LOCUS       NM_007583               2887 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, gamma subunit 2
            (Cacng2), mRNA.
ACCESSION   NM_007583 NM_175346
VERSION     NM_007583.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2887)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2887)
  AUTHORS   Stincic,T., Gayet-Primo,J., Taylor,W.R. and Puthussery,T.
  TITLE     TARPgamma2 Is Required for Normal AMPA Receptor Expression and
            Function in Direction-Selective Circuits of the Mammalian Retina
  JOURNAL   eNeuro 10 (8) (2023)
   PUBMED   37491367
  REMARK    GeneRIF: TARPgamma2 Is Required for Normal AMPA Receptor Expression
            and Function in Direction-Selective Circuits of the Mammalian
            Retina.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2887)
  AUTHORS   Hassan,M., Grattan,D.R. and Leitch,B.
  TITLE     Developmental Inhibitory Changes in the Primary Somatosensory
            Cortex of the Stargazer Mouse Model of Absence Epilepsy
  JOURNAL   Biomolecules 13 (1), 186 (2023)
   PUBMED   36671571
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2887)
  AUTHORS   Hassan,M., Adotevi,N.K. and Leitch,B.
  TITLE     Altered GABAA Receptor Expression in the Primary Somatosensory
            Cortex of a Mouse Model of Genetic Absence Epilepsy
  JOURNAL   Int J Mol Sci 23 (24), 15685 (2022)
   PUBMED   36555327
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2887)
  AUTHORS   Schirmer,C., Abboud,M.A., Lee,S.C., Bass,J.S., Mazumder,A.G.,
            Kamen,J.L. and Krishnan,V.
  TITLE     Home-cage behavior in the Stargazer mutant mouse
  JOURNAL   Sci Rep 12 (1), 12801 (2022)
   PUBMED   35896608
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2887)
  AUTHORS   Qiao,X., Hefti,F., Knusel,B. and Noebels,J.L.
  TITLE     Selective failure of brain-derived neurotrophic factor mRNA
            expression in the cerebellum of stargazer, a mutant mouse with
            ataxia
  JOURNAL   J Neurosci 16 (2), 640-648 (1996)
   PUBMED   8551348
REFERENCE   7  (bases 1 to 2887)
  AUTHORS   Qiao,X. and Noebels,J.L.
  TITLE     Developmental analysis of hippocampal mossy fiber outgrowth in a
            mutant mouse with inherited spike-wave seizures
  JOURNAL   J Neurosci 13 (11), 4622-4635 (1993)
   PUBMED   8229188
REFERENCE   8  (bases 1 to 2887)
  AUTHORS   Buchhalter,J.R.
  TITLE     Animal models of inherited epilepsy
  JOURNAL   Epilepsia 34 Suppl 3, S31-S41 (1993)
   PUBMED   8500431
  REMARK    Review article
REFERENCE   9  (bases 1 to 2887)
  AUTHORS   Qiao,X.X. and Noebels,J.L.
  TITLE     Genetic and phenotypic heterogeneity of inherited spike-wave
            epilepsy: two mutant gene loci with independent cerebral
            excitability defects
  JOURNAL   Brain Res 555 (1), 43-50 (1991)
   PUBMED   1933329
REFERENCE   10 (bases 1 to 2887)
  AUTHORS   Noebels,J.L., Qiao,X., Bronson,R.T., Spencer,C. and Davisson,M.T.
  TITLE     Stargazer: a new neurological mutant on chromosome 15 in the mouse
            with prolonged cortical seizures
  JOURNAL   Epilepsy Res 7 (2), 129-135 (1990)
   PUBMED   2289471
  REMARK    Erratum:[Epilepsy Res 1992 Mar;11(1):72]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589650.20 and BC103563.1.
            
            On Nov 2, 2007 this sequence version replaced NM_007583.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF077739.1, AK045362.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-319               AL589650.20        18360-18678
            320-1443            BC103563.1         1-1124
            1444-2887           AL589650.20        142574-144017
FEATURES             Location/Qualifiers
     source          1..2887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 36.92 cM"
     gene            1..2887
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="calcium channel, voltage-dependent, gamma subunit
                     2"
                     /db_xref="GeneID:12300"
                     /db_xref="MGI:MGI:1316660"
     exon            1..600
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..1361
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="neuronal voltage-gated calcium channel gamma-2
                     subunit; TARP gamma-2; transmembrane AMPAR regulatory
                     protein gamma-2"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-2
                     subunit"
                     /protein_id="NP_031609.1"
                     /db_xref="CCDS:CCDS27608.1"
                     /db_xref="GeneID:12300"
                     /db_xref="MGI:MGI:1316660"
                     /translation="MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKS
                     VSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVR
                     ASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISAN
                     AGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYL
                     QASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGVKGFNTLPSTEISMYTLSRD
                     PLKAATTPTATYNSDRDNSFLQVHNCIQKDSKDSLHANTANRRTTPV"
     exon            601..684
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /inference="alignment:Splign:2.1.0"
     exon            685..825
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /inference="alignment:Splign:2.1.0"
     exon            826..2887
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1659..1664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="hexamer: ATTAAA"
     regulatory      1671..1676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="hexamer: AATAAA"
     polyA_site      1678
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="major polyA site"
     polyA_site      1692
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="major polyA site"
     regulatory      1724..1729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="hexamer: AATAAA"
     polyA_site      1754
                     /gene="Cacng2"
                     /gene_synonym="B230105C07Rik; B930041E13Rik; stargazer;
                     stargazin; stg; wag; waggler"
                     /note="major polyA site"
ORIGIN      
        1 gaattcggct gtaccctggc gcgctgtgga agccatctcc aaattagcga tcacatatgg
       61 aaactggaga ccagaatttt aggaaaagag attaaggcat ctcacttggg ggggtggggg
      121 ggtgtctttt tatttatttt cccttttttt aaaaaaatcg ctgcaactgg aacagttttt
      181 tgatctcaaa aggcaagcct ctcttcccgt gtgatcttta taatttacac acttttccgt
      241 gagctttctt atctcccttt ttttatatct ctccatattc tctattcaca catatatcca
      301 ttatattagt agtggaatta ccaatcgcac cctcacacac acgctcctga gaaccagaag
      361 tcggttgggt gtttatataa tgaagaatta tggggctgtt tgatcgaggt gttcaaatgc
      421 ttttaaccac cgttggtgct ttcgctgcct tcagcttgat gaccatcgct gtgggaaccg
      481 actattggct gtactccaga ggggtttgca agaccaaaag tgtcagtgag aatgaaacca
      541 gcaagaagaa cgaggaagtt atgacccatt ccggattatg gagaacctgc tgcctcgaag
      601 ggaacttcaa aggtctgtgc aagcaaatcg accactttcc ggaagacgcg gactacgaag
      661 ctgacaccgc agagtatttc ctccgggccg tgagggcctc gagtatcttc ccgatcctga
      721 gtgtgatcct gcttttcatg ggtggcctct gcatcgcggc gagcgagttc tacaagacac
      781 gccacaacat catcctgagt gctggcatct tcttcgtgtc tgcaggtctt agtaatatca
      841 tcgggatcat cgtgtatata tcagccaatg ctggagaccc ctccaagagt gactccaaaa
      901 agaacagcta ctcctacggc tggtccttct acttcggggc cctgtccttc atcatcgccg
      961 agatggtcgg ggtgctggcc gtgcacatgt ttatcgaccg ccacaaacag ctgcgggcca
     1021 cggcccgcgc caccgactac ctccaggcct ccgccatcac ccgcatcccc agctaccgct
     1081 accgctacca gcgccgcagc cgctccagct cgcgctccac cgagccctct cactccagag
     1141 acgcctcgcc cgtgggcgtg aagggcttca acaccctgcc gtccacggag atctccatgt
     1201 acaccctcag tagggacccc ctgaaggctg ccaccacgcc caccgccacc tacaactcgg
     1261 acagggataa cagctttctc caggtccaca actgtatcca gaaggacagc aaggactctc
     1321 tccacgccaa cacagccaac cgccggacca cgcccgtatg aagaccgtgg gacgggggac
     1381 cctggggagg cttggcccgc gggcggggga gggaccacag cagccacggg gagaccttcc
     1441 atacgcaaaa aacaacaaac aagcaaacaa gcaaacgaac aaacaaacaa caaacaaaca
     1501 aaacaaaaaa caaaacaaaa aaaagagaaa aacatagcaa gtaaattaaa aaaaaaaaaa
     1561 gaacaaacta caagaagaac aaaatcaaaa ccacaggcta tgcgggggga aaatataacc
     1621 gagggaagac aaactttaaa caaagcaaga gggataaaat taaaatagaa aataaatcta
     1681 aaagaaaatg catgatttcc catgtaccat tattttaaca tttaataaaa accaatttaa
     1741 atgaaaaaat aaaagggaac caagataatg taaagcaaaa aaacaaaaaa caaaaaaaaa
     1801 aaataacaaa aaaataacaa aaaaatgagg aaagcaagag agtatttatt agggttttat
     1861 gttgcctttg ttttttgttt tcgggttttt ttgttttaac tgcagggaga gtttaaaaat
     1921 aaaaaaaata aaaataaatt aaaaaaaaaa cacccgcatt cttttccctt taaccccagc
     1981 gggccctgcc tcccggggag agtaaggggt agagactcag ggccctcggg gccaggggag
     2041 caatggtcac tgccaagccc cttgatccct ggctgggccc tgggatgctg gagaagttca
     2101 atggctctgc gaccaactct atccagcacc aataaggcag ttgcaggcct ccaggtgact
     2161 caagcccttg gtccgcccct gtctgttagg tgcctggagg tggcgcactt ggggctaccc
     2221 cgccccaggt tcccggtcct taatggtcct taatggccct taacccactg tgatgacttc
     2281 ctaggccttg aggaaaggga aggagaagga atggctgctg gtggctcaca gagaagccag
     2341 acccctggaa tcctcagggg gagccttggg gggtgggggg gcagtaaccc cgagctcctg
     2401 tccttggagg caggagacac ccacccccag gggatataga gcagccgtcc ctcctcaccc
     2461 ctcacctcag ggccactaga tgaccctggg gcgatggtgg acccccacac tcacaggccc
     2521 ccagacccct gggaagggga ctctttgacc ctttgggggt ccatggactc actgatgccc
     2581 ctctgggggc ccagggagcc caacaatgac attgcaaaaa ggtttctttt tacaaaagaa
     2641 aaaggaaaaa caagtggtga ttttttttaa aaaaaaagaa ttaaaaaaaa aaccacagac
     2701 tataaataaa tgtaaatata taataagtga atttacttgc aagaaaatca agtagtattt
     2761 ttttctttta attcttttcc agctttaaac tgtgaaaaaa atcggggtgg ggtgggggac
     2821 ttaaaattta gcagggaact tgtaaagaca aaacaaacaa acaaaaaaac aaatatagaa
     2881 atccatt
//
