LOCUS       NM_054084                962 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus calcitonin-related polypeptide, beta (Calcb),
            transcript variant 1, mRNA.
ACCESSION   NM_054084
VERSION     NM_054084.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 962)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 962)
  AUTHORS   Manion,J., Musser,M.A., Kuziel,G.A., Liu,M., Shepherd,A., Wang,S.,
            Lee,P.G., Zhao,L., Zhang,J., Marreddy,R.K.R., Goldsmith,J.D.,
            Yuan,K., Hurdle,J.G., Gerhard,R., Jin,R., Rakoff-Nahoum,S., Rao,M.
            and Dong,M.
  TITLE     C. difficile intoxicates neurons and pericytes to drive neurogenic
            inflammation
  JOURNAL   Nature 622 (7983), 611-618 (2023)
   PUBMED   37699522
REFERENCE   3  (bases 1 to 962)
  AUTHORS   Yang,D., Jacobson,A., Meerschaert,K.A., Sifakis,J.J., Wu,M.,
            Chen,X., Yang,T., Zhou,Y., Anekal,P.V., Rucker,R.A., Sharma,D.,
            Sontheimer-Phelps,A., Wu,G.S., Deng,L., Anderson,M.D., Choi,S.,
            Neel,D., Lee,N., Kasper,D.L., Jabri,B., Huh,J.R., Johansson,M.,
            Thiagarajah,J.R., Riesenfeld,S.J. and Chiu,I.M.
  TITLE     Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to
            drive mucus production and gut barrier protection
  JOURNAL   Cell 185 (22), 4190-4205 (2022)
   PUBMED   36243004
REFERENCE   4  (bases 1 to 962)
  AUTHORS   Yan,Y., Ramanan,D., Rozenberg,M., McGovern,K., Rastelli,D.,
            Vijaykumar,B., Yaghi,O., Voisin,T., Mosaheb,M., Chiu,I.,
            Itzkovitz,S., Rao,M., Mathis,D. and Benoist,C.
  TITLE     Interleukin-6 produced by enteric neurons regulates the number and
            phenotype of microbe-responsive regulatory T cells in the gut
  JOURNAL   Immunity 54 (3), 499-513 (2021)
   PUBMED   33691135
REFERENCE   5  (bases 1 to 962)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 962)
  AUTHORS   Thompson,B.J., Washington,M.K., Kurre,U., Singh,M., Rula,E.Y. and
            Emeson,R.B.
  TITLE     Protective roles of alpha-calcitonin and beta-calcitonin
            gene-related peptide in spontaneous and experimentally induced
            colitis
  JOURNAL   Dig Dis Sci 53 (1), 229-241 (2008)
   PUBMED   17530400
REFERENCE   7  (bases 1 to 962)
  AUTHORS   Tsujikawa,K., Yayama,K., Hayashi,T., Matsushita,H., Yamaguchi,T.,
            Shigeno,T., Ogitani,Y., Hirayama,M., Kato,T., Fukada,S.,
            Takatori,S., Kawasaki,H., Okamoto,H., Ikawa,M., Okabe,M. and
            Yamamoto,H.
  TITLE     Hypertension and dysregulated proinflammatory cytokine production
            in receptor activity-modifying protein 1-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 104 (42), 16702-16707 (2007)
   PUBMED   17923674
  REMARK    GeneRIF: These results indicate that CGRP signaling through
            CLR/RAMP1 receptors plays a crucial role in the regulation of both
            blood pressure by vascular relaxation and proinflammatory cytokine
            production from dendritic cells.
REFERENCE   8  (bases 1 to 962)
  AUTHORS   Andrieu,D., Meziane,H., Marly,F., Angelats,C., Fernandez,P.A. and
            Muscatelli,F.
  TITLE     Sensory defects in Necdin deficient mice result from a loss of
            sensory neurons correlated within an increase of developmental
            programmed cell death
  JOURNAL   BMC Dev Biol 6, 56 (2006)
   PUBMED   17116257
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 962)
  AUTHORS   Young,H.M., Turner,K.N. and Bergner,A.J.
  TITLE     The location and phenotype of proliferating neural-crest-derived
            cells in the developing mouse gut
  JOURNAL   Cell Tissue Res 320 (1), 1-9 (2005)
   PUBMED   15714282
REFERENCE   10 (bases 1 to 962)
  AUTHORS   Thomas,P.M., Nasonkin,I., Zhang,H., Gagel,R.F. and Cote,G.J.
  TITLE     Structure of the mouse calcitonin/calcitonin gene-related peptide
            alpha and beta genes
  JOURNAL   DNA Seq 12 (2), 131-135 (2001)
   PUBMED   11761712
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC111865.1 and AI324836.1.
            
            On Jan 18, 2008 this sequence version replaced NM_054084.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111865.1, DV065557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               BC111865.1         1-567
            568-962             AI324836.1         1-395               c
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 60.19 cM"
     gene            1..962
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /note="calcitonin-related polypeptide, beta"
                     /db_xref="GeneID:116903"
                     /db_xref="MGI:MGI:2151254"
     exon            1..80
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            81..176
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..480
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /note="calcitonin gene-related peptide 2; CGRP-II;
                     beta-type CGRP; calcitonin gene-related peptide II"
                     /codon_start=1
                     /product="calcitonin gene-related peptide 2 precursor"
                     /protein_id="NP_473425.2"
                     /db_xref="CCDS:CCDS21764.1"
                     /db_xref="GeneID:116903"
                     /db_xref="MGI:MGI:2151254"
                     /translation="MDFWKFFPFLALSSIWVLCLASSLQAAPFRSALESSLDLGTLGD
                     QEKHLLLAALMQDYEQMKARKLEQEEQETKGSRVTAQKRSCNTATCVTHRLADLLSRS
                     GGVLKDNFVPTDVGSEAFGRRRRRDLQA"
     exon            177..317
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            318..504
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..962
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      941..946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /note="hexamer: ATTAAA"
     polyA_site      962
                     /gene="Calcb"
                     /gene_synonym="Calc2; CGRP2"
                     /note="major polyA site"
ORIGIN      
        1 ggacaagacg cctacagccg tgtgtgtgtg ctcttctgca gtggacactt cactctcgct
       61 gttccaacac gggctagcag agacatcatg gacttttgga agttctttcc ttttctggct
      121 ctcagcagca tatgggtcct gtgcctggcc agcagcctcc aggctgcccc tttcaggtcc
      181 gctttggaga gcagcctaga cctgggcacc ctcggcgacc aggaaaaaca tctcttgctt
      241 gctgcactga tgcaggacta tgagcagatg aaggccagga agctggaaca ggaggagcaa
      301 gagactaagg gctcccgtgt cactgctcag aagagatcct gcaacactgc cacctgtgtg
      361 acccatcggc tggcagacct gctgagcaga tcaggaggtg tgctgaagga caactttgtg
      421 cccaccgatg tgggctctga agccttcggc cgccgccgcc gcagggacct gcaggcctga
      481 gtcactagca gctccaggaa gaaggttaca taaagttgaa ctcaccatgc ctattaattt
      541 tgtattaaac aacccgatgt gaaggcctca aggacaatgt gtatgcttgc atcctgatag
      601 ataatgaggg aaaccaccgt tgttacttga gaggaatgaa accaagtata aatgagttaa
      661 ttctgtgttt gtttgcatta tttttatact gagtctgtgg ccagtcaaat atgatggtgt
      721 ctcccactgg catcctttgc agcaaaccaa ataggttctc caagagccat ccagccaatg
      781 gtagcagctt tgttgaacct tagggagatg tgaaatcact gcctcttgta gccactgggg
      841 acctatggta gaggagatgc tgtgccttga tgtctcagaa catgattgca aatttattta
      901 aggaaatgtc aaaattgtac catttgtgaa cttcatcaag attaaaacat attttggata
      961 ca
//
