LOCUS       NM_030197               5740 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus CDK2 associated, cullin domain 1 (Cacul1), transcript
            variant 1, mRNA.
ACCESSION   NM_030197 XM_129335
VERSION     NM_030197.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5740)
  AUTHORS   Jang,M.J., Park,U.H., Kim,J.W., Choi,H., Um,S.J. and Kim,E.J.
  TITLE     CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARgamma
            and inhibit adipogenesis
  JOURNAL   Cell Death Dis 8 (12), 3201 (2017)
   PUBMED   29233982
  REMARK    GeneRIF: CACUL1 reciprocally regulates SIRT1 and LSD1 to repress
            PPARgamma and inhibit adipogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5740)
  AUTHORS   Kigoshi,Y., Fukuda,T., Endo,T., Hayasaka,N., Iemura,S., Natsume,T.,
            Tsuruta,F. and Chiba,T.
  TITLE     CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2
  JOURNAL   Sci Rep 5, 12857 (2015)
   PUBMED   26238671
  REMARK    GeneRIF: Cacul1 regulates the antioxidant response by stabilizing
            Nrf2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5740)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108409.8.
            
            On Jan 6, 2023 this sequence version replaced NM_030197.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147382.1, AK036606.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AC108409.8         126893-127547       c
            656-782             AC108409.8         110733-110859       c
            783-885             AC108409.8         109727-109829       c
            886-981             AC108409.8         92011-92106         c
            982-1084            AC108409.8         89575-89677         c
            1085-1174           AC108409.8         83979-84068         c
            1175-1313           AC108409.8         80701-80839         c
            1314-1357           AC108409.8         76030-76073         c
            1358-5740           AC108409.8         71270-75652         c
FEATURES             Location/Qualifiers
     source          1..5740
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 56.52 cM"
     gene            1..5740
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /note="CDK2 associated, cullin domain 1"
                     /db_xref="GeneID:78832"
                     /db_xref="MGI:MGI:1926082"
     exon            1..655
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1398
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CDK2-associated and cullin domain-containing protein 1"
                     /codon_start=1
                     /product="CDK2-associated and cullin domain-containing
                     protein 1 isoform 1"
                     /protein_id="NP_084473.1"
                     /db_xref="CCDS:CCDS38034.1"
                     /db_xref="GeneID:78832"
                     /db_xref="MGI:MGI:1926082"
                     /translation="MEESMEEEEMLTYEAMMDDQNHNNWEAAADSFRQPPPAPPLPPP
                     PPPRPSSSIPDPGRELPGGQLLAVHAGSMERKGPKEGLPMGPPPLPEPNGVIMMLKSC
                     DAAAAVAKTAPAPTSSSTININTSTSKFLMNVITIEDYKSTYWPKLDGAIDQLLTQSP
                     GDYIPISYEQIYSCVYKCVCQQHSEQMYSDLIKKITSHLERVSKELQASPPDLYIERF
                     NIALGQYMGALQSIVPLFIYMNKFYIETKLNRDLKDDLIKLFTEHVAEKHIYSLMPLL
                     LEAQSTPFQVTPSTMANIVKGLYTLRPEWVQMAPTLFSKFIPNILPPAVESELSEYAA
                     QDQKLQRELIQNGFTRGDQSRKRAGDELAYNSPSACASSRGYR"
     exon            656..782
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            783..885
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            886..981
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1084
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1174
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1313
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1357
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..5740
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3535..3540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3555
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /note="major polyA site"
     regulatory      5696..5701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /note="hexamer: AATAAA"
     regulatory      5717..5722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5722
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
     polyA_site      5740
                     /gene="Cacul1"
                     /gene_synonym="2700078E11Rik; 2810417M16Rik;
                     9830127L17Rik; D130033C15Rik"
ORIGIN      
        1 agaagaaact gctgtaaaat gtcgtgaggg acgtcagccc tttgcggctg cctctcagaa
       61 ccagaccccg ggagtgccca cctcagtcag cggttcctcc ggcggagtcg tcttgacgga
      121 gggcgaaagc gctcggtgcg ccactggatt ttccgccgca cccgcgaggg ctccgggcga
      181 tgtgaactcg aggcggcttc tgcgctccca ggcccggggg ctgaggtggg cgggcaggtg
      241 cctgggaagc cgcggcccgg cgggatggag gagagcatgg aggaggagga aatgctcacc
      301 tacgaggcaa tgatggacga ccagaatcac aacaactggg aggccgccgc ggacagtttc
      361 cgccagcctc cgccggcccc gccgctgccc ccgccgccgc cgccgcggcc ctcgtcgtcc
      421 atcccggatc caggccgaga actcccgggg ggacagctgc tggctgtgca cgcgggctcc
      481 atggagagga agggtcctaa ggaagggctc ccgatggggc ctccgccctt gccggaacca
      541 aacggggtga tcatgatgtt gaagagctgc gacgcagccg ccgcggtggc caagacggcc
      601 cctgccccca cctccagctc cactatcaac atcaacacct ccacctccaa gttcctaatg
      661 aatgttataa caattgaaga ttataagagc acatactggc caaaattaga tggtgccata
      721 gatcaacttt taacccagag tcctggtgac tatataccta tatcctatga acagatttac
      781 agttgtgtgt ataagtgtgt gtgccagcag cactcagaac agatgtacag tgatctgatt
      841 aaaaaaataa ccagccactt agagcgagtc tccaaggagc tgcaggccag ccctccagac
      901 ctctatattg aaagatttaa tatagctctg ggacagtata tgggagcatt gcagagcatc
      961 gtgcctcttt tcatatatat gaataagttt tacatagaaa ctaagcttaa cagagactta
     1021 aaagatgacc ttataaaact gtttacggaa catgttgcag agaagcacat ttacagccta
     1081 atgcctttac ttttagaagc ccagtcaaca ccatttcagg tcacaccttc aactatggca
     1141 aatattgtga aaggcctgta cactctcaga ccagaatggg ttcagatggc tccgacattg
     1201 ttttctaagt ttattccaaa cattcttccc ccggctgtgg aatctgaact ttctgagtac
     1261 gctgcccaag atcaaaagct tcaaagagaa cttatacaga acggttttac cagaggtgat
     1321 cagtcccgga agagagctgg agatgagttg gcttataaca gtccatctgc ttgtgcaagt
     1381 tccagggggt atagatagtg acggttgaac tatgtttctc ccaagagaag acacactgga
     1441 gctacagaaa ctgttccagg cacagtgagg cctgcaccac tcaggagctc tgtcaaaggc
     1501 tgttctcaga gaggataccg gacttctttc tttgattttt cagtttttaa aaacaagaac
     1561 taacaaaaac aattgctgct agactggggg gtgattatga aatgggacaa tcttttatct
     1621 acagagcaag tgtcttggag agtggccgtt gataaagtga agctcaatgt ttgaatcagc
     1681 ttcctccaga aatacaagaa cgaaagaatc tttttgtttt gttttgtttt gttttgtttt
     1741 ttttaaaagc actcatcttg ttcatttgtg gacttggaac atggtgtctc atgtcaagat
     1801 atctttgctt aaaaccaagc agatgttata atacagtgtt ttcacccatg ccccaaacaa
     1861 tctgttttaa attcagattg gtctgtgttt agcagttagc cttgtggagg aaaatgctaa
     1921 taactgcttt tactatttct ttccctatta attcccgttt tcaactgtgt gccttgagct
     1981 ttgtgcactt tgcagctatg tgaccatgtc atcaatctca cgatgcttcc tgaagaagtt
     2041 gatgtctcag accggctcac caaagcctct ggtatggctt tgtgtttgta gcagaacctg
     2101 attgagaaaa tggaagcact tgaggctggt cagaatttac cctgctgtcc cagctctcat
     2161 ggggaccaac tcttactgag tggtttccat tctgctactg cctcacccga tatcagcctc
     2221 gagtggagtg gagccctgtt ttcaggctat gatactgtag agactgccaa cagtgggagc
     2281 tactccctgg atccctcttg ggccgagtag tttttaaagc caaatatggt gaatagttct
     2341 tggcccatct cattttaatg ggtgcgttta atacatataa aaggtcagct ccactctgta
     2401 tcttgtaaac atcatgtttg atatttgaat gcaccaggga gagtgtgctg tttgaaggct
     2461 ccggtaaagc tatattacct gttttgctac accaacagtg caacaaaaca acagttcttc
     2521 gcaaaagtct gaagcttatt tagttgtgtc tcaataataa acaaaactag acatggcaag
     2581 ggaaaagtat tttccttctc agttttgctt gaatgtgaag tgagcgttgg ctttgtgcta
     2641 ccaggctcca tctgacagtg atgctgacca ttcagagaat gcctcccccc aagctactgc
     2701 taccatctca gtgggcagca gagttagaaa tggaatacca gggacaagaa cattacccag
     2761 tagcagtcct gtgtttgtaa acaatgttcc aggggaagaa cagttaaaag ctgatagctt
     2821 gaatctttca ggtacttgtc tgcagttggt agaatttatg gggggggggg ggttaattgg
     2881 cttcattcca tttgggttat attgaagaat ctgagtaggg acaagtggac tcatactatg
     2941 gtctgtacag ccttttctgc tctaatgtcg aggggaaagt tttcatttta tcaaaaagcc
     3001 cagtttactt ttctgatgga atgctcacca cagagttgta aatatcattt tgaactggtt
     3061 tcttctacac agctttaata tttttgacaa tagtaaagtt ggaacacttc ttgaaacata
     3121 ataggttagt ggttccgtgt cttaattata ccctcccccc cccccaggag agagtgctct
     3181 tctttttctc taaaagaatt ttgcctatat aaaagcatta tattaaataa attggcatta
     3241 acgtgggtgc tgttgtgtta gtaaattaat ggagaaacag tcatactaat tctgtgttag
     3301 cacaaaatag gcagggaaaa cctgtgaagt tcttgttctc tgagtcagag ctgggtgggt
     3361 accactgtgc tggtactgaa aggcgtgggg caggaaagtg agtgtgctgc tgatggattc
     3421 gtcctggtaa ccagtaagtt aagcaaggct ttacagtttg taaaacttca gctgaaatgg
     3481 acacttcttg ttaactgaaa tctctacagg agtcttagtc gccaactatg aggaaataaa
     3541 atctgttcac tctcattttg tatttcctga aagtattttc atgtgtactt gtggtcttgc
     3601 aagtacagtt tttctatccc tgctgaggac cgctttctca atcagatcct taaagctcaa
     3661 attttgtgta gctcagttag tcactgaaat acagttgatt tggctaaagg gcaaatgtgt
     3721 acatttgcct aaaaggcctt taaaaaatta aaagccagga gggttatctt caagtaatgg
     3781 tttgaaagaa taaacagatg atggtgttga gagacaatgc tcattttaaa agttgacctt
     3841 acacttgggt caccatgtta tctactgacc tgctgtcata actgcattct gacctggcag
     3901 gaattatttt cttgggggcc agaaagtaaa atttagtggt ctgacttgcc taatagttcc
     3961 taggcagggt tgttcactta catgcgcaat tagtaatgat tgtgcattac taaaatttct
     4021 caaggtcttt tattacaagt cactcattcc cctttttgct agtgtgaagt tggtttgtat
     4081 gtatgtaggt gagactgcag aggaatggat gtccctggtc atgacatgac actgtgtatg
     4141 tctctagagc ccagttttgt ctagctgctg ccctcttgtc gtttactttc tgtcaggttg
     4201 caaatttgca cacatgaatg atccctcagg aacagtttgc acactcctca cctcagtata
     4261 ctctgtatag accaaacagc attaaaggtt atcagcacaa gaggcttcct acacctacta
     4321 gcagaggcca tggtgagctt gcagacaaaa ctggtttctg caggtaatgg gaagaggagc
     4381 acatacagag tttgtttaag tgacctccca cttctcccta taaccagagt aagaaacctt
     4441 ccagattttg ttggcttatt agaactatgg ttttttgttt gtttttgttt ttttcttctt
     4501 ttctgcttcc cctctctcac agtaattatt tctatggtta gtatgtaggg gaattgccct
     4561 tgagctaaga ttcaactgtt cattaagcag ctatcattaa actaagcatt atgcaatgaa
     4621 tatgcactaa tctgagataa gaaacaacta aaaaagaaaa aaacaaaccg tgcattagct
     4681 attcatctgt tagagtttgt tttttaatgg tatattcttg agcttttagc ttggaatatt
     4741 gtttgctttt atccaagtat aggtttctta gggggatgtt aaaattcaag gttggaatgt
     4801 gacaccctta actgacatct gaagtatcaa ctttttctgt tgatgactgc ttttagtata
     4861 atactgtgca aaatgttcat ttttaccaga atttcaagca gaaatcatag ggaaatctta
     4921 gagaaatggc tctgttgtgc ttttattacc acatggaaat tttccttggc ttctgacccc
     4981 aagaatattt ggaaggaggt gtttgttctt tcccaaagga aatgctccct ctctggtccc
     5041 ctgctgctta gctgcagtca ctgcctcatc cctcctgcac tattgaagac cttaaacctc
     5101 cttccagagt cagtgatggg tctgccccct tcgtgcagga ccaatctctc tgccttgaag
     5161 atcttttagg cttggtctgc tggattacac ctcttggaag gttgtcagca tggctcttgg
     5221 gttaagagtt gagtgacttg taaaacaaaa caaaacaaaa ccctttgtat tgattgtgac
     5281 tactaaactc agtaagactg ggtgttctcc tcaaggtggt gatgctgttg gttcttttta
     5341 gtcttatatg ttaatgttac agccatggat attcagagaa attatttgaa catcaagtcc
     5401 tgggaaattg gctcaaataa atgcttatac aaaatttgga gatcatgtgc aggctaaagg
     5461 agtttgccac ccaccagcat agcagagcaa atgaagcatt gctgtctttt ttcctgacat
     5521 ttgtcatctg gcactgtcct ttactactta tttgctgaac gtgactaaag cgcttcctga
     5581 gctggggtac aaagctgctg gcctgggctc tctccttata aacatatggt agattttgaa
     5641 tcgctcctct gtattagttg tatattctca ctctaaagta ttgtggttaa tgaaaaataa
     5701 atcttgtaca gatgtcatta aacttgcttt ttaagttttg
//
