LOCUS       NM_009790               4140 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus calmodulin 1 (Calm1), transcript variant 2, mRNA.
ACCESSION   NM_009790
VERSION     NM_009790.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4140)
  AUTHORS   Liu,Y., Li,H., Pang,Y., Li,Y. and Li,S.
  TITLE     MiR-202-3p Targets Calm1 and Suppresses Inflammation in a Mouse
            Model of Acute Respiratory Distress Syndrome
  JOURNAL   Cell Biochem Biophys 82 (2), 1135-1143 (2024)
   PUBMED   38635101
  REMARK    GeneRIF: MiR-202-3p Targets Calm1 and Suppresses Inflammation in a
            Mouse Model of Acute Respiratory Distress Syndrome.
REFERENCE   2  (bases 1 to 4140)
  AUTHORS   Wren,L.M., DeKeyser,J.M., Barefield,D.Y., Hawkins,N.A.,
            McNally,E.M., Kearney,J.A., Wasserstrom,J.A. and George,A.L. Jr.
  TITLE     Sex and Gene Influence Arrhythmia Susceptibility in Murine Models
            of Calmodulinopathy
  JOURNAL   Circ Arrhythm Electrophysiol 16 (9), e010891 (2023)
   PUBMED   37589122
REFERENCE   3  (bases 1 to 4140)
  AUTHORS   Garcia-Anoveros,J., Clancy,J.C., Foo,C.Z., Garcia-Gomez,I.,
            Zhou,Y., Homma,K., Cheatham,M.A. and Duggan,A.
  TITLE     Tbx2 is a master regulator of inner versus outer hair cell
            differentiation
  JOURNAL   Nature 605 (7909), 298-303 (2022)
   PUBMED   35508658
REFERENCE   4  (bases 1 to 4140)
  AUTHORS   Zhang,H.L., Han,W., Du,Y.Q., Zhao,B., Yang,P. and Yin,D.M.
  TITLE     SRC3 acetylates calmodulin in the mouse brain to regulate synaptic
            plasticity and fear learning
  JOURNAL   J Biol Chem 297 (3), 101044 (2021)
   PUBMED   34358562
  REMARK    GeneRIF: SRC3 acetylates calmodulin in the mouse brain to regulate
            synaptic plasticity and fear learning.
REFERENCE   5  (bases 1 to 4140)
  AUTHORS   Zhang,H.L., Zhao,B., Han,W., Sun,Y.B., Yang,P., Chen,Y., Ni,D.,
            Zhang,J. and Yin,D.M.
  TITLE     Acetylation of calmodulin regulates synaptic plasticity and fear
            learning
  JOURNAL   J Biol Chem 297 (3), 101034 (2021)
   PUBMED   34339735
REFERENCE   6  (bases 1 to 4140)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
REFERENCE   7  (bases 1 to 4140)
  AUTHORS   Danchin,A., Sezer,O., Glaser,P., Chalon,P. and Caput,D.
  TITLE     Cloning and expression of mouse-brain calmodulin as an activator of
            Bordetella pertussis adenylate cyclase in Escherichia coli
  JOURNAL   Gene 80 (1), 145-149 (1989)
   PUBMED   2551780
REFERENCE   8  (bases 1 to 4140)
  AUTHORS   Rasmussen,C.D. and Means,A.R.
  TITLE     Calmodulin is required for cell-cycle progression during G1 and
            mitosis
  JOURNAL   EMBO J 8 (1), 73-82 (1989)
   PUBMED   2469574
REFERENCE   9  (bases 1 to 4140)
  AUTHORS   Kluxen,F.W., Schoffl,F., Berchtold,M.W. and Jockusch,H.
  TITLE     Opposite regulation of the mRNAs for parvalbumin and p19/6.8 in
            myotonic mouse muscle
  JOURNAL   Eur J Biochem 176 (1), 153-158 (1988)
   PUBMED   3138114
REFERENCE   10 (bases 1 to 4140)
  AUTHORS   Bender,P.K., Dedman,J.R. and Emerson,C.P. Jr.
  TITLE     The abundance of calmodulin mRNAs is regulated in phosphorylase
            kinase-deficient skeletal muscle
  JOURNAL   J Biol Chem 263 (20), 9733-9737 (1988)
   PUBMED   3384819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY294999.1, AK150978.1,
            BC054805.1, AC159633.2 and AW489089.1.
            
            On Sep 15, 2015 this sequence version replaced NM_009790.4.
            
            Summary: This gene encodes a member of the EF-hand calcium-binding
            protein family. The encoded protein acts as a calcium sensor and is
            involved in relaying signals to calcium-sensitive proteins, enzymes
            and ion channels. The protein-calcium complex binds target proteins
            to regulate several cellular processes, including smooth muscle
            contraction, inflammation, apoptosis and the immune response.
            Mutations in the human gene are associated with catecholaminergic
            polymorphic ventricular tachycardia and long QT syndrome 14.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon resulting in the use of an alternate start codon
            compared to variant 1. The encoded isoform (2) has a distinct
            N-terminus and is shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054805.1, SRR11927932.3724600.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BY294999.1         2-93
            93-1612             AK150978.1         2-1521
            1613-2120           BC054805.1         1507-2014
            2121-2121           AC159633.2         81374-81374
            2122-4107           BC054805.1         2016-4001
            4108-4140           AW489089.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..4140
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 50.43 cM"
     gene            1..4140
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="calmodulin 1"
                     /db_xref="GeneID:12313"
                     /db_xref="MGI:MGI:88251"
     exon            1..282
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..729
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /EC_number="2.7.11.19"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="calmodulin-1 isoform 2"
                     /protein_id="NP_033920.1"
                     /db_xref="CCDS:CCDS36523.1"
                     /db_xref="GeneID:12313"
                     /db_xref="MGI:MGI:88251"
                     /translation="MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNP
                     TEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYIS
                     AAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK"
     exon            283..313
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..457
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..564
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..700
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..4125
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1593..1598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="hexamer: AATAAA"
     polyA_site      1616
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="major polyA site"
     regulatory      4087..4092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="hexamer: AATAAA"
     polyA_site      4118
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
ORIGIN      
        1 ggctgccgca gcgccgccct gcgcgaggcg gtactgccgc ggcggaggga taccgcgcac
       61 cgtatatata tcgcggcaca caggctcgcg ctacggcagt ggtgctggga gtctcgtgtc
      121 cgtggtgccg ttactcgaag tcgggcggcg gctgaggctc agcgcacaac gcaggtagcg
      181 cgttagcagc agcagaagcg gaggcacctc ggcggtcaca gcccctgcgc tggtgcagcc
      241 accctcgcct gctccgttct tccttccttc gctcgcacca tggctgatca gctgactgaa
      301 gagcagattg ctgaattcaa ggaagctttc tccctattcg ataaagatgg tgacggcacc
      361 atcacaacca aggaactggg gaccgtcatg cggtcactgg gtcagaaccc aacagaagcc
      421 gagctgcagg atatgatcaa cgaagtggat gctgatggca atggcaccat tgacttccca
      481 gagttcttga ctatgatggc tagaaaaatg aaagacacag atagcgaaga agagatccgc
      541 gaggccttcc gagtgtttga caaggatggg aatggttaca tcagtgcggc agaactgcgc
      601 cacgtcatga caaacttagg agaaaagcta acagatgaag aagtagatga aatgatcaga
      661 gaagcagata ttgatggcga cggacaagtc aactatgaag aattcgtaca gatgatgact
      721 gcaaaatgaa gacctacttt caactacttt tccccctcta gaagaatcaa attgaaatct
      781 tttacttacc tcttacaaaa aaaagaaaaa aaaagaaaaa gttcatttct tcattctgtt
      841 tgtatctagc gaagctgaat gtcagaagcc cctctgtcca cacacaaagt ctgcatgtat
      901 tggtcggtgg tcctgcccct aaagtcaagc ccctacatca gttttacagt ataaatactc
      961 gtactacctt ataaggaagc acttagtgga ctccttaaag ttccatttgc taatgattaa
     1021 tacactgttt gggctggcca gtttctcatg catgcagctt gatgattgag cacagtcagg
     1081 catttgtatt aaaactgaaa aatggaaaaa acaaattcaa aatctcagat ggcttctagt
     1141 tcaatctgtt cagataaatt gtcagcagcc agtttactgc aagcaaacat ttaaaattgg
     1201 tttacctcag gatgattgat gtgcagagaa tgggggaagg ctaaactctg agacacagcc
     1261 ccagaagtag gacagtcctc atcaagtgcc ccagtcccat ggtgacagtg acaccctggt
     1321 ggcgagcccg agtgtgatgg ttcattgctg tgcgcattgc attggagtga ctgaacaaca
     1381 aggctgtcac caaatcccac acattttatt aagaaatgtt tcctaaggga gcatttttgg
     1441 actgtgtttt aaaacctagt gaaccatgac tcggagccag cagagtaggc tgtgtctgtg
     1501 gacttgagca caccatcaac attgctgttc aggaaatgat aatttacgtc cattccaagt
     1561 tgtaaatgct agtcttttat tttttttttt ccaataaaaa gaccattaac ttaaaagtgg
     1621 tgttaaatgc tttgtaaagc tgagattgga agggggacaa ggccaaggcc gctggagggg
     1681 aggtcagcat acacagagac acgcaacatc cagtgcaagc tggatttccc accaggttct
     1741 ctagccacaa ctcctgaaac cagacagact cggagttctt tgccgtctat gaccacgtaa
     1801 gtcttgttat tttctgtgtt gtgtgcacat gcgcagatca cagtcaggtg atgttcagac
     1861 tagagccctg gtgagagaag gcgtctccag cgtacagtta ggatgtcttg gctgtgctgc
     1921 tgctgacctg ttgtaactac atgaggccat ctgtgcggga gacatgattt agtgtgtctg
     1981 tattcctata ctcactgtgt atggcaaaag caggccagac aaagacacta cctttgattc
     2041 agtttgtaat ttatggttat acttatcttt agccgctata cttctttatt attattattt
     2101 aactgccttt tctccccgtt aagtacagtt agtgcataac actgtagctt gagagcaaag
     2161 aaacgaaaca atatcccaga atgaatttcc tgtctaatta caaacctgta accaaaacgt
     2221 agacctgctg gtactggtcc cttccaaggc actggtctac ttaaaaagcc ccccttagaa
     2281 gtgtgttgca tttaaaaaac aagggcctta tacatttttc agggtgttaa ctggttgtat
     2341 ctgactagca aggagctttg gcttccaagt tcgggggtgt cggagctgca ggcttctagc
     2401 aaggcaatga gaagcccttg gcaaccacgt gggtgcactc ggggctaacc tctagatccc
     2461 tggttgctcc ctctcctgct ccctgtcttt ctggcgtttt gtagctcctt agattttttt
     2521 tttttttttt tctgccagag ggatgggtcc gagcagtaga gaggaagaca ttgcctgagc
     2581 acctctgctc atccttggac tgggtggttg gcacaggctg atgactttga ctttggtatc
     2641 tgaatcgtta ggtattccct cctggtagag aggactgggg gagggggggt tccaggtgtg
     2701 aagaagtgaa tggcagtgga tatgtcttgt aagaggatta aatcacccag ttgatgaccc
     2761 ggtctcaggc ttgtctgtaa cctcttggtg atttcaaagg ggtttggagg tgacttttta
     2821 aaaaattgcc tcctatcttt taccaagtct gtagaagctg ggtagatgat gctttaacag
     2881 cccatagcct gtcctaaaag cttacctcca aaacaggatt cttgtgtaac taggaatcct
     2941 gcatgagaac cagaaaccct aacctccgag gaatgtgaag ctggggtttg gaactgtagg
     3001 aggcagagtc gtcccccccc cccccacttc agccttctgg catcctgggg cacaggcagc
     3061 ccagggcttg gtgttggcag tttgagttcg tgagatagaa agagtggggt gtcaaggcag
     3121 tacccctgag gtcagataac actttcctgt aaactgtccc tcacttataa ctactctata
     3181 aatatataca tatatttata taaatatata tatataaagt gactagttaa ctggcatcct
     3241 gctttagcct gagacttgcc ctaagaaact gctgagccct tggcacacct ctacatagtg
     3301 tgttttctgt ctgttggggg gagctgttga acaaggcaaa catcttgata gttcagatgg
     3361 gctttaatgt actgttgcca gggaaggctt tttctgattt tttgacaaat ttttgcacac
     3421 tttaattggt gtctttgagc aacttaaaca cattgaagat gagctattgt acatattttt
     3481 atattctctt tataagtgca tgtccaactt gtaactatat tgtaaggaat ggctgcccgg
     3541 taggcctagt gttatgtcac acaagaggaa tagcatctat cattcgcccc tcagcatcct
     3601 gggaacttct tcttgaatga agactgtaaa tttggtcaag tcaactctta gttcagttat
     3661 cttaatcatt tgaatgattt attgtgtgtc ctatgtgtat ttctctttgg cagcgaccag
     3721 agttacactg atgtgtccca actgacccac tcagctggcg gtcacctact taattttttt
     3781 caatacccct tgaagttgtc cggtagaagt cagattattt gccatctatc cctttgagta
     3841 agaaatcagg gatgtgtgct cctcccctat atcgacgatg ttcattaaaa cacctatagc
     3901 aaggatggtg gtggtccttc tgttaccgaa gtcacccttc actgtggctg tttgacaaag
     3961 agttgtactt ggacgttgtg taaatcttga gataaactgt tttggagatt taaccacctc
     4021 tctgacgggg gaccaactct atggaaattg taaataagtt ttatttataa acctggcact
     4081 gtattcaata aacatttctg cagcctttca tctcttaact gtgaaaaaaa aaaaaaaaaa
//
