LOCUS       NM_133189               2342 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, gamma subunit 7
            (Cacng7), transcript variant 1, mRNA.
ACCESSION   NM_133189 XM_006540441
VERSION     NM_133189.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Liu,H., Zhou,R., Li,S., Dong,J., Fang,Y., Luo,Y., Su,H., Lai,B.,
            Liang,L., Zhang,D., Zhang,Y., Shyy,J.Y., Zhou,B., Yuan,Z. and
            Wang,Y.
  TITLE     Epigenetic repression of Cend1 by lysine-specific demethylase 1 is
            essential for murine heart development
  JOURNAL   iScience 27 (1), 108722 (2023)
   PUBMED   38226173
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Yamazaki,M., Le Pichon,C.E., Jackson,A.C., Cerpas,M., Sakimura,K.,
            Scearce-Levie,K. and Nicoll,R.A.
  TITLE     Relative contribution of TARPs gamma-2 and gamma-7 to cerebellar
            excitatory synaptic transmission and motor behavior
  JOURNAL   Proc Natl Acad Sci U S A 112 (4), E371-E379 (2015)
   PUBMED   25583485
  REMARK    GeneRIF: Thus, gamma-7 is capable of supporting a component of
            excitatory transmission in PCs, sufficient to maintain essentially
            normal motor behavior, in the absence of gamma-2.
REFERENCE   3  (bases 1 to 2342)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 2342)
  AUTHORS   Studniarczyk,D., Coombs,I., Cull-Candy,S.G. and Farrant,M.
  TITLE     TARP gamma-7 selectively enhances synaptic expression of
            calcium-permeable AMPARs
  JOURNAL   Nat Neurosci 16 (9), 1266-1274 (2013)
   PUBMED   23872597
  REMARK    GeneRIF: The results of this study suggested that TARPed synaptic
            receptors in granule cells require both gamma-2 and gamma-7 and
            reveal an unexpected basis for the loss of AMPAR-mediated
            transmission in stargazer mice.
REFERENCE   5  (bases 1 to 2342)
  AUTHORS   Kato,A.S., Gill,M.B., Ho,M.T., Yu,H., Tu,Y., Siuda,E.R., Wang,H.,
            Qian,Y.W., Nisenbaum,E.S., Tomita,S. and Bredt,D.S.
  TITLE     Hippocampal AMPA receptor gating controlled by both TARP and
            cornichon proteins
  JOURNAL   Neuron 68 (6), 1082-1096 (2010)
   PUBMED   21172611
  REMARK    GeneRIF: TARP gamma-7 causes AMPA receptors to 'resensitize' upon
            continued glutamate application.
REFERENCE   6  (bases 1 to 2342)
  AUTHORS   Yamazaki,M., Fukaya,M., Hashimoto,K., Yamasaki,M., Tsujita,M.,
            Itakura,M., Abe,M., Natsume,R., Takahashi,M., Kano,M., Sakimura,K.
            and Watanabe,M.
  TITLE     TARPs gamma-2 and gamma-7 are essential for AMPA receptor
            expression in the cerebellum
  JOURNAL   Eur J Neurosci 31 (12), 2204-2220 (2010)
   PUBMED   20529126
  REMARK    GeneRIF: Results suggest that TARPs gamma-2 and gamma-7
            cooperatively promote synaptic expression of cerebellar AMPA
            receptors, and the latter also promotes glial expression.
REFERENCE   7  (bases 1 to 2342)
  AUTHORS   Kato,A.S., Zhou,W., Milstein,A.D., Knierman,M.D., Siuda,E.R.,
            Dotzlaf,J.E., Yu,H., Hale,J.E., Nisenbaum,E.S., Nicoll,R.A. and
            Bredt,D.S.
  TITLE     New transmembrane AMPA receptor regulatory protein isoform,
            gamma-7, differentially regulates AMPA receptors
  JOURNAL   J Neurosci 27 (18), 4969-4977 (2007)
   PUBMED   17475805
  REMARK    GeneRIF: Gamma-7 is a new member of the transmembrane AMPA receptor
            regulatory protein (TARP) family that can differentially influence
            AMPA receptors in cerebellar neurons. (TARP gamma-7)
REFERENCE   8  (bases 1 to 2342)
  AUTHORS   Moss,F.J., Viard,P., Davies,A., Bertaso,F., Page,K.M., Graham,A.,
            Canti,C., Plumpton,M., Plumpton,C., Clare,J.J. and Dolphin,A.C.
  TITLE     The novel product of a five-exon stargazin-related gene abolishes
            Ca(V)2.2 calcium channel expression
  JOURNAL   EMBO J 21 (7), 1514-1523 (2002)
   PUBMED   11927536
REFERENCE   9  (bases 1 to 2342)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   10 (bases 1 to 2342)
  AUTHORS   Burgess,D.L., Gefrides,L.A., Foreman,P.J. and Noebels,J.L.
  TITLE     A cluster of three novel Ca2+ channel gamma subunit genes on
            chromosome 19q13.4: evolution and expression profile of the gamma
            subunit gene family
  JOURNAL   Genomics 71 (3), 339-350 (2001)
   PUBMED   11170751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC217111.9.
            
            On Jun 17, 2019 this sequence version replaced NM_133189.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032173.1, BC141277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               AC217111.9         30845-31056
            213-437             AC217111.9         34576-34800
            438-524             AC217111.9         36465-36551
            525-665             AC217111.9         36906-37046
            666-811             AC217111.9         63967-64112
            812-2342            AC217111.9         64711-66241
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 1.95 cM"
     gene            1..2342
                     /gene="Cacng7"
                     /note="calcium channel, voltage-dependent, gamma subunit
                     7"
                     /db_xref="GeneID:81904"
                     /db_xref="MGI:MGI:1932374"
     exon            1..212
                     /gene="Cacng7"
                     /inference="alignment:Splign:2.1.0"
     exon            213..437
                     /gene="Cacng7"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1069
                     /gene="Cacng7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     voltage-dependent calcium channel gamma-7 subunit;
                     neuronal voltage-gated calcium channel gamma-7 subunit;
                     TARP gamma-7; transmembrane AMPAR regulatory protein
                     gamma-7"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-7
                     subunit isoform 1"
                     /protein_id="NP_573452.3"
                     /db_xref="CCDS:CCDS39725.1"
                     /db_xref="GeneID:81904"
                     /db_xref="MGI:MGI:1932374"
                     /translation="MSHCSSRALTLLSSVFGACGLLLVGIAVSTDYWLYMEEGTVLPQ
                     NQTTEVKMALHAGLWRVCFFAGREKGRCVASEYFLEPEINLVTENTENILKTVRTATP
                     FPMVSLFLVFTAFVISNIGHIRPQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEV
                     MNRPSSSEQYFHYRYGWSFAFAASSFLLKEGAGVMSVYLFTKRYAEEEMYRPHPAFYR
                     PRLSDCSDYSGQFLQPEAWRRGRSPSDISSDVSIQMTQNYPPAIKYPDHLHISTSPC"
     exon            438..524
                     /gene="Cacng7"
                     /inference="alignment:Splign:2.1.0"
     exon            525..665
                     /gene="Cacng7"
                     /inference="alignment:Splign:2.1.0"
     exon            666..811
                     /gene="Cacng7"
                     /inference="alignment:Splign:2.1.0"
     exon            812..2342
                     /gene="Cacng7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2323..2328
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng7"
                     /note="hexamer: AATAAA"
     polyA_site      2342
                     /gene="Cacng7"
                     /note="major polyA site"
ORIGIN      
        1 gctcccggct gcgtccgctg agtgaggccg cgggcgaggg gggtgggggg tgggaggccc
       61 ggagggggcc gggacgccgg gctcgggggc gggggcgggg ggcgcgggca ccggagaccc
      121 cggtggcggc agcggcggcc ggggaaaacc gcggggccgg tcatgcggct gcggggcccg
      181 cggcccggag cgtccgccca gccctgagag aggccccaca gggcgccccc cgccgctcag
      241 gatgagtcac tgcagcagcc gcgccctgac cctgctgagc agcgtgtttg gtgcctgcgg
      301 cctgctcctt gtgggcatcg cggtcagcac ggactactgg ctgtacatgg aggaggggac
      361 cgttttgccg cagaaccaga ccaccgaggt caagatggcg ctgcacgctg gcctctggag
      421 agtctgcttc tttgcaggtc gggagaaggg gcgctgtgtg gcttctgagt actttcttga
      481 accagagatc aacttggtga cggaaaacac ggagaatatt ctgaagacag tgcgcacggc
      541 tacacccttc cctatggtca gtctcttcct cgtgttcacc gcctttgtca tcagcaacat
      601 cggccacatc cgacctcaga ggaccattct tgcgttcgtt tctggcatct ttttcatttt
      661 atcaggtctc tccttggtgg tgggcttggt cctatacatc tccagcatca acgacgaggt
      721 catgaacagg cccagcagct ctgagcagta ctttcactat cgctacgggt ggtcctttgc
      781 cttcgctgct tcctcttttc ttctcaaaga gggggccgga gtcatgtccg tgtacttgtt
      841 caccaagcgc tacgcggagg aagagatgta tcgcccgcac ccggccttct accgaccgcg
      901 tctcagcgac tgctccgact actccggcca gtttctgcag cccgaggcgt ggcgtcgagg
      961 ccgcagccct tccgacatct ctagcgacgt ctccattcag atgacgcaaa attacccccc
     1021 ggccatcaag tacccggacc atctccacat ctccacttcg ccgtgctgag gctggagtcc
     1081 ctccctttcc tctttctccc tcccctctcc cgcgcctcac ccatgaagcc ccaattcctt
     1141 aaggaactct aggctgaagg atgctgtgcc atctccaagt tcctacccat catcctcatt
     1201 tcaacggctc cacccttttt ccaatctctc ctcactgatt cattatactt ccaaattatt
     1261 ccttcctcac ctcgcccccg tgagcccgcc cctttccctt aggtccctcc ccaccggtta
     1321 attccaaccg agtttactat cttctggtgg tatcttgcac ctagctcccc caactccgcc
     1381 agactcccgc ttccggtagg ggtgctgggt tggagagtgg gtgtagcagc cactggaatg
     1441 ccctggaact cccgctccat tctctttgca caccaccagg tgccctgcag gtcgctggtg
     1501 gcggcgggtg gggatgagct tgctctgcct acagggatat gactatgact gaccatgacc
     1561 tttctgttgc ctttccggga ctccattttc tctcttttct cctctggaag gtgaccttct
     1621 gtctttcttc taatgtattc ttcttcttcc tccccccact tcctcctcct cctccgcctt
     1681 tccctctccc acctcctctt cccatttatc ttttcctccc tccacctgct cacccgaagc
     1741 ccctaggtgc atccagcctc tcacaccaaa caaggatggg accccagggt ggagggaggt
     1801 tccctcatgc tatctccact cctgtgcccg cctcttcccc ctcgaggttc cttcggggga
     1861 gggaggggca gtagcggggg ttaacacccc ccaaaacctc cgtcttccat tttctggtac
     1921 tccctctcat ccatgtccct cttcccacct caaatcccca aactctggcc tctttcaagg
     1981 gcccgttctc ccccttggac agattggggg ggggcggggg aggtcgccag aaaaccgccc
     2041 atcccactcc ctttattagg ggaggagggc gaggtagcac agtgttaaca cacacggaac
     2101 cagaacggcc ccggggtggg gggagggggc aggggaggga cgggggcttt tagtttgcat
     2161 cttagggggg aggggggagg gagaacagca gcagttataa cctgtcttta cgcagcgatt
     2221 tttaatgagt ctgggggagg ggggagggaa gcaataaggg tggggaaccg gtggggtggg
     2281 gggcctggct ctgttattta ccgtgtatca tatgtaaata tcaataaact ttatttcaaa
     2341 ca
//
