LOCUS       NP_694803               1304 aa            linear   ROD 02-MAY-2024
DEFINITION  calcium-dependent secretion activator 2 isoform 1 [Mus musculus].
ACCESSION   NP_694803
VERSION     NP_694803.3
DBSOURCE    REFSEQ: accession NM_153163.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1304)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1304)
  AUTHORS   Guo,Y., Xiang,P., Sun,X., Liu,W., Zhou,J., Yin,B., Hou,L.,
            Qiang,B., Li,H., Shu,P. and Peng,X.
  TITLE     Docking protein 6 (DOK6) selectively docks the neurotrophic
            signaling transduction to restrain peripheral neuropathy
  JOURNAL   Signal Transduct Target Ther 9 (1), 32 (2024)
   PUBMED   38351062
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1304)
  AUTHORS   Cattaneo,P., Hayes,M.G.B., Baumgarten,N., Hecker,D., Peruzzo,S.,
            Aslan,G.S., Kunderfranco,P., Larcher,V., Zhang,L., Contu,R.,
            Fonseca,G., Spinozzi,S., Chen,J., Condorelli,G., Dimmeler,S.,
            Schulz,M.H., Heinz,S., Guimaraes-Camboa,N. and Evans,S.M.
  TITLE     DOT1L regulates chamber-specific transcriptional networks during
            cardiogenesis and mediates postnatal cell cycle withdrawal
  JOURNAL   Nat Commun 13 (1), 7444 (2022)
   PUBMED   36460641
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1304)
  AUTHORS   Fujima,S., Yamaga,R., Minami,H., Mizuno,S., Shinoda,Y.,
            Sadakata,T., Abe,M., Sakimura,K., Sano,Y. and Furuichi,T.
  TITLE     CAPS2 Deficiency Impairs the Release of the Social Peptide
            Oxytocin, as Well as Oxytocin-Associated Social Behavior
  JOURNAL   J Neurosci 41 (20), 4524-4535 (2021)
   PUBMED   33846232
REFERENCE   5  (residues 1 to 1304)
  AUTHORS   Yoo,H., Yang,S.H., Kim,J.Y., Yang,E., Park,H.S., Lee,S.J.,
            Rhyu,I.J., Turecki,G., Lee,H.W. and Kim,H.
  TITLE     Down-regulation of habenular calcium-dependent secretion activator
            2 induces despair-like behavior
  JOURNAL   Sci Rep 11 (1), 3700 (2021)
   PUBMED   33580180
  REMARK    GeneRIF: Down-regulation of habenular calcium-dependent secretion
            activator 2 induces despair-like behavior.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1304)
  AUTHORS   Sadakata,T., Washida,M. and Furuichi,T.
  TITLE     Alternative splicing variations in mouse CAPS2: differential
            expression and functional properties of splicing variants
  JOURNAL   BMC Neurosci 8, 25 (2007)
   PUBMED   17428348
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1304)
  AUTHORS   Speidel,D., Bruederle,C.E., Enk,C., Voets,T., Varoqueaux,F.,
            Reim,K., Becherer,U., Fornai,F., Ruggieri,S., Holighaus,Y.,
            Weihe,E., Bruns,D., Brose,N. and Rettig,J.
  TITLE     CAPS1 regulates catecholamine loading of large dense-core vesicles
  JOURNAL   Neuron 46 (1), 75-88 (2005)
   PUBMED   15820695
REFERENCE   8  (residues 1 to 1304)
  AUTHORS   Sadakata,T., Mizoguchi,A., Sato,Y., Katoh-Semba,R., Fukuda,M.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     The secretory granule-associated protein CAPS2 regulates
            neurotrophin release and cell survival
  JOURNAL   J Neurosci 24 (1), 43-52 (2004)
   PUBMED   14715936
  REMARK    GeneRIF: results suggest that CAPS2 mediates the
            depolarization-dependent release of NT-3 and BDNF from granule
            cells, leading to regulation in cell differentiation and survival
            during cerebellar development
REFERENCE   9  (residues 1 to 1304)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
  REMARK    GeneRIF: identification, cloning, and comparative characterization
            of a second mammalian CAPS isoform, CAPS2; concluded that at the
            functional level, CAPS2 is largely redundant with CAPS1
REFERENCE   10 (residues 1 to 1304)
  AUTHORS   Cisternas,F.A., Vincent,J.B., Scherer,S.W. and Ray,P.N.
  TITLE     Cloning and characterization of human CADPS and CADPS2, new members
            of the Ca2+-dependent activator for secretion protein family
  JOURNAL   Genomics 81 (3), 279-291 (2003)
   PUBMED   12659812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153831.4, AC155850.6, AC153636.2, AC167725.9 and AC153639.4.
            
            On Nov 22, 2006 this sequence version replaced NP_694803.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1, also known as
            CAPS2b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB291947.1, AK038568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 10.57 cM"
     Protein         1..1304
                     /product="calcium-dependent secretion activator 2 isoform
                     1"
                     /note="calcium-dependent secretion activator 2; cerebellum
                     postnatal development associated protein 2"
                     /calculated_mol_wt=148423
     Region          1..78
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BYR5.2)"
     Site            61
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BYR5.2)"
     Region          369..452
                     /region_name="C2"
                     /note="Protein kinase C conserved region 2 (CalB);
                     smart00239"
                     /db_xref="CDD:214577"
     Region          485..604
                     /region_name="PH_CADPS"
                     /note="Ca2+-dependent activator protein (also called CAPS)
                     Pleckstrin homology (PH) domain; cd01234"
                     /db_xref="CDD:269940"
     Region          802..1253
                     /region_name="MUN"
                     /note="MUN domain; pfam06292"
                     /db_xref="CDD:461870"
     Region          1282..1304
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BYR5.2)"
     Site            1298
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BYR5.2)"
     CDS             1..1304
                     /gene="Cadps2"
                     /gene_synonym="A230044C21Rik; Caps-2; Caps2; Cpd2"
                     /coded_by="NM_153163.5:165..4079"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS39439.1"
                     /db_xref="GeneID:320405"
                     /db_xref="MGI:MGI:2443963"
ORIGIN      
        1 mldpssseee sdegleeesr evlvapgvsq rappaaareg rrdapgrsgg gsgggaarpv
       61 spspsvlseg rnepelqlde eqerrirlql yvfvvrciay pfnakqptdm arrqqklnkq
      121 qlqllkerfq aflngetqiv adeafcnavr syyevflksd rvarmvqsgg csandfrevf
      181 kkniekrvrs lpeidglske tvlsswiaky daiyrgeedl ckqpnrmtls avselilske
      241 qlyemfqqil gikklehqll ynacqldnad eqaaqirrel dgrlqlaekm akerrfprfi
      301 skemesmyie elrasvnllm anleslpvsk ggpefklqkl krsqnsafld lgdeneiqls
      361 ksdvvlsftl eivimevqgl ksvapnrivy ctmeveggek lqtdqaeasr pqwgtqgdfn
      421 tthprpvvkv klftestgvl aledkelgrv vlyptsnssk saelhrmtvp knsqdsdlki
      481 klavrmdkpa hmkhsgylya lgqkvwkrwk kryfvlvqvs qytfamcsyr ekksepqelm
      541 qlegytvdyt dphpglqggq vffnavkegd tvifasddeq drilwvqamy ratgqsykpv
      601 pavqsqklnp kggalhadaq lyadrfqkhg mdefisaspc kldhaflfri lqrqtldhrl
      661 ndsysclgwf spgqvfvlde ycarygvrgc hrhlcyltel mehsengavi dptllhysfa
      721 fcashvhgnr pdgigtvsve ekerfeeikd rlssllenqi shfrycfpfg rpegalkatl
      781 sllervlmkd iatpipaeev kkvvrkclek aalinytrlt eyakiegpae ketetmnqat
      841 parkleevlh laelcievlq qneehhaegr eafawwpdll aehaekfwal ftvdmdtale
      901 aqpqdswdsf plfqllnnfl rndtllcngk fhkhlqeifv plvvryvdlm esaiaqsihr
      961 gfeqetwqpv knianslpnv alpkvpslpl nlpqipsfst ppwmaslyes tngsttsedl
     1021 fwkldalqmf vfdlhwpeqe fahhleqrlk lmasdmieac vkrtrtafel klqkankttd
     1081 lripasvctm fnvlvdakkq stklcaldgg qeqqyhskid dlidntvkei iallvskfvs
     1141 vlegvlskls rydegtffss ilsftvkaaa kyvdvpkpgm dladtyimfv rqnqdilrek
     1201 vneemyiekl fdqwysnsmk vicvwladrl dlqlhiyqlk tlikivkkty rdfrlqgvle
     1261 gtlnsktydt lhrrltveea tasvsegggl qgitmkdsde eeeg
//
