LOCUS       NM_019431               3649 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, gamma subunit 4
            (Cacng4), mRNA.
ACCESSION   NM_019431
VERSION     NM_019431.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3649)
  AUTHORS   Luan,C., Ye,Y., Singh,T., Barghouth,M., Eliasson,L., Artner,I.,
            Zhang,E. and Renstrom,E.
  TITLE     The calcium channel subunit gamma-4 is regulated by MafA and
            necessary for pancreatic beta-cell specification
  JOURNAL   Commun Biol 2, 106 (2019)
   PUBMED   30911681
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3649)
  AUTHORS   Schwenk,J., Harmel,N., Brechet,A., Zolles,G., Berkefeld,H.,
            Muller,C.S., Bildl,W., Baehrens,D., Huber,B., Kulik,A., Klocker,N.,
            Schulte,U. and Fakler,B.
  TITLE     High-resolution proteomics unravel architecture and molecular
            diversity of native AMPA receptor complexes
  JOURNAL   Neuron 74 (4), 621-633 (2012)
   PUBMED   22632720
REFERENCE   3  (bases 1 to 3649)
  AUTHORS   Menuz,K., Kerchner,G.A., O'Brien,J.L. and Nicoll,R.A.
  TITLE     Critical role for TARPs in early development despite broad
            functional redundancy
  JOURNAL   Neuropharmacology 56 (1), 22-29 (2009)
   PUBMED   18634809
REFERENCE   4  (bases 1 to 3649)
  AUTHORS   Matsuda,S., Miura,E., Matsuda,K., Kakegawa,W., Kohda,K.,
            Watanabe,M. and Yuzaki,M.
  TITLE     Accumulation of AMPA receptors in autophagosomes in neuronal axons
            lacking adaptor protein AP-4
  JOURNAL   Neuron 57 (5), 730-745 (2008)
   PUBMED   18341993
REFERENCE   5  (bases 1 to 3649)
  AUTHORS   Milstein,A.D., Zhou,W., Karimzadegan,S., Bredt,D.S. and Nicoll,R.A.
  TITLE     TARP subtypes differentially and dose-dependently control synaptic
            AMPA receptor gating
  JOURNAL   Neuron 55 (6), 905-918 (2007)
   PUBMED   17880894
REFERENCE   6  (bases 1 to 3649)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   7  (bases 1 to 3649)
  AUTHORS   Letts,V.A., Mahaffey,C.L., Beyer,B. and Frankel,W.N.
  TITLE     A targeted mutation in Cacng4 exacerbates spike-wave seizures in
            stargazer (Cacng2) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (6), 2123-2128 (2005)
   PUBMED   15677329
REFERENCE   8  (bases 1 to 3649)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 3649)
  AUTHORS   Klugbauer,N., Dai,S., Specht,V., Lacinova,L., Marais,E., Bohn,G.
            and Hofmann,F.
  TITLE     A family of gamma-like calcium channel subunits
  JOURNAL   FEBS Lett 470 (2), 189-197 (2000)
   PUBMED   10734232
REFERENCE   10 (bases 1 to 3649)
  AUTHORS   Burgess,D.L., Davis,C.F., Gefrides,L.A. and Noebels,J.L.
  TITLE     Identification of three novel Ca(2+) channel gamma subunit genes
            reveals molecular diversification by tandem and chromosome
            duplication
  JOURNAL   Genome Res 9 (12), 1204-1213 (1999)
   PUBMED   10613843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645853.12 and AL645947.9.
            
            On Jun 19, 2019 this sequence version replaced NM_019431.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.643023.1, BC138506.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-462               AL645853.12        34517-34978         c
            463-546             AL645947.9         216061-216144       c
            547-687             AL645947.9         210867-211007       c
            688-3649            AL645947.9         206497-209458       c
FEATURES             Location/Qualifiers
     source          1..3649
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.29 cM"
     gene            1..3649
                     /gene="Cacng4"
                     /note="calcium channel, voltage-dependent, gamma subunit
                     4"
                     /db_xref="GeneID:54377"
                     /db_xref="MGI:MGI:1859167"
     exon            1..462
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
     exon            463..546
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
     exon            547..687
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
     exon            688..3649
                     /gene="Cacng4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng4"
                     /note="hexamer: AAGAAA"
     polyA_site      2153
                     /gene="Cacng4"
                     /note="major polyA site"
     polyA_site      2158
                     /gene="Cacng4"
     regulatory      3627..3632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng4"
                     /note="hexamer: AATAAA"
     polyA_site      3647
                     /gene="Cacng4"
ORIGIN      
        1 agcccgcccg gcggcccgcg tagcccgcgc agccctcact cgccgccgcg cctcggagtt
       61 tgagccccgc gcagccggag cgcaggcacg cccggggcgc ggggtcggag cgcgcagcgc
      121 ggcgccgccc cccggccctc ggccccccag cccctggagc ccccggagcc gcgcgccgag
      181 ggaggagggc gggcgggcgc ggcgggccgg gccggcgggc ggcggactat gaggcgccca
      241 ccatggtgcg atgcgaccgc gggctgcaga tgctgctgac cacggccgga gccttcgccg
      301 ccttctcgct catggccatc gccatcggca ccgactactg gctgtactcc agcgcgcaca
      361 tctgcaacgg caccaacctg accatggacg acgggccccc gccccgccgc gctcgcggcg
      421 acctcaccca ttcgggactg tggcgggtgt gttgcatcga aggcatctat agagggcact
      481 gcttccggat caaccacttc ccagaggaca atgattacga ccacgacagc tccgagtacc
      541 tcctccgcat tgtgcgagcc tccagtgtct ttcccatcct cagcaccatt ctgctcctgc
      601 tcggagggct ctgcatcggc gctgggagga tctacagccg caagaacaat attgtcctca
      661 gcgcgggaat cctctttgtg gcggcaggcc tcagtaatat catcggtatc atcgtctaca
      721 tttccagcaa cacgggcgac cccagtgaca aacgtgacga agacaaaaag aaccattaca
      781 actacggctg gtctttttac tttggagccc tgtcgtttat tgtggcggag accgtgggcg
      841 tcctggctgt aaacatttac attgagaaaa ataaagagtt gaggtttaag accaagcggg
      901 agttccttaa ggcctcttcc tcctctcctt acgccaggat gccgagctac aggtaccggc
      961 gacggcggtc caggtccagt tcaaggtcca cggaggcctc accctccagg gatgcatctc
     1021 ccgtgggcct gaagatcacc ggagccattc ccatgggtga gctgtccatg tacacgctat
     1081 ccagagaacc ccttaaggtg accacagctg cgagctacag tccggaccag gacgctggct
     1141 tcctgcagat gcatgacttc ttccaacagg acctaaagga aggtttccat gtcagcatgc
     1201 tgaaccggcg gacgactccc gtgtgacccg cccacccctc tcggcacagg cctcccccaa
     1261 ggtggctgtt tgtgtgacac agaacagggt gacccttaag attatagaca gtgaagtgga
     1321 gctgagtgcg atcctccctg gcctccagaa gacgccatgg gctagctcag agtgagggga
     1381 gtctggagat tggaatcagg gataaggtag aaacagaagg ctgactttct cccgaggtag
     1441 gctgttctgc tgccctctgg gtttttggaa cttctcaaga ggcccaagaa ttttcaagaa
     1501 gctgcatcag cctgcctctt gggaaccaag aaaccagtca tgccagatgt caaacgcatc
     1561 ctccctcgct gggcactggg ccacagggag gcttcttccg ggcactggga cctctggcct
     1621 cccatcgact gtttcctgcc cagatgttcc tgtgtcctgg agcccaacat gagcctaagc
     1681 tcattccatt cccctctgtg tctccctcag cctctgtctg gccccctggt ggagctggtg
     1741 gttgtaaata tcacccattc tgaagagaaa gctctatggc taactggtgc ttcggcctcg
     1801 agctgtcctg gggcctgctg ctctccacct caggagatca ggaaaccagg gcaaattcgg
     1861 aggctctgct ggctttcata cctgcttctg gaagtttccg ctgagctcag aatgtacagg
     1921 acatactgac taatcttgga ggtccagagg gtttcacgga tctgagggat ggtgggcatg
     1981 tggcctttga ctctgtcctt ccacactggc ctgaggaacc actctgtccc ctgagggccc
     2041 tgctggggca cggagccata ctcccacttc caacctggtg ttctgacaca gatgtacaag
     2101 cttaaagatt tgaaagggaa acctgagagt gaacagagga aagaaagaaa gaaggaaaga
     2161 aggaaaggaa gaaaggaaga aaggaagaaa ggaagaaagg aagaaagaaa gaaagaaaga
     2221 aagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagaaagaaa gagcatcatt
     2281 ttccaagtgg ttatgagggt ggcatactga agaacatcgt cagaagacca agctgtactc
     2341 acctctttat cctgaaaaag agcaacacca cctcccctca actcctgcca ttataattta
     2401 ttctgcccac accaggactc ggtgagcatt tgactcaagg tgccatgctg ggctttctgt
     2461 ctttgcctga atccaagaat gtgttctgtg tcctacagtt tgtccaacca atccccctct
     2521 tcctcaaggc ggacgaaaaa taaataaata accagatgag tgtgtccagg ttcgaaagaa
     2581 ctctccagaa agtgaaactc accctctttt ctataacacg cgtgctttct aaagatcagt
     2641 cgtttcttac tttttgagac ttcttaatcc acttttgaac agtagtctgc tgtgaccccg
     2701 gtaactgtct tacttagaag tgacaacacg ccaattctta cctcagtcac ctgctcgtgg
     2761 agccccccga cccccacccc ctaggctaac tcggagttca gacgcaggtc catctgtcct
     2821 ttcctgcccc cgccccacca ccggaagaag acaacccata tcctagctcc agccggttgc
     2881 ctatgagatg gtgagctgag acatgagcat gccaaggctc ctttgcctgc tcagaaccat
     2941 gccctcctgg ccaggttggc tcctcagtat gtgtccaagc atgtgccgca aatgagcgcc
     3001 aatgtcaaga catgtgtggt ctgtccctgc tgcaggccct ctccctgcct acctccccac
     3061 ccaccctccc ctctcctcta ccaccattat tacatctaac aaggctgaag gaagccccag
     3121 cccccaggga gacccaggag ctgtcccatg tctcttctgg caatagagca gcagcctgtg
     3181 gtaaacttcc atgcaagcta ccaccatccc aactgtggtc ccagaagttt ccatgattcc
     3241 acctaaaaaa gctgtgttcc gatgactcct acctcttgtc cggttccagg cagagtgcac
     3301 aggcccactc cagggaccaa gaaggagata ggaagaagag agacgggggt agaacccagg
     3361 gagaaggcct cagtggcccc agcccttgca accttcctcc tgctgactgc cggcctcact
     3421 ctggagaact tggtctccag ctttgctctc cctatgagac aaagggagta gaactggacc
     3481 ttcctgctga caggctcagg tctgagccca ccttcctacc cttcttctgt cccaacccct
     3541 ccccaatgtg tttcaccagt taagcccctg tgactctgta cccatcaatg gtttgggatt
     3601 gttagttctg tctttttttt taatgaaata aaaacatttt taaaatgtt
//
