LOCUS       NM_001199301            3771 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, gamma subunit 5
            (Cacng5), transcript variant 1, mRNA.
ACCESSION   NM_001199301
VERSION     NM_001199301.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3771)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3771)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 3771)
  AUTHORS   Moss,F.J., Viard,P., Davies,A., Bertaso,F., Page,K.M., Graham,A.,
            Canti,C., Plumpton,M., Plumpton,C., Clare,J.J. and Dolphin,A.C.
  TITLE     The novel product of a five-exon stargazin-related gene abolishes
            Ca(V)2.2 calcium channel expression
  JOURNAL   EMBO J 21 (7), 1514-1523 (2002)
   PUBMED   11927536
REFERENCE   4  (bases 1 to 3771)
  AUTHORS   Chu,P.J., Robertson,H.M. and Best,P.M.
  TITLE     Calcium channel gamma subunits provide insights into the evolution
            of this gene family
  JOURNAL   Gene 280 (1-2), 37-48 (2001)
   PUBMED   11738816
REFERENCE   5  (bases 1 to 3771)
  AUTHORS   Burgess,D.L., Davis,C.F., Gefrides,L.A. and Noebels,J.L.
  TITLE     Identification of three novel Ca(2+) channel gamma subunit genes
            reveals molecular diversification by tandem and chromosome
            duplication
  JOURNAL   Genome Res 9 (12), 1204-1213 (1999)
   PUBMED   10613843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034065.1 and AK032548.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034065.1, AK032260.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1625              AK034065.1         2-1626
            1626-3771           AK032548.1         1534-3679
FEATURES             Location/Qualifiers
     source          1..3771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.44 cM"
     gene            1..3771
                     /gene="Cacng5"
                     /note="calcium channel, voltage-dependent, gamma subunit
                     5"
                     /db_xref="GeneID:140723"
                     /db_xref="MGI:MGI:2157946"
     exon            1..156
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            157..392
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1024
                     /gene="Cacng5"
                     /note="neuronal voltage-gated calcium channel gamma-5
                     subunit; TARP gamma-5; transmembrane AMPAR regulatory
                     protein gamma-5"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-5
                     subunit"
                     /protein_id="NP_001186230.1"
                     /db_xref="CCDS:CCDS25572.1"
                     /db_xref="GeneID:140723"
                     /db_xref="MGI:MGI:2157946"
                     /translation="MSACGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGIILPQ
                     NQSTEVKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNSQMTSESTVNVLKMIRSATP
                     FPLVSLFFMFIGFILSNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEM
                     LNRTKDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMYRPHPGFYR
                     PRLSNCSDYSGQFLHPDAWIRGRSPSDISSDASLQMNSNYPALLKCPDYDQMSSSPC"
     exon            393..479
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            480..620
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            621..766
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     exon            767..3771
                     /gene="Cacng5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3683..3688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng5"
                     /note="hexamer: TATAAA"
     polyA_site      3705
                     /gene="Cacng5"
                     /note="major polyA site"
ORIGIN      
        1 agtccagtgt tccagcggcg gccacccgca cggtagctgg cgcagagcag ctccggcgga
       61 ccggacgggg cgggcgtccg gcaagcagcg cggcaccttt caccgcgcgc agcccacaag
      121 ggaccttcca ggcgagtctg gggtcgtgac cgtgagccca ttctgcactc cttgctgccc
      181 atcaccatcc aggaagatga gcgcctgtgg gaggaaggcc ctgaccctgc tgagcagcgt
      241 ctttgccgtc tgcggcctgg ggctgctggg tatcgcggtc agcacggact actggctcta
      301 cctggaagaa ggcataatcc tcccacagaa ccagagcaca gaggtcaaga tgtccctgca
      361 ctcgggcctc tggcgggtct gcttcctcgc tggtgaggag cgaggacgct gttttaccat
      421 agagtatgtg atgcccatga actcccagat gacgtcagaa tccactgtca atgttctaaa
      481 aatgattcgc tcagccacgc cgttccccct cgtcagcctc ttcttcatgt tcattgggtt
      541 tatcctgagc aacatcgggc acatccgtcc gcaccggacc atactggcct ttgtctccgg
      601 catcttcttt atcctctctg gcctctctct tgtggtgggc ctggtgctgt acatctccag
      661 catcaatgac gagatgctca acagaaccaa ggatgcagag acctatttca actacaagta
      721 tggatggtca tttgcctttg ctgccatctc cttcctttta acagagagtg ctggggtgat
      781 gtctgtgtac ctgttcatga agaggtacac tgctgaggac atgtacagac ctcacccagg
      841 cttctaccgg ccacgtctga gcaactgctc cgattactct ggccagtttc tacatccaga
      901 tgcctggatc cggggccgca gcccctcgga catctccagc gacgcctcgc tacagatgaa
      961 cagcaactac ccagctttgc tcaagtgccc agactatgac cagatgtcat catctccctg
     1021 ctgagccagc cccagcctcc tccccacctg aactgtggat ggctggacag cgttcccctc
     1081 tccccctgag ctaaggccca ggctgttccc tgcttagcca ttgttacttg accacatctt
     1141 ctccctgcac ccagagtagc tagcatcctt cggtgggcat cagagcctgg agtcagaggc
     1201 atgctgattg gctgagagca tgggtgaagc cccgcctcta gagtgccaat catagccacg
     1261 ggctccaggg atgccagcag cactccatgt tgtgctgtgc aggaagatgc ctgtgttcta
     1321 gttgagtttt gttcctgcac ttccaggtta gccaaggcca ggctggagtt gccaagtctc
     1381 tgatacagac aaaggcagac ttgaatgctt gcctaccagc ctggctctcc atccatgagc
     1441 tggactgtga gaccaaaagg tgattctgct cccgtggtct ggctggctca gaaatctcaa
     1501 gcagactgtt ccttttatgt catcggactc tctccacaaa acacatctct ctgtgtagca
     1561 ctgccctccc cccaggccct ggaccatcca gactttcatc cttctaaaac acagctgccc
     1621 tggtctggga ctaaggtaag tattcagcaa tgccaatgac gtcacaaagg tgttaatggc
     1681 ggaagatgtc ttaatacaca tgaccccttg ataagctatt tcatggggcc ttttgatgcc
     1741 ttaacccaaa gtagtgactg ataatgagaa atcaagaatt tgacagtttt gtgttcagag
     1801 cgccaagcac tgtgtacaac cctggggggt tgactttcag agaccctatt tccatcctag
     1861 gctctaagtt ctaatcgtgt agacaggttt ctgtaccgcc taagtacacc atagctgtaa
     1921 gctagatttg atggttcagt gcgttttgag cccaaacaag ctagatttcc ggatgatccg
     1981 gctgccctgc tgatggtgcc tgtgaacatc tggacgttgc caacttaatc ctaatatggg
     2041 aaagcatccg cttcccagtt tcatggcata tgtgggcaaa tcacgtgcct ccagagtgcc
     2101 agacaatgtg acaactgctt ccctgatggg aactcggagc tgggaggctg caggcacttc
     2161 tgagaagtcc acaaaactcc catagtcccc caggtgtcgg ctcagctgga ccattgttcg
     2221 ttctgagagc tgtgagaggc aagccaatgt ggcattctct gtgtggtgta tttttgccgg
     2281 gcccattctt gcctcgttct ctttaagatg ccaaatgtac ccgaatatac aaagccacag
     2341 tgggtgactt gcaggctctg gcaagtggca caggaaacca cacagctggc gcctacagaa
     2401 ggacgatgac tcagtcagca tggaagaggc cagaagttca atatcaagtt gtcagaggac
     2461 tgatctccga ggcatccgct cctggcttac agatggccgc cttcttgctg tgtgatcatg
     2521 tgctgcacct gagacctgag gctttttttt ttgcatattc aaattacctt ttaaaaggac
     2581 acaccagagg ctggggataa taactcagtt agtgagttct ggcctagcat gcatgaagcc
     2641 ctggatttga ccgaacactg tataatccag gtgtggtggt atacattagt aatcctaaca
     2701 cttggaatgc agaggcagaa acatcttcaa ggtcactctc aactacgcag ctagtttgag
     2761 actaacctgg gctgcatgcg actaacctgg gctacgtgag actatgtctc aagaaatttt
     2821 aaaatcaggt atggattaga gctcattcca ataaattcaa tgatcactat taataactat
     2881 gaatataatc atttaagtac ccatgtacaa ttatattcac attctgaggt accggagatt
     2941 ggggtctcag agtacaaatc tgggagaggg cacggctcag cccctaacat gcagattgct
     3001 ttgtagatat tactccatca gtgtcacaga gagtggaggg gaaagagaag cttacttttg
     3061 cctgtcggtt cagtccctga gtcaatcctt gggcgaaccc tccagttctg aaatgctcag
     3121 ctgggactgc ctccacacat cccctccaca gccacagcca cacctccagt gatccagtcc
     3181 acattgttct tgtgtgccag tttctgtatc ttcctgtgat gtgagggcgg cgggcagccc
     3241 tggcttcccg cttcttgggt gtctcgcaat ggctgtggtt cacttttgcc gctgttttcc
     3301 agagtctgtt tggagacggc taagaggtat tttcaagctg gatgcgcgtc tgggtgcgct
     3361 cgactccaac ttttgtcaat gttattaaca cctgtgatgt acttttctct ctctaaaaca
     3421 cttctctatc accgtgccag gcttgcttgt gtacacaagg aaaaaaaaca gaatctaatc
     3481 ctccctgtaa gctgactgcc gaccgtgtgt tgttagagca tgctatctcc agtctgaggc
     3541 tgagctgtca agtccaaggg cgttcccacc ctggaatggg tcatgcgcac ttactgtagt
     3601 aatgggtctg ggtccctttc ttccccatga ggggatggga gaatgtatca acacatacca
     3661 ccatcataat ttcttttcca tctataaacc gatttcaaaa aactattcat tgtctttcct
     3721 tggacaaaat atttgtatca cacactcaaa tgtataaacc cagctcttgt c
//
