LOCUS       NM_001313934            4020 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus calmodulin 1 (Calm1), transcript variant 1, mRNA.
ACCESSION   NM_001313934
VERSION     NM_001313934.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4020)
  AUTHORS   Liu,Y., Li,H., Pang,Y., Li,Y. and Li,S.
  TITLE     MiR-202-3p Targets Calm1 and Suppresses Inflammation in a Mouse
            Model of Acute Respiratory Distress Syndrome
  JOURNAL   Cell Biochem Biophys 82 (2), 1135-1143 (2024)
   PUBMED   38635101
  REMARK    GeneRIF: MiR-202-3p Targets Calm1 and Suppresses Inflammation in a
            Mouse Model of Acute Respiratory Distress Syndrome.
REFERENCE   2  (bases 1 to 4020)
  AUTHORS   Wren,L.M., DeKeyser,J.M., Barefield,D.Y., Hawkins,N.A.,
            McNally,E.M., Kearney,J.A., Wasserstrom,J.A. and George,A.L. Jr.
  TITLE     Sex and Gene Influence Arrhythmia Susceptibility in Murine Models
            of Calmodulinopathy
  JOURNAL   Circ Arrhythm Electrophysiol 16 (9), e010891 (2023)
   PUBMED   37589122
REFERENCE   3  (bases 1 to 4020)
  AUTHORS   Garcia-Anoveros,J., Clancy,J.C., Foo,C.Z., Garcia-Gomez,I.,
            Zhou,Y., Homma,K., Cheatham,M.A. and Duggan,A.
  TITLE     Tbx2 is a master regulator of inner versus outer hair cell
            differentiation
  JOURNAL   Nature 605 (7909), 298-303 (2022)
   PUBMED   35508658
REFERENCE   4  (bases 1 to 4020)
  AUTHORS   Zhang,H.L., Han,W., Du,Y.Q., Zhao,B., Yang,P. and Yin,D.M.
  TITLE     SRC3 acetylates calmodulin in the mouse brain to regulate synaptic
            plasticity and fear learning
  JOURNAL   J Biol Chem 297 (3), 101044 (2021)
   PUBMED   34358562
  REMARK    GeneRIF: SRC3 acetylates calmodulin in the mouse brain to regulate
            synaptic plasticity and fear learning.
REFERENCE   5  (bases 1 to 4020)
  AUTHORS   Zhang,H.L., Zhao,B., Han,W., Sun,Y.B., Yang,P., Chen,Y., Ni,D.,
            Zhang,J. and Yin,D.M.
  TITLE     Acetylation of calmodulin regulates synaptic plasticity and fear
            learning
  JOURNAL   J Biol Chem 297 (3), 101034 (2021)
   PUBMED   34339735
REFERENCE   6  (bases 1 to 4020)
  AUTHORS   Baughman,G., Harrigan,M.T., Campbell,N.F., Nurrish,S.J. and
            Bourgeois,S.
  TITLE     Genes newly identified as regulated by glucocorticoids in murine
            thymocytes
  JOURNAL   Mol Endocrinol 5 (5), 637-644 (1991)
   PUBMED   2072923
REFERENCE   7  (bases 1 to 4020)
  AUTHORS   Danchin,A., Sezer,O., Glaser,P., Chalon,P. and Caput,D.
  TITLE     Cloning and expression of mouse-brain calmodulin as an activator of
            Bordetella pertussis adenylate cyclase in Escherichia coli
  JOURNAL   Gene 80 (1), 145-149 (1989)
   PUBMED   2551780
REFERENCE   8  (bases 1 to 4020)
  AUTHORS   Rasmussen,C.D. and Means,A.R.
  TITLE     Calmodulin is required for cell-cycle progression during G1 and
            mitosis
  JOURNAL   EMBO J 8 (1), 73-82 (1989)
   PUBMED   2469574
REFERENCE   9  (bases 1 to 4020)
  AUTHORS   Kluxen,F.W., Schoffl,F., Berchtold,M.W. and Jockusch,H.
  TITLE     Opposite regulation of the mRNAs for parvalbumin and p19/6.8 in
            myotonic mouse muscle
  JOURNAL   Eur J Biochem 176 (1), 153-158 (1988)
   PUBMED   3138114
REFERENCE   10 (bases 1 to 4020)
  AUTHORS   Bender,P.K., Dedman,J.R. and Emerson,C.P. Jr.
  TITLE     The abundance of calmodulin mRNAs is regulated in phosphorylase
            kinase-deficient skeletal muscle
  JOURNAL   J Biol Chem 263 (20), 9733-9737 (1988)
   PUBMED   3384819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK145841.1, BC054805.1,
            AC159633.2 and AW489089.1.
            
            Summary: This gene encodes a member of the EF-hand calcium-binding
            protein family. The encoded protein acts as a calcium sensor and is
            involved in relaying signals to calcium-sensitive proteins, enzymes
            and ion channels. The protein-calcium complex binds target proteins
            to regulate several cellular processes, including smooth muscle
            contraction, inflammation, apoptosis and the immune response.
            Mutations in the human gene are associated with catecholaminergic
            polymorphic ventricular tachycardia and long QT syndrome 14.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145841.1, BY736796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1492              AK145841.1         2-1493
            1493-2000           BC054805.1         1507-2014
            2001-2001           AC159633.2         81374-81374
            2002-3987           BC054805.1         2016-4001
            3988-4020           AW489089.1         1-33                c
FEATURES             Location/Qualifiers
     source          1..4020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 50.43 cM"
     gene            1..4020
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="calmodulin 1"
                     /db_xref="GeneID:12313"
                     /db_xref="MGI:MGI:88251"
     exon            1..162
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..609
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /EC_number="2.7.11.19"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="calmodulin-1 isoform 1"
                     /protein_id="NP_001300863.1"
                     /db_xref="CCDS:CCDS83995.1"
                     /db_xref="GeneID:12313"
                     /db_xref="MGI:MGI:88251"
                     /translation="MGRGEPGDVQGLDRGLGVSSATFRPPDQPSRESPLACGPLLPPG
                     GRGAGADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMIN
                     EVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTN
                     LGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK"
     exon            163..193
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            194..337
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            338..444
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..580
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     exon            581..4005
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1473..1478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="hexamer: AATAAA"
     polyA_site      1496
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="major polyA site"
     regulatory      3967..3972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
                     /note="hexamer: AATAAA"
     polyA_site      3998
                     /gene="Calm1"
                     /gene_synonym="Calm; CaM; Cam1"
ORIGIN      
        1 gaccgcggag aatgaatggg tcgcggcgag ccgggagacg tacagggctt ggaccgcggc
       61 ctcggggtgt cctcagccac cttcagaccc cctgaccagc ccagtcggga gtcccccctc
      121 gcttgcggtc ccctccttcc tcccgggggg cgcggcgcgg gcgctgatca gctgactgaa
      181 gagcagattg ctgaattcaa ggaagctttc tccctattcg ataaagatgg tgacggcacc
      241 atcacaacca aggaactggg gaccgtcatg cggtcactgg gtcagaaccc aacagaagcc
      301 gagctgcagg atatgatcaa cgaagtggat gctgatggca atggcaccat tgacttccca
      361 gagttcttga ctatgatggc tagaaaaatg aaagacacag atagcgaaga agagatccgc
      421 gaggccttcc gagtgtttga caaggatggg aatggttaca tcagtgcggc agaactgcgc
      481 cacgtcatga caaacttagg agaaaagcta acagatgaag aagtagatga aatgatcaga
      541 gaagcagata ttgatggcga cggacaagtc aactatgaag aattcgtaca gatgatgact
      601 gcaaaatgaa gacctacttt caactacttt tccccctcta gaagaatcaa attgaaatct
      661 tttacttacc tcttacaaaa aaaagaaaaa aaaagaaaaa gttcatttct tcattctgtt
      721 tgtatctagc gaagctgaat gtcagaagcc cctctgtcca cacacaaagt ctgcatgtat
      781 tggtcggtgg tcctgcccct aaagtcaagc ccctacatca gttttacagt ataaatactc
      841 gtactacctt ataaggaagc acttagtgga ctccttaaag ttccatttgc taatgattaa
      901 tacactgttt gggctggcca gtttctcatg catgcagctt gatgattgag cacagtcagg
      961 catttgtatt aaaactgaaa aatggaaaaa acaaattcaa aatctcagat ggcttctagt
     1021 tcaatctgtt cagataaatt gtcagcagcc agtttactgc aagcaaacat ttaaaattgg
     1081 tttacctcag gatgattgat gtgcagagaa tgggggaagg ctaaactctg agacacagcc
     1141 ccagaagtag gacagtcctc atcaagtgcc ccagtcccat ggtgacagtg acaccctggt
     1201 ggcgagcccg agtgtgatgg ttcattgctg tgcgcattgc attggagtga ctgaacaaca
     1261 aggctgtcac caaatcccac acattttatt aagaaatgtt tcctaaggga gcatttttgg
     1321 actgtgtttt aaaacctagt gaaccatgac tcggagccag cagagtaggc tgtgtctgtg
     1381 gacttgagca caccatcaac attgctgttc aggaaatgat aatttacgtc cattccaagt
     1441 tgtaaatgct agtcttttat tttttttttt ccaataaaaa gaccattaac ttaaaagtgg
     1501 tgttaaatgc tttgtaaagc tgagattgga agggggacaa ggccaaggcc gctggagggg
     1561 aggtcagcat acacagagac acgcaacatc cagtgcaagc tggatttccc accaggttct
     1621 ctagccacaa ctcctgaaac cagacagact cggagttctt tgccgtctat gaccacgtaa
     1681 gtcttgttat tttctgtgtt gtgtgcacat gcgcagatca cagtcaggtg atgttcagac
     1741 tagagccctg gtgagagaag gcgtctccag cgtacagtta ggatgtcttg gctgtgctgc
     1801 tgctgacctg ttgtaactac atgaggccat ctgtgcggga gacatgattt agtgtgtctg
     1861 tattcctata ctcactgtgt atggcaaaag caggccagac aaagacacta cctttgattc
     1921 agtttgtaat ttatggttat acttatcttt agccgctata cttctttatt attattattt
     1981 aactgccttt tctccccgtt aagtacagtt agtgcataac actgtagctt gagagcaaag
     2041 aaacgaaaca atatcccaga atgaatttcc tgtctaatta caaacctgta accaaaacgt
     2101 agacctgctg gtactggtcc cttccaaggc actggtctac ttaaaaagcc ccccttagaa
     2161 gtgtgttgca tttaaaaaac aagggcctta tacatttttc agggtgttaa ctggttgtat
     2221 ctgactagca aggagctttg gcttccaagt tcgggggtgt cggagctgca ggcttctagc
     2281 aaggcaatga gaagcccttg gcaaccacgt gggtgcactc ggggctaacc tctagatccc
     2341 tggttgctcc ctctcctgct ccctgtcttt ctggcgtttt gtagctcctt agattttttt
     2401 tttttttttt tctgccagag ggatgggtcc gagcagtaga gaggaagaca ttgcctgagc
     2461 acctctgctc atccttggac tgggtggttg gcacaggctg atgactttga ctttggtatc
     2521 tgaatcgtta ggtattccct cctggtagag aggactgggg gagggggggt tccaggtgtg
     2581 aagaagtgaa tggcagtgga tatgtcttgt aagaggatta aatcacccag ttgatgaccc
     2641 ggtctcaggc ttgtctgtaa cctcttggtg atttcaaagg ggtttggagg tgacttttta
     2701 aaaaattgcc tcctatcttt taccaagtct gtagaagctg ggtagatgat gctttaacag
     2761 cccatagcct gtcctaaaag cttacctcca aaacaggatt cttgtgtaac taggaatcct
     2821 gcatgagaac cagaaaccct aacctccgag gaatgtgaag ctggggtttg gaactgtagg
     2881 aggcagagtc gtcccccccc cccccacttc agccttctgg catcctgggg cacaggcagc
     2941 ccagggcttg gtgttggcag tttgagttcg tgagatagaa agagtggggt gtcaaggcag
     3001 tacccctgag gtcagataac actttcctgt aaactgtccc tcacttataa ctactctata
     3061 aatatataca tatatttata taaatatata tatataaagt gactagttaa ctggcatcct
     3121 gctttagcct gagacttgcc ctaagaaact gctgagccct tggcacacct ctacatagtg
     3181 tgttttctgt ctgttggggg gagctgttga acaaggcaaa catcttgata gttcagatgg
     3241 gctttaatgt actgttgcca gggaaggctt tttctgattt tttgacaaat ttttgcacac
     3301 tttaattggt gtctttgagc aacttaaaca cattgaagat gagctattgt acatattttt
     3361 atattctctt tataagtgca tgtccaactt gtaactatat tgtaaggaat ggctgcccgg
     3421 taggcctagt gttatgtcac acaagaggaa tagcatctat cattcgcccc tcagcatcct
     3481 gggaacttct tcttgaatga agactgtaaa tttggtcaag tcaactctta gttcagttat
     3541 cttaatcatt tgaatgattt attgtgtgtc ctatgtgtat ttctctttgg cagcgaccag
     3601 agttacactg atgtgtccca actgacccac tcagctggcg gtcacctact taattttttt
     3661 caatacccct tgaagttgtc cggtagaagt cagattattt gccatctatc cctttgagta
     3721 agaaatcagg gatgtgtgct cctcccctat atcgacgatg ttcattaaaa cacctatagc
     3781 aaggatggtg gtggtccttc tgttaccgaa gtcacccttc actgtggctg tttgacaaag
     3841 agttgtactt ggacgttgtg taaatcttga gataaactgt tttggagatt taaccacctc
     3901 tctgacgggg gaccaactct atggaaattg taaataagtt ttatttataa acctggcact
     3961 gtattcaata aacatttctg cagcctttca tctcttaact gtgaaaaaaa aaaaaaaaaa
//
