LOCUS       NM_001347100            4144 bp    mRNA    linear   ROD 11-APR-2023
DEFINITION  Mus musculus caldesmon 1 (Cald1), transcript variant 1, mRNA.
ACCESSION   NM_001347100 XM_017321321
VERSION     NM_001347100.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4144)
  AUTHORS   Abou Nader N, Menard A, Levasseur A, St-Jean G, Boerboom D,
            Zamberlam G and Boyer A.
  TITLE     Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis
            Development and Alters Somatic Cell Fate
  JOURNAL   Int J Mol Sci 23 (21), 13585 (2022)
   PUBMED   36362374
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4144)
  AUTHORS   Putz S, Barthel LS, Frohn M, Metzler D, Barham M, Pryymachuk G,
            Trunschke O, Lubomirov LT, Hescheler J, Chalovich JM, Neiss WF,
            Koch M, Schroeter MM and Pfitzer G.
  TITLE     Caldesmon ablation in mice causes umbilical herniation and alters
            contractility of fetal urinary bladder smooth muscle
  JOURNAL   J Gen Physiol 153 (7) (2021)
   PUBMED   34115104
  REMARK    GeneRIF: Caldesmon ablation in mice causes umbilical herniation and
            alters contractility of fetal urinary bladder smooth muscle.
REFERENCE   3  (bases 1 to 4144)
  AUTHORS   Godin P, Tsoi M, Paquet M and Boerboom D.
  TITLE     YAP and TAZ are required for the postnatal development and the
            maintenance of the structural integrity of the oviduct
  JOURNAL   Reproduction 160 (2), 307-318 (2020)
   PUBMED   32520726
REFERENCE   4  (bases 1 to 4144)
  AUTHORS   de Groot NE, van den Hoogenhof MMG, Najafi A, van der Made I, van
            der Velden J, Beqqali A, Pinto YM and Creemers EE.
  TITLE     Heterozygous loss of Rbm24 in the adult mouse heart increases
            sarcomere slack length but does not affect function
  JOURNAL   Sci Rep 10 (1), 7687 (2020)
   PUBMED   32376900
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4144)
  AUTHORS   Jia X, Min L, Zhu S, Zhang S and Huang X.
  TITLE     Loss of sonic hedgehog gene leads to muscle development disorder
            and megaesophagus in mice
  JOURNAL   FASEB J 32 (10), 5703-5715 (2018)
   PUBMED   29768039
REFERENCE   6  (bases 1 to 4144)
  AUTHORS   Guo H and Wang CL.
  TITLE     Specific disruption of smooth muscle caldesmon expression in mice
  JOURNAL   Biochem Biophys Res Commun 330 (4), 1132-1137 (2005)
   PUBMED   15823561
REFERENCE   7  (bases 1 to 4144)
  AUTHORS   Carvalho RL, Jonker L, Goumans MJ, Larsson J, Bouwman P, Karlsson
            S, Dijke PT, Arthur HM and Mummery CL.
  TITLE     Defective paracrine signalling by TGFbeta in yolk sac vasculature
            of endoglin mutant mice: a paradigm for hereditary haemorrhagic
            telangiectasia
  JOURNAL   Development 131 (24), 6237-6247 (2004)
   PUBMED   15548578
REFERENCE   8  (bases 1 to 4144)
  AUTHORS   Bergwerff M, DeRuiter MC, Hall S, Poelmann RE and Gittenberger-de
            Groot AC.
  TITLE     Unique vascular morphology of the fourth aortic arches: possible
            implications for pathogenesis of type-B aortic arch interruption
            and anomalous right subclavian artery
  JOURNAL   Cardiovasc Res 44 (1), 185-196 (1999)
   PUBMED   10615402
REFERENCE   9  (bases 1 to 4144)
  AUTHORS   Yamada H, Akishita M, Ito M, Tamura K, Daviet L, Lehtonen JY, Dzau
            VJ and Horiuchi M.
  TITLE     AT2 receptor and vascular smooth muscle cell differentiation in
            vascular development
  JOURNAL   Hypertension 33 (6), 1414-1419 (1999)
   PUBMED   10373225
REFERENCE   10 (bases 1 to 4144)
  AUTHORS   Walker G, Kerrick WG and Bourguignon LY.
  TITLE     The role of caldesmon in the regulation of receptor capping in
            mouse T-lymphoma cell
  JOURNAL   J Biol Chem 264 (1), 496-500 (1989)
   PUBMED   2909534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102668.12 and AC153627.2.
            
            On Nov 15, 2016 this sequence version replaced XM_017321321.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.109061.1,
                                           ERR3363658.3245130.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC102668.12        106288-106449       c
            163-251             AC102668.12        42737-42825         c
            252-363             AC102668.12        18879-18990         c
            364-510             AC153627.2         84052-84198         c
            511-907             AC153627.2         79972-80368         c
            908-1053            AC153627.2         72399-72544         c
            1054-1318           AC153627.2         70089-70353         c
            1319-1459           AC153627.2         67863-68003         c
            1460-1503           AC153627.2         63834-63877         c
            1504-1582           AC153627.2         63658-63736         c
            1583-1720           AC153627.2         60894-61031         c
            1721-1816           AC153627.2         59789-59884         c
            1817-1897           AC153627.2         54859-54939         c
            1898-4144           AC153627.2         50518-52764         c
FEATURES             Location/Qualifiers
     source          1..4144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.07 cM"
     gene            1..4144
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /note="caldesmon 1"
                     /db_xref="GeneID:109624"
                     /db_xref="MGI:MGI:88250"
     exon            1..162
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            163..251
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            252..363
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..1903
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="caldesmon isoform 1"
                     /protein_id="NP_001334029.1"
                     /db_xref="CCDS:CCDS85029.1"
                     /db_xref="GeneID:109624"
                     /db_xref="MGI:MGI:88250"
                     /translation="MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRR
                     ARQERLRQKQEEESLGQVTDQVEAHVQNSVPDEESKPASSNTQVEGDEEAALLERLAR
                     REERRQKRLQEALERQKEFDPTITDGSLSGPSRRMQNDSAENETAEGEEKRESRSGRY
                     EVEETEVVIKSYQKNSYQDAEDKKKEEKEEEEQEKLKGGSLGENQIKDEKIKKDKEPK
                     EEVKSFLDRKKGFTEVKAQNGEFMTHKLKQTENAFSPSRSGGRASGDKEAEGAPQVEA
                     GKRLEELRRRRGETENEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEE
                     ADRKAREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSEDKKPFKCFTPKGSSLKIEE
                     RAEFLNKSVQKSGVRSTHQAAVVSKIDSRLEQYTNAIEGTKASKPMKPAASDLPVPAE
                     GVRNIKSMWEKGSVFSAPSASGTPNKETAGLKVGVSSRINEWLTKSPDGNKSPAPKPS
                     DLRPGDVSGKRNLWEKQSVDKVTSPTKV"
     exon            364..510
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            511..907
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1053
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1318
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1459
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1503
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1582
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1720
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1816
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1897
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..4144
                     /gene="Cald1"
                     /gene_synonym="4833423D12Rik; C920027I18Rik; caldesmon"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccaagga agggcggtct gcagttttat tgaatagagc agtgtgcatt aggctgcctg
       61 cctgcctgcc tgcctgcttg ctctcttgct gggttgctta aaggaatccc tgctttcaga
      121 cagcaggaca tccctccttg ggaagaagtt gctgccctag agatagtcaa taacagattt
      181 caagatcatc aaatccaacc cacgggggtg gacagtcaaa ggttcagaag tagacacctg
      241 actgcttctg tatcaagata ttatctgggt tccctaaacc cgaaacctca ctatggatga
      301 ttttgaacgt cgcagagaac tcaggagaca aaagagggag gagatgcggc tggaggcaga
      361 aagaattgcc tatcagagaa atgatgatga cgaagaagag gctgccaggg aacggcgccg
      421 ccgggcccgg caggaaaggc tgcggcagaa gcaagaggaa gaatccttgg gacaggtgac
      481 agaccaggtg gaggcccatg tccagaacag tgtccccgat gaagagtcta agccagcctc
      541 ctcaaacact caggtagaag gtgacgagga ggctgcctta ctggagcgcc tggctagacg
      601 agaagagaga cgtcaaaaac gccttcagga agccttagag cgtcagaagg agtttgatcc
      661 gaccataaca gatggcagtc tctcaggccc aagccgaaga atgcaaaatg actccgccga
      721 aaatgagaca gcagaggggg aagaaaaaag agagagtcgc tcaggacggt atgaggtgga
      781 agaaacagaa gtggtcatca agtcctacca gaagaacagc tatcaggatg ctgaagacaa
      841 aaagaaagaa gaaaaggaag aggaggagca agagaagctg aagggaggga gccttggcga
      901 aaatcagatc aaagatgaga agattaaaaa ggacaaagag cccaaagaag aagtcaagag
      961 cttcttggat agaaagaaag gatttacaga agtgaaggcg cagaatggag aattcatgac
     1021 ccacaaactt aaacaaaccg agaatgcttt cagccccagc cgttcaggag gccgggccag
     1081 tggggacaag gaagctgaag gtgccccaca agtggaagcc ggcaagaggc tggaggagct
     1141 gcgccgacgc cgcggggaga cggagaacga agagtttgaa aaactcaaac agaagcaaca
     1201 ggaggcagcc ttggagctgg aagagctgaa gaaaaagagg gaagagagaa ggaaggtcct
     1261 ggaggaagag gagcagagaa gaaagcagga ggaggctgat cgaaaagcta gggaggagga
     1321 agagaagagg aggttaaagg aagagatcga aaggagaagg gcagaagctg ctgagaagcg
     1381 ccagaagatg ccagaggatg gcctgtcaga ggacaagaag ccgttcaagt gcttcactcc
     1441 taaaggctcg tctctcaaga tagaggaacg agcagagttt ttgaataaat ctgtgcagaa
     1501 aagtggtgtc agatctactc accaagcagc agtagtctcc aagattgaca gccggctgga
     1561 gcagtacacc aatgcaatcg agggaacaaa ggcttcgaaa cctatgaagc cagcagcatc
     1621 ggatctccct gttcctgccg agggcgtccg caatatcaag agcatgtggg agaaggggag
     1681 cgtgttctca gccccctctg cctcaggaac acccaataag gaaactgctg gcctgaaggt
     1741 gggagtttcc agccgcatta acgaatggct aactaaatca ccagatggca acaagtcacc
     1801 tgctcccaag ccttctgact tgaggccagg agatgtatct ggcaagcgga acctctggga
     1861 aaagcaatct gtggataagg tcacttcccc cactaaggtc tgaaacaatc ggagaaagaa
     1921 cccaactgca agccatctcg ctgggccagc tcagttggag agggctaatc gctctgttta
     1981 tatttatgtt ttccaatatc ccagtaaatc catgtatatg ctcactatat ttaataacca
     2041 caactagaga tgttcatggt caaagtactg cctttgcaga ggagcctgtt tctaaagaaa
     2101 ccatgctgtg aagtaaactc gctactgtca tatgaacagt gacaccaacc acatcggaag
     2161 tcaacaaaag gaaactgagc ttaagattat ctgaggaatg tatgcagtat ctaggggcga
     2221 aacgaccccg taggctttgt tttgtctcag tacagacatc atgtttctgc actttagact
     2281 aaagcatgaa agaaattatc taaataggca atcaaaactc tctgaaaata atccacttca
     2341 tatctgatgt agggcagtaa tgattgtctg ttttaaaaaa gatgtattgt tgagatattg
     2401 ctttttttct atgctgattc atacctaaat tggctgatta ctttagctga cagtggtact
     2461 gacttttttt caggttagtt gctttgtgga tttctttggt agtgatagta gactgaatca
     2521 catttagata acccaactat gtaatgaatg tgcatacgtg taaacagaca cactaatggt
     2581 agattactct ttcatgtgct agactattat atttcatagt atgtccttgt aactaactga
     2641 tatcacagct tttgaagatt aaggatcaca atagtatatt aatatttcat atttgccaac
     2701 agaaatatgg agttaggtat agctatgttt tcaatgccca atgacttata agaaaaaaag
     2761 tattggaaaa aaaaagagaa tacaagtgtc aaaattggtt gaaatttctt ataagacata
     2821 gtatttagtt tataattgag ggcagtcttg aagtccagtg tgaattttat taagtctaca
     2881 atctggacaa agctcaaacc ctgcttattt gcgaccgtga tgttcacccc cacccccacc
     2941 ccacgtcaaa aagttgacct gtattatatc taaggtgtct ccttctctac cacttagaac
     3001 caagcatttt ggtgactagt gcacaaatta gtattcatgt agatgtctaa agaaagacca
     3061 actttgcctc ctgtagaagc aggcaggtaa cgtgagcaga agcatggcag tcctatcttt
     3121 atgtactcac actctttaaa ttaaatgttt ccgcctttat tagtcagttg gtacggtcat
     3181 aagttgataa catcttgaaa tttgaatttt ttatgtaaat tttagtagtt ttactccccc
     3241 ctcccaccaa ggctctttaa ggaactcatc attcatatat cagatcctat tttagcttac
     3301 gtctttattc ttcccaatag ataaaagtac tctagtgtct tacaaaaatg ttcttatcta
     3361 gaacattcta tgcatacagc gtcattgtac aaactcatac ctcagctgac ttaaccaaaa
     3421 ttatcttagt ctccactcct tccacagtag gagagcctct aacatttcca atccacagat
     3481 ttcttttcaa gaggaaaggg ttggcttgag ggtttttcaa gggttggcct tgaaaaagtc
     3541 tatctttctc gtgaattagt aagagttagt tggattccct agcttttagc aaacttgggc
     3601 caaaggaaga aaagccacta agactgcaca agtcatctac ccccgacaga gtagacacaa
     3661 gtctatggta agacgaacag agtgcacatg gcacacccat gaaaatgact tccatcgttg
     3721 gagtacaatg gatcaaagtt cgatcttagg cagatgctga gggatcatgc tcatgttaat
     3781 gaggccttct cttgctatat cttacaggct ttttgcttgt tgtttttgct tttaagaacg
     3841 ttcaaagttg tgagatgact gttttgatcc taaattttat tccaacattt ggatgacgat
     3901 gagttttagg gtagattttt ctccgtttgg atttaacctt tgaagaagca aattcctcct
     3961 ctacttgttt gattacagct ctctgttatc tttaagagag gaaactgcaa gctgactagc
     4021 atgttctgtg aatctgccat tgttaaaaaa ccttataaac acttaatatt tttcactgat
     4081 aattgatcgc tgcaataaaa atatattgtg aaaatgcatc cacaataaat ggaattcttc
     4141 caga
//
