LOCUS       NM_007589               1216 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus calmodulin 2 (Calm2), transcript variant 1, mRNA.
ACCESSION   NM_007589
VERSION     NM_007589.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1216)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1216)
  AUTHORS   Wren,L.M., DeKeyser,J.M., Barefield,D.Y., Hawkins,N.A.,
            McNally,E.M., Kearney,J.A., Wasserstrom,J.A. and George,A.L. Jr.
  TITLE     Sex and Gene Influence Arrhythmia Susceptibility in Murine Models
            of Calmodulinopathy
  JOURNAL   Circ Arrhythm Electrophysiol 16 (9), e010891 (2023)
   PUBMED   37589122
REFERENCE   3  (bases 1 to 1216)
  AUTHORS   Qu,F., Li,W., Xu,J., Zhang,R., Ke,J., Ren,X., Meng,X., Qin,L.,
            Zhang,J., Lu,F., Zhou,X., Luo,X., Zhang,Z., Wang,M., Wu,G., Pei,D.,
            Chen,J., Cui,G., Suo,S. and Peng,G.
  TITLE     Three-dimensional molecular architecture of mouse organogenesis
  JOURNAL   Nat Commun 14 (1), 4599 (2023)
   PUBMED   37524711
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1216)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 1216)
  AUTHORS   Berchtold,M.W., Munk,M., Kulej,K., Porth,I., Lorentzen,L.,
            Panina,S., Zacharias,T., Larsen,M.R. and la Cour,J.M.
  TITLE     The heart arrhythmia-linked D130G calmodulin mutation causes
            premature inhibitory autophosphorylation of CaMKII
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (12), 119119 (2021)
   PUBMED   34391760
  REMARK    GeneRIF: The heart arrhythmia-linked D130G calmodulin mutation
            causes premature inhibitory autophosphorylation of CaMKII.
REFERENCE   6  (bases 1 to 1216)
  AUTHORS   Arnold,D.B. and Heintz,N.
  TITLE     A calcium responsive element that regulates expression of two
            calcium binding proteins in Purkinje cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (16), 8842-8847 (1997)
   PUBMED   9238065
REFERENCE   7  (bases 1 to 1216)
  AUTHORS   Skinner,T.L., Kerns,R.T. and Bender,P.K.
  TITLE     Three different calmodulin-encoding cDNAs isolated by a modified
            5'-RACE using degenerate oligodeoxyribonucleotides
  JOURNAL   Gene 151 (1-2), 247-251 (1994)
   PUBMED   7828884
REFERENCE   8  (bases 1 to 1216)
  AUTHORS   Danchin,A., Sezer,O., Glaser,P., Chalon,P. and Caput,D.
  TITLE     Cloning and expression of mouse-brain calmodulin as an activator of
            Bordetella pertussis adenylate cyclase in Escherichia coli
  JOURNAL   Gene 80 (1), 145-149 (1989)
   PUBMED   2551780
REFERENCE   9  (bases 1 to 1216)
  AUTHORS   Rasmussen,C.D. and Means,A.R.
  TITLE     Calmodulin is required for cell-cycle progression during G1 and
            mitosis
  JOURNAL   EMBO J 8 (1), 73-82 (1989)
   PUBMED   2469574
REFERENCE   10 (bases 1 to 1216)
  AUTHORS   Bender,P.K., Dedman,J.R. and Emerson,C.P. Jr.
  TITLE     The abundance of calmodulin mRNAs is regulated in phosphorylase
            kinase-deficient skeletal muscle
  JOURNAL   J Biol Chem 263 (20), 9733-9737 (1988)
   PUBMED   3384819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY095488.1, BC100301.1 and BY660536.1.
            
            On Apr 25, 2009 this sequence version replaced NM_007589.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152303.1, AK160636.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BY095488.1         2-86
            86-1200             BC100301.1         1-1115
            1201-1216           BY660536.1         346-361
FEATURES             Location/Qualifiers
     source          1..1216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.49 cM"
     gene            1..1216
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /note="calmodulin 2"
                     /db_xref="GeneID:12314"
                     /db_xref="MGI:MGI:103250"
     exon            1..143
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /inference="alignment:Splign:2.1.0"
     exon            144..174
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /inference="alignment:Splign:2.1.0"
     exon            175..318
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /inference="alignment:Splign:2.1.0"
     exon            319..425
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /inference="alignment:Splign:2.1.0"
     exon            426..561
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /inference="alignment:Splign:2.1.0"
     exon            562..1216
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /note="hexamer: AATAAA"
     polyA_site      1205
                     /gene="Calm2"
                     /gene_synonym="1500001E21Rik; Cam2; CamC"
                     /note="major polyA site"
ORIGIN      
        1 gaggcggagg gatctggcgg agggaggcgg agggaggtgt ttatgaggag ctgggggcgg
       61 aggaggagaa ttagtccgag tggagcgagc gagtcgagcg gttgtctggt cgcgtctcgg
      121 aaacccgtag cccttgcagc atggctgacc aactgactga agagcagatt gcagagttca
      181 aagaagcttt ctcactattt gacaaggacg gggatgggac aataacaaca aaggagctgg
      241 ggacagtgat gaggtccctg gggcagaacc ccacagaagc agaactgcag gacatgatca
      301 atgaagtaga tgcggatggt aatggcacaa ttgatttccc tgaatttctg acaatgatgg
      361 caagaaaaat gaaagacaca gacagtgaag aagagattag agaagcattc cgtgtgtttg
      421 ataaggatgg caatggctat attagtgcag cagagcttcg ccatgtgatg acaaaccttg
      481 gcgagaagtt aacagatgaa gaggtcgatg agatgatcag ggaagcagac attgacgggg
      541 acggtcaggt aaactacgaa gagtttgtac aaatgatgac agcgaagtga agacattgta
      601 cagaatgtgt taaatttctt gtacaaaatt gtttatttgc cttttctttg tttgtaactt
      661 atctgtaaaa ggttcccccc ccctactgtc aaaaaatatg catgtatagt aattaggact
      721 tcattcctcc atgttttctt cccttatctt actgtcattg tccttaaacc ttattttaga
      781 aaattgatga agtaacatgt tgcatgtggc ttactctggc tatatctaag cccgtctgca
      841 catctaaact tagatggagt tggtccaatg agggaacatc tgggttatgc cttttttaaa
      901 gtagctttta ggaactgtca gcatgttgtt gttgaagtgt ggagctgtaa ctctgcgtgg
      961 actgtggaca gtcaacaata tgtacttaaa agttgcacta ttgcaaaacg ggtgttttat
     1021 ccaggtactc ggacactatt tttttgtact gctggtattg taccaggaac attttctttt
     1081 attgttactt gctttttaaa ctttgtttag ccacttaaag aaaacctgct catggcacaa
     1141 cttgcctcaa atccattcca agttgtatat ttgttttcca ataaaaaaaa ttacaattta
     1201 cccaattgtt gctctg
//
