LOCUS       NM_001042617            5475 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus Ca2+-dependent secretion activator (Cadps), transcript
            variant 2, mRNA.
ACCESSION   NM_001042617
VERSION     NM_001042617.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5475)
  AUTHORS   Sitbon,J., Nestvogel,D., Kappeler,C., Nicolas,A., Maciuba,S.,
            Henrion,A., Troudet,R., Courtois,E., Grannec,G., Latapie,V.,
            Barau,C., Le Corvoisier,P., Pietrancosta,N., Henry,C., Leboyer,M.,
            Etain,B., Nosten-Bertrand,M., Martin,T.F.J., Rhee,J. and Jamain,S.
  TITLE     CADPS functional mutations in patients with bipolar disorder
            increase the sensitivity to stress
  JOURNAL   Mol Psychiatry 27 (2), 1145-1157 (2022)
   PUBMED   35169262
  REMARK    GeneRIF: CADPS functional mutations in patients with bipolar
            disorder increase the sensitivity to stress.
REFERENCE   2  (bases 1 to 5475)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5475)
  AUTHORS   Shumate,K.M., Tas,S.T., Kavalali,E.T. and Emeson,R.B.
  TITLE     RNA editing-mediated regulation of calcium-dependent activator
            protein for secretion (CAPS1) localization and its impact on
            synaptic transmission
  JOURNAL   J Neurochem 158 (2), 182-196 (2021)
   PUBMED   33894004
  REMARK    GeneRIF: RNA editing-mediated regulation of calcium-dependent
            activator protein for secretion (CAPS1) localization and its impact
            on synaptic transmission.
REFERENCE   4  (bases 1 to 5475)
  AUTHORS   Ishii,C., Shibano,N., Yamazaki,M., Arima,T., Kato,Y., Ishii,Y.,
            Shinoda,Y., Fukazawa,Y., Sadakata,T., Sano,Y. and Furuichi,T.
  TITLE     CAPS1 is involved in hippocampal synaptic plasticity and
            hippocampus-associated learning
  JOURNAL   Sci Rep 11 (1), 8656 (2021)
   PUBMED   33883618
  REMARK    GeneRIF: CAPS1 is involved in hippocampal synaptic plasticity and
            hippocampus-associated learning.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5475)
  AUTHORS   Nestvogel,D.B., Merino,R.M., Leon-Pinzon,C., Schottdorf,M., Lee,C.,
            Imig,C., Brose,N. and Rhee,J.S.
  TITLE     The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation
            of Sensory Evoked Responses in Mouse Visual Cortex
  JOURNAL   Cell Rep 30 (10), 3261-3269 (2020)
   PUBMED   32160535
  REMARK    GeneRIF: The Synaptic Vesicle Priming Protein CAPS-1 Shapes the
            Adaptation of Sensory Evoked Responses in Mouse Visual Cortex.
REFERENCE   6  (bases 1 to 5475)
  AUTHORS   Sadakata,T., Itakura,M., Kozaki,S., Sekine,Y., Takahashi,M. and
            Furuichi,T.
  TITLE     Differential distributions of the Ca2+ -dependent activator protein
            for secretion family proteins (CAPS2 and CAPS1) in the mouse brain
  JOURNAL   J Comp Neurol 495 (6), 735-753 (2006)
   PUBMED   16506193
  REMARK    GeneRIF: The two CAPS family proteins are complementarily
            distributed throughout the various brain regions of mice.
REFERENCE   7  (bases 1 to 5475)
  AUTHORS   Speidel,D., Bruederle,C.E., Enk,C., Voets,T., Varoqueaux,F.,
            Reim,K., Becherer,U., Fornai,F., Ruggieri,S., Holighaus,Y.,
            Weihe,E., Bruns,D., Brose,N. and Rettig,J.
  TITLE     CAPS1 regulates catecholamine loading of large dense-core vesicles
  JOURNAL   Neuron 46 (1), 75-88 (2005)
   PUBMED   15820695
REFERENCE   8  (bases 1 to 5475)
  AUTHORS   Sadakata,T., Mizoguchi,A., Sato,Y., Katoh-Semba,R., Fukuda,M.,
            Mikoshiba,K. and Furuichi,T.
  TITLE     The secretory granule-associated protein CAPS2 regulates
            neurotrophin release and cell survival
  JOURNAL   J Neurosci 24 (1), 43-52 (2004)
   PUBMED   14715936
REFERENCE   9  (bases 1 to 5475)
  AUTHORS   Speidel,D., Varoqueaux,F., Enk,C., Nojiri,M., Grishanin,R.N.,
            Martin,T.F., Hofmann,K., Brose,N. and Reim,K.
  TITLE     A family of Ca2+-dependent activator proteins for secretion:
            comparative analysis of structure, expression, localization, and
            function
  JOURNAL   J Biol Chem 278 (52), 52802-52809 (2003)
   PUBMED   14530279
REFERENCE   10 (bases 1 to 5475)
  AUTHORS   Cisternas,F.A., Vincent,J.B., Scherer,S.W. and Ray,P.N.
  TITLE     Cloning and characterization of human CADPS and CADPS2, new members
            of the Ca2+-dependent activator for secretion protein family
  JOURNAL   Genomics 81 (3), 279-291 (2003)
   PUBMED   12659812
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116395.21, AK122453.1 and BC079679.1.
            
            Transcript Variant: This variant (2) has multiple differences in
            the coding region but maintains the reading frame, compared to
            variant 1. This variant encodes isoform 2 which is 6 aa shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-776               AC116395.21        49376-50151
            777-1304            AK122453.1         777-1304
            1305-1912           BC079679.1         1279-1886
            1913-4229           AK122453.1         1913-4229
            4230-5475           BC079679.1         6627-7872
FEATURES             Location/Qualifiers
     source          1..5475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 6.37 cM"
     gene            1..5475
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /note="Ca2+-dependent secretion activator"
                     /db_xref="GeneID:27062"
                     /db_xref="MGI:MGI:1350922"
     exon            1..776
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..4409
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Ca2+-dependent activator protein for secretion;
                     calcium-dependent secretion activator 1; calcium-dependent
                     activator protein for secretion 1; Ca<2+>dependent
                     activator protein for secretion"
                     /codon_start=1
                     /product="calcium-dependent secretion activator 1 isoform
                     2"
                     /protein_id="NP_001036082.1"
                     /db_xref="CCDS:CCDS36807.1"
                     /db_xref="GeneID:27062"
                     /db_xref="MGI:MGI:1350922"
                     /translation="MLDPSSSEEESDEILEEERGKDVLGSAASGARLSPSRTSEGSAG
                     SAGMGGSGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEE
                     LERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKISKQQLQTVKDRFQA
                     FLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVR
                     SLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQ
                     NILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEME
                     NMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDV
                     LLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTT
                     HALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKI
                     KLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQE
                     LLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQS
                     HKPVPPTQVQKLNAKGGNVPQLDAPISQFSGLKDADRAQKHGMDEFISSNPCNFDHAS
                     LFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERA
                     ENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITH
                     FRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLS
                     EYAKIEENQKDAENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEPHVDKGEAFA
                     WWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFH
                     KHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVKSLTSNLPNVNLPNVNLPKV
                     PNLPVNIPLGIPQMPTFSAPSWMAAIYDADNGSGTSEDLFWKLDALQTFIRDLHWPEE
                     EFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDA
                     KAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEG
                     TLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQ
                     WYNSSMNIICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETI
                     RNRLTVEEATASVSEGGGLQGISMKDSDEEDEEDD"
     exon            777..890
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1223
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1304
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1538
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1660
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1772
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1912
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1979
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2088
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2301
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2313
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2450
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2638
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2740
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2804
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2928
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2929..2946
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3053
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..3074
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3231
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3232..3373
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3374..3520
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3521..3676
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3677..3824
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3825..3899
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..3983
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            3984..4016
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            4017..4124
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..4229
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     exon            4230..5460
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5439..5444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /note="hexamer: AATAAT"
     polyA_site      5460
                     /gene="Cadps"
                     /gene_synonym="CAPS; CAPS1; mKIAA1121"
                     /note="major polyA site"
ORIGIN      
        1 acactcggca tcttttctgg aggcgccttc ttcagcggct gcagatggca tccggctgcg
       61 ggctccgggc tcgcaattga ttctcgccct tgcccacctc gggtgcacac acgcacctct
      121 cccttctcct cctcccctcg cgctcctggg tctgcgctca gctcgcgctc gccgggcgga
      181 ggaagcagtc gcggcggccg aagctgagca gcagcgctcg ctctccctga cctaggaaga
      241 agcgcctacc cggacagccg acccttggct gcctccagcg ccccccacct tttgcacccc
      301 aaggcggggg ctccggggac ccccctctcc caggcgctac catgctggac ccttcgtcca
      361 gcgaagagga gtcagatgag atcctggaag aggagagggg caaggatgtg ctgggctcgg
      421 ccgcgtctgg agcgcgcctg tctcccagcc gcaccagcga gggctcggca ggcagcgccg
      481 ggatgggggg cagtggcgcc ggggccgggg tgggcgccgg cggcggtggg ggtagcggcg
      541 cgagcagcgg cggcggggcc ggggggctgc agcccagcag ccgcgccggc ggcggccggc
      601 cttccagccc tagcccgtcg gtggtgagcg agaaggagaa ggaagagttg gagaggctgc
      661 agaaggagga ggaagagagg aagaagaggc tgcagctgta cgtgttcgtg atgcgctgca
      721 tcgcctaccc cttcaacgcc aagcagccca ccgacatggc tcggcggcag cagaagatca
      781 gcaaacagca gctacagact gtcaaagacc ggttccaggc ttttctcaat ggggagaccc
      841 aaatcgtagc tgatgaagcc tttatgaatg ctgtccagag ctactatgag gtgtttctca
      901 agagtgaccg tgtggcccgc atggtgcaga gtgggggctg ctcagccaat gactctcggg
      961 aggtcttcaa gaaacacatc gagaagaggg tgcgcagcct acctgagatt gacggcctca
     1021 gcaaggagac agtgctaagc tcttggatgg ccaagtttga tgccatctac cgtggtgagg
     1081 aggaccccag gaagcagcaa gcccggatga cagccagtgc agcttctgag ttgattctga
     1141 gcaaggaaca gctctatgag atgtttcaga acattcttgg gatcaagaag tttgaacatc
     1201 aactcctgta taatgcctgt cagctggaca atccagatga gcaggcagcc cagatcagac
     1261 gagagctgga tggacgtctc caaatggcag atcaaatagc cagggaacgc aaatttccta
     1321 agttcgtatc caaagaaatg gaaaacatgt acattgagga gctgaagtcc tccgtcaacc
     1381 tgctcatggc caacttggag agcatgccgg tgtccaaggg tggagagttc aagctacaga
     1441 aactgaaacg cagtcacaat gcttccatca ttgacatggg tgaggagagt gagaaccagc
     1501 tttctaagtc agatgtcctg ctgtccttct ccttggaggt ggtgatcatg gaagtccaag
     1561 gccttaagtc cttggctcca aatcgaattg tatactgcac aatggaggtg gagggtggag
     1621 agaaacttca gacagatcaa gcagaggctt ctaaaccaac ctggggcact caaggcgact
     1681 tctccacaac ccatgcgctg ccagctgtta aagtaaaact attcacagag agcactggtg
     1741 tcctggcctt ggaagacaag gaactcgggc gggtgatcct ccatcccacc ccaaatagcc
     1801 ccaaacaatc tgagtggcac aaaatgacag tctccaaaaa ctgccccgat caagacctca
     1861 aaatcaaact tgctgtccga atggataagc ctcaaaacat gaagcactct gggtacttat
     1921 ggaccattgg taagaatgtg tggaagaggt ggaagaagag gttctttgtg ttggtgcagg
     1981 tcagccagta cacttttgcc atgtgcagct atcgagaaaa gaaggcagag cctcaggaac
     2041 tcctacagct ggacggctac accgtggatt acaccgaccc tcagccaggt ttggagggtg
     2101 gccgagcctt cttcaatgca gtcaaagaag gagacacggt gatatttgca agtgatgatg
     2161 aacaagatcg aattttgtgg gtccaagcta tgtacagggc cactggccag tcgcacaaac
     2221 ctgttccccc tacccaggtg cagaagctca acgccaaggg cggaaatgtg cctcagctgg
     2281 atgcccccat ctcacaattt tctggactga aggacgcaga tagagctcag aagcatggca
     2341 tggatgaatt tatctcttcc aacccctgta actttgacca cgcttccctc tttgagatgg
     2401 tgcagcggct gactttggat cacagactta atgattccta ttcttgcctg ggctggttca
     2461 gtcctggcca ggtgtttgtg ttagatgagt attgcgccag aaatggagtc cgaggatgtc
     2521 accggcatct ctgctacctt agagacttgc tggaacgagc agaaaatggc gcgatgattg
     2581 accccacgct tcttcactac agctttgcct tctgcgcgtc ccatgtccat ggtaacaggc
     2641 ctgatggaat cggaactgtg actgttgaag aaaaagaacg ctttgaagaa atcaaagaga
     2701 gactccgagt tctgctggaa aatcaaatta cacatttcag gtactgcttt ccatttggtc
     2761 gacctgaagg tgctttgaaa gctactctct cactcttgga acgggttttg atgaaagata
     2821 ttgtcactcc agtaccacaa gaagaggtca aaactgtcat ccgtaaatgc ctagagcagg
     2881 ctgctctagt caactactca cgcctatctg agtatgccaa aattgaagag aatcaaaagg
     2941 atgcagaaaa tgtaggccgc ttaatcactc ccgccaaaaa gctcgaagac acaatccgtc
     3001 ttgctgaact agtcatcgaa gtactgcaac aaaacgagga gcaccacgcc gagccacatg
     3061 ttgataaagg agaagccttt gcgtggtggt cagacttaat ggtggagcat gcggagacgt
     3121 tcctgtcact ctttgcagtg gacatggatg cagccttaga ggtgcaaccc ccagacacgt
     3181 gggacagttt cccactcttc cagctgctga atgactttct ccgtacagac tataatttgt
     3241 gcaatggaaa gtttcacaaa cacctgcagg acctgttcgc cccacttgtt gttagatatg
     3301 tggatctgat ggagtcctcc attgcacaat ctatccacag gggctttgag cgggagtcat
     3361 gggagccagt caagagttta accagtaacc tacccaatgt gaacctaccc aatgtgaacc
     3421 tacccaaagt accaaatcta ccagttaaca tccctctagg catcccacag atgcccactt
     3481 tttcggcacc gtcatggatg gctgctatat atgatgctga taatggatca ggtacatcag
     3541 aagatttgtt ctggaaactt gatgcccttc agactttcat ccgtgaccta cactggcctg
     3601 aggaagagtt tggaaaacac ttagagcagc ggctaaaact gatggcaagt gacatgattg
     3661 agtcctgcgt caaaagaacc aggattgcat ttgaagttaa gctgcaaaaa accagtcgat
     3721 caacagattt tcgagtccca cagtcaatat gcaccatgtt taatgttatg gttgatgcca
     3781 aagctcaatc aacaaaactt tgcagcatgg aaatgggcca agagcatcaa taccattcaa
     3841 aaatagatga actaattgaa gaaaccgtta aagaaatgat cacacttttg gtggcaaagt
     3901 ttgtaactat attggaaggc gtactggcaa agttatccag atatgacgag gggactttgt
     3961 tttcttcgtt tctgtcattc acggtgaagg cagcttccaa gtatgtggac gtgcctaaac
     4021 ccgggatgga cgtggccgac gcctacgtga ctttcgtccg ccattctcag gatgtccttc
     4081 gtgataaggt caatgaggag atgtatatag aaaggttatt tgatcaatgg tacaacagct
     4141 ccatgaacat catctgcacg tggctgaccg acaggatgga cctgcagctc cacatttacc
     4201 agctgaaaac cctgatcagg atggtaaaga aaacctatag agatttccga ttgcaagggg
     4261 tcctggattc caccttaaac agcaagacct atgagaccat ccgaaaccgt ctcactgtgg
     4321 aggaagctac agcgtcagtg agtgagggtg ggggcttaca aggtatcagc atgaaggaca
     4381 gtgatgagga agatgaagaa gatgattaga ccattctctg ggtccaagag tccattggga
     4441 tggagtcctg taatcaatgc atgtctttag tctgttagtt aaccccatta ggtaattttc
     4501 tgtcaaccac catccccatg agatgtttac caatacaatt accattttag ctgcgtggta
     4561 ccaagattag caaatggttt cctgatttct gtgtctatat gtttacaagc aatatggaac
     4621 accattctta aacactgttc atggaaagaa tacatagttc agctgctagg tgtgtccctt
     4681 ttgttagcag aacaaaatga tgcttcatcc tgtactacag atacacggat tggaagtgga
     4741 catggaagca agtgtgtttc catgtctctg tttcatgtat gtgggtacca ggtatttaaa
     4801 ttagtacata aattaattta agtgcataga gctgcttggt tttggtctct gttttgttct
     4861 tgttttatga gaaggggaaa aggcatggtc ccaaaaacca actttagctt ttctcatccc
     4921 ctaaaactaa aagcaatgga ccacttgtgt cccagcaaac ccagctttgc atttatccat
     4981 gtagtttagt tccccctacc aaaaaagtta catatcaatg gattaattat tttcattgtc
     5041 atagcaaggg ggccacgtga tcaggaagta gcatcaagta agtttcagac caactgtctt
     5101 ctgtgaaagt ttatcctagt aaatgtcaca ttttgctttt ctgtttcaat aactgtatat
     5161 gtaaaaaaaa ttattgaaat gaaaacccta gactataaat gtatttataa taagatatgg
     5221 atatttcctt cagtagactg taaccataac ttcaattatt ttgttccaca ctgtttttta
     5281 tatctgtcat gtacattgca ctttgatctg taactgagcg accctggggt ctgctataga
     5341 gctgtttctt tctgtggaaa gtagtggatc catcttgctt tttgccttat ataaaagcct
     5401 acagttgtaa aagtgtggga aactgtggct cctcaataaa taattattca aatgtcctaa
     5461 aaaaaaaaaa aaaaa
//
