LOCUS       NP_001399743             430 aa            linear   ROD 14-MAY-2024
DEFINITION  cell adhesion molecule 3 isoform 1 precursor [Mus musculus].
ACCESSION   NP_001399743 XP_006497123
VERSION     NP_001399743.1
DBSOURCE    REFSEQ: accession NM_001412814.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Kawashima,R., Matsushita,K., Mandai,K., Sugita,Y., Maruo,T.,
            Mizutani,K., Midoh,Y., Oguchi,A., Murakawa,Y., Kuniyoshi,K.,
            Sato,R., Furukawa,T., Nishida,K. and Takai,Y.
  TITLE     Necl-1/CADM3 regulates cone synapse formation in the mouse retina
  JOURNAL   iScience 27 (4), 109577 (2024)
   PUBMED   38623325
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Song,B.G., Kwon,S.Y., Kyung,J.W., Roh,E.J., Choi,H., Lim,C.S.,
            An,S.B., Sohn,S. and Han,I.
  TITLE     Synaptic Cell Adhesion Molecule 3 (SynCAM3) Deletion Promotes
            Recovery from Spinal Cord Injury by Limiting Glial Scar Formation
  JOURNAL   Int J Mol Sci 23 (11), 6218 (2022)
   PUBMED   35682897
  REMARK    GeneRIF: Synaptic Cell Adhesion Molecule 3 (SynCAM3) Deletion
            Promotes Recovery from Spinal Cord Injury by Limiting Glial Scar
            Formation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Song,W., Li,Q., Wang,T., Li,Y., Fan,T., Zhang,J., Wang,Q., Pan,J.,
            Dong,Q., Sun,Z.S. and Wang,Y.
  TITLE     Putative complement control protein CSMD3 dysfunction impairs
            synaptogenesis and induces neurodevelopmental disorders
  JOURNAL   Brain Behav Immun 102, 237-250 (2022)
   PUBMED   35245678
REFERENCE   4  (residues 1 to 430)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Sukhanov,N., Vainshtein,A., Eshed-Eisenbach,Y. and Peles,E.
  TITLE     Differential Contribution of Cadm1-Cadm3 Cell Adhesion Molecules to
            Peripheral Myelinated Axons
  JOURNAL   J Neurosci 41 (7), 1393-1400 (2021)
   PUBMED   33397712
  REMARK    GeneRIF: Differential Contribution of Cadm1-Cadm3 Cell Adhesion
            Molecules to Peripheral Myelinated Axons.
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Zhou,Y., Du,G., Hu,X., Yu,S., Liu,Y., Xu,Y., Huang,X., Liu,J.,
            Yin,B., Fan,M., Peng,X., Qiang,B. and Yuan,J.
  TITLE     Nectin-like molecule 1 is a protein 4.1N associated protein and
            recruits protein 4.1N from cytoplasm to the plasma membrane
  JOURNAL   Biochim Biophys Acta 1669 (2), 142-154 (2005)
   PUBMED   15893517
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Kakunaga,S., Ikeda,W., Itoh,S., Deguchi-Tawarada,M., Ohtsuka,T.,
            Mizoguchi,A. and Takai,Y.
  TITLE     Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific
            immunoglobulin-like cell-cell adhesion molecule localizing at
            non-junctional contact sites of presynaptic nerve terminals, axons
            and glia cell processes
  JOURNAL   J Cell Sci 118 (Pt 6), 1267-1277 (2005)
   PUBMED   15741237
  REMARK    GeneRIF: Necl-1 is a neural-tissue-specific Ca2+-independent
            immunoglobulin-like cell-cell adhesion molecule which potentially
            has membrane-associated guanylate kinase subfamily member-binding
            activity and localizes at the non-junctional cell-cell contact
            sites
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Thuret,S., Bhatt,L., O'Leary,D.D. and Simon,H.H.
  TITLE     Identification and developmental analysis of genes expressed by
            dopaminergic neurons of the substantia nigra pars compacta
  JOURNAL   Mol Cell Neurosci 25 (3), 394-405 (2004)
   PUBMED   15033168
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Fukami,T., Satoh,H., Williams,Y.N., Masuda,M., Fukuhara,H.,
            Maruyama,T., Yageta,M., Kuramochi,M., Takamoto,S. and Murakami,Y.
  TITLE     Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the
            human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2)
  JOURNAL   Gene 323, 11-18 (2003)
   PUBMED   14659875
REFERENCE   10 (residues 1 to 430)
  AUTHORS   Shingai,T., Ikeda,W., Kakunaga,S., Morimoto,K., Takekuni,K.,
            Itoh,S., Satoh,K., Takeuchi,M., Imai,T., Monden,M. and Takai,Y.
  TITLE     Implications of nectin-like
            molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion
            and transmembrane protein localization in epithelial cells
  JOURNAL   J Biol Chem 278 (37), 35421-35427 (2003)
   PUBMED   12826663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084073.22.
            
            On Oct 19, 2022 this sequence version replaced XP_006497123.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.25565.1,
                                           SRR7652917.4021.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 80.33 cM"
     Protein         1..430
                     /product="cell adhesion molecule 3 isoform 1 precursor"
                     /note="immunoglobulin superfamily, member 4B; nectin-lke
                     1; TSLC1-like protein 1; nectin-like protein 1; synaptic
                     cell adhesion molecule 3"
                     /calculated_mol_wt=44601
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2110
     Region          64..158
                     /region_name="IgV_1_Necl-1"
                     /note="First (N-terminal) immunoglobulin (Ig)-like domain
                     of nectin-like molecule-1 (Necl-1); member of the V-set of
                     Ig superfamily (IgSF) domains; cd05882"
                     /db_xref="CDD:143290"
     Region          64..67
                     /region_name="Ig strand A"
                     /note="Ig strand A [structural motif]"
                     /db_xref="CDD:143290"
     Region          65..83
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:143290"
     Region          68..74
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:143290"
     Region          76..84
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:143290"
     Region          84..89
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:143290"
     Site            order(90,93,98..99,101,107,109,145)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:143290"
     Region          90..97
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:143290"
     Region          90..96
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:143290"
     Region          98..109
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:143290"
     Region          100..104
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:143290"
     Region          106..109
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:143290"
     Region          110..145
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:143290"
     Region          114..121
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:143290"
     Region          124..130
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:143290"
     Region          137..145
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:143290"
     Region          146..149
                     /region_name="CDR3"
                     /note="CDR3 [structural motif]"
                     /db_xref="CDD:143290"
     Region          149..158
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:143290"
     Region          151..158
                     /region_name="FR4"
                     /note="FR4 [structural motif]"
                     /db_xref="CDD:143290"
     Region          159..261
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Region          180..184
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          194..198
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          224..228
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          238..243
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          254..257
                     /region_name="Ig strand G"
                     /note="Ig strand G [structural motif]"
                     /db_xref="CDD:409353"
     Region          271..348
                     /region_name="IG_like"
                     /note="Immunoglobulin like; smart00410"
                     /db_xref="CDD:214653"
     Region          282..286
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          296..300
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          314..318
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          328..333
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          386..401
                     /region_name="4.1m"
                     /note="putative band 4.1 homologues' binding motif;
                     smart00294"
                     /db_xref="CDD:128590"
     CDS             1..430
                     /gene="Cadm3"
                     /gene_synonym="BIgR; Igsf4b; Necl-1; Necl1; SynCAM3;
                     Tsll1"
                     /coded_by="NM_001412814.1:155..1447"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:94332"
                     /db_xref="MGI:MGI:2137858"
ORIGIN      
        1 mgapsalpll lllacswapg ganlsqdgyw qeqdlelgtp apleealsst vwsnpdllas
       61 qdsqpwtsde tvvaggtvvl kcqvkdheds slqwsnpaqq tlyfgekral rdnriqlvss
      121 tphelsisis nvaladegey tcsiftmpvr takslvtvlg ipqkpiitgy ksslreketa
      181 tlncqssgsk paaqltwrkg dqelhgdqtr iqedpngktf tvsssvsfqv treddganiv
      241 csvnheslkg adrstsqrie vlytptamir pepahpregq klllhcegrg npvpqqyvwv
      301 kegsepplkm tqesalifpf lnksdsgtyg ctatsnmgsy tayftlnvnd pspvpsssst
      361 yhaiiggiva fivflllill iflghylirh kgtyltheak gsddapdadt aiinaeggqs
      421 ggddkkeyfi
//
