LOCUS       NM_207675               4387 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus cell adhesion molecule 1 (Cadm1), transcript variant
            1, mRNA.
ACCESSION   NM_207675
VERSION     NM_207675.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4387)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 4387)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4387)
  AUTHORS   Fu,J., Liu,X., Yin,B., Shu,P. and Peng,X.
  TITLE     NECL2 regulates blood-testis barrier dynamics in mouse testes
  JOURNAL   Cell Tissue Res 392 (3), 811-826 (2023)
   PUBMED   36872374
  REMARK    GeneRIF: NECL2 regulates blood-testis barrier dynamics in mouse
            testes.
REFERENCE   4  (bases 1 to 4387)
  AUTHORS   de Arce,K.P., Ribic,A., Chowdhury,D., Watters,K., Thompson,G.J.,
            Sanganahalli,B.G., Lippard,E.T.C., Rohlmann,A., Strittmatter,S.M.,
            Missler,M., Hyder,F. and Biederer,T.
  TITLE     Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal
            cortex synapses and cognitive functions
  JOURNAL   Nat Commun 14 (1), 459 (2023)
   PUBMED   36709330
  REMARK    GeneRIF: Concerted roles of LRRTM1 and SynCAM 1 in organizing
            prefrontal cortex synapses and cognitive functions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4387)
  AUTHORS   Govek,K.W., Chen,S., Sgourdou,P., Yao,Y., Woodhouse,S., Chen,T.,
            Fuccillo,M.V., Epstein,D.J. and Camara,P.G.
  TITLE     Developmental trajectories of thalamic progenitors revealed by
            single-cell transcriptome profiling and Shh perturbation
  JOURNAL   Cell Rep 41 (10), 111768 (2022)
   PUBMED   36476860
REFERENCE   6  (bases 1 to 4387)
  AUTHORS   Biederer,T., Sara,Y., Mozhayeva,M., Atasoy,D., Liu,X.,
            Kavalali,E.T. and Sudhof,T.C.
  TITLE     SynCAM, a synaptic adhesion molecule that drives synapse assembly
  JOURNAL   Science 297 (5586), 1525-1531 (2002)
   PUBMED   12202822
  REMARK    GeneRIF: SynCAM1 is expressed in brain and localized to pre- and
            postsynaptic sites of neurons.  SynCAM1 is a homophilic cell
            adhesion molecule that induces formation of presynaptic terminals
            by neurons.
REFERENCE   7  (bases 1 to 4387)
  AUTHORS   Fukami,T., Satoh,H., Fujita,E., Maruyama,T., Fukuhara,H.,
            Kuramochi,M., Takamoto,S., Momoi,T. and Murakami,Y.
  TITLE     Identification of the Tslc1 gene, a mouse orthologue of the human
            tumor suppressor TSLC1 gene
  JOURNAL   Gene 295 (1), 7-12 (2002)
   PUBMED   12242005
  REMARK    GeneRIF: The Tslc1 gene is mapped on mouse chromosome 9, a synteny
            of human chromosome 11q, and is composed of ten exons, the
            exon-intron junctions being highly conserved between human and
            mouse.
REFERENCE   8  (bases 1 to 4387)
  AUTHORS   Urase,K., Soyama,A., Fujita,E. and Momoi,T.
  TITLE     Expression of RA175 mRNA, a new member of the immunoglobulin
            superfamily, in developing mouse brain
  JOURNAL   Neuroreport 12 (15), 3217-3221 (2001)
   PUBMED   11711859
REFERENCE   9  (bases 1 to 4387)
  AUTHORS   Wakayama,T., Ohashi,K., Mizuno,K. and Iseki,S.
  TITLE     Cloning and characterization of a novel mouse immunoglobulin
            superfamily gene expressed in early spermatogenic cells
  JOURNAL   Mol Reprod Dev 60 (2), 158-164 (2001)
   PUBMED   11553913
REFERENCE   10 (bases 1 to 4387)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053839.1, AK013911.1 and CAAA01092855.1.
            
            On Jul 20, 2005 this sequence version replaced NM_207675.1.
            
            Transcript Variant: This variant (1) encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013911.1, SRR1660815.28685.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1024              AK053839.1         2-1025
            1025-1305           AK013911.1         1119-1399
            1306-4387           CAAA01092855.1     118534-121615
FEATURES             Location/Qualifiers
     source          1..4387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 25.83 cM"
     gene            1..4387
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /note="cell adhesion molecule 1"
                     /db_xref="GeneID:54725"
                     /db_xref="MGI:MGI:1889272"
     exon            1..154
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1392
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; immunosuperfamily protein Bl2; nectin-like 2;
                     immunoglobulin superfamily member 4A; NECL-2; TSLC-1;
                     nectin-like protein 2; synaptic cell adhesion molecule;
                     tumor suppressor in lung cancer 1; spermatogenic
                     immunoglobulin superfamily"
                     /codon_start=1
                     /product="cell adhesion molecule 1 isoform a precursor"
                     /protein_id="NP_997558.2"
                     /db_xref="CCDS:CCDS23149.1"
                     /db_xref="GeneID:54725"
                     /db_xref="MGI:MGI:1889272"
                     /translation="MASAVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPT
                     GDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQL
                     LNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAV
                     EGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDG
                     VPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAFELTCEAIGKP
                     QPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVY
                     DPPTTIPPPTTTTTTTTTTTTTILTIITDTTATTEPAVHDSRAGEEGTIGAVDHAVIG
                     GVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEE
                     KKEYFI"
     exon            155..301
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            302..454
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..592
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..751
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..851
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1024
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1108
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1141
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1273
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..4387
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1439..1444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /note="hexamer: GATAAA"
     polyA_site      1462
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /note="major polyA site"
     regulatory      1566..1571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /note="hexamer: AACAAA"
     polyA_site      1589
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
     regulatory      4362..4367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
                     /note="hexamer: AATAAA"
     polyA_site      4387
                     /gene="Cadm1"
                     /gene_synonym="2900073G06Rik; 3100001I08Rik; Bl2; Igsf4;
                     Igsf4a; Necl2; RA175; RA175A; RA175B; RA175C; RA175N;
                     SgIGSF; ST17; SynCam; Tslc1"
ORIGIN      
        1 agtctgaggc aggtgcccga catggcgagt gctgtgctgc cgagcggatc ccagtgtgcg
       61 gcggcagcgg ctgtggcggc ggcggcggcg cctccagggc tccggctccg gctcctgctg
      121 ttgctccttt cggccgcggc actgatcccc acaggtgatg gacagaatct gtttactaaa
      181 gacgtgacag tgattgaagg agaagtggca accatcagct gccaggtcaa taagagtgac
      241 gactcagtga tccagctcct gaaccccaac aggcagacca tttacttcag ggacttcagg
      301 cctttgaagg acagcaggtt tcagctgctg aatttttcta gcagtgaact caaagtgtca
      361 ctgacgaatg tctcaatctc ggatgaaggg agatacttct gccagctcta cacggacccc
      421 ccacaggaga gttacaccac catcacagtc ctggttcctc cacgtaactt gatgatcgat
      481 atccagaaag acacggcagt tgaaggggag gagattgaag tcaactgtac tgccatggcc
      541 agcaagccag cgacgaccat caggtggttc aaagggaaca aggaactcaa aggcaaatca
      601 gaggtggagg agtggtcgga catgtacact gtgaccagtc agctgatgct gaaggtgcac
      661 aaggaggacg acggggtccc ggtgatctgc caggtggagc accctgcggt cactggaaac
      721 ctgcagaccc agcgctatct agaagtgcag tataaaccgc aagtgcatat ccagatgact
      781 taccctctgc aaggcctaac ccgggaaggg gatgcatttg agttaacgtg tgaagccatc
      841 gggaagcccc agcctgtgat ggtaacttgg gtgagagtcg atgatgaaat gcctcaacat
      901 gccgtactgt ctgggccaaa cctgttcatc aataacctaa acaaaacaga taacggtact
      961 taccgctgtg aggcttccaa catagtggga aaggctcatt cggactatat gctgtatgta
     1021 tacgatcccc ccacaactat ccctcctccc acaacaacca ccaccactac caccaccacc
     1081 accaccacca tccttaccat catcacagac accacggcga cgacagaacc agcagttcac
     1141 gattctcgag caggtgaaga ggggaccatt ggggcagtgg accacgcagt gattggtggc
     1201 gtcgtagccg tggtggtgtt tgccatgcta tgcttgctca tcattctggg ccgctatttt
     1261 gccagacata aaggtacata cttcactcat gaagccaaag gagccgatga cgcagcagac
     1321 gcagacacag ctataatcaa tgcagaagga ggacagaaca actccgaaga aaagaaagag
     1381 tacttcatct agatcagcct ttttgttcca atgaggtgtc caactggcct gtttagatga
     1441 taaagagaca gtgatactgg aactttcgag aagctcgtgt ggttttttgt tttgttttgt
     1501 ttttttatga gtgggtggag agatgcgaga ctgggaaggc ttgggatttg caatgtacaa
     1561 acaaaaacaa agaatgttct ttgaaagtac actctgctgt ttgacacctc tttttaatct
     1621 ggttttaatt tgctttgggt tttgggtttt tttggttttt tgtttttttc atttatattt
     1681 cttcctacca agtcaaactt gggtacttgg atttggtttc ggtagattgc agaaaattct
     1741 gtgccttgtt tttcattcgt ttgttgtgtt tcttccctct tgcccattta tttttcccaa
     1801 aatcaaattt gtttttttcc ccctcccaaa cctcccattt tttggaattg acctgctgga
     1861 attcctaaga ctttctccct gttgccagtt tcttttattt gtgttaacgg tgactgcttt
     1921 ctgttccaaa ttcagtttca taaaaggaaa accagcacaa tttagatttc atagttcaga
     1981 atttagtgtc tccatgatgc atccttctct gttgttgtaa agatttgggt gaagaaaaaa
     2041 aaaaaaaaag aaaaaaaaaa gaaaaaaaaa agaaaacact gaaaactctt tgctgctgcc
     2101 catgtcttaa atacgtagag cagcgaagac tagaaacgta gactgtgacc cagacgctgt
     2161 cgtctgctgt ggatcttcat tactgtacag ggttatctgc aagtgaggtg tgtcgcaatg
     2221 agattgaatc tgtcgttaat tctttatctg taggcggctc agtatagatt accccacgct
     2281 gtgcagaaag tttttggagt ggaaaggtct cctccttcct cgttgcccta aacagacccg
     2341 acatgtgagg tctgtctgtt ttatgtaagt ggacaaattt gagatgtcac aggaggggaa
     2401 gcagggaggg ggtacgacag ttctgctctg attatttcta ctctcaacaa ttccatccac
     2461 ctttcccaat tggccttact gctcactaat gcaggagaga gcaagtccgt gtgccgtgtg
     2521 actgactgga ggggacaggc tttgtttagg ttttttttac ccccactttg gttttggttc
     2581 tgggttgttt tgctttgttt tgttttcctt tgttcttatt aaggacggca gtgggctgtg
     2641 tcctgtgtgt actgtatgtt acagacaccg tcctgctggg acacttgtcc tgctgggatt
     2701 cccagctccc acccccaact cctctcattc cttcagattt ggcttgacaa aggcaggagg
     2761 tacaaaagaa gggccaattt tgttctggaa aggtcagagc ccagagtcga ggtgggaaag
     2821 tggcatatag ggatttccag ttacttaatc aaaactcaaa atgtgagtgt ttctgtcttt
     2881 cgtgcactag gcctggcctc ttacctcagc cttaagaacc atctgccaaa aactactcat
     2941 ctcgcatgat ggcagccaga gcgcatagct actaaaataa gtttccgtga acatatctta
     3001 caccggagcc tgaggaaaga tagaggcgca aaggaaccct ttgcattctc taaagctaag
     3061 tgggggtttg cagaagtgct ggggtcatct agcagtagtt ctgaaggaca gaacctaaac
     3121 tcttaccaca cgtgtcggta agctccagac tccaaaacag cccctctgga aagatggcat
     3181 cagaaaagat agatctatct atatatataa atatataaat atatattata tataacattt
     3241 tcagtcagta cttttggatt ttgcaaggtg catttttact attgttacat tatgtggaaa
     3301 acctacgctg atttatttaa ggggaaaaaa gtgtcgactc tgttctttga aagcgtattt
     3361 ctttttcttg tctttatttt aacttctgat agaaccactg caatatgggg gccttttggg
     3421 aacggactgg tttgtaaagg aaaattcatt atggagcagt gttttgttaa cccctctcct
     3481 gcccctaggc acttaaccaa gacaaaaagc cacaaggaac atcccttttt caaaaatttt
     3541 ataatgtgca tctattccga gcccttagca cccatcctga ccatagtgac catatcaaag
     3601 ggtgacaacc agttagcatg tcgttgaaag ggtttttcag ctgttctttt tagaaaaaaa
     3661 atatatataa aaaatattta aaaaaaaaca aaaaacaaac aaacacaaaa aaactaccat
     3721 tgttcacaga attggcatct cattttcggg accgcccatc tttctgtttt gacaagtgta
     3781 cagtagtgca gtgttctgat gtaactttat ggcttacaat gttgacatgt ctcaggttcc
     3841 tgtgtttcaa ttggtgtttt tccgtctcag gtagattgca aagtgtaggc cccacacatt
     3901 ggaaaaataa taataataat aaataataat aataataata ataataaaac aaagcaaaaa
     3961 caggaaatta tggattttag ttgtatattg gtttatgtat ttttcttaag tatacagtgc
     4021 actgtttgaa atgtattgtt gagtattact ttgtacaggt tgatcacttt ttttagagtg
     4081 aagaaagaac aaacttgggt tttttttgtg ttttttttaa aggagtataa aataatgaag
     4141 gatgtataat tgatgccaaa taagcttgtt ctttagtcac gatgacgtct tgtttttccc
     4201 tctaggccag ttctgtttct aaggtgtaca aggaccatgt tacagtgtaa gaaactccac
     4261 atccgtgtgt tcccattcgc attttgtatc ggttcatgta taccattttt acaaaaagaa
     4321 aaaagaaaaa aaaagaagta ctataaaata tctgtcttct taataaaaaa attaatgtta
     4381 caagtga
//
