LOCUS       NM_001033954            1022 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus calcitonin/calcitonin-related polypeptide, alpha
            (Calca), transcript variant 2, mRNA.
ACCESSION   NM_001033954
VERSION     NM_001033954.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1022)
  AUTHORS   Korkutata,M., De Luca,R., Fitzgerald,B., Khanday,M.A., Arrigoni,E.
            and Scammell,T.E.
  TITLE     Afferent Projections to the Calca/CGRP-Expressing Parabrachial
            Neurons in Mice
  JOURNAL   J Comp Neurol 533 (1), e70018 (2025)
   PUBMED   39801453
REFERENCE   2  (bases 1 to 1022)
  AUTHORS   Xia,H., Jerde,T.J. and Fehrenbacher,J.C.
  TITLE     Sensory innervation in the prostate and a role for calcitonin
            gene-related peptide in prostatic epithelial proliferation
  JOURNAL   Front Mol Neurosci 17, 1497735 (2024)
   PUBMED   39744541
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1022)
  AUTHORS   Ryu,S., Zhang,J., Simoes,R., Liu,X., Guo,Z., Feng,L., Unsinger,J.,
            Hotchkiss,R.S. and Cao,Y.Q.
  TITLE     Regulatory T cells require peripheral CCL2-CCR2 signaling to
            facilitate the resolution of medication overuse headache-related
            behavioral sensitization
  JOURNAL   J Headache Pain 25 (1), 197 (2024)
   PUBMED   39528947
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1022)
  AUTHORS   Park,S., Zhu,A., Cao,F. and Palmiter,R.D.
  TITLE     Parabrachial Calca neurons mediate second-order conditioning
  JOURNAL   Nat Commun 15 (1), 9721 (2024)
   PUBMED   39521770
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1022)
  AUTHORS   Hou,Y., Sun,L., LaFleur,M.W., Huang,L., Lambden,C., Thakore,P.I.,
            Geiger-Schuller,K., Kimura,K., Yan,L., Zang,Y., Tang,R., Shi,J.,
            Barilla,R., Deng,L., Subramanian,A., Wallrapp,A., Choi,H.S.,
            Kye,Y.C., Ashenberg,O., Schiebinger,G., Doench,J.G., Chiu,I.M.,
            Regev,A., Sharpe,A.H. and Kuchroo,V.K.
  TITLE     Neuropeptide signalling orchestrates T cell differentiation
  JOURNAL   Nature 635 (8038), 444-452 (2024)
   PUBMED   39415015
REFERENCE   6  (bases 1 to 1022)
  AUTHORS   Ahren,B. and Sundler,F.
  TITLE     Localization of calcitonin gene-related peptide and islet amyloid
            polypeptide in the rat and mouse pancreas
  JOURNAL   Cell Tissue Res 269 (2), 315-322 (1992)
   PUBMED   1423499
REFERENCE   7  (bases 1 to 1022)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   8  (bases 1 to 1022)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     The syntenic relationship of proximal mouse chromosome 7 and the
            myotonic dystrophy gene region on human chromosome 19q
  JOURNAL   Genomics 6 (2), 324-332 (1990)
   PUBMED   2307474
REFERENCE   9  (bases 1 to 1022)
  AUTHORS   Barton,D.E., Kwon,B.S. and Francke,U.
  TITLE     Human tyrosinase gene, mapped to chromosome 11 (q14----q21),
            defines second region of homology with mouse chromosome 7
  JOURNAL   Genomics 3 (1), 17-24 (1988)
   PUBMED   3146546
REFERENCE   10 (bases 1 to 1022)
  AUTHORS   Lalley,P.A., Sakaguchi,A.Y., Eddy,R.L., Honey,N.H., Bell,G.I.,
            Shen,L.P., Rutter,W.J., Jacobs,J.W., Heinrich,G., Chin,W.W. et al.
  TITLE     Mapping polypeptide hormone genes in the mouse: somatostatin,
            glucagon, calcitonin, and parathyroid hormone
  JOURNAL   Cytogenet Cell Genet 44 (2-3), 92-97 (1987)
   PUBMED   2882956
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ060164.1, BC028771.1,
            BB749493.1 and BU842988.1.
            
            On Nov 27, 2007 this sequence version replaced NM_001033954.2.
            
            Summary: This gene encodes the peptide hormones calcitonin,
            calcitonin gene-related peptide (CGRP) and katacalcin. Alternative
            splicing of the mRNA results in multiple variants that encode
            either calcitonin or CGRP preproproteins. Post-translational
            processing of the calcitonin and CGRP propeptides results in either
            calcitonin and katacalcin, or CGRP, respectively. Calcitonin and
            katacalcin modulate calcium levels in the blood stream. CGRP can
            function as a vasodilator and play a role in the transmission of
            pain. The human homolog of CGRP was found to have antimicrobial
            activity. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (2) lacks the 3' terminal exon and
            has two alternate 3' exons, compared to variant 1. The resulting
            isoform (Cgrp) is shorter and has a distinct C-terminus, compared
            to isoform Calca. Both variants 2 and 3 encode the same isoform
            Cgrp.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028771.1, AF330212.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                CJ060164.1         2-68
            68-719              BC028771.1         1-652
            720-992             BB749493.1         168-440
            993-1022            BU842988.1         283-312
FEATURES             Location/Qualifiers
     source          1..1022
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 59.99 cM"
     gene            1..1022
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /note="calcitonin/calcitonin-related polypeptide, alpha"
                     /db_xref="GeneID:12310"
                     /db_xref="MGI:MGI:2151253"
     exon            1..146
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /inference="alignment:Splign:2.1.0"
     exon            147..241
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..542
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /note="isoform Cgrp preproprotein is encoded by transcript
                     variant 2; alpha-type CGRP; calcitonin gene-related
                     peptide I"
                     /codon_start=1
                     /product="calcitonin gene-related peptide 1 isoform Cgrp
                     preproprotein"
                     /protein_id="NP_001029126.1"
                     /db_xref="CCDS:CCDS21762.1"
                     /db_xref="GeneID:12310"
                     /db_xref="MGI:MGI:2151253"
                     /translation="MGFLKFSPFLVVSILLLYQACSLQAVPLRSILESSPGMATLSEE
                     EVRLLAALVQDYMQMKARELEQEEEQEAEGSSVTAQKRSCNTATCVTHRLAGLLSRSG
                     GVVKDNFVPTNVGSEAFGRRRRDLQA"
     exon            242..382
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /inference="alignment:Splign:2.1.0"
     exon            383..566
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /inference="alignment:Splign:2.1.0"
     exon            567..994
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      969..974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /note="hexamer: AACAAA"
     polyA_site      987
                     /gene="Calca"
                     /gene_synonym="CA; Calc; Calc1; Cgrp; CGRP-1; CGRP1; Ct;
                     Ctn"
                     /note="major polyA site"
ORIGIN      
        1 cccgactcac cacggcggga ataagagcag ctgcaggcgc tgggaggcac aggagccact
       61 gccaggatca agagtcaccg cttcgcaagc actgcctggc tccatcagga tccccgcagg
      121 ctcagctcca aggcaccgct caccaggaag gcatcatggg cttcctgaag ttctcccctt
      181 tcctggttgt cagcatcttg ctcctgtacc aggcatgcag cctccaggca gtgcctttga
      241 ggtcaatctt ggaaagcagc ccaggcatgg ccactctcag tgaagaagaa gttcgcctgc
      301 tggctgcact ggtgcaggac tatatgcaga tgaaagccag ggagctggag caggaggaag
      361 agcaggaggc tgagggctct agtgtcactg ctcagaagag atcctgcaac actgccacct
      421 gtgtgaccca tcggctggca ggtctgctga gcagatcagg aggtgtggtg aaggacaact
      481 ttgttcccac caatgtgggc tctgaagcct tcggccgccg ccgcagggac cttcaggcct
      541 gaacagataa cagccccaga atgaaggtta cacaataaag ataaactcta attctattca
      601 tgtataatta aagttatgta taagaaaggc tgatgaaaga cacatatatt tgcatccttc
      661 ttagtattga aaaacccttc tccctttgac aggagctaaa gctaagtgca gaataagttg
      721 cctattgtgc atcgtgttgt atgtgactct gtatccaata aacatgacag catggttctg
      781 gcttatctgg tagcaaatat ggtccccata aaccatcctg ttgatgttga tgactctgct
      841 aaacctcaag gggatatgaa acactgcctc ttgctcttct ggggacacat ggtaatgttg
      901 tgactcaatg gaaccatatg cttaaagaac tcttaatatt gtcacttgtg aatgtaatca
      961 aaattaaaaa caaatgtatt ttcaatatcc tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1021 aa
//
