LOCUS       NM_175449               1095 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus calcium homeostasis modulator family member 6
            (Calhm6), mRNA.
ACCESSION   NM_175449
VERSION     NM_175449.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1095)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1095)
  AUTHORS   Danielli,S., Ma,Z., Pantazi,E., Kumar,A., Demarco,B., Fischer,F.A.,
            Paudel,U., Weissenrieder,J., Lee,R.J., Joyce,S., Foskett,J.K. and
            Bezbradica,J.S.
  TITLE     The ion channel CALHM6 controls bacterial infection-induced
            cellular cross-talk at the immunological synapse
  JOURNAL   EMBO J 42 (7), e111450 (2023)
   PUBMED   36861806
REFERENCE   3  (bases 1 to 1095)
  AUTHORS   Kasamatsu,J., Azuma,M., Oshiumi,H., Morioka,Y., Okabe,M.,
            Ebihara,T., Matsumoto,M. and Seya,T.
  TITLE     INAM plays a critical role in IFN-gamma production by NK cells
            interacting with polyinosinic-polycytidylic acid-stimulated
            accessory cells
  JOURNAL   J Immunol 193 (10), 5199-5207 (2014)
   PUBMED   25320282
  REMARK    GeneRIF: INAM plays a critical role in IFN-gamma production by NK
            cells.
REFERENCE   4  (bases 1 to 1095)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1095)
  AUTHORS   Ebihara,T., Azuma,M., Oshiumi,H., Kasamatsu,J., Iwabuchi,K.,
            Matsumoto,K., Saito,H., Taniguchi,T., Matsumoto,M. and Seya,T.
  TITLE     Identification of a polyI:C-inducible membrane protein that
            participates in dendritic cell-mediated natural killer cell
            activation
  JOURNAL   J Exp Med 207 (12), 2675-2687 (2010)
   PUBMED   21059856
  REMARK    Erratum:[J Exp Med. 2015 Jul 27;212(8):1337. doi:
            10.1084/jem.2009157307012015c.. PMID: 26169938]
REFERENCE   6  (bases 1 to 1095)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042270.1 and AI450214.1.
            
            On Apr 23, 2009 this sequence version replaced NM_175449.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095946.1, AK153519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1031              AK042270.1         1-1031
            1032-1095           AI450214.1         1-64                c
FEATURES             Location/Qualifiers
     source          1..1095
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 18.85 cM"
     gene            1..1095
                     /gene="Calhm6"
                     /gene_synonym="A630077B13Rik; Fam26f; INAM"
                     /note="calcium homeostasis modulator family member 6"
                     /db_xref="GeneID:215900"
                     /db_xref="MGI:MGI:2443082"
     exon            1..582
                     /gene="Calhm6"
                     /gene_synonym="A630077B13Rik; Fam26f; INAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1005
                     /gene="Calhm6"
                     /gene_synonym="A630077B13Rik; Fam26f; INAM"
                     /note="protein FAM26F; family with sequence similarity 26,
                     member F; IFN regulatory factor 3-dependent NK-activating
                     molecule"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 6"
                     /protein_id="NP_780658.2"
                     /db_xref="CCDS:CCDS23775.1"
                     /db_xref="GeneID:215900"
                     /db_xref="MGI:MGI:2443082"
                     /translation="MEKFKAVLDLQRKHRNALGYSLVTLLTAGGEKIFSSVVFQCPCT
                     ATWNLPYGLVFLLVPALALFLLGYALSARTWRLLTGCCSRSARFSSGLRSAFVCAQLS
                     MTAAFAPLTWVAVALLEGSFYQCAVSGSARLAPYLCKGRDPNCNATLPQAPCNKQKVE
                     MQEILSQLKAQSQVFGWILIAAVIILLLLVKSVTRCFSPVSYLQLKFWEIYWEKEKQI
                     LQNQAAENATQLAEENVRCFFECSKPKECNTPSSKDWQEISALYTFNPKNQFYSMLHK
                     YVSREEMSGSVRSVEGDAVIPALGFVDDMSMTNTHEL"
     exon            583..1082
                     /gene="Calhm6"
                     /gene_synonym="A630077B13Rik; Fam26f; INAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1061..1066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calhm6"
                     /gene_synonym="A630077B13Rik; Fam26f; INAM"
                     /note="hexamer: AATAAA"
     polyA_site      1082
                     /gene="Calhm6"
                     /gene_synonym="A630077B13Rik; Fam26f; INAM"
                     /note="major polyA site"
ORIGIN      
        1 acacggttca ctcaaccttc ctgagaagca gagcctgtgg ggtgtccagt gtgagcagaa
       61 cccatggaaa agttcaaggc agtgctggac ctgcagagaa agcaccgcaa cgccctgggc
      121 tatagcctgg tgaccctact gacggctggt ggggagaaga tcttctcctc agtggtgttc
      181 cagtgtccct gcactgccac ctggaacctg ccctacggcc tggtgttcct gctggtgcct
      241 gccctcgcgc ttttcctcct gggatatgcg ctgagcgcgc gcacatggcg cctgctcacc
      301 ggctgctgct cccggagcgc gcgattcagt tcggggttgc gcagcgcgtt cgtgtgcgcc
      361 cagctcagca tgaccgcggc attcgcgccc ctcacctggg tggccgtggc gctgctcgag
      421 ggctctttct accaatgtgc tgtcagcggg agcgcgcgct tggcgccata cctgtgcaag
      481 ggccgcgacc ccaactgcaa tgccacgcta ccgcaggctc cctgcaacaa gcagaaggtg
      541 gaaatgcagg agatcctgag ccagctcaag gctcagtctc aggtgttcgg ttggattctg
      601 atagctgccg ttattatctt acttcttctt gttaagtctg tgacccgatg cttctctccg
      661 gttagttatc tgcagttaaa attctgggaa atctattggg aaaaggagaa gcagattctt
      721 caaaatcaag ctgcagagaa tgcgacacag ttggccgaag agaatgttag atgtttcttt
      781 gagtgctcga agccgaagga atgcaacact ccaagcagta aagactggca ggaaatctca
      841 gcgttgtaca cattcaatcc caagaaccag ttctacagca tgctgcacaa gtatgttagc
      901 agagaagaaa tgagcggcag tgtccgctct gtggaaggag atgcagtgat ccctgccctt
      961 ggctttgtag atgacatgtc catgactaac actcacgaac tatgatctta cacaagaaca
     1021 gaaaaaaaaa atgttttgaa ttgttgcttt tatataaaaa aataaatatt ggtatatttt
     1081 aaaaaaaaaa aaaaa
//
