LOCUS       NM_009788               2867 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus calbindin 1 (Calb1), mRNA.
ACCESSION   NM_009788
VERSION     NM_009788.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Wang,H., Lou,R., Wang,Y., Hao,L., Wang,Q., Li,R., Su,J., Liu,S.,
            Zhou,X., Gao,X., Hao,Q., Chen,Z., Xu,Y., Wu,C., Zheng,Y., Guo,Q.
            and Bai,L.
  TITLE     Parallel gut-to-brain pathways orchestrate feeding behaviors
  JOURNAL   Nat Neurosci 28 (2), 320-335 (2025)
   PUBMED   39627537
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Inskeep,K.A., Crase,B., Dayarathna,T. and Stottmann,R.W.
  TITLE     SMPD4-mediated sphingolipid metabolism regulates brain and primary
            cilia development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39470011
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   Parvathy,S., Basu,B., Surya,S., Jose,R., Meera,V., Riya,P.A.,
            Jyothi,N.P., Sanalkumar,R., Praz,V., Riggi,N., Nair,B.S.,
            Gulia,K.K., Kumar,M., Binukumar,B.K. and James,J.
  TITLE     TLX3 regulates CGN progenitor proliferation during cerebellum
            development and its dysfunction can lead to autism
  JOURNAL   iScience 27 (12), 111260 (2024)
   PUBMED   39628587
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Renaux,E., Baudouin,C., Schakman,O., Gay,O., Martin,M.,
            Marchese,D., Achouri,Y., Rezsohazy,R., Gofflot,F. and Clotman,F.
  TITLE     Arid3c identifies an uncharacterized subpopulation of V2
            interneurons during embryonic spinal cord development
  JOURNAL   Front Cell Neurosci 18, 1466056 (2024)
   PUBMED   39479525
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Shamley,D.R., Opperman,L.A., Buffenstein,R. and Ross,F.P.
  TITLE     Ontogeny of calbindin-D28K and calbindin-D9K in the mouse kidney,
            duodenum, cerebellum and placenta
  JOURNAL   Development 116 (2), 491-496 (1992)
   PUBMED   1286620
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Opperman,L.A., Saunders,T.J., Bruns,D.E., Boyd,J.C., Mills,S.E. and
            Bruns,M.E.
  TITLE     Estrogen inhibits calbindin-D28k expression in mouse uterus
  JOURNAL   Endocrinology 130 (3), 1728-1735 (1992)
   PUBMED   1537319
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Fletcher,C., Norman,D.J. and Heintz,N.
  TITLE     Genetic mapping of meander tail, a mouse mutation affecting
            cerebellar development
  JOURNAL   Genomics 9 (4), 647-655 (1991)
   PUBMED   2037292
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Rhoten,W.B. and Christakos,S.
  TITLE     Cellular gene expression for calbindin-D28k in mouse kidney
  JOURNAL   Anat Rec 227 (2), 145-151 (1990)
   PUBMED   2350003
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Wolff,G.L., Greenman,D.L., Frigeri,L.G., Morrissey,R.L., Suber,R.L.
            and Felton,R.P.
  TITLE     Diabetogenic response to streptozotocin varies among obese yellow
            and among lean agouti (BALB/c x VY)F1 hybrid mice
  JOURNAL   Proc Soc Exp Biol Med 193 (2), 155-163 (1990)
   PUBMED   2137249
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048517.1, AK038856.1 and BB668373.1.
            
            On Apr 26, 2007 this sequence version replaced NM_009788.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.58736.1,
                                           SRR1660817.274567.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1881              AK048517.1         2-1882
            1882-2840           AK038856.1         1884-2842
            2841-2867           BB668373.1         391-417
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 6.66 cM"
     gene            1..2867
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="calbindin 1"
                     /db_xref="GeneID:12307"
                     /db_xref="MGI:MGI:88248"
     exon            1..214
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..921
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="D-28K; PCD-29; calbindin D28; spot 35 protein;
                     vitamin D-dependent calcium-binding protein, avian-type;
                     calbindin-28K; calbindin 1, 28kDa; calbindin-D (28k);
                     CalbindinD28K"
                     /codon_start=1
                     /product="calbindin"
                     /protein_id="NP_033918.1"
                     /db_xref="CCDS:CCDS17984.1"
                     /db_xref="GeneID:12307"
                     /db_xref="MGI:MGI:88248"
                     /translation="MAESHLQSSLITASQFFEIWLHFDADGSGYLEGKELQNLIQELL
                     QARKKAGLELSPEMKSFVDQYGQRDDGKIGIVELAHVLPTEENFLLLFRCQQLKSCEE
                     FMKTWRKYDTDHSGFIETEELKNFLKDLLEKANKTVDDTKLAEYTDLMLKLFDSNNDG
                     KLELTEMARLLPVQENFLLKFQGIKMCGKEFNKAFELYDQDGNGYIDENELDALLKDL
                     CEKNKQELDINNITTYKKNIMALSDGGKLYRTDLALILSAGDN"
     exon            215..291
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            292..366
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            367..450
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            451..507
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            508..585
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            586..641
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            642..681
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            682..735
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            736..807
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     exon            808..2867
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1701..1706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="hexamer: ATTAAA"
     polyA_site      1722
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="major polyA site"
     polyA_site      1903
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
     regulatory      2261..2266
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="hexamer: CATAAA"
     polyA_site      2283
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
     regulatory      2345..2350
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="hexamer: AATAAA"
     polyA_site      2366
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="hexamer: AATAAA"
     polyA_site      2483
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
     regulatory      2580..2585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="hexamer: AATAAA"
     polyA_site      2601
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
     regulatory      2640..2645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="hexamer: AATAAA"
     polyA_site      2663
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
     regulatory      2786..2791
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
                     /note="hexamer: ATTAAA"
     polyA_site      2810
                     /gene="Calb1"
                     /gene_synonym="Brain-2; Calb; Calb-1; CB"
ORIGIN      
        1 ggagaactcc ggaggacgcc cgaacggagc agcaccgcgg acagcgcccc gccgcgccgc
       61 gcccagctca gcctgcgcag ccctctcgcc cgaggttcgc gctccgcgca ctctcaaact
      121 agccgctgca ccacgatggc agaatcccac ctgcagtcat ctctgatcac agcctcacag
      181 ttttttgaga tctggcttca tttcgacgct gacggaagtg gttacctgga aggaaaggag
      241 ctgcagaact tgatccagga gcttctgcag gcgcgaaaga aggctggatt ggagctatca
      301 ccggaaatga aatcctttgt ggatcaatat ggacagagag atgatggaaa aataggaatt
      361 gtagagttgg ctcacgtctt acccacagaa gagaatttct tgctgctctt tcgatgccag
      421 caactgaagt cctgcgagga attcatgaag acttggagaa agtatgatac tgaccacagc
      481 ggcttcatcg aaaccgagga acttaagaac tttctaaagg acctactaga gaaagcaaac
      541 aagactgtgg atgatacaaa actagcagag tacacagacc tcatgctgaa actatttgat
      601 tcaaataatg acggaaagct ggaactgaca gagatggcca ggttactacc agtgcaggaa
      661 aatttccttc ttaaattcca gggaatcaaa atgtgtggga aagagttcaa taaggctttt
      721 gagttatatg atcaggatgg caacggatac atagatgaaa atgagctgga tgctttgctg
      781 aaagatctgt gtgagaagaa caaacaggaa ttggatatta acaatattac tacatacaag
      841 aagaacataa tggccttgtc ggatggaggg aagctgtacc gaacagacct tgctcttatt
      901 ctttctgctg gagacaacta gagttggtga ccacaaccac ttgctagtga tacattgtat
      961 ctaaaaccat aactgtgcgc tataaagaag taggctgtat tttcttttat atctgtaaat
     1021 tctactgcat atagagaact attcaggatg tgtggcacat tcttttctgc ttgtttctac
     1081 actgtttgta atgtacagtt tttgtaagca tataaatgaa aagaagaaag accatgctta
     1141 ggccagtcag tacaatcaat tttgaaaaat gaatctacca tggttttgcg tttataaata
     1201 cagatgaaca cttggatttc cccgaaaatc taccatctca aaacttctag tgtcagattg
     1261 taaatgaata tctgtcattg agtaaaagaa taactcatgg caagccaact gtttttattt
     1321 taggcaacca taggactgtc acccaaagca cctctgtgct gcttctatct ggcggaaggg
     1381 atgggcttct gcctctgaag caccaaatat caacagttaa ttatggcttt attctgaaac
     1441 gatctcccta gagatttagt gtactgatca gtgacatgtc tactgcttaa atataaacca
     1501 cactattgac tccagctggc ttggtaaggg aaggtagcca gatgacacat aactatgtct
     1561 gattctatgc ctatatttcc aagaagtcta ctgccagaga gtatgaccat agcccatttt
     1621 ctaaattatt ttcatgtgtt ccagatgaca attattctag taaactgctg ttttatgtca
     1681 tattctctgt gtgctctctg attaaactca atgtactgag tattttggtg tctagtttgc
     1741 ctacttcctg gattttctat gtagaactgt tcatttccac caagggtatc tgctgcctct
     1801 gaaaatattt ttttctagct ataactactc tatttttaat atgtaattga attttaatgt
     1861 aagattcaca gcaacctgat tattgaatgt tatttcatca aaacttgtgt attctgtgga
     1921 ttctatggtt catattgaga tcagcattca aaatagctct atttctatct ggagaattcc
     1981 agatgagttg aagacagtaa cagaagagaa atactagtgt aatcatttat cttattagca
     2041 aatgatattc taaaaccttc actgacccac atgtaactct gtttcgtgta tcctttagct
     2101 agtgtgtcct ctgctggtta ttggtgacaa aaatctaatt aattgcctgg attctttatt
     2161 gtgaagcaag atacaatgac aaagtctatg aaatttatag ttatcaccta atgcaggttt
     2221 gggtcaggtt ggatttaagc actttttttc aattgttgtt cataaaaata acaacaaaac
     2281 caagtatgga ctctttccct caagaatgaa tataaaagga atctgtcaca cacaaaaaca
     2341 aacaaataaa taacaacaga aacccactat atcccaggat ggggagaagt gatacactgg
     2401 ctttacttcg gcacgtattt ggaagcagtg actttagact gaatttaact accaagaata
     2461 aaggaaatta cattactctt tcatatttgt ttctacccca aagtgttaat tgtcatgtaa
     2521 tctgttatca attagggtag aaaagtagat atcgtgaatc attatagccg aaggactcta
     2581 ataaaaattt tgctcagtga atgacttaga ggtatgagca gttttaaaga ttagccaaca
     2641 ataaatccta gaatatgcaa atatttagag atttcctttt cctcaagtga tttggcaaca
     2701 atttttatgc aaggtctgaa aagaaataag acaaagatgt gttaaacttt atttatagaa
     2761 aaaatgtcta ttcaacaaaa tagacattaa aaatgtctat tcagtcaaaa tagtaccaag
     2821 tttggcattc ttactaatag tagtagaaca aatcctataa tagtcac
//
