LOCUS       NM_133190               2116 bp    mRNA    linear   ROD 21-SEP-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, gamma subunit 8
            (Cacng8), mRNA.
ACCESSION   NM_133190
VERSION     NM_133190.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2116)
  AUTHORS   van der Spek,S.J.F., Pandya,N.J., Koopmans,F., Paliukhovich,I., van
            der Schors,R.C., Otten,M., Smit,A.B. and Li,K.W.
  TITLE     Expression and Interaction Proteomics of GluA1- and
            GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition
  JOURNAL   Cells 11 (22), 3648 (2022)
   PUBMED   36429079
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2116)
  AUTHORS   Bai,W.J., Luo,X.G., Jin,B.H., Zhu,K.S., Guo,W.Y., Zhu,X.Q., Qin,X.,
            Yang,Z.X., Zhao,J.J., Chen,S.R., Wang,R., Hao,J., Wang,F.,
            Shi,Y.S., Kong,D.Z. and Zhang,W.
  TITLE     Deficiency of transmembrane AMPA receptor regulatory protein
            gamma-8 leads to attention-deficit hyperactivity disorder-like
            behavior in mice
  JOURNAL   Zool Res 43 (5), 851-870 (2022)
   PUBMED   36031768
  REMARK    GeneRIF: Deficiency of transmembrane AMPA receptor regulatory
            protein gamma-8 leads to attention-deficit hyperactivity
            disorder-like behavior in mice.
REFERENCE   3  (bases 1 to 2116)
  AUTHORS   Peng,S.X., Wang,Y.Y., Zhang,M., Zang,Y.Y., Wu,D., Pei,J., Li,Y.,
            Dai,J., Guo,X., Luo,X., Zhang,N., Yang,J.J., Zhang,C., Gao,X.,
            Liu,N. and Shi,Y.S.
  TITLE     SNP rs10420324 in the AMPA receptor auxiliary subunit TARP gamma-8
            regulates the susceptibility to antisocial personality disorder
  JOURNAL   Sci Rep 11 (1), 11997 (2021)
   PUBMED   34099816
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2116)
  AUTHORS   Zhang,D., Watson,J.F., Matthews,P.M., Cais,O. and Greger,I.H.
  TITLE     Gating and modulation of a hetero-octameric AMPA glutamate receptor
  JOURNAL   Nature 594 (7863), 454-458 (2021)
   PUBMED   34079129
  REMARK    GeneRIF: Gating and modulation of a hetero-octameric AMPA glutamate
            receptor.
REFERENCE   5  (bases 1 to 2116)
  AUTHORS   Yu,J., Rao,P., Clark,S., Mitra,J., Ha,T. and Gouaux,E.
  TITLE     Hippocampal AMPA receptor assemblies and mechanism of allosteric
            inhibition
  JOURNAL   Nature 594 (7863), 448-453 (2021)
   PUBMED   33981040
REFERENCE   6  (bases 1 to 2116)
  AUTHORS   Shi,Y., Lu,W., Milstein,A.D. and Nicoll,R.A.
  TITLE     The stoichiometry of AMPA receptors and TARPs varies by neuronal
            cell type
  JOURNAL   Neuron 62 (5), 633-640 (2009)
   PUBMED   19524523
REFERENCE   7  (bases 1 to 2116)
  AUTHORS   Menuz,K., Kerchner,G.A., O'Brien,J.L. and Nicoll,R.A.
  TITLE     Critical role for TARPs in early development despite broad
            functional redundancy
  JOURNAL   Neuropharmacology 56 (1), 22-29 (2009)
   PUBMED   18634809
REFERENCE   8  (bases 1 to 2116)
  AUTHORS   Tomita,S., Byrd,R.K., Rouach,N., Bellone,C., Venegas,A.,
            O'Brien,J.L., Kim,K.S., Olsen,O., Nicoll,R.A. and Bredt,D.S.
  TITLE     AMPA receptors and stargazin-like transmembrane AMPA
            receptor-regulatory proteins mediate hippocampal kainate
            neurotoxicity
  JOURNAL   Proc Natl Acad Sci U S A 104 (47), 18784-18788 (2007)
   PUBMED   18000041
REFERENCE   9  (bases 1 to 2116)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   10 (bases 1 to 2116)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
  REMARK    GeneRIF: Discusses evidence for non-AUG translation start codon for
            Cacng8.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC217111.9.
            
            [WARNING] On Jan 16, 2025 this sequence was replaced by
            NM_133190.4.
            
            On Jun 17, 2019 this sequence version replaced NM_133190.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF361350.1, SRR7652917.248265.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on single protein-coding
                                        transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-463               AC217111.9         92062-92524
            464-547             AC217111.9         109195-109278
            548-688             AC217111.9         110087-110227
            689-2116            AC217111.9         112859-114286
FEATURES             Location/Qualifiers
     source          1..2116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 1.98 cM"
     gene            1..2116
                     /gene="Cacng8"
                     /note="calcium channel, voltage-dependent, gamma subunit
                     8"
                     /db_xref="GeneID:81905"
                     /db_xref="MGI:MGI:1932376"
     exon            1..463
                     /gene="Cacng8"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1455
                     /gene="Cacng8"
                     /note="non-AUG (CUG) translation initiation codon;
                     neuronal voltage-gated calcium channel gamma-8 subunit;
                     TARP gamma-8; transmembrane AMPAR regulatory protein
                     gamma-8"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-8
                     subunit"
                     /protein_id="NP_573453.2"
                     /db_xref="CCDS:CCDS57471.1"
                     /db_xref="GeneID:81905"
                     /db_xref="MGI:MGI:1932376"
                     /translation="MESLKRWNEERGLWCEKGVQVLLTTIGAFAAFGLMTIAISTDYW
                     LYTRALICNTTNLTAGDDGPPHRGGSGSSEKKDPGGLTHSGLWRICCLEGLKRGVCVK
                     INHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILG
                     AGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVI
                     GVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSS
                     SRGSSEASPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLASAGGGGSGAGV
                     GAYGGAAGAAGGGGAGSERDRGSSAGFLTLHNAFPKEAASGVTVTVTGPPAAPAPAPA
                     PPAPAAPAPGTLSKEAAASNTNTLNRKTTPV"
     exon            464..547
                     /gene="Cacng8"
                     /inference="alignment:Splign:2.1.0"
     exon            548..688
                     /gene="Cacng8"
                     /inference="alignment:Splign:2.1.0"
     exon            689..2116
                     /gene="Cacng8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2088..2093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng8"
                     /note="hexamer: CATAAA"
     polyA_site      2116
                     /gene="Cacng8"
                     /note="major polyA site"
ORIGIN      
        1 ctggagacta tggcttcact ctgaccttcg cctctgcagc cacctgctcg ctgcccccgg
       61 ccccctctgg ccccttgagg ccccccagct tctgcctgtg ctgtgatccc cccagccgcc
      121 ggcacggccc cgcctccgct gccccggtgg tggcccacgg ccccccggtt gccagtggtg
      181 aaactggagt cattgaaacg ctggaatgaa gagaggggtt tgtggtgtga aaagggcgtt
      241 caggtactac tgaccaccat cggcgccttc gcggcttttg gcctcatgac catcgccatc
      301 agcactgact actggctcta cacaagagct ctcatctgca acaccaccaa cctcacagca
      361 ggtgatgacg gaccacccca tcgtgggggc agtggctcct ccgagaagaa ggaccctggg
      421 ggcctcacac attcaggcct ctggcggata tgctgcctgg aagggttgaa aagaggtgtc
      481 tgcgtgaaga tcaaccactt cccggaggac acggactacg accacgacag cgcggagtac
      541 ctgctccgag tagtccgggc ttccagcatc tttcctatcc tgagcgccat cctgctgctg
      601 ctcgggggcg tgtgcgtagc tgcctcccgc gtctacaagt ccaaaaggaa catcatcctg
      661 ggcgcaggga tcctgttcgt ggcagcaggc ttgagcaaca tcatcggggt gattgtgtac
      721 atatcggcca acgccggcga gcctggcccc aagagggacg aggagaagaa aaaccactac
      781 tcgtacggct ggtccttcta cttcggcggg ctgtccttca tcctggctga ggtgatcgga
      841 gtactggccg tcaacatcta catcgagcgc agccgcgagg cacactgcca atcacgctcg
      901 gacctgctca aggccggcgg cggcgcgggc ggcagtggcg ggagcggccc ctcggccatc
      961 ctccgtctgc ccagttaccg cttccgctac cgccgccgct cccgctccag ctcccgaggc
     1021 tccagcgagg cgtcgccatc ccgggatgcg tctcccggcg gccccggggg cccgggcttc
     1081 gcctccacgg acatctccat gtacacgctc agccgcgacc cgtccaaggg cagcgtggct
     1141 gcggggctgg cgagcgccgg tggcggcggc agcggtgccg gcgtgggtgc ctacggcggg
     1201 gcggccgggg cggcgggggg cggcggggcg ggctcggagc gggaccgcgg gagctcggcg
     1261 ggttttctca cgctgcacaa cgccttcccc aaggaagcgg cgtccggcgt cacggtcaca
     1321 gtcaccggac cgcccgctgc acccgcgccc gcgcccgcgc cgcccgctcc tgcagcgccc
     1381 gcgcccggga ccctgtccaa agaggccgcg gcgtccaaca ccaacacgct caacaggaaa
     1441 accacgcccg tgtaggggcg tgcgccctcg cgggggagcc ggggggcgtg tccggggcgc
     1501 gtgcgcgggc gcgcgtgcaa cgaggccgcc ggatcagggt gccccccagg tctatccccg
     1561 cgagcgcgct ggacaccgct gggccttcta gcccctctcc gcaccctcta cccgcccctg
     1621 ggggcgtggg gaaccccgtc acgctccgaa acagggaccc ttggggaggg ggacgggacg
     1681 ggaaaggggt tccagcgtgg gagcgctgtg ttttattttt gtgttgggaa gatttcaggg
     1741 gagggaggga gggcccgtgg tgttttttgc agttttgaga tgttttcttt ttaaatgttt
     1801 tgctgtgtgc atgtggaggc ggggcggggg gaggggaggg agggactccc agcccagccc
     1861 agcccagccc agcccaactc ctggagaggg gcacataaca catgaatata gggttacatc
     1921 tacaactata tatacacatg ttctgtataa agagaccagc agaaggcaaa ggccaaggga
     1981 gagacgcgct cacatttagt tcactttttc atctttcaac aagggcttat taagcaccta
     2041 ctgtgtacca ggtgatggta cagaaggtgg tgctagagag gaggggacat aaacgcaagg
     2101 cgcatccgtt cattca
//
