LOCUS       NM_007590               2233 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus calmodulin 3 (Calm3), mRNA.
ACCESSION   NM_007590 XR_105094 XR_107871
VERSION     NM_007590.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Bae,B., Gruner,H.N., Lynch,M., Feng,T., So,K., Oliver,D.,
            Mastick,G.S., Yan,W., Pieraut,S. and Miura,P.
  TITLE     Elimination of Calm1 long 3'-UTR mRNA isoform by CRISPR-Cas9 gene
            editing impairs dorsal root ganglion development and hippocampal
            neuron activation in mice
  JOURNAL   RNA 26 (10), 1414-1430 (2020)
   PUBMED   32522888
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Jin,Y.H., Wu,X.S., Shi,B., Zhang,Z., Guo,X., Gan,L., Chen,Z. and
            Wu,L.G.
  TITLE     Protein Kinase C and Calmodulin Serve As Calcium Sensors for
            Calcium-Stimulated Endocytosis at Synapses
  JOURNAL   J Neurosci 39 (48), 9478-9490 (2019)
   PUBMED   31628181
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Kobayashi,H., Saragai,S., Naito,A., Ichio,K., Kawauchi,D. and
            Murakami,F.
  TITLE     Calm1 signaling pathway is essential for the migration of mouse
            precerebellar neurons
  JOURNAL   Development 142 (2), 375-384 (2015)
   PUBMED   25519244
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Nakada,T., Flucher,B.E., Kashihara,T., Sheng,X., Shibazaki,T.,
            Horiuchi-Hirose,M., Gomi,S., Hirose,M. and Yamada,M.
  TITLE     The proximal C-terminus of alpha(1C) subunits is necessary for
            junctional membrane targeting of cardiac L-type calcium channels
  JOURNAL   Biochem J 448 (2), 221-231 (2012)
   PUBMED   22928916
REFERENCE   5  (bases 1 to 2233)
  AUTHORS   Park,J.H., Ryu,J.M., Yun,S.P., Kim,M.O. and Han,H.J.
  TITLE     Fibronectin stimulates migration through lipid raft dependent NHE-1
            activation in mouse embryonic stem cells: involvement of RhoA,
            Ca(2+)/CaM, and ERK
  JOURNAL   Biochim Biophys Acta 1820 (10), 1618-1627 (2012)
   PUBMED   22683701
REFERENCE   6  (bases 1 to 2233)
  AUTHORS   Kim,J., Ashworth,L., Branscomb,E. and Stubbs,L.
  TITLE     The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc
            finger gene-rich region of human chromosome 19q13.4
  JOURNAL   Genome Res 7 (5), 532-540 (1997)
   PUBMED   9149948
REFERENCE   7  (bases 1 to 2233)
  AUTHORS   Stubbs,L., Carver,E.A., Shannon,M.E., Kim,J., Geisler,J.,
            Generoso,E.E., Stanford,B.G., Dunn,W.C., Mohrenweiser,H.,
            Zimmermann,W., Watt,S.M. and Ashworth,L.K.
  TITLE     Detailed comparative map of human chromosome 19q and related
            regions of the mouse genome
  JOURNAL   Genomics 35 (3), 499-508 (1996)
   PUBMED   8812484
REFERENCE   8  (bases 1 to 2233)
  AUTHORS   Skinner,T.L., Kerns,R.T. and Bender,P.K.
  TITLE     Three different calmodulin-encoding cDNAs isolated by a modified
            5'-RACE using degenerate oligodeoxyribonucleotides
  JOURNAL   Gene 151 (1-2), 247-251 (1994)
   PUBMED   7828884
REFERENCE   9  (bases 1 to 2233)
  AUTHORS   Rasmussen,C.D. and Means,A.R.
  TITLE     Calmodulin is required for cell-cycle progression during G1 and
            mitosis
  JOURNAL   EMBO J 8 (1), 73-82 (1989)
   PUBMED   2469574
REFERENCE   10 (bases 1 to 2233)
  AUTHORS   Bender,P.K., Dedman,J.R. and Emerson,C.P. Jr.
  TITLE     The abundance of calmodulin mRNAs is regulated in phosphorylase
            kinase-deficient skeletal muscle
  JOURNAL   J Biol Chem 263 (20), 9733-9737 (1988)
   PUBMED   3384819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE853985.1 and BC050926.1.
            
            On or before Dec 17, 2010 this sequence version replaced
            XR_107871.1, XR_105094.1, NM_007590.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151610.1, AK165568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               BE853985.1         19-178
            161-2233            BC050926.1         83-2155
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..2233
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /note="calmodulin 3"
                     /db_xref="GeneID:12315"
                     /db_xref="MGI:MGI:103249"
     exon            1..192
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..639
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /EC_number="2.7.11.19"
                     /note="caM"
                     /codon_start=1
                     /product="calmodulin-3"
                     /protein_id="NP_031616.1"
                     /db_xref="CCDS:CCDS39789.1"
                     /db_xref="GeneID:12315"
                     /db_xref="MGI:MGI:103249"
                     /translation="MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNP
                     TEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYIS
                     AAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK"
     exon            193..223
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /inference="alignment:Splign:2.1.0"
     exon            224..367
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /inference="alignment:Splign:2.1.0"
     exon            368..474
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /inference="alignment:Splign:2.1.0"
     exon            475..610
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /inference="alignment:Splign:2.1.0"
     exon            611..2208
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      754..759
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /note="hexamer: GATAAA"
     polyA_site      780
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /note="major polyA site"
     regulatory      2189..2194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /note="hexamer: AATAAA"
     polyA_site      2208
                     /gene="Calm3"
                     /gene_synonym="Cam3; CaMA; Camc"
                     /note="major polyA site"
ORIGIN      
        1 cggggccggg cgaggcgggg cgcgcgcggc ggccgttgag ggaccgttgg ggcgggcggc
       61 ggcggcggtg gcgcgcgctg cgggcaaaga gtgtggaggc gcggacgcgc ggcggagctc
      121 gagctgctgc agctgctgcc gccgccagag taacctcgat ccccgagctc cggataccgg
      181 tgcctcgcca tggctgacca gctgactgag gaacagattg cagagttcaa ggaagccttc
      241 tccctcttcg acaaggatgg agatggcacc attaccacca aggagctggg gactgtgatg
      301 agatcgctgg gacagaaccc cactgaggcg gagctgcagg acatgattaa tgaggtggat
      361 gctgatggca atgggaccat tgacttccca gagttcttga ccatgatggc cagaaagatg
      421 aaggatacag acagcgagga ggagatacga gaggccttcc gtgtctttga caaggatggg
      481 aatggctata ttagcgctgc cgagctgcgt cacgtcatga cgaacctggg ggagaagctg
      541 acagatgagg aagtggatga gatgatccga gaggccgaca ttgatggaga tggccaggtc
      601 aattatgaag agtttgtaca gatgatgact gcgaagtgaa ggcccgggca gctggccatg
      661 cccgttctcc tgatctcttc tcgcgctctc ctctcttcaa cactcccctg cgtacccggt
      721 tctagcaaac agcaattgat tgactgagaa tctgataaag caccaaaaga tttgtcccaa
      781 gctgcatgac tgctctctct ccttcctcct gactgtccct ccacgccctc accgcttcct
      841 ttggccttcc ccttccattc ccagtctcca ggcctgatgc attcacaagg tgaaccccat
      901 tgccctgccc tggggagcct ctgccctcct cctccagccc ggatggctct cctccggttt
      961 tggtttgttt ccttttgttt gcccttcttt tgggtgccgg ggtggccacc attcctgtcc
     1021 ctgctcagtg gggaggggag caaggccttc tgccaggtgg aggagcatgt cccctgccac
     1081 tgtcgcatgc accccagccc tgtgactctg tgtgcaagcc cagcagcctg tggggcgggg
     1141 tgccaagagg ggatgacggg acgttccagg accgagggag ttgaggatgt gacccaggac
     1201 ggggggcggg ggggggggtt gtgtgtgtgg aagggtggga agaggcagga aggccttgga
     1261 agctaacatg ctttcgctac tggaggggga ctgcatagag tggacggcac tcgggtctcg
     1321 ctgccgctgt tctgaaacca tctggctggc tttctgaggt caggctgggt ggggggctgt
     1381 catcggccat gctgccgatc atactcgccc tcctcatccc tccagccatg tcccgctgtt
     1441 ctgtaaatac ctggtgctaa catcccatgc cgctcccccg tggcaccccc agccacctgc
     1501 ccagttcagg gctggtccag gaatggatgt gggggatggt cgctgtgtaa tgtgccggtg
     1561 atcttttttt ccccttcccc tttatgcccc ttaaaacttt gatttttgtc ctaaacatgc
     1621 cgggccaact aaagggtggg gagaggagag atgcgcccca ccatgctcac aagaaccaac
     1681 ctgcaataaa cacttctatg ggccgccgcg cagagcacgc agcgggcacc tcctgcccct
     1741 ccgtggtgac ttggcatcgc tttctgccct cgccctgcct gccccactcc ccagcggaga
     1801 gcatgatccg cacccttgct tctgactcta gcctctggga cacgtcagtc aacgcgggca
     1861 gttcggtctg ggttcctttc ctttctctgt tctcatctgg ccccccaggg tgatcttgtt
     1921 gctttttgct gggacctgcc agctttgaga ctctccaccc cttggcacca gccttaaggg
     1981 agggagggac agagcaaatc aggagaccca gcctagagtt gagggcaagg gcaggtaggc
     2041 gtgaggctgt ggactttgcg gaatgtttcg gggttttatt ttggtttttt gtttttcctt
     2101 tttttttttt ttttttaaac aaacaaacaa accgggcaat attgtgttca gttcaagctg
     2161 tgaagaaaaa tatatatcaa tgttttccaa taaaatacag tgactaccaa aaaaaaaaaa
     2221 aaaaaaaaaa aaa
//
