LOCUS       NP_001257947             331 aa            linear   ROD 01-MAY-2025
DEFINITION  calcium-binding and coiled-coil domain-containing protein 2 [Mus
            musculus].
ACCESSION   NP_001257947
VERSION     NP_001257947.1
DBSOURCE    REFSEQ: accession NM_001271018.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 331)
  AUTHORS   Lu,J., Zhang,J., Jiang,H., Hu,Z., Zhang,Y., He,L., Yang,J., Xie,Y.,
            Wu,D., Li,H., Zeng,K., Tan,P., Xiao,Q., Song,Z., Pan,C., Bai,X. and
            Yu,X.
  TITLE     Vangl2 suppresses NF-kappaB signaling and ameliorates sepsis by
            targeting p65 for NDP52-mediated autophagic degradation
  JOURNAL   Elife 12, 87935 (2024)
   PUBMED   39269442
  REMARK    GeneRIF: Vangl2 suppresses NF-kappaB signaling and ameliorates
            sepsis by targeting p65 for NDP52-mediated autophagic degradation.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 331)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 331)
  AUTHORS   Sun,M., Zhang,W., Bi,Y., Xu,H., Abudureyimu,M., Peng,H., Zhang,Y.
            and Ren,J.
  TITLE     NDP52 Protects Against Myocardial Infarction-Provoked Cardiac
            Anomalies Through Promoting Autophagosome-Lysosome Fusion via
            Recruiting TBK1 and RAB7
  JOURNAL   Antioxid Redox Signal 36 (16-18), 1119-1135 (2022)
   PUBMED   34382418
  REMARK    GeneRIF: NDP52 Protects Against Myocardial Infarction-Provoked
            Cardiac Anomalies Through Promoting Autophagosome-Lysosome Fusion
            via Recruiting TBK1 and RAB7.
REFERENCE   4  (residues 1 to 331)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 331)
  AUTHORS   Kim,S., Lee,D., Song,J.C., Cho,S.J., Yun,S.M., Koh,Y.H., Song,J.,
            Johnson,G.V. and Jo,C.
  TITLE     NDP52 associates with phosphorylated tau in brains of an Alzheimer
            disease mouse model
  JOURNAL   Biochem Biophys Res Commun 454 (1), 196-201 (2014)
   PUBMED   25450380
  REMARK    GeneRIF: expression and association of NDP52 with
            autophagy-regulated gene proteins including LC3, as well as
            phosphorylated tau and amyloid-beta in brains of an Alzheimer
            disease model
REFERENCE   6  (residues 1 to 331)
  AUTHORS   Cosme-Cruz,R., Martinez,F.P., Perez,K.J. and Tang,Q.
  TITLE     H2B homology region of major immediate-early protein 1 is essential
            for murine cytomegalovirus to disrupt nuclear domain 10, but is not
            important for viral replication in cell culture
  JOURNAL   J Gen Virol 92 (Pt 9), 2006-2019 (2011)
   PUBMED   21632568
  REMARK    GeneRIF: The authors conclude that the dispersion of ND10 by major
            immediate-early protein 1 (IE1) appears not to be important for
            murine cytomegalovirus replication in a mouse-cell culture.
REFERENCE   7  (residues 1 to 331)
  AUTHORS   Cosme,R.C., Martinez,F.P. and Tang,Q.
  TITLE     Functional interaction of nuclear domain 10 and its components with
            cytomegalovirus after infections: cross-species host cells versus
            native cells
  JOURNAL   PLoS One 6 (4), e19187 (2011)
   PUBMED   21552525
  REMARK    GeneRIF: ND10 and ND10 components might be important defensive
            factors against the CMV cross-species infection
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 331)
  AUTHORS   Bortvin,A., Eggan,K., Skaletsky,H., Akutsu,H., Berry,D.L.,
            Yanagimachi,R., Page,D.C. and Jaenisch,R.
  TITLE     Incomplete reactivation of Oct4-related genes in mouse embryos
            cloned from somatic nuclei
  JOURNAL   Development 130 (8), 1673-1680 (2003)
   PUBMED   12620990
REFERENCE   9  (residues 1 to 331)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603682.36.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145542.1, BY735862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..331
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.4 cM"
     Protein         1..331
                     /product="calcium-binding and coiled-coil
                     domain-containing protein 2"
                     /note="nuclear domain 10 protein 52 like 1; nuclear domain
                     10 protein NDP52"
                     /calculated_mol_wt=40005
     Region          18..120
                     /region_name="SKICH"
                     /note="SKICH domain; pfam17751"
                     /db_xref="CDD:465482"
     Region          128..131
                     /region_name="CLIR.
                     /evidence=ECO:0000250|UniProtKB:Q13137"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A6M5.1)"
     Region          189..310
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A6M5.1)"
     Region          190..193
                     /region_name="LIR-like.
                     /evidence=ECO:0000250|UniProtKB:Q13137"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A6M5.1)"
     Region          292..302
                     /region_name="Interaction with LGALS8.
                     /evidence=ECO:0000250|UniProtKB:Q13137"
                     /note="propagated from UniProtKB/Swiss-Prot (A2A6M5.1)"
     CDS             1..331
                     /gene="Calcoco2"
                     /gene_synonym="2410154J16Rik; Ndp52; Ndp52l1"
                     /coded_by="NM_001271018.2:36..1031"
                     /db_xref="CCDS:CCDS59567.1"
                     /db_xref="GeneID:76815"
                     /db_xref="MGI:MGI:1343177"
ORIGIN      
        1 mdqcpiptll ehgnfsqvlf nnvekfyapr gdimcyytlt ekfiprrkdw igifkvgwkt
       61 tqeyytfmwa plpkdqnkds atqqeiqfka yylpkdvery qfcyvdedgl vrgtsvpfqf
      121 cpdpdedimv vinkekveem eqlseelyqq nqelkdkyad lheqlqrkqv aleatqrvnk
      181 tlehkveeka swekekaswe eekasweeek asweeekasw eeekasweee kasweeekas
      241 weeekaswee ekasweeeka sweeekaswe eekasweeek asweeekasw ekekasweee
      301 kaswekekap wevekapwke vkaywwndlh r
//
