LOCUS       NM_001403399            7172 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus carbamoyl-phosphate synthetase 2, aspartate
            transcarbamylase, and dihydroorotase (Cad), transcript variant 4,
            mRNA.
ACCESSION   NM_001403399 XM_006504091
VERSION     NM_001403399.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7172)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7172)
  AUTHORS   Tu,H.F., Ko,C.J., Lee,C.T., Lee,C.F., Lan,S.W., Lin,H.H., Lin,H.Y.,
            Ku,C.C., Lee,D.Y., Chen,I.C., Chuang,Y.H., Del Cano-Ochoa,F.,
            Ramon-Maiques,S., Ho,C.C., Lee,M.S. and Chang,G.D.
  TITLE     Afatinib Exerts Immunomodulatory Effects by Targeting the
            Pyrimidine Biosynthesis Enzyme CAD
  JOURNAL   Cancer Res 81 (12), 3270-3282 (2021)
   PUBMED   33771897
REFERENCE   3  (bases 1 to 7172)
  AUTHORS   Saul,M.C., Stevenson,S.A., Zhao,C., Driessen,T.M., Eisinger,B.E.
            and Gammie,S.C.
  TITLE     Genomic variants in an inbred mouse model predict mania-like
            behaviors
  JOURNAL   PLoS One 13 (5), e0197624 (2018)
   PUBMED   29768498
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7172)
  AUTHORS   Deng,Y., Wang,Z.V., Gordillo,R., Zhu,Y., Ali,A., Zhang,C., Wang,X.,
            Shao,M., Zhang,Z., Iyengar,P., Gupta,R.K., Horton,J.D., Hill,J.A.
            and Scherer,P.E.
  TITLE     Adipocyte Xbp1s overexpression drives uridine production and
            reduces obesity
  JOURNAL   Mol Metab 11, 1-17 (2018)
   PUBMED   29551634
REFERENCE   5  (bases 1 to 7172)
  AUTHORS   Gao,L., Huang,K., Jiang,D.S., Liu,X., Huang,D., Li,H., Zhang,X.D.
            and Huang,K.
  TITLE     Novel role for caspase-activated DNase in the regulation of
            pathological cardiac hypertrophy
  JOURNAL   Hypertension 65 (4), 871-881 (2015)
   PUBMED   25646292
  REMARK    GeneRIF: CAD functions as a necessary modulator of the hypertrophic
            response by regulating the mitogen-activated protein
            kinase-extracellular signal-regulated kinase 1/2 signaling pathway
            in the heart.
REFERENCE   6  (bases 1 to 7172)
  AUTHORS   Maga,A.M., Navarro,N., Cunningham,M.L. and Cox,T.C.
  TITLE     Quantitative trait loci affecting the 3D skull shape and size in
            mouse and prioritization of candidate genes in-silico
  JOURNAL   Front Physiol 6, 92 (2015)
   PUBMED   25859222
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7172)
  AUTHORS   Rainger,J., Bengani,H., Campbell,L., Anderson,E., Sokhi,K., Lam,W.,
            Riess,A., Ansari,M., Smithson,S., Lees,M., Mercer,C., McKenzie,K.,
            Lengfeld,T., Gener Querol,B., Branney,P., McKay,S., Morrison,H.,
            Medina,B., Robertson,M., Kohlhase,J., Gordon,C., Kirk,J.,
            Wieczorek,D. and Fitzpatrick,D.R.
  TITLE     Miller (Genee-Wiedemann) syndrome represents a clinically and
            biochemically distinct subgroup of postaxial acrofacial dysostosis
            associated with partial deficiency of DHODH
  JOURNAL   Hum Mol Genet 21 (18), 3969-3983 (2012)
   PUBMED   22692683
REFERENCE   8  (bases 1 to 7172)
  AUTHORS   Mathew,R., Kongara,S., Beaudoin,B., Karp,C.M., Bray,K.,
            Degenhardt,K., Chen,G., Jin,S. and White,E.
  TITLE     Autophagy suppresses tumor progression by limiting chromosomal
            instability
  JOURNAL   Genes Dev 21 (11), 1367-1381 (2007)
   PUBMED   17510285
  REMARK    Erratum:[Genes Dev. 2007 Jul 1;21(13):1701]
REFERENCE   9  (bases 1 to 7172)
  AUTHORS   Boyd,K.E., Wells,J., Gutman,J., Bartley,S.M. and Farnham,P.J.
  TITLE     c-Myc target gene specificity is determined by a post-DNAbinding
            mechanism
  JOURNAL   Proc Natl Acad Sci U S A 95 (23), 13887-13892 (1998)
   PUBMED   9811896
REFERENCE   10 (bases 1 to 7172)
  AUTHORS   Hoogenraad,N.J., Levine,R.L. and Kretchmer,N.
  TITLE     Copurification of carbamoyl phosphate synthetase and aspartate
            transcarbamoylase from mouse spleen
  JOURNAL   Biochem Biophys Res Commun 44 (4), 981-988 (1971)
   PUBMED   5125237
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109608.14.
            
            On Mar 30, 2022 this sequence version replaced XM_006504091.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.5348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC109608.14        104466-104706       c
            242-381             AC109608.14        104120-104259       c
            382-511             AC109608.14        101304-101433       c
            512-654             AC109608.14        100683-100825       c
            655-796             AC109608.14        100380-100521       c
            797-968             AC109608.14        99898-100069        c
            969-1154            AC109608.14        99538-99723         c
            1155-1267           AC109608.14        99291-99403         c
            1268-1413           AC109608.14        98876-99021         c
            1414-1545           AC109608.14        98543-98674         c
            1546-1779           AC109608.14        98152-98385         c
            1780-2001           AC109608.14        97824-98045         c
            2002-2190           AC109608.14        97536-97724         c
            2191-2315           AC109608.14        97177-97301         c
            2316-2446           AC109608.14        96910-97040         c
            2447-2559           AC109608.14        92702-92814         c
            2560-2804           AC109608.14        92277-92521         c
            2805-3051           AC109608.14        91856-92102         c
            3052-3150           AC109608.14        91298-91396         c
            3151-3375           AC109608.14        90915-91139         c
            3376-3558           AC109608.14        90646-90828         c
            3559-3777           AC109608.14        90269-90487         c
            3778-3945           AC109608.14        89816-89983         c
            3946-4128           AC109608.14        89025-89207         c
            4129-4233           AC109608.14        88830-88934         c
            4234-4473           AC109608.14        87398-87637         c
            4474-4555           AC109608.14        87119-87200         c
            4556-4722           AC109608.14        86779-86945         c
            4723-4887           AC109608.14        86520-86684         c
            4888-5019           AC109608.14        86229-86360         c
            5020-5221           AC109608.14        85810-86011         c
            5222-5412           AC109608.14        85314-85504         c
            5413-5553           AC109608.14        85092-85232         c
            5554-5655           AC109608.14        84807-84908         c
            5656-5752           AC109608.14        84317-84413         c
            5753-5803           AC109608.14        83981-84031         c
            5804-5848           AC109608.14        83649-83693         c
            5849-6018           AC109608.14        83378-83547         c
            6019-6093           AC109608.14        83210-83284         c
            6094-6306           AC109608.14        82616-82828         c
            6307-6432           AC109608.14        82284-82409         c
            6433-6588           AC109608.14        81996-82151         c
            6589-6690           AC109608.14        81806-81907         c
            6691-6785           AC109608.14        81519-81613         c
            6786-7172           AC109608.14        81023-81409         c
FEATURES             Location/Qualifiers
     source          1..7172
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.95 cM"
     gene            1..7172
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /note="carbamoyl-phosphate synthetase 2, aspartate
                     transcarbamylase, and dihydroorotase"
                     /db_xref="GeneID:69719"
                     /db_xref="MGI:MGI:1916969"
     exon            1..241
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            242..381
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            382..511
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            512..654
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            655..796
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            797..968
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1154
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1267
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1413
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1545
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1779
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..2001
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2190
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2315
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2446
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2559
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2804
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..3051
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            3052..3150
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3375
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            3376..3558
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..3777
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..3945
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            3946..4128
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..4233
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            4234..4473
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            4474..4555
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            4556..4722
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4887
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..5019
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5020..5221
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5222..5412
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5413..5553
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5554..5655
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5656..5752
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5753..5803
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5804..5848
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            5849..6018
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            6019..6093
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            6094..6306
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            6307..6432
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            6433..6588
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            6589..6690
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            6691..6785
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     exon            6786..7172
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7154..7159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /note="hexamer: AATAAA"
     polyA_site      7172
                     /gene="Cad"
                     /gene_synonym="2410008J01Rik; Cpad"
                     /note="major polyA site"
ORIGIN      
        1 actacgctta gggctctggc ttgccgctcc cgcctgctct ccagcgcccc gcgcagcgag
       61 ccacgtggac caactccggc gcgcggtgtt cgcttggttc cagtggggct cgccgcgcct
      121 cccgcgtctg cgtgcttgcc ctgtctcagc tccgacccga tggcggccct ggtgttggag
      181 gacgggtcgg tgctgcaggg ccggcccttt ggggccgctg tgtcgactgc tggggaagtg
      241 gtgtttcaga ccggcatggt cggctaccca gaggccctca ctgacccttc ctacaaagct
      301 cagatcctag tgctaacgta tcctctcatc ggcaactacg gcattccctc agatgaagag
      361 gacgagttcg gcctgagcaa gtggtttgaa tcctcggaga tccacgtggc gggacttgta
      421 gtgggagaat gctgtcccac acccagccac tggagtgcca actgcaccct gcatgagtgg
      481 ctgcaacagc gtggcatccc cggcctgcaa ggagtggaca ctcgggagct gactaagaag
      541 ttgcgggagc aagggtctct tttggggaag ctggtccaga aagggacaga gccgtcagcc
      601 ctgccattcg tggaccccaa tgccaggccc ctggcaccag aggtctctat taagactcca
      661 cgggtattca atgcaggggg tgcccctcgg atctgtgctc tggattgtgg cctcaagtat
      721 aatcagatcc gatgtctctg ccagcttggg gctgaagtta ccgtggtacc ctgggaccac
      781 gagttagaca gtcagaaata tgacggtctc ttcctaagta atggacccgg tgaccctgcc
      841 tcttacccgg gtgtggtgtc cacactgagc cgagtcttgt ctgaacctaa cccccgacct
      901 gtgtttggaa tctgccttgg acaccagctg ttggctttag ccatcggggc caaaacttac
      961 aagatgagat acggaaaccg aggccacaac cagccctgtt tactggtggg cactgggcgc
     1021 tgctttctga cgtcccagaa tcatgggttt gcagtggacg cagattcgct gccagcaggc
     1081 tgggctcctc tgttcaccaa tgccaatgac tgttccaatg aaggcatagt gcacgacagc
     1141 ctgcccttct tcagtgtcca gtttcaccca gagcaccggg ccggcccttc agatatggaa
     1201 ctgctcttcg atgtatttct agaaactgtg agagaggctg cagctgggaa cattgggggc
     1261 cagacagtaa gagaacgctt ggctcagcgc ctctgtcccc ctgagctccc cattcctggt
     1321 tctgggctcc cgcctccacg aaaggttcta atcctaggct cagggggcct ctccattggc
     1381 caagctggag aatttgacta ctcgggctct caggcaatta aagccctaaa ggaggaaaac
     1441 atccagacat tactaatcaa ccccaacatt gccacagtgc agacttctca ggggctggca
     1501 gacaaggtct atttccttcc cataacactt cactacgtaa cccaggtaat tcgtaatgaa
     1561 cgcccagatg gtgtgttact gacttttggg ggtcaaacag ccctgaactg cggtgtggag
     1621 ctgaccaaag ctggggtact ggctcgatat ggggtccggg tcttgggtac acccgtggag
     1681 accattgaac tgactgagga ccgacgagcc ttcgctgcca ggatggctga gatcggagag
     1741 catgtcgccc ccagtgaagc ggcaaattct cttgaacagg ctcaggcagc tgccgagcga
     1801 ctaggctacc ctgtgctggt gcgagcagcc tttgccctgg gtggtctcgg ttctggcttt
     1861 gcttccacca aagaggaact ctcagctctt gtggctccag cttttgccca taccagtcag
     1921 gtgctgatag acaagtctct gaagggctgg aaggagattg aatatgaggt ggtgagagac
     1981 gcctatggca actgcgtaac ggtatgcaac atggagaact tagacccact gggcattcat
     2041 actggtgaat ccatagtggt ggctccgagc cagacactga atgacagaga gtaccagctt
     2101 ctgcgacgga cagctatcaa ggtcactcag cacctgggca ttgtcgggga gtgcaatgta
     2161 cagtatgctt tgaaccccga gtctgagcag tattacatca ttgaagtgaa tgccaggctc
     2221 tcccgaagct ctgccctggc cagtaaggcc acaggctatc cactagccta tgtggcagcc
     2281 aagctagcat tgggcattcc cctgccagag ctcagaaact ctgttacggg aggaacagca
     2341 gcctttgagc ccagcctgga ctactgcgtg gtaaagattc ctcgctggga cctcagcaag
     2401 ttcctacgtg tcagtacgaa gattgggagt tgcatgaaga gtgttggcga ggtcatgggc
     2461 atcgggcggt cctttgagga ggccttccaa aaggccctgc gcatggtcga tgagaactgc
     2521 gtaggcttcg accatacagt aaagccagtc agcgacatgg agctggagac tccgacggat
     2581 aagcggatct ttgtggtggc tgccgctctg tgggctggct actctgtgga gcgcctctac
     2641 gagctcaccc gcattgattg ctggttcctg caccggatga agcgcattgt gacccacgcc
     2701 cagttgctgg aacaacaccg tggacaagct ttaccccaag acctgctgca ccaggccaag
     2761 tgcctcggct tctcagacaa gcagattgcc ctggcagtcc tgagcacaga gctggctgtt
     2821 cggaagctgc gtcaggaact ggggatctgc ccagcggtga aacagattga cacagttgca
     2881 gctgagtggc cagcccagac aaattacctg tacctgacat actggggcaa cacccatgac
     2941 ctcgactttc gggcacctca cgtcctggtc cttggctctg gtgtctaccg gattggctcc
     3001 agtgttgagt ttgattggtg tgctgtgggt tgcatccagc agctccggaa gatgggttat
     3061 aagaccatca tggtgaacta caacccagag acagtcagca ccgactatga tatgtgtgac
     3121 cgactctact ttgatgagat ctcttttgag gtggtgatgg acatctatga gttagagaac
     3181 cccgaaggtg tgatcctgtc catgggtggg cagctgccca acaacatggc catggctttg
     3241 catcggcagc agtgccgagt gctgggcacc tcccccgaag ccatcgactc agccgagaac
     3301 cgattcaagt tctcccggct cctagatacc atcggtatca gccagcctca gtggcgagag
     3361 ctcagtgacc ttgagtctgc tcgccagttc tgccacacgg tcgggtaccc ctgcgtagtg
     3421 cgcccctcct atgtgctcag cggtgctgct atgaatgtgg cgtacaccga cggggacctg
     3481 gagcgtttcc tgagcagtgc ggccgccgtc tctaaggagc accccgtagt catctccaag
     3541 ttcattcagg aagcaaagga gatcgacgtg gacgcggtgg cctgtgacgg catcgtgtcg
     3601 gccattgcca tctctgagca cgtggagaat gcaggtgtgc attcaggtga tgccacgctg
     3661 gtgacccccc cacaagacat caccccgaaa actctggagc ggatcaaagc cattgtgcat
     3721 gctgtgggcc aggagctaca ggttacagga cccttcaatc tgcagctcat tgccaaggat
     3781 gaccagctga aggttattga atgcaacgtg cgtgtatctc gctctttccc cttcgtgtcc
     3841 aagacactgg gtgttgatct agtagccttg gccacaagga tcatcatggg ggagaaagta
     3901 gagcccgtgg ggctcatgac tggctctgga gtcgtgggag taaaggtacc tcagttctcc
     3961 ttctcacgct tggccggtgc cgacgtggta cttggtgtgg agatgaccag tactggagag
     4021 gtggccggct tcggagagag ccgttgtgaa gcctacctca aagccatgct cagcactggc
     4081 tttaagatcc cagagaagaa catcctgctg actattggca gctacaagaa caaaagtgag
     4141 ctgctcccaa ctgtgcggtt gctggagagc ctgggctaca gcctctatgc cagcctgggt
     4201 acggcagact tctacactga gcacggggtc aaggtaacag ctgtggactg gcactttgaa
     4261 gaggcggtgg atggtgagtg cccaccacaa cggagcatct tggatcagct ggctgaaaat
     4321 cactttgagc tagtgattaa cctgtccatg cgtggggctg ggggtcggcg tctttcctcc
     4381 ttcgttacca agggctaccg tacccggcgt ctggccgctg atttctctgt gcctctcatc
     4441 attgacatca agtgcaccaa actctttgtg gaggccctag gccagatcgg cccagcccct
     4501 cctttgaaag tgcacgttga ctgcatgacc tcccagaagc tagtgcgcct gcccggattg
     4561 attgatgtcc acgtgcacct tcgggaacca ggtgggacac acaaagagga ctttgcctca
     4621 ggcacagctg ctgccttggc tgggggtgtc accatggttt gtgctatgcc taatacccga
     4681 ccccccatca ttgatgctcc tgctctcgcc cttgcccaga agctggcaga ggctggcgcc
     4741 cgctgtgact ttaccttatt ccttggagcc tcatctgaga acgcggggac tctgggtgct
     4801 gtggccggct ctgcagcagg cctgaagctc tacctcaacg agaccttctc tgagctgcgg
     4861 ctggacagtg tggcccagtg gatggagcat tttgaaacct ggcctgccca cctccccatt
     4921 gtggcccatg cagagcggca gagtgtcgct gcggtcctca tggtggctca gctgacccag
     4981 cgtccagtgc acatatgtca tgtggctcgg aaggaagaga tcctgttgat taaaactgca
     5041 aaggcgcagg ggctgccagt gacctgtgag gtcgctcctc accacctgtt cctaaaccgg
     5101 gaagacttgg agcgcctggg acctgggaag ggagaggtcc gtcctgagct tgggtcccga
     5161 gaggatatgg aagccctgtg ggagaatatg gcagtcatcg actgttttgc ctcagaccac
     5221 gctccccata ccttggaaga gaagtgtggg cccaagcctc cacctggctt cccgggccta
     5281 gagaccatgt tgccgctgct gctgacagct gtgagcgagg gccgcctcag tctggatgac
     5341 ctgctgcagc gattgcacca caaccctcgg cggatcttcc acctgcctct ccaggaggac
     5401 acctatgtag aggtggatct ggagcatgag tggacagtcc ccagccacat gcccttctct
     5461 aaggcccgct ggaccccatt tgaaggacag aaggtgaagg gcacagtgcg ccgtgtggtc
     5521 ttgcgagggg aggtcgccta tattgatgga caggtgctgg tacccccggg ctatggacaa
     5581 gatgtacgga agtggccgca gggggttgtt ccccagcccc ctccttcaac tcccgccacc
     5641 accgaaatca ccacgacacc tgagcgacca cgccgagtca tcccgggcct tcctgatggc
     5701 cgcttccacc tgccaccccg catccaccgg gcctctgacc caggtctgcc agctctgtac
     5761 ctccgcccag gagctgggat ctcatggggc agcagagcat gggctgagga acctaaagag
     5821 aagccaccca ggaaggtagt ggaaccagag ctgatgggaa cccctgatgg tccctgctac
     5881 cctgcaccac cagtacctag acaggcatca ccccagaacc tagggtcttc tggcctgctg
     5941 cacccccaga tgtcgcccct actgcactcc ctagtgggcc agcacatcct gtctgtcaag
     6001 cagttcacta aggatcagat gtctcatctg ttcaatgtgg cgcacacgct acggatgatg
     6061 gtacagaagg agcggagcct cgacatcctg aaggggaagg tcatggcctc catgttctac
     6121 gaggtgagca cccgcaccag tagctccttc gcagcagcca tggcccggct cgggggcgct
     6181 gttctcagct tctcagaagc tacatcctcc gtccaaaagg gcgagtccct tgctgactcg
     6241 gtgcagacca tgagttgcta tgctgatgtc attgtgctcc gacaccctca gcctggagcc
     6301 gtggagctgg cagccaagca ctgtcgcagg ccagtgatca atgctgggga tggagttggg
     6361 gagcacccca cacaggccct gctggacatc ttcaccattc gagaagagct ggggactgtc
     6421 aatggcatga cgatcactat ggtcggtgac ctgaagcatg gacgcacagt gcactccctg
     6481 gcctgcctgc tcacccagta ccgtgtgagc ctacgctacg tggcacctcc cagcctgcgc
     6541 atgccaccca gtgtacggga ctttgtggcc tcccgaggca ccaagcagga ggagtttgag
     6601 agcatcgagg aggcgctgcc cgacacagac gtgctctaca tgactcggat ccagaaagaa
     6661 cgatttggct ctgtccagga atatgaagct tgctttggtc agttcatcct cactcctcac
     6721 atcatgaccc gggccaagaa gaagatggtg gtgatgcacc caatgccccg tgtcaatgag
     6781 ataagtgtgg aggtggactc ggacccccgg gcagcctact tccgccaagc tgagaacggc
     6841 atgtacatcc gcatggccct gcttgccacc gtgcttggcc gtttctaggt cccagcttcc
     6901 tttcttgtct cttcaggccc agctgctggg caaggaatcc cgatgccccc cccacggggg
     6961 cagcacactt agcagacaat cctggagcat acagatagcc caagcacata gatgtactaa
     7021 actgggacca tgctttaggc tccagacgag agtcttttct aacttgggga tgcagtctca
     7081 gatactgggg gcccctctgc ctcatctcca ttcttacacc tcaaatctgt acagttactt
     7141 ttgtactgac tgtaataaac agccaaacag tt
//
