     Role of Scarf and its binding target proteins in epidermal calcium
            homeostasis
  JOURNAL   J Biol Chem 282 (25), 18645-18653 (2007)
   PUBMED   17470426
  REMARK    GeneRIF: Scarf plays a critical role as a Ca2+ sensor, potentially
            regulating the function of its binding target proteins in a
            Ca2+-dependent manner in the process of restoration of epidermal
            Ca2+ gradient as well as during epidermal barrier formation
REFERENCE   7  (bases 1 to 936)
  AUTHORS   Hwang,M., Kalinin,A. and Morasso,M.I.
  TITLE     The temporal and spatial expression of the novel Ca++-binding
            proteins, Scarf and Scarf2, during development and epidermal
            differentiation
  JOURNAL   Gene Expr Patterns 5 (6), 801-808 (2005)
   PUBMED   15922673
  REMARK    GeneRIF: expression pattern for Scarf and Scarf2 transcripts and
            proteins in the developing mouse epidermis.
REFERENCE   8  (bases 1 to 936)
  AUTHORS   Hwang,M. and Morasso,M.I.
  TITLE     The novel murine Ca2+-binding protein, Scarf, is differentially
            expressed during epidermal differentiation
  JOURNAL   J Biol Chem 278 (48), 47827-47833 (2003)
   PUBMED   12970338
REFERENCE   9  (bases 1 to 936)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   10 (bases 1 to 936)
  AUTHORS   Koshizuka,Y., Ikegawa,S., Sano,M., Nakamura,K. and Nakamura,Y.
  TITLE     Isolation of novel mouse genes associated with ectopic ossification
            by differential display method using ttw, a mouse model for ectopic
            ossification
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 163-168 (2001)
   PUBMED   11856874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009956.1 and AI131917.1.
            
            On May 25, 2007 this sequence version replaced NM_020036.3.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-913               AK009956.1         2-914
            914-936             AI131917.1         24-46               c
FEATURES             Location/Qualifiers
     source          1..936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.15 cM"
     gene            1..936
                     /gene="Calm4"
                     /gene_synonym="2310037J09Rik; DD112; Scarf"
                     /note="calmodulin 4"
                     /db_xref="GeneID:80796"
                     /db_xref="MGI:MGI:1931464"
     exon            1..915
                     /gene="Calm4"
                     /gene_synonym="2310037J09Rik; DD112; Scarf"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..586
                     /gene="Calm4"
                     /gene_synonym="2310037J09Rik; DD112; Scarf"
                     /note="calcium binding gene, DD112; skin
                     calmodulin-related factor; calcium-binding protein Dd112"
                     /codon_start=1
                     /product="calmodulin-4"
                     /protein_id="NP_064420.2"
                     /db_xref="CCDS:CCDS26215.1"
                     /db_xref="GeneID:80796"
                     /db_xref="MGI:MGI:1931464"
                     /translation="MSHGFTKEEVAEFQAAFNRFDKNKDGHISVEELGDVMKQLGKNL
                     PEKDLKALISKLDTDGDGKISFEEFLTAIEKYKKGHRAGELRAVFNVLDQNGDGYITV
                     DELKESLSKLGESLSQEELEDMIRVADVDQDGKVKYEEFVRLHVEN"
     regulatory      896..901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm4"
                     /gene_synonym="2310037J09Rik; DD112; Scarf"
                     /note="hexamer: AATAAA"
     polyA_site      915
                     /gene="Calm4"
                     /gene_synonym="2310037J09Rik; DD112; Scarf"
                     /note="major polyA site"
ORIGIN      
        1 aaggctacct atagctcagc tcttcaacag gcacagcttc agagcccagc agtagccttg
       61 agcactggac cagaaaccgc aggagcagca gactgacatc cagttgacac caatctcaga
      121 agctttgtaa ggtacagaga tgtctcacgg gtttactaag gaggaggtcg ctgagttcca
      181 ggcagctttc aataggtttg acaagaataa ggatggccat atcagcgtcg aggaacttgg
      241 agatgtaatg aagcagctgg gcaagaacct cccagagaag gacctgaagg ctctcatctc
      301 caagttggac acagatggtg atggcaagat cagctttgaa gaattcttga cagccataga
      361 gaagtacaag aaagggcaca gagcagggga gctgcgggct gtgttcaatg tccttgacca
      421 gaatggtgat ggctacatca ctgtggatga gctcaaggaa agcttgtcca agttaggcga
      481 gtccctttcc caggaggagc tggaggacat gatccgtgtg gctgacgtgg accaagatgg
      541 gaaggtgaaa tatgaggagt ttgtgcgcct ccacgttgaa aattgagact gctggtcaca
      601 agctccaact cgtcgtctat ctgcctgtct ctgacaggca cttgtgcctt cttgcggagc
      661 tctgcttttg tggtggtgtt aaaaagaaga gaagtctgtg tggtgtatgg aaactatctc
      721 atgagtgagg aagactttat tggctctgga tgctgtgcca tctggagctg ctcactagtc
      781 ccctctctgc ctgctgagac tctggtcaga ggatggtttc cttgggtgtg tctctcctct
      841 ccctcttgct gtggaatggg cgcttcctac ctcccagggc tcttataact ctttaaataa
      901 aaaggatgca aattcaaaaa aaaaaaaaaa aaaaaa
//
