LOCUS       NM_133746               2049 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus calcium homeostasis modulator family member 2
            (Calhm2), mRNA.
ACCESSION   NM_133746
VERSION     NM_133746.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2049)
  AUTHORS   Choi,S.W., Kwon,J.W., Kang,T.M., Park,K.S. and Kim,S.J.
  TITLE     Calcium homeostasis modulator 2 (Calhm2) as slowly activating
            membrane current channel in mouse B cells
  JOURNAL   Biochem Biophys Res Commun 699, 149561 (2024)
   PUBMED   38280307
  REMARK    GeneRIF: Calcium homeostasis modulator 2 (Calhm2) as slowly
            activating membrane current channel in mouse B cells.
REFERENCE   2  (bases 1 to 2049)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2049)
  AUTHORS   Li,X., Xiong,M., Gao,Y., Xu,X. and Ke,C.
  TITLE     Upregulation of Calhm2 in the anterior cingulate cortex contributes
            to the maintenance of bilateral mechanical allodynia and comorbid
            anxiety symptoms in inflammatory pain conditions
  JOURNAL   Brain Res Bull 204, 110808 (2023)
   PUBMED   37926398
  REMARK    GeneRIF: Upregulation of Calhm2 in the anterior cingulate cortex
            contributes to the maintenance of bilateral mechanical allodynia
            and comorbid anxiety symptoms in inflammatory pain conditions.
REFERENCE   4  (bases 1 to 2049)
  AUTHORS   Liao,Y., Wang,Y., Tao,Q.Q., Yang,C., Wang,J., Cheng,J., Ma,J.,
            Wu,Z.Y., Pan,R.Y. and Yuan,Z.
  TITLE     CALHM2 V136G polymorphism reduces astrocytic ATP release and is
            associated with depressive symptoms and Alzheimer's disease risk
  JOURNAL   Alzheimers Dement 19 (10), 4407-4420 (2023)
   PUBMED   37493186
  REMARK    GeneRIF: CALHM2 V136G polymorphism reduces astrocytic ATP release
            and is associated with depressive symptoms and Alzheimer's disease
            risk.
            Erratum:[Alzheimers Dement. 2024 Aug;20(8):5809. doi:
            10.1002/alz.13822.. PMID: 38923157]
REFERENCE   5  (bases 1 to 2049)
  AUTHORS   Bo,X., Xie,F., Zhang,J., Gu,R., Li,X., Li,S., Yuan,Z. and Cheng,J.
  TITLE     Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease
            pathology by inhibiting EFHD2-STAT3 signaling in microglia
  JOURNAL   Theranostics 13 (6), 1809-1822 (2023)
   PUBMED   37064868
  REMARK    GeneRIF: Deletion of Calhm2 alleviates MPTP-induced Parkinson's
            disease pathology by inhibiting EFHD2-STAT3 signaling in microglia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2049)
  AUTHORS   Cheng,J., Dong,Y., Ma,J., Pan,R., Liao,Y., Kong,X., Li,X., Li,S.,
            Chen,P., Wang,L., Yu,Y. and Yuan,Z.
  TITLE     Microglial Calhm2 regulates neuroinflammation and contributes to
            Alzheimer's disease pathology
  JOURNAL   Sci Adv 7 (35) (2021)
   PUBMED   34433553
  REMARK    GeneRIF: Microglial Calhm2 regulates neuroinflammation and
            contributes to Alzheimer's disease pathology.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2049)
  AUTHORS   Ma,J., Qi,X., Yang,C., Pan,R., Wang,S., Wu,J., Huang,L., Chen,H.,
            Cheng,J., Wu,R., Liao,Y., Mao,L., Wang,F.C., Wu,Z., An,J.X.,
            Wang,Y., Zhang,X., Zhang,C. and Yuan,Z.
  TITLE     Calhm2 governs astrocytic ATP releasing in the development of
            depression-like behaviors
  JOURNAL   Mol Psychiatry 23 (4), 883-891 (2018)
   PUBMED   29180673
  REMARK    Erratum:[Mol Psychiatry. 2018 Apr;23(4):1091. doi:
            10.1038/mp.2017.254.. Jun, M [corrected to Ma, J]; Xiaolong, Q
            [corrected to Qi, X]; Chaojuan, Y [corrected to Yang, C]; Ruiyuan,
            P [corrected to Pan, R]; Shukun, W [corrected to Wang, S]; Junbing,
            W [corrected to Wu, J]; Li, H [corrected to Huang, L]; Hong, C
            [corrected. PMID: 29311664]
REFERENCE   8  (bases 1 to 2049)
  AUTHORS   Taruno,A., Sun,H., Nakajo,K., Murakami,T., Ohsaki,Y., Kido,M.A.,
            Ono,F. and Marunaka,Y.
  TITLE     Post-translational palmitoylation controls the voltage gating and
            lipid raft association of the CALHM1 channel
  JOURNAL   J Physiol 595 (18), 6121-6145 (2017)
   PUBMED   28734079
REFERENCE   9  (bases 1 to 2049)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   10 (bases 1 to 2049)
  AUTHORS   Wu,J., Peng,S., Wu,R., Hao,Y., Ji,G. and Yuan,Z.
  TITLE     Generation of Calhm1 knockout mouse and characterization of calhm1
            gene expression
  JOURNAL   Protein Cell 3 (6), 470-480 (2012)
   PUBMED   22723178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040739.1 and BC096564.1.
            
            On Aug 28, 2009 this sequence version replaced NM_133746.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170068.1, AK040739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1474              AK040739.1         2-1475
            1475-1475           BC096564.1         626-626
            1476-2049           AK040739.1         1477-2050
FEATURES             Location/Qualifiers
     source          1..2049
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 39.28 cM"
     gene            1..2049
                     /gene="Calhm2"
                     /gene_synonym="2810048G17Rik; Fam26b"
                     /note="calcium homeostasis modulator family member 2"
                     /db_xref="GeneID:72691"
                     /db_xref="MGI:MGI:1919941"
     exon            1..390
                     /gene="Calhm2"
                     /gene_synonym="2810048G17Rik; Fam26b"
                     /inference="alignment:Splign:2.1.0"
     exon            391..1107
                     /gene="Calhm2"
                     /gene_synonym="2810048G17Rik; Fam26b"
                     /inference="alignment:Splign:2.1.0"
     CDS             553..1524
                     /gene="Calhm2"
                     /gene_synonym="2810048G17Rik; Fam26b"
                     /note="calcium homeostasis modulator 2"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 2"
                     /protein_id="NP_598507.3"
                     /db_xref="CCDS:CCDS29889.1"
                     /db_xref="GeneID:72691"
                     /db_xref="MGI:MGI:1919941"
                     /translation="MAALIAENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAF
                     HCPCSPARNYLYGLTAIGVPALALFLIGVILNNHTWNLVAECQYRRAKNCSAAPNFLL
                     LSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAGDKGFPPAHATEVLARF
                     PCGEGPANLSSFREEVSRRLKYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEA
                     YWAQYRTNEDQLFQRTAEVHSRVLAANNVRRFFGFVALNKDDEELVAKFPVEGTQPRP
                     QWNAITGVYLYRENQGLPLYSRLHKWAQGLTGNGTAPDNVEMALLTA"
     exon            1108..2049
                     /gene="Calhm2"
                     /gene_synonym="2810048G17Rik; Fam26b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2023..2028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calhm2"
                     /gene_synonym="2810048G17Rik; Fam26b"
                     /note="hexamer: GATAAA"
     polyA_site      2045
                     /gene="Calhm2"
                     /gene_synonym="2810048G17Rik; Fam26b"
                     /note="major polyA site"
ORIGIN      
        1 ctctgtttct gcctcgcgcc gccctcagca gccctccctc ttctgcctgg cgccaggagg
       61 ctgtttttcc attctctggc tagaaagttc cacgccactg tttctttctc tctcttttct
      121 ggagttaaat ttgtctgcag atgcctgcac ttcatctgta gacgcctcca gttaagtttg
      181 tttgtaactg ggcccaaagc tccgttgcgt tgcgttcaaa cgctgggccc ggatcctacg
      241 cggacctggg tgcaaaagca aagccggcag tgaaccccgt gaggccactt tgcctcgcgg
      301 tcaggagcac cttcccagtg tctgcgggag cccacactgc tgtcaatcca tcaggaatcc
      361 aaggccacgg gggcctgcaa ccagccctag gaagcaccag ttcagccact gcaggagcta
      421 aaatggcatg atcatgctct gctgtcagct gtcctccggc ctgctgcgcg ccttactagt
      481 ctcaccagaa gccctcagtt ctgccctctt ctgcctcctc ctgcgcatcc catccccggc
      541 ccgccagtca ccatggcggc cttgattgca gagaacttcc gcttcctgtc tctcttcttc
      601 aagagcaagg atgtgatgat tttcaatggg ctggtggccc tgggcacggt gggcagtcag
      661 gagctgttct cagtggtggc cttccactgt ccctgctcac ccgcccggaa ctacctgtat
      721 ggactgacag caattggcgt gcctgcgctg gccctcttcc ttatcggagt cattctcaac
      781 aaccacactt ggaacctagt cgccgagtgc cagtaccgga gggccaagaa ctgctccgcg
      841 gcccccaact tcctcctcct aagctcaatc ctgggccgtg cagctgtggc tccagtcacc
      901 tggtctgtca tctccctgct ccgaggggag gcctatgtct gtgctctcag tgagtttgtg
      961 gacccctcct cgctcacagc tggggataaa ggcttccccc cagcccatgc tacggaggtc
     1021 ctagccaggt tcccttgtgg agagggcccc gccaacctat cgagcttccg agaggaggtc
     1081 agccgcaggc tcaagtatga gtctcagctc ttcggatggc tgctcatcgg tgtggtggcc
     1141 atcctggtgt tcctgaccaa gtgcctcaaa cattactgct cgccactcag ctaccgtcag
     1201 gaggcctact gggctcagta ccgtaccaac gaggaccagt tgttccagcg cacagcagag
     1261 gtgcattcga gggtgctggc cgccaacaac gtgcgccgtt tctttggctt tgtggctctc
     1321 aacaaggatg acgaagagct ggtcgccaag ttcccagtgg aaggcacaca gccacggcca
     1381 cagtggaacg ctatcactgg ggtctatctg taccgagaga accagggcct cccactctac
     1441 agccgcctac acaagtgggc ccagggtctg acaggtaatg gcacagcccc tgacaatgtg
     1501 gagatggccc tgctcactgc ttaagagcct gcttctatgc tctgtaagcg gaactagtca
     1561 cagactaact cctcatggcg tgctcatttc agcatcaggt gacttttctg ctatctacag
     1621 tgtcttgggc atagacataa aacaaccagt agtttgtaaa gatcctgtgg accacaaggt
     1681 tcacagaaat tgaggtgggg tgagggtagg gagggggtag ggactggcct accgaagtca
     1741 tttctcccgt ggccactagc acactctgct cacagctatc agaaagtact ttcctagagc
     1801 tggtctttag tatgacaggg ccgatcttag gtgggcctca gagttgagaa tcatcagctg
     1861 gtgaagcctg ttgacaaccc actgggaagc cttcattgta tagtacactt tgtgcagtta
     1921 atttgtgtct aattgcatag gagcacccca gctcccagtg tactgctagg aagctgccct
     1981 gattgtatat ctctggccag attttatata tttaaacttt ttgataaagc ttttcttact
     2041 ttaaatgcc
//
