LOCUS       NM_001377018            3624 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus calcitonin receptor (Calcr), transcript variant 4,
            mRNA.
ACCESSION   NM_001377018
VERSION     NM_001377018.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3624)
  AUTHORS   Zhu,W., Zhou,Z., Wu,C., Huang,Z., Zhao,R., Wang,X., Luo,L., Liu,Y.,
            Zhong,W., Zhao,Z., Ai,G., Zhong,J., Liu,S., Liu,W., Pang,X., Sun,Y.
            and Zeng,G.
  TITLE     miR-148b-5p regulates hypercalciuria and calcium-containing
            nephrolithiasis
  JOURNAL   Cell Mol Life Sci 81 (1), 369 (2024)
   PUBMED   39182194
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3624)
  AUTHORS   Kuriki,M., Korb,A., Comai,G. and Tajbakhsh,S.
  TITLE     Interplay between Pitx2 and Pax7 temporally governs specification
            of extraocular muscle stem cells
  JOURNAL   PLoS Genet 20 (6), e1010935 (2024)
   PUBMED   38875306
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3624)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3624)
  AUTHORS   Fukumitsu,K., Huang,A.J., McHugh,T.J. and Kuroda,K.O.
  TITLE     Role of Calcr expressing neurons in the medial amygdala in social
            contact among females
  JOURNAL   Mol Brain 16 (1), 10 (2023)
   PUBMED   36658598
  REMARK    GeneRIF: Role of Calcr expressing neurons in the medial amygdala in
            social contact among females.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3624)
  AUTHORS   Zhang,C., Vincelette,L.K., Reimann,F. and Liberles,S.D.
  TITLE     A brainstem circuit for nausea suppression
  JOURNAL   Cell Rep 39 (11), 110953 (2022)
   PUBMED   35705049
REFERENCE   6  (bases 1 to 3624)
  AUTHORS   Vaughan,K.T., Mikami,A., Paschal,B.M., Holzbaur,E.L., Hughes,S.M.,
            Echeverri,C.J., Moore,K.J., Gilbert,D.J., Copeland,N.G.,
            Jenkins,N.A. and Vallee,R.B.
  TITLE     Multiple mouse chromosomal loci for dynein-based motility
  JOURNAL   Genomics 36 (1), 29-38 (1996)
   PUBMED   8812413
REFERENCE   7  (bases 1 to 3624)
  AUTHORS   Primo-Parmo,S.L., Sorenson,R.C., Teiber,J. and La Du,B.N.
  TITLE     The human serum paraoxonase/arylesterase gene (PON1) is one member
            of a multigene family
  JOURNAL   Genomics 33 (3), 498-507 (1996)
   PUBMED   8661009
REFERENCE   8  (bases 1 to 3624)
  AUTHORS   Lee,S.K., Goldring,S.R. and Lorenzo,J.A.
  TITLE     Expression of the calcitonin receptor in bone marrow cell cultures
            and in bone: a specific marker of the differentiated osteoclast
            that is regulated by calcitonin
  JOURNAL   Endocrinology 136 (10), 4572-4581 (1995)
   PUBMED   7664679
REFERENCE   9  (bases 1 to 3624)
  AUTHORS   Ikegame,M., Rakopoulos,M., Zhou,H., Houssami,S., Martin,T.J.,
            Moseley,J.M. and Findlay,D.M.
  TITLE     Calcitonin receptor isoforms in mouse and rat osteoclasts
  JOURNAL   J Bone Miner Res 10 (1), 59-65 (1995)
   PUBMED   7747631
REFERENCE   10 (bases 1 to 3624)
  AUTHORS   Yamin,M., Gorn,A.H., Flannery,M.R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G., Tapp,D.R., Krane,S.M. and Goldring,S.R.
  TITLE     Cloning and characterization of a mouse brain calcitonin receptor
            complementary deoxyribonucleic acid and mapping of the calcitonin
            receptor gene
  JOURNAL   Endocrinology 135 (6), 2635-2643 (1994)
   PUBMED   7988453
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161368.2 and AC066688.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2507984.1,
                                           SRR7652917.1130305.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AC161368.2         103061-103093
            34-217              AC161368.2         103276-103459
            218-220             AC066688.4         176365-176367       c
            221-328             AC066688.4         166095-166202       c
            329-407             AC066688.4         136066-136144       c
            408-561             AC066688.4         131708-131861       c
            562-672             AC066688.4         130235-130345       c
            673-785             AC066688.4         127792-127904       c
            786-877             AC066688.4         124591-124682       c
            878-1004            AC066688.4         121629-121755       c
            1005-1115           AC066688.4         120632-120742       c
            1116-1269           AC066688.4         113270-113423       c
            1270-1330           AC066688.4         106992-107052       c
            1331-1397           AC066688.4         106844-106910       c
            1398-1616           AC066688.4         105685-105903       c
            1617-1658           AC066688.4         104675-104716       c
            1659-3624           AC066688.4         98821-100786        c
FEATURES             Location/Qualifiers
     source          1..3624
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 1.81 cM"
     gene            1..3624
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /note="calcitonin receptor"
                     /db_xref="GeneID:12311"
                     /db_xref="MGI:MGI:101950"
     exon            1..33
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            34..220
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            221..328
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1907
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /note="isoform 1b precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="calcitonin receptor isoform 1b precursor"
                     /protein_id="NP_001363947.1"
                     /db_xref="GeneID:12311"
                     /db_xref="MGI:MGI:101950"
                     /translation="MTPRRSRVKRRNLRKPKMRFLLVNRFTLLLLLLVSPTPVLQAPT
                     NLTDSGLDQEPFLYLVGRKKLLDAQYKCYDRIHQLPSYEGEGLYCNRTWDGWMCWDDT
                     PAGATAYQHCPDYFPDFDTAEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTSEKLQ
                     NAYVLYYLALVGHSLSIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILNSIIIIIH
                     LVEVVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLSAHEGKMDPHASEVISCKVL
                     HFLHQYMMSCNYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPIVPTIIHAIT
                     RALYYNDNCWLSAETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMRQTHEAESYMY
                     LKAVKATMVLVPLLGIQFVVFPWRPSNKVLGKIYDYLMHSLIHFQGFFVATIYCFCNH
                     EVQVTLKRQWTQFKIQWSQRWGRRRRPTNRVVSAPRAVAFAEPDGLPIYICHQEPRNP
                     PISNNEGEESTEMIPMNVIQQDASA"
     exon            329..407
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            408..561
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            562..672
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            673..785
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            786..877
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1004
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1115
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1269
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1330
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1397
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1616
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1658
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..3624
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3546..3551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /note="hexamer: AATACA"
     regulatory      3558..3563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /note="hexamer: ATTAAA"
     polyA_site      3571
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /note="major polyA site"
     polyA_site      3597
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
     regulatory      3600..3605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
                     /note="hexamer: AATACA"
     polyA_site      3624
                     /gene="Calcr"
                     /gene_synonym="Clr; Ct-r"
ORIGIN      
        1 atctcggagc gagcagcggc aggcactgct aaggagagcc agccgcccaa gactctgggc
       61 ggactgcacc tggctggctt gcagacaact cttggttgga gaggtgctta cttctgcgcc
      121 tcaccctgcc gttggcatcc cctgcctgca gatgcccagt gaagtctgcg ttcctgagaa
      181 cacctgagct gtgcccagac atccagcaag agaattcctg catccaccta aggtaagtgc
      241 cattagagcg ccttccagag gagaagaaac cgagggagca gggctactac acagaggatt
      301 tgaaaatgac tccaaggagg tccagagtga aaaggcggaa tctccgcaaa ccgaagatga
      361 ggttccttct cgtgaacagg ttcaccctgc tgctcctgct cctagtgagc ccaactccag
      421 ttcttcaggc tcctaccaat ctcactgact ccggccttga tcaggagcca ttcctgtact
      481 tggttggccg caagaagctg ctggatgctc agtacaaatg ctatgaccgg attcatcagt
      541 tgccctctta tgaaggagaa ggtctgtact gcaaccgcac ctgggatggc tggatgtgct
      601 gggacgacac tcccgctgga gccacagcct atcagcactg ccctgactac ttcccggact
      661 ttgacacagc agaaaaggtt tcaaaatact gtgatgaaaa tggagagtgg tttagacacc
      721 ctgacagcaa ccgaacctgg tccaactata ctctgtgcaa cgctttcact tctgagaaac
      781 tgcaaaatgc gtacgttctt tattacctgg ctcttgtggg tcactccttg tcgattgctg
      841 ctttggttgc ttccatgctg atcttctgga ttttcaagaa ccttagctgc cagagggtga
      901 ccttgcacaa gcacatgttc cttacttata ttctgaattc tatcattatc atcatccacc
      961 tggttgaggt tgtgcccaat ggagatctgg tgcggcggga tcctatgcat atttttcatc
     1021 ataacacaca tatgtggaca atgcagtggg aactgtcacc acccttaccc ctgagtgcac
     1081 acgagggaaa gatggaccct catgccagtg aagtgataag ttgcaaggtt ctacactttt
     1141 tacatcagta catgatgtct tgcaactact tctggatgct ctgcgagggg atctatcttc
     1201 atactctgat tgtcatggct gtgtttaccg acgagcaacg cctacgctgg tactatcttc
     1261 ttggctgggg gttcccgata gtgccaacca ttatccacgc catcactcgt gccctctact
     1321 acaacgacaa ctgctggctg agtgcagaaa cccacttgct ttacatcatc catggacccg
     1381 tcatggtggc tctggtggtc aacttcttct ttcttctcaa cattgtccgc gtgcttgtga
     1441 ccaagatgag gcaaacccac gaggccgagt cctacatgta cctgaaggct gtgaaggcca
     1501 ccatggtcct tgtgcccctg ctggggatcc agtttgttgt gtttccctgg aggccctcca
     1561 acaaggtgct tgggaagatc tatgattatc tcatgcactc tctgattcat ttccagggat
     1621 tctttgtggc gactatctac tgcttctgca accatgaggt gcaagtcacc ctgaagcgcc
     1681 agtggacgca gttcaagatc cagtggagcc aacgctgggg aaggcgccgc cgccccacca
     1741 accgcgtagt tagtgctcct cgggctgtag ccttcgctga gccagatggc ctccccattt
     1801 acatctgcca tcaggaacca cggaatcctc caatcagcaa caacgaaggc gaggagagta
     1861 ctgaaatgat ccccatgaac gtcatccagc aagacgcatc cgcttgaatg tgaagccacc
     1921 ccaagcattg tgatccactg agccttcatt tcctggggaa agacagacca tgtgtttcaa
     1981 gtgattccca tcctcccagg agctgaccat atcatttgtg aagaagtgtt aagtgaattt
     2041 gtccatagtg aatttgaaga aagtgattct tggtactatt gctttgggag tcagtctagg
     2101 aatagagtct cccattgcaa cttgtgaact ccatcattca tcctggactg agatgactgt
     2161 gttcgtagga aagcaggcaa ggtgttcaaa agatgtcaca ctattgacct agttcagata
     2221 cagggtgctc cttgtgaatt ttgagccatt tgtaccgttg agaaattaaa atcactctca
     2281 atgtttttaa atttgacact ggattttgaa ttagactatt tctgtatttg actacagatc
     2341 tggtttttaa tgtttttatt tcagtcagtt cctatattac acatgttacc atccatacaa
     2401 tgtcaactac acatatagca tgacctctga aagatggtgt gtcttttata acatgatcca
     2461 gttcaccagg cagacccaaa tgctgtaatg aattgatctg aaccttgtat gtgctttggt
     2521 cactgacatt tataagttgg gaggtcacca agaacctatc accaaattta tcacaaaact
     2581 gccctccaaa atgtaacaat ctttaaagag agttttccac tttcctaaac tacaggattt
     2641 ataaaacaaa tcactccaag gtttataaag cagattacct cttgcccttg ggtgctatct
     2701 agcagtaaga gaaagatttg tttacgactg gtaattaaaa gactccatac aagtccatta
     2761 actgccttcc acccagcttc aaagctaaac aagatccctg tgtttttcaa gaagactctg
     2821 tgtggctaat tacaaatcag tttcttgttg acctcttgct tgctgctatt agcaaaacaa
     2881 gagggggaaa aaacccacaa tgtagggact tcaaatttaa cctcatatta attcatctta
     2941 aattaaaaac agagcttctc atcaaaaccc agtactatat ctccataccc ctctttactc
     3001 cccagtagga gatcatctaa gatccatgaa taaaccaata ccatcacaga tttctgaatc
     3061 tgcaacagta accagtcatc attacttaat ttgtatgcta aatgaggagc ttttttgaga
     3121 ccctcaaaat ctcctctcac ctttgtaatc ttttgtcact gcctttcaga ggtgatttag
     3181 ttgtgtaaag acaaaagtaa cttgatttgt tctggttaca tgcttggtgt acccagagaa
     3241 aactgtattt caatagcaac tgtggacctt ggatactgag agttgccttt accaaaatgg
     3301 aaggacggat tgaaggaagg atgttttttc aatcacagtg ttacctggtg atgtccctat
     3361 gttttgttta cacacatcga aatcagtgta tttcaggcag ctctagtaca aatgtgataa
     3421 tatattgaag tgtttgagat gttattgtgc ttatgtagta ggagctgatg aaatcaaact
     3481 gacttaccat aacattgcat gtcataccta aattgtgtga aacgcttctg ctgtgtacat
     3541 gtataaatac agagcatatt aaaaaggcaa agatgtatat tggcatattt ttataaagaa
     3601 atacatttgt catctttcat tcat
//
