LOCUS       NM_018782               4761 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus calcitonin receptor-like (Calcrl), mRNA.
ACCESSION   NM_018782
VERSION     NM_018782.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4761)
  AUTHORS   Kiritoshi,T., Yakhnitsa,V., Singh,S., Wilson,T.D., Chaudhry,S.,
            Neugebauer,B., Torres-Rodriguez,J.M., Lin,J.L., Carrasquillo,Y. and
            Neugebauer,V.
  TITLE     Cells and circuits for amygdala neuroplasticity in the transition
            to chronic pain
  JOURNAL   Cell Rep 43 (9), 114669 (2024)
   PUBMED   39178115
REFERENCE   2  (bases 1 to 4761)
  AUTHORS   Wu,M., Song,G., Li,J., Song,Z., Zhao,B., Liang,L., Li,W., Hu,H.,
            Tu,H., Li,S., Li,P., Zhang,B., Wang,W., Zhang,Y., Zhang,W.,
            Zheng,W., Wang,J., Wen,Y., Wang,K., Li,A., Zhou,T., Zhang,Y. and
            Li,H.
  TITLE     Innervation of nociceptor neurons in the spleen promotes germinal
            center responses and humoral immunity
  JOURNAL   Cell 187 (12), 2935-2951 (2024)
   PUBMED   38772371
REFERENCE   3  (bases 1 to 4761)
  AUTHORS   Nelson-Maney,N.P., Balint,L., Beeson,A.L., Serafin,D.S.,
            Kistner,B.M., Douglas,E.S., Siddiqui,A.H., Tauro,A.M. and
            Caron,K.M.
  TITLE     Meningeal lymphatic CGRP signaling governs pain via cerebrospinal
            fluid efflux and neuroinflammation in migraine models
  JOURNAL   J Clin Invest 134 (15), e175616 (2024)
   PUBMED   38743922
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4761)
  AUTHORS   Zhu,F., Yu,D., Qin,X., Qian,Y., Ma,J., Li,W., Liu,Q., Wang,C.,
            Zhang,Y., Li,Y., Jiang,D., Wang,S. and Xia,P.
  TITLE     The neuropeptide CGRP enters the macrophage cytosol to suppress the
            NLRP3 inflammasome during pulmonary infection
  JOURNAL   Cell Mol Immunol 20 (3), 264-276 (2023)
   PUBMED   36600053
REFERENCE   5  (bases 1 to 4761)
  AUTHORS   Bowen,A.J., Huang,Y.W., Chen,J.Y., Pauli,J.L., Campos,C.A. and
            Palmiter,R.D.
  TITLE     Topographic representation of current and future threats in the
            mouse nociceptive amygdala
  JOURNAL   Nat Commun 14 (1), 196 (2023)
   PUBMED   36639374
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4761)
  AUTHORS   Flahaut,M., Rossier,B.C. and Firsov,D.
  TITLE     Respective roles of calcitonin receptor-like receptor (CRLR) and
            receptor activity-modifying proteins (RAMP) in cell surface
            expression of CRLR/RAMP heterodimeric receptors
  JOURNAL   J Biol Chem 277 (17), 14731-14737 (2002)
   PUBMED   11854283
  REMARK    GeneRIF: role in cell surface expression of CRLR/RAMP heterodimeric
            receptors
REFERENCE   7  (bases 1 to 4761)
  AUTHORS   Ono,Y., Okano,I., Kojima,M., Okada,K. and Kangawa,K.
  TITLE     Decreased gene expression of adrenomedullin receptor in mouse lungs
            during sepsis
  JOURNAL   Biochem Biophys Res Commun 271 (1), 197-202 (2000)
   PUBMED   10777702
REFERENCE   8  (bases 1 to 4761)
  AUTHORS   Husmann,K., Sexton,P.M., Fischer,J.A. and Born,W.
  TITLE     Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid
            sequence, expression and function
  JOURNAL   Mol Cell Endocrinol 162 (1-2), 35-43 (2000)
   PUBMED   10854696
REFERENCE   9  (bases 1 to 4761)
  AUTHORS   Derst,C., Engel,H., Grzeschik,K. and Daut,J.
  TITLE     Genomic structure and chromosome mapping of human and mouse RAMP
            genes
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 115-118 (2000)
   PUBMED   11060459
REFERENCE   10 (bases 1 to 4761)
  AUTHORS   Bidegain,M., Roos,B.A., Hill,E.L., Howard,G.A. and Balkan,W.
  TITLE     Calcitonin gene-related peptide (CGRP) in the developing mouse limb
  JOURNAL   Endocr Res 21 (4), 743-755 (1995)
   PUBMED   8582325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137210.1, AF146525.1, DY245973.1, AF209905.1 and CB595628.1.
            
            On Nov 18, 2008 this sequence version replaced NM_018782.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137210.1, AB015595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-630               AK137210.1         2-631
            631-1889            AF146525.1         308-1566
            1890-2151           AK137210.1         1889-2150
            2152-2587           AF146525.1         1829-2264
            2588-2588           DY245973.1         660-660
            2589-2630           AF146525.1         2266-2307
            2631-2802           AF146525.1         2318-2489
            2803-3844           AF209905.1         2072-3113
            3845-4371           CB595628.1         97-623
            4372-4761           AF146525.1         4058-4447
FEATURES             Location/Qualifiers
     source          1..4761
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.38 cM"
     gene            1..4761
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /note="calcitonin receptor-like"
                     /db_xref="GeneID:54598"
                     /db_xref="MGI:MGI:1926944"
     exon            1..197
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            198..265
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            266..346
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            347..481
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            482..568
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            569..698
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            699..809
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            810..922
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1014
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1141
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1295
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1356
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1423
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1642
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1684
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..4737
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4716..4721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /note="hexamer: AAGAAA"
     polyA_site      4737
                     /gene="Calcrl"
                     /gene_synonym="CRLR"
                     /note="major polyA site"
ORIGIN      
        1 agaacaagcc ctctcttcgc agcgtgcact tctgccttag gaccggcggg ctctgttgcc
       61 tggacctcac gctgcctgca ggaccacatt gcaaagcttt ccacacctcg cctccgggaa
      121 actcttgtgc agtatctcag aaaatcaaac tccctcctga gactattccc acagaatttc
      181 cttaggagct gtgccagggc cctatgatga tacagcaaca tcttgtgcta ccaactgtca
      241 aaactttgga tggtctaaca ctcaggtcat gacccttgta attaagaaat tcttgaagac
      301 aatattcagg agaaaatgtg atttgagtct ggagacaatt gtgtatgtat acttttctta
      361 agatattaaa aaacaaatcc aaggtcacag gttgcttatt gatagaagag aaacaatacg
      421 gatagaagag aaatcagaaa attgcttatg attgacaaga acagctgcag cagctaccta
      481 gcttgaacat acagcacatt tcatttggac tctaataatg gataaaaagc atatactatg
      541 ttttctggtt ctcttgcctc ttaatatggc tctcatctca gcagagtcgg aagaaggcgt
      601 gaaccaaaca gacttgggag tcactagaaa caagatcatg acggctcaat atgaatgtta
      661 ccagaagatc atgcaggacc ccattcaaca agcagaaggc ctttactgca ataggacctg
      721 ggacggatgg ctatgctgga atgacgttgc agcagggacg gaatcaatgc agtactgccc
      781 tgactatttt caggattttg atccttcaga gaaggttaca aagatctgtg accaagatgg
      841 acactggttt cggcatccgg atagtaatag aacatggacc aactacaccc tgtgtaataa
      901 cagcacgcat gagaaagtga agacagccct gaatctgttc tacctaacta taattggaca
      961 tggattatct attgcatctc tgatcatctc tctcatcata tttttttact tcaagagcct
     1021 aagttgccaa cggatcacat tgcataaaaa cctgttcttt tcatttattt gtaattcgat
     1081 tgtaacaatc atccacctca cggcagtggc caataaccag gccttagtgg ccacaaatcc
     1141 tgtgagctgc aaagtgtctc agtttatcca tctctacctg atgggctgta actacttctg
     1201 gatgctctgt gaaggcgttt acctgcacac actcatcgtg gtggctgtgt ttgcggagaa
     1261 gcagcacttg atgtggtatt attttctcgg ctgggggttt cctctgcttc ctgcctgcat
     1321 ccacgccatt gccagaagct tgtattacaa cgacaattgc tggatcagct cagacactca
     1381 tctcctctac attatccatg gtccgatttg tgctgctttg ttggtaaatc tctttttcct
     1441 attaaatatt gtacgtgttc tcatcaccaa gttgaaagtt acacaccaag tggaatccaa
     1501 tctctacatg aaagccgtaa gagctactct catcttggta ccactacttg gcattgaatt
     1561 tgtgcttttt ccgtggcggc ctgaaggaaa ggttgcagag gaggtgtatg actatgtcat
     1621 gcacattttg atgcactttc agggtctttt ggtggctact attttctgct tctttaatgg
     1681 agaggttcaa gcaattctga gaagaaattg gaaccagtat aaaatccaat ttggaaatgg
     1741 cttttcccac tctgatgctc tccgcagtgc atcctacaca gtgtcaacaa tcagtgacat
     1801 gcaagggtac agccatgact gccccactga acacttaaat ggaaaaagca tccaggatat
     1861 tgaaaatgtt gccttaaaat cagaaaatat gtatgatcta gtgatgtgaa aatatataaa
     1921 atcacacact tgaacctatg attttatagc caaaagattg gatagccagc aaatggattt
     1981 ctggaatacc atgaagaaag ccctcaaatg aaatgggaat tgtatggata aatgtttaac
     2041 aaccctctct ctatggggga gaaaagcctc aatttatatt gttggccagt aactactcct
     2101 accataactg atttcaagtt accaacctga catcactgaa tgtgtaattg gaaagaaaat
     2161 aagcacaaac aactcccagg agctgacatg ttctggaacc tgcacagcac tgcatgccct
     2221 cagagatgga agtctgtgca cactctcacc cacactgacc agaactctgc tcttctcatc
     2281 tgaggagacc tcactcggac ttacagacat gaaaggaaag tttggttttt gttataaaac
     2341 tcctcatcct tttgtcattt ggtgatagtg aatggtttgt ccagaaacac tttaaccctc
     2401 tttataactt ctcttgtaga ctagacaaag agttcattat ctctgtggtc tcatgttact
     2461 ttctttaaga aaagcaactg agcagaattc ccatgggctt cttagttgct gctacatatt
     2521 gttgtatcct gtggtatatg cactctgaat cactagggag acatattggt agaagctaca
     2581 ccttgtcagc tctctctctc tctctctctc tctctctctc tctctctctc ggcaagaata
     2641 ggaggaaatc agttttctgg aatctgtaaa tagaaacttt ggcctttcca tttctactgt
     2701 gtagataagt aagtgatcaa ccattttaca tgaagggaat caatgaagga tttcttttta
     2761 tcttgggaat ctgagagaga gagagagaga gagagagaga gaaagagaga gagagagaga
     2821 gagagagaga gagaggttgt acaaatgaaa ctgtaagtac tctgtaattt tattttattg
     2881 tttcaattca aaacacaacc taggtaactt ttaaagcaga tagatgatgc aacattatat
     2941 gcaacttagt atctgatact gtgtctgggc tgatttattt tatagtaaaa tagaatcatg
     3001 aattctatac ttggtaaata ttttaaggac aaacagatac cagcatcaga agtttgagaa
     3061 ctaaaaacaa accccagaaa tatcaatgat aagatatgaa atatttattt aaaaatgtaa
     3121 agccataatt ttacaagcat gatatatttg gtgtgctgac atactgcttc caatatgaca
     3181 tattccaatt tgatgacaac tcattcaaat tcagaaatta tgaacaacta ctgtaagaag
     3241 tgctagtctg ctacatttgt gggctttaat tcactaaatt atagctttac tgatttttac
     3301 taaatgaaga tacatgcttt tgaaaaagac ccaggttatt atttttttat gaaccacaga
     3361 ggaattttct ctatgtaata acactgtttc agtatttcag tagactactg tggatgataa
     3421 tacaagccac gggaagactt gaacttacca ctcattgagg atgaagtgtc agatatttaa
     3481 gtaataatta aattaagaca gaagaagatt ttgcttgtga gtttaagtga cattttaaat
     3541 ggatttagtt tttccaatat tgcttggttt ggagtttctg aagaacaaga ttgacttcag
     3601 ttagtaaaag tcactctggg gacagttaca tgagtccatg ttttttaaag tgtgtctgtc
     3661 agtttacagt ggatgagagg agtgactcag ccctcactca ttgtcttaag ctatagaaga
     3721 gaataaatta aaaagttgtt tgaaactgtc aaggaaaaga attcaaatta tcaagcactg
     3781 atgtattaca tgatctgaca gacatatttg taattttctt tttttttttt ctttcttttt
     3841 tttttatatt tgtaattttc tgaactttca gctgcttaaa ccgtacaaac cttcctttta
     3901 ataccttcag actttaggta ttgattattc atatcttcgc tgacagtgtt cgtgtaattc
     3961 tgcattcttc taaacaaact gtcaagtatt aacaataaat ggtagtacag aatgccgaat
     4021 taccagagaa catacttaaa aggtattgta attttaagtt ttattatttt tttactatac
     4081 cgagtgtagc tgagattttt ttactgccaa tatctactgt ggtgtcattc tcagccatag
     4141 cagtctaaga ttagtcagta ttagttttgt aatagtattt ttgaagctgg atttctctaa
     4201 agctgaagtg ccaattaaaa tatttctata atgcttgtag aaaaaaaatc caaaaatttt
     4261 gaaagaaaac ttctctggtg cctaaaaatt aacttgggga gtttttagct tttaaaagtt
     4321 gcatctatta tttttctcta atactttgtt agagtcatgg ctgacacttt tagaagcgac
     4381 tttgtatttt tttgttgata aaccagcctt cctggaggtt agtgtttttt caaatataac
     4441 aaactgtgta gggtttagga gtagtcagtg ttatacttac tgtttagata ttttaatgtg
     4501 aatctatttt aatttccttt gtgttttaat ttgctcatag aaacattata tgtaaaacat
     4561 actcaagttc acttaaaaga actcatattt tatcgacata aaatctctac ttaggtttta
     4621 tgagaatatt aaagttgtaa gttatcactc actttcacgc atcctccctg gactatagag
     4681 caattgaatt cctcacaaaa ttcttgcagc aaataaagaa atactttgca aaataaaaaa
     4741 aaaaaaaaaa aaaaaaaaaa a
//
