LOCUS       NM_027381               2724 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cactin, spliceosome C complex subunit (Cactin), mRNA.
ACCESSION   NM_027381 XM_618787 XM_901292 XM_916201 XM_924158 XM_988045
VERSION     NM_027381.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC150986.1, AY934504.1 and BY651766.1.
            
            On Apr 9, 2009 this sequence version replaced NM_027381.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150986.1, AY934504.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                BC150986.1         1-94
            95-2715             AY934504.1         1-2621
            2716-2724           BY651766.1         411-419
FEATURES             Location/Qualifiers
     source          1..2724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2724
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /note="cactin, spliceosome C complex subunit"
                     /db_xref="GeneID:70312"
                     /db_xref="MGI:MGI:1917562"
     exon            1..344
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2427
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /codon_start=1
                     /product="splicing factor Cactin"
                     /protein_id="NP_081657.1"
                     /db_xref="CCDS:CCDS35995.1"
                     /db_xref="GeneID:70312"
                     /db_xref="MGI:MGI:1917562"
                     /translation="MRGAGRQMGRDSRSRSRSVGRRGRKQRSRSRGRSRSRSRSRSRS
                     RSRSRSRSRSHGRSSRRRREHERRRERKRRSRGRRSDSEGEQRQKSRRRSQSLRPPRW
                     HSQNQSSCSDSGEERAQGSWARKGHRRSWSPGSSASSLDSPRRSRSPGTATLALSQQQ
                     SLQERLRLREERKQQEELLKAFETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTN
                     TDNPFGDNNLLGTFIWNKALEKKGISHLEEKELKERNKRIQEDNRLELQKVKQLRLER
                     EREKAMREQELELLQREKEAEHFKTWEEQEDSFHLRQAKLRSKIRIRDGRAKPIDLLA
                     KYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNVDFWRDMTTIT
                     EDEIAKLRKLEASGKGPGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAG
                     GPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLFKLKQEQGVESEPLFPILKSE
                     PSAAHSPEPEERPPSPGTSVDPVEPVEPEEATAPGEAEGEAEGEAVLMEEDLIQQSLA
                     DYDAGRYSPRLLTAHELPLDAHVLEPHEDLQRLQLSRQQLQATGDASESAEDIFFRRA
                     REGMGQDEAQFSVEMPLGGRAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNP
                     PPKIVQGYKFNIFYPDLIRKRATPEYFLEACADNRDFAILRFHAGPPYEDIAFKIVSR
                     EWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR"
     exon            345..912
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1058
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1221
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1336
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1529
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1649
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1936
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2724
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2696..2701
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /note="hexamer: AATAGA"
     polyA_site      2715
                     /gene="Cactin"
                     /gene_synonym="2510012J08Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagggagtaa gtcattccct gtgatcaggc gcactttgga cagtccttag agcgccgcgc
       61 caaaggaaag cccccggcgc caagcttcct ggttgtttac gcgcgcgcat gcgcggcgcg
      121 ggccgccaaa tgggtcggga ctctcgctcg cgctcacggt ctgtgggtcg caggggtcgg
      181 aagcagcgga gtcgaagccg gggccggagc cgcagccgga gtcggagtcg gagtcggagt
      241 cggagtcgga gccggagccg gagccggagc catgggcgga gcagccgaag gcgacgggaa
      301 cacgagcggc ggcgcgaacg caagcggcgc agccgagggc gcaggtcaga ttcggaagga
      361 gagcagcggc agaagtctag gaggcgaagc cagagccttc gaccaccccg atggcactca
      421 cagaaccagt cctcatgctc tgactcgggt gaggagcggg ctcagggctc ctgggcccgt
      481 aagggtcaca ggcgctcgtg gtccccgggg tcatcagcgt ctagcttgga ctccccaaga
      541 cgctcccgga gtcccgggac agctaccctg gccctgagcc agcagcagag cctgcaggaa
      601 cggctgcggc ttcgtgagga gcggaagcag caagaagagc tgctcaaggc cttcgagacg
      661 cctgaggaga agcgtgcgcg gcgactggcc aagaaggaag ctaaggaacg caagaagcgg
      721 gagaagatgg gctggggtga ggagtacatg ggctacacca acaccgacaa cccctttgga
      781 gacaacaacc tgctcggcac cttcatctgg aacaaggcct tggagaagaa gggcatcagc
      841 cacctggagg agaaggagct gaaggagcgc aacaagagga tccaggaaga caaccgtctg
      901 gagctgcaaa aggtcaaaca gctgcggcta gagcgggaac gggagaaagc catgagggag
      961 caggagctgg agttgctgca gcgggagaag gaggcagaac actttaagac gtgggaggag
     1021 caagaggaca gcttccactt gcggcaggcc aagcttcgct ccaagatccg aatccgagat
     1081 gggcgagcta agcccatcga cctcctggcc aagtacatca gcgcagagga tgacgacctg
     1141 gcggtggaga tgcacgagcc ctacaccttc ctcaacggcc tcactgtggc ggacatggag
     1201 gacctactag aagacatcca ggtgtacatg gaactagagc agggcaagaa tgtggacttc
     1261 tggcgggaca tgacgaccat cacagaggat gagattgcca agctccgcaa gctggaggcc
     1321 tctggcaagg gcccaggtga gcgccgtgag ggagtcaatg cctcagtcag ctccgatgtg
     1381 cagtcggtgt tcaagggaaa gacgtacaac cagctgcagg tcatcttcca gggcatcgag
     1441 ggcaagatcc gggccggggg ccccaacctg gacatgggct attgggagag cctgctgcag
     1501 cagttgcgtg cacacatggc cagggccagg ctccgtgagc gccaccaaga tgttcttaga
     1561 cagaagctgt tcaagctgaa gcaggagcag ggtgtggaga gcgagccgct gttccccatc
     1621 ctcaagtcgg agccctcggc cgcccacagc cccgaacctg aggagcgacc ccccagcccc
     1681 gggacttcag tggacccagt ggagcctgtg gaacctgagg aggccacagc accaggagaa
     1741 gcagaggggg aggcagaagg ggaggcagtg ctgatggagg aagacctgat ccagcagagc
     1801 ctggcggact atgacgccgg ccgctacagc ccacggctgc tcacggcaca cgagctgcct
     1861 ctggacgcac acgtgctgga gcctcacgag gacctgcagc gcctgcagct gtctcgccag
     1921 cagcttcagg ctacaggtga tgcgagtgag agcgctgagg acatcttctt ccggcgtgcg
     1981 agggagggca tggggcagga tgaggcacag ttcagcgtgg agatgccact gggcggccgg
     2041 gcctatctgt gggccgacaa gtaccggccg cgaaaacctc gcttcttcaa ccgcgtgcac
     2101 acgggcttcg agtggaacaa atataaccag acgcattatg acttcgacaa ccctccaccc
     2161 aagattgtgc agggctacaa attcaacatc ttctacccag acctcatccg taagcgcgcc
     2221 acacctgagt acttcctgga ggcttgtgca gacaaccggg actttgccat tctgcgcttc
     2281 catgcgggac cgccctacga ggacatcgcc ttcaagatcg tcagtcgtga gtgggagtat
     2341 tcgcaccgcc atggcttccg ctgccagttc gccaatggaa tcttccagct ctggttccac
     2401 ttcaagcgct accgctaccg tcggtgacac ctgtgggctg cctgcccctg tcaggctggc
     2461 ccctggacag ctcccaggtg ggaaggccaa gaggaccagg aggcctcctt cagaagccgt
     2521 aggaatctgt ggacttcagt caccagcact gtgctggccg cagcccctct ggcagatccc
     2581 tgcctgtcct gaaaggattt ttaactgttc ttgggaagac tgcttggggt ggcagaaagg
     2641 tcttgtttcc atggacttgt tcaaccgggg aaccccgtgt ggttttgata catttaatag
     2701 aaagcttatt ctaaactggc ttct
//
