LOCUS       NM_009786               2115 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus calcyclin binding protein (Cacybp), mRNA.
ACCESSION   NM_009786
VERSION     NM_009786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Topolska-Wos AM, Rosinska S and Filipek A.
  TITLE     MAP kinase p38 is a novel target of CacyBP/SIP phosphatase
  JOURNAL   Amino Acids 49 (6), 1069-1076 (2017)
   PUBMED   28283909
  REMARK    GeneRIF: involvement of CacyBP/SIP in the regulation of p38 kinase
            activity, in addition to that of ERK1/2, might point to the
            function of CacyBP/SIP in pro-survival and pro-apoptotic pathways.
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Ning X, Chen Y, Wang X, Li Q and Sun S.
  TITLE     The potential role of CacyBP/SIP in tumorigenesis
  JOURNAL   Tumour Biol 37 (8), 10785-10791 (2016)
   PUBMED   26873490
  REMARK    GeneRIF: Calcyclin-binding protein/Siah-1-interacting protein
            (CacyBP/SIP) was initially described as a binding partner of S100A6
            in the Ehrlich ascites tumor cells and later as a
            Siah-1-interacting protein. Its role has been studied in various
            mouse tumors and cell lines. Review.
            Review article
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Rosinska S, Lesniak W and Filipek A.
  TITLE     Distinct effect of CacyBP/SIP on the ERK1/2-CREB-BDNF pathway in
            undifferentiated and differentiated neuroblastoma NB2a cells
  JOURNAL   Neurochem Int 97, 65-72 (2016)
   PUBMED   27180052
  REMARK    GeneRIF: In undifferentiated and differentiated tumor cells, CacyBP
            level has an effect on the ERK1/2-CREB-BDNF pathway.
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Ishihara K, Kanai S, Sago H, Yamakawa K and Akiba S.
  TITLE     Comparative proteomic profiling reveals aberrant cell proliferation
            in the brain of embryonic Ts1Cje, a mouse model of Down syndrome
  JOURNAL   Neuroscience 281, 1-15 (2014)
   PUBMED   25261685
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Lim R, Winteringham LN, Williams JH, McCulloch RK, Ingley E, Tiao
            JY, Lalonde JP, Tsai S, Tilbrook PA, Sun Y, Wu X, Morris SW and
            Klinken SP.
  TITLE     MADM, a novel adaptor protein that mediates phosphorylation of the
            14-3-3 binding site of myeloid leukemia factor 1
  JOURNAL   J Biol Chem 277 (43), 40997-41008 (2002)
   PUBMED   12176995
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Filipek A, Jastrzebska B, Nowotny M and Kuznicki J.
  TITLE     CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds
            EF-hand proteins of the S100 family
  JOURNAL   J Biol Chem 277 (32), 28848-28852 (2002)
   PUBMED   12042313
  REMARK    GeneRIF: binds EF-hand proteins of the S100 family [CacyBP/SIP]
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   Filipek A, Jastrzebska B, Nowotny M, Kwiatkowska K, Hetman M,
            Surmacz L, Wyroba E and Kuznicki J.
  TITLE     Ca2+-dependent translocation of the calcyclin-binding protein in
            neurons and neuroblastoma NB-2a cells
  JOURNAL   J Biol Chem 277 (23), 21103-21109 (2002)
   PUBMED   11927578
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Nowotny M, Bhattacharya S, Filipek A, Krezel AM, Chazin W and
            Kuznicki J.
  TITLE     Characterization of the interaction of calcyclin (S100A6) and
            calcyclin-binding protein
  JOURNAL   J Biol Chem 275 (40), 31178-31182 (2000)
   PUBMED   10884380
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   Filipek A and Kuznicki J.
  TITLE     Molecular cloning and expression of a mouse brain cDNA encoding a
            novel protein target of calcyclin
  JOURNAL   J Neurochem 70 (5), 1793-1798 (1998)
   PUBMED   9572262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154873.6 and AK013924.1.
            
            [WARNING] On Dec 26, 2023 this sequence was replaced by
            NM_009786.3.
            
            On Feb 26, 2011 this sequence version replaced NM_009786.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089043.1, BC025948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AC154873.6         207428-207499       c
            73-1313             AK013924.1         4-1244
            1314-2115           AC154873.6         196974-197775       c
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 69.61 cM"
     gene            1..2115
                     /gene="Cacybp"
                     /gene_synonym="SIP"
                     /note="calcyclin binding protein"
                     /db_xref="GeneID:12301"
                     /db_xref="MGI:MGI:1270839"
     exon            1..246
                     /gene="Cacybp"
                     /gene_synonym="SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            247..463
                     /gene="Cacybp"
                     /gene_synonym="SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            464..560
                     /gene="Cacybp"
                     /gene_synonym="SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            561..660
                     /gene="Cacybp"
                     /gene_synonym="SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            661..758
                     /gene="Cacybp"
                     /gene_synonym="SIP"
                     /inference="alignment:Splign:2.1.0"
     exon            759..2115
                     /gene="Cacybp"
                     /gene_synonym="SIP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctggggg cgggactaga ctcggagggg cggggccttg ggaggctccg gtggagcctt
       61 gcgaaggttc cagagccgtc tcgtgcggag ggcgggccgc cgtgtcgcgc cgggtctgtg
      121 gagctcgctg ccggcgctgc gacgctcgtg ggtggcgtgt tcggcttttc ctgtctgctt
      181 cggtgcaccg ctgcagctcc ggcctcgggt ctgacgcgcg acggcatggc ttccgttttg
      241 gaagagttgc agaaagacct agaagaggtc aaagtattgc tggaaaagtc cactaggaaa
      301 agactacgtg atactcttac aagtgaaaag tccaagattg agacggaact caagaacaag
      361 atgcaacaga agtcgcagaa gaaaccagaa cttgataatg aaaagccagc tgctgtggtt
      421 gctcctctta caacaggata caccgtgaaa atcagtaatt atggatggga tcagtcagat
      481 aagtttgtga aaatctacat taccttgact ggcgtccatc aggtgcccac tgagaacgtg
      541 caggtgcact tcacagagag gtcatttgat cttctggtaa aaaacctcaa tggcaagaat
      601 tactccatga ttgtgaacaa tcttttgaaa cctatctctg tggaaagcag ttcaaaaaaa
      661 gtcaagactg atacagtaat tattctatgt agaaagaaag cagaaaacac aagatgggac
      721 tacttaacac aggtggaaaa ggaatgcaaa gagaaagaaa agccttccta cgacacggag
      781 gcagacccta gtgagggatt aatgaatgtt ctaaagaaaa tttatgaaga cggagacgat
      841 gatatgaagc gaaccattaa taaagcgtgg gtggaatcca gagagaagca agccagagaa
      901 gacacggaat tttgaggctt ttaaaagtcc gtatgggaac tgtgatgtgg aatgctcgtg
      961 ttccagtaag gggatgttgt tgaactgcac atatttgttc atgtgggtat gtagttttga
     1021 cagataaata tttacaccgc cttttaagta aagatagcag attctccatt tcttactgga
     1081 ggatttgatt taaataaata agcttattaa actgtttcct tcattagcac cccagacatt
     1141 tcgtttcaga aaaggctata tggcactctt actgaaaatg taaaaaggaa gtcttgcata
     1201 atgaaaatgt tatgtcacag acttttgttc tggctgggag atagaataca gaagtgtttg
     1261 tctgtagttg acattagatc ccagtaatgt aaacaataaa gcaaaatttt tgcataaaat
     1321 tcaaatttgt gcaaagttac tacagagctg ttccattatt accatgtgtt accatatact
     1381 gctaattgat ttaagtatac ttatgaatat aaaattaaac aaaatacaaa ggacaaaaat
     1441 agacaaacat cgtgttgata agtactatca tggttcagat ggcttaaaaa taaccatgac
     1501 gcgaaaactt gaaaacgccc atttattcct ttgttcaata aagttggagt tttacttaaa
     1561 agatgagttc tgcaatctgt tttgagtgta ttcaaagtta agctttgtca ctgtactcga
     1621 gtaagtttca gaaagccgta agggcttagc aatggcttag ctgttaaatg ataggctcac
     1681 catcaaaaag aaagcaatta gatgcctaga aaaaaagcca gtcgatcaca acaactacca
     1741 ttaaggatta ggtaaaagtc agaacttaca attaatgtat agaaagggta gctggaagtg
     1801 tattgagctg tgaagtaagc agactggtaa acacatgaac ttattgcatg caggagattt
     1861 ggcgtttgta gggagatgaa gcattaatga tagcagtgta ataagacagc catatgctca
     1921 cacttacagc atctaagatc tcactgtcaa aaataaagtt atgcaagtac ttaaagagat
     1981 ggaattccat tatgacctag gactggggaa gaagtcttga tttaaaaagt aaaaggaaaa
     2041 tacatggcaa aaaaatacac ataagcacaa accaatgacc tactaaggtt tccagtaact
     2101 ataaatcatt catag
//
