LOCUS       NM_007586               1449 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus calbindin 2 (Calb2), transcript variant 1, mRNA.
ACCESSION   NM_007586 XM_001000960
VERSION     NM_007586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1449)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1449)
  AUTHORS   Renaux,E., Baudouin,C., Schakman,O., Gay,O., Martin,M.,
            Marchese,D., Achouri,Y., Rezsohazy,R., Gofflot,F. and Clotman,F.
  TITLE     Arid3c identifies an uncharacterized subpopulation of V2
            interneurons during embryonic spinal cord development
  JOURNAL   Front Cell Neurosci 18, 1466056 (2024)
   PUBMED   39479525
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1449)
  AUTHORS   Naffaa,M.M. and Yin,H.H.
  TITLE     A cholinergic signaling pathway underlying cortical circuit
            activation of quiescent neural stem cells in the lateral ventricle
  JOURNAL   Sci Signal 17 (855), eadk8810 (2024)
   PUBMED   39316665
REFERENCE   4  (bases 1 to 1449)
  AUTHORS   Eid,L., Lokmane,L., Raju,P.K., Tene Tadoum,S.B., Jiang,X.,
            Toulouse,K., Lupien-Meilleur,A., Charron-Ligez,F., Toumi,A.,
            Backer,S., Lachance,M., Lavertu-Jolin,M., Montseny,M.,
            Lacaille,J.C., Bloch-Gallego,E. and Rossignol,E.
  TITLE     Both GEF domains of the autism and developmental epileptic
            encephalopathy-associated Trio protein are required for proper
            tangential migration of GABAergic interneurons
  JOURNAL   Mol Psychiatry (2024) In press
   PUBMED   39300136
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   5  (bases 1 to 1449)
  AUTHORS   Virtanen,H.T., Choopanian,P., Porokuokka,L.L., Forsgard,R.,
            Garton,D.R., Olfat,S., Korpela,R., Mirzaie,M. and Andressoo,J.O.
  TITLE     Interindividual Variation in Gut Nitrergic Neuron Density Is
            Regulated By GDNF Levels and ETV1
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (6), 101405 (2024)
   PUBMED   39299667
REFERENCE   6  (bases 1 to 1449)
  AUTHORS   Abbott,L.C. and Jacobowitz,D.M.
  TITLE     Development of calretinin-immunoreactive unipolar brush-like cells
            and an afferent pathway to the embryonic and early postnatal mouse
            cerebellum
  JOURNAL   Anat Embryol (Berl) 191 (6), 541-559 (1995)
   PUBMED   7677260
REFERENCE   7  (bases 1 to 1449)
  AUTHORS   Ogawa,M., Miyata,T., Nakajima,K., Yagyu,K., Seike,M., Ikenaka,K.,
            Yamamoto,H. and Mikoshiba,K.
  TITLE     The reeler gene-associated antigen on Cajal-Retzius neurons is a
            crucial molecule for laminar organization of cortical neurons
  JOURNAL   Neuron 14 (5), 899-912 (1995)
   PUBMED   7748558
REFERENCE   8  (bases 1 to 1449)
  AUTHORS   del Rio,J.A., Martinez,A., Fonseca,M., Auladell,C. and Soriano,E.
  TITLE     Glutamate-like immunoreactivity and fate of Cajal-Retzius cells in
            the murine cortex as identified with calretinin antibody
  JOURNAL   Cereb Cortex 5 (1), 13-21 (1995)
   PUBMED   7719127
REFERENCE   9  (bases 1 to 1449)
  AUTHORS   Soriano,E., Del Rio,J.A., Martinez,A. and Super,H.
  TITLE     Organization of the embryonic and early postnatal murine
            hippocampus. I. Immunocytochemical characterization of neuronal
            populations in the subplate and marginal zone
  JOURNAL   J Comp Neurol 342 (4), 571-595 (1994)
   PUBMED   7913715
REFERENCE   10 (bases 1 to 1449)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163615.5.
            
            On Feb 5, 2019 this sequence version replaced NM_007586.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017646.1, SRR9219383.57747.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC163615.5         173242-173410
            170-246             AC163615.5         184458-184534
            247-336             AC163615.5         186712-186801
            337-417             AC163615.5         188744-188824
            418-474             AC163615.5         192042-192098
            475-552             AC163615.5         192863-192940
            553-608             AC163615.5         193356-193411
            609-648             AC163615.5         193800-193839
            649-702             AC163615.5         194100-194153
            703-774             AC163615.5         195731-195802
            775-1449            AC163615.5         198254-198928
FEATURES             Location/Qualifiers
     source          1..1449
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.44 cM"
     gene            1..1449
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /note="calbindin 2"
                     /db_xref="GeneID:12308"
                     /db_xref="MGI:MGI:101914"
     exon            1..169
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..891
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calretinin"
                     /codon_start=1
                     /product="calretinin isoform 1"
                     /protein_id="NP_031612.1"
                     /db_xref="CCDS:CCDS22661.1"
                     /db_xref="GeneID:12308"
                     /db_xref="MGI:MGI:101914"
                     /translation="MAGPQQQPPYLHLAELTASQFLEIWKHFDADGNGYIEGKELENF
                     FQELEKARKGSGMMSKSDNFGEKMKEFMQKYDKNSDGKIEMAELAQILPTEENFLLCF
                     RQHVGSSAEFMEAWRKYDTDRSGYIEANELKGFLSDLLKKANRPYDEPKLQEYTQTIL
                     RMFDLNGDGKLGLSEMSRLLPVQENFLLKFQGMKLTSEEFNAIFTFYDKDGSGYIDEN
                     ELDALLKDLYEKNKKEMNIQQLTTYRKSVMSLAEAGKLYRKDLEIVLCSEPPV"
     exon            170..246
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            247..336
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            337..417
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            418..474
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            475..552
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            553..608
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            609..648
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            649..702
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            703..774
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     exon            775..1449
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /note="hexamer: AATAAA"
     polyA_site      1443
                     /gene="Calb2"
                     /gene_synonym="CR"
                     /note="major polyA site"
ORIGIN      
        1 gcgagaacca gagccaagcg gcaccgagtg acagcgcgct gagagagagg cttaagatct
       61 ccggagcggc tcgccatggc tggcccgcag cagcagcccc cttacctgca cctggccgag
      121 ctgactgcat cccagttcct ggaaatctgg aagcactttg atgctgacgg aaatgggtac
      181 attgaaggta aagagctaga gaacttcttc caggagctgg agaaggcaag gaagggttct
      241 ggcatgatgt ccaagagcga caattttgga gagaagatga aggagttcat gcagaagtat
      301 gataagaact cagatgggaa aattgagatg gcggagctgg cgcagatcct gccgaccgaa
      361 gagaatttcc ttttgtgctt caggcagcac gtgggctcca gcgctgagtt tatggaggct
      421 tggcggaagt atgacacaga cagaagtggc tacatcgaag ccaatgagct caagggattc
      481 ctgtctgacc tcctgaagaa ggccaacagg ccctatgatg aacctaagct ccaggagtac
      541 acccagacca tactacggat gtttgactta aatggagatg gcaaattggg tctctcagag
      601 atgtctagac tcttgcctgt acaagagaac ttcctgctga aatttcaggg tatgaagctg
      661 acctcagaag agttcaatgc catcttcaca ttttatgaca aggatggaag cggctatatt
      721 gatgagaatg aactggacgc cctcctgaag gatctgtatg agaagaacaa gaaggagatg
      781 aacatccaac agctcaccac ctacaggaag agtgtcatgt ccttggccga ggcagggaag
      841 ctctacagaa aggacctgga gattgtgctc tgcagtgagc cccccgtgta aaggggtgaa
      901 gggacagggg ctgcttctgc gcctcccttg aaccccgccc ccgctgtcct gactctcttg
      961 acactccttc ccagacctcc ccaccccctg ccacctgcac acaccagcct gtggatctgg
     1021 aaaggagaga tggagagagg gtggctggta gggttcctta ggcctgatag acagttgtgc
     1081 ctgcgttggg tcacggttgg tgggcggggc tgcaggggaa gcttctgtcg tctccgctgc
     1141 gatgcatgag ttccttcgct gtatgattta ggcttctgag tcccacagag tggactcctt
     1201 cctcttgctg cgccacccct ccccctttct ccccggtcca ccgctgaccc cggacttcca
     1261 ggttctgccc accagcttgc ttaatgatct agctgtcttc tcagagctac tgtggagggt
     1321 gactgccctc tccttgtgtt cttgacgtgt gtgttccttt tctctttggc ttcccctgtc
     1381 ttcttgttta ccaaagaaga gtttacagag aataaagtgg aaatgttctg tcgcggacac
     1441 tcacccgtt
//
