LOCUS       NM_001081271            1047 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus calcium homeostasis modulator 1 (Calhm1), mRNA.
ACCESSION   NM_001081271 XM_621506
VERSION     NM_001081271.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Ikuta,R., Kakinohana,Y. and Hamada,S.
  TITLE     Ultrastructural localization of calcium homeostasis modulator 1 in
            mouse taste buds
  JOURNAL   Chem Senses 49 (2024)
   PUBMED   38761122
  REMARK    GeneRIF: Ultrastructural localization of calcium homeostasis
            modulator 1 in mouse taste buds.
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Ohmoto,M., Jyotaki,M., Yee,K.K. and Matsumoto,I.
  TITLE     A Transcription Factor Etv1/Er81 Is Involved in the Differentiation
            of Sweet, Umami, and Sodium Taste Cells
  JOURNAL   eNeuro 10 (4) (2023)
   PUBMED   37045597
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   Sclafani,A. and Ackroff,K.
  TITLE     Fat preference deficits and experience-induced recovery in global
            taste-deficient Trpm5 and Calhm1 knockout mice
  JOURNAL   Physiol Behav 246, 113695 (2022)
   PUBMED   34998826
  REMARK    GeneRIF: Fat preference deficits and experience-induced recovery in
            global taste-deficient Trpm5 and Calhm1 knockout mice.
REFERENCE   5  (bases 1 to 1047)
  AUTHORS   Okui,M., Murakami,T., Sun,H., Ikeshita,C., Kanamura,N. and
            Taruno,A.
  TITLE     Posttranslational regulation of CALHM1/3 channel: N-linked
            glycosylation and S-palmitoylation
  JOURNAL   FASEB J 35 (5), e21527 (2021)
   PUBMED   33788965
REFERENCE   6  (bases 1 to 1047)
  AUTHORS   Taruno,A., Vingtdeux,V., Ohmoto,M., Ma,Z., Dvoryanchikov,G., Li,A.,
            Adrien,L., Zhao,H., Leung,S., Abernethy,M., Koppel,J., Davies,P.,
            Civan,M.M., Chaudhari,N., Matsumoto,I., Hellekant,G., Tordoff,M.G.,
            Marambaud,P. and Foskett,J.K.
  TITLE     CALHM1 ion channel mediates purinergic neurotransmission of sweet,
            bitter and umami tastes
  JOURNAL   Nature 495 (7440), 223-226 (2013)
   PUBMED   23467090
  REMARK    GeneRIF: CALHM1 is a voltage-gated ATP-release channel required for
            sweet, bitter and umami taste perception
REFERENCE   7  (bases 1 to 1047)
  AUTHORS   Dreses-Werringloer,U., Vingtdeux,V., Zhao,H., Chandakkar,P.,
            Davies,P. and Marambaud,P.
  TITLE     CALHM1 controls the Ca(2)-dependent MEK, ERK, RSK and MSK signaling
            cascade in neurons
  JOURNAL   J Cell Sci 126 (Pt 5), 1199-1206 (2013)
   PUBMED   23345406
  REMARK    GeneRIF: The study identifies a previously uncharacterized
            mechanism of control of Ca(2+)-dependent ERK1/2 signaling in
            neurons, and further establishes CALHM1 as a critical ion channel
            for neuronal signaling and function.
REFERENCE   8  (bases 1 to 1047)
  AUTHORS   Siebert,A.P., Ma,Z., Grevet,J.D., Demuro,A., Parker,I. and
            Foskett,J.K.
  TITLE     Structural and functional similarities of calcium homeostasis
            modulator 1 (CALHM1) ion channel with connexins, pannexins, and
            innexins
  JOURNAL   J Biol Chem 288 (9), 6140-6153 (2013)
   PUBMED   23300080
  REMARK    GeneRIF: Structural and functional similarities of calcium
            homeostasis modulator 1 (CALHM1) ion channel with connexins,
            pannexins, and innexins.
REFERENCE   9  (bases 1 to 1047)
  AUTHORS   Ma,Z., Siebert,A.P., Cheung,K.H., Lee,R.J., Johnson,B., Cohen,A.S.,
            Vingtdeux,V., Marambaud,P. and Foskett,J.K.
  TITLE     Calcium homeostasis modulator 1 (CALHM1) is the pore-forming
            subunit of an ion channel that mediates extracellular Ca2+
            regulation of neuronal excitability
  JOURNAL   Proc Natl Acad Sci U S A 109 (28), E1963-E1971 (2012)
   PUBMED   22711817
  REMARK    GeneRIF: CALHM1 is an evolutionarily conserved ion channel family
            that detects membrane voltage and extracellular Ca(2+) levels and
            plays a role in cortical neuronal excitability and Ca(2+)
            homeostasis
REFERENCE   10 (bases 1 to 1047)
  AUTHORS   Wu,J., Peng,S., Wu,R., Hao,Y., Ji,G. and Yuan,Z.
  TITLE     Generation of Calhm1 knockout mouse and characterization of calhm1
            gene expression
  JOURNAL   Protein Cell 3 (6), 470-480 (2012)
   PUBMED   22723178
  REMARK    GeneRIF: Calhm1 was of rare abundance in brain tissues
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC124724.4.
            
            On Feb 6, 2007 this sequence version replaced XM_621506.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849388,
                              SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               AC124724.4         20506-21057
            553-1047            AC124724.4         23151-23645
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 39.36 cM"
     gene            1..1047
                     /gene="Calhm1"
                     /gene_synonym="EG546729"
                     /note="calcium homeostasis modulator 1"
                     /db_xref="GeneID:546729"
                     /db_xref="MGI:MGI:3643383"
     CDS             1..1047
                     /gene="Calhm1"
                     /gene_synonym="EG546729"
                     /codon_start=1
                     /product="calcium homeostasis modulator protein 1"
                     /protein_id="NP_001074740.1"
                     /db_xref="CCDS:CCDS38015.1"
                     /db_xref="GeneID:546729"
                     /db_xref="MGI:MGI:3643383"
                     /translation="MDKFRMIFQFLQSNQESFMNGICGIMALASAQMYSAFDFNCPCL
                     PGYNVVYSLGILLTPPLVLFLLGLVMNNNISMLAEEWKRPAGRRAKDPAVLRYMFCSM
                     AQRALIAPVVWVAVTLLDGKCFLCAFCTAVPVATLGNGSLVPGLPAPELARLLARVPC
                     PEIYDGNWLLAREVAVRYLRCISQALGWSFVLLTTLLAFVVRSVRPCFTQVAFLKSKY
                     WSHYIDIERKLFDETCTEHAKAFAKVCIQQFFEAMNHDLELGHTHGVLATATATATAT
                     EAVQSPSDRTEEEREKLRGITDQGTMNRLLTSWHKCKPPLRLGQEAPLMSNGWAGGEP
                     RPPRKEVATYFSKV"
     exon            1..552
                     /gene="Calhm1"
                     /gene_synonym="EG546729"
                     /inference="alignment:Splign:2.1.0"
     exon            553..1047
                     /gene="Calhm1"
                     /gene_synonym="EG546729"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggataagt ttcggatgat cttccagttc ttgcaatcca accaagagtc cttcatgaat
       61 ggcatctgtg gcatcatggc gctggccagt gcgcagatgt attctgcctt tgacttcaac
      121 tgcccctgct tacccggcta caacgtggtc tacagcctgg gcatactgct gacgcctccc
      181 ctggtgctct tcctgcttgg tctggtcatg aacaacaaca tatccatgct agctgaagag
      241 tggaagcgcc ccgcaggtcg ccgggccaag gacccagctg ttctacgcta catgttctgt
      301 tccatggccc agagagctct catcgcccct gtcgtctggg tggctgtcac actgctggat
      361 ggcaagtgct ttctctgtgc cttctgcaca gctgtgcccg tggccacact aggcaatggc
      421 agcctggtgc cgggcctgcc tgctccagaa cttgctcgcc tactggctcg ggtaccctgc
      481 cctgagatct atgatgggaa ctggctgcta gcccgagagg tggccgtgcg gtatttgcgc
      541 tgcatctctc aggcactggg ttggtccttc gtgctgctga ccacattact agcgttcgtg
      601 gtacgctctg tgcgtccctg cttcacgcag gtcgcctttc tcaagagcaa gtactggtcc
      661 cactacattg acattgagcg caagctcttc gatgagacat gcacagagca tgccaaagcc
      721 tttgctaagg tatgtatcca gcagttcttt gaagccatga accatgacct ggaactgggt
      781 catacccacg gagtactggc cacggccaca gccacagcca cagccacaga ggctgtccaa
      841 agtccctcgg acaggacaga agaagagagg gagaagttgc gtggcatcac tgaccaaggc
      901 accatgaata ggctactcac aagctggcac aaatgcaaac caccactgag gctgggccag
      961 gaggcaccac tgatgagcaa cggctgggct gggggcgagc cccggcctcc acgcaaggaa
     1021 gtggccacct acttcagcaa agtgtga
//
