LOCUS       NM_007582               1225 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, gamma subunit 1
            (Cacng1), mRNA.
ACCESSION   NM_007582
VERSION     NM_007582.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1225)
  AUTHORS   Okada,R., Fujita,S.I., Suzuki,R., Hayashi,T., Tsubouchi,H.,
            Kato,C., Sadaki,S., Kanai,M., Fuseya,S., Inoue,Y., Jeon,H.,
            Hamada,M., Kuno,A., Ishii,A., Tamaoka,A., Tanihata,J., Ito,N.,
            Shiba,D., Shirakawa,M., Muratani,M., Kudo,T. and Takahashi,S.
  TITLE     Transcriptome analysis of gravitational effects on mouse skeletal
            muscles under microgravity and artificial 1 g onboard environment
  JOURNAL   Sci Rep 11 (1), 9168 (2021)
   PUBMED   33911096
  REMARK    GeneRIF: Transcriptome analysis of gravitational effects on mouse
            skeletal muscles under microgravity and artificial 1 g onboard
            environment.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1225)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1225)
  AUTHORS   Dolphin,A.C.
  TITLE     Voltage-gated calcium channels and their auxiliary subunits:
            physiology and pathophysiology and pharmacology
  JOURNAL   J Physiol 594 (19), 5369-5390 (2016)
   PUBMED   27273705
  REMARK    Review article
REFERENCE   4  (bases 1 to 1225)
  AUTHORS   Bannister,R.A. and Beam,K.G.
  TITLE     Ca(V)1.1: The atypical prototypical voltage-gated Ca(2) channel
  JOURNAL   Biochim Biophys Acta 1828 (7), 1587-1597 (2013)
   PUBMED   22982493
  REMARK    Review article
REFERENCE   5  (bases 1 to 1225)
  AUTHORS   Gach,M.P., Cherednichenko,G., Haarmann,C., Lopez,J.R., Beam,K.G.,
            Pessah,I.N., Franzini-Armstrong,C. and Allen,P.D.
  TITLE     Alpha2delta1 dihydropyridine receptor subunit is a critical element
            for excitation-coupled calcium entry but not for formation of
            tetrads in skeletal myotubes
  JOURNAL   Biophys J 94 (8), 3023-3034 (2008)
   PUBMED   18192372
  REMARK    GeneRIF: Thus, we conclude that the alpha(2)delta(1)
            dihydropyridine receptor subunit is physiologically necessary for
            sustaining Ca(2+) transients in response to prolonged
            depolarization or repeated trains of action potentials.
REFERENCE   6  (bases 1 to 1225)
  AUTHORS   Ursu,D., Schuhmeier,R.P., Freichel,M., Flockerzi,V. and Melzer,W.
  TITLE     Altered inactivation of Ca2+ current and Ca2+ release in mouse
            muscle fibers deficient in the DHP receptor gamma1 subunit
  JOURNAL   J Gen Physiol 124 (5), 605-618 (2004)
   PUBMED   15504904
REFERENCE   7  (bases 1 to 1225)
  AUTHORS   Ursu,D., Sebille,S., Dietze,B., Freise,D., Flockerzi,V. and
            Melzer,W.
  TITLE     Excitation-contraction coupling in skeletal muscle of a mouse
            lacking the dihydropyridine receptor subunit gamma1
  JOURNAL   J Physiol 533 (Pt 2), 367-377 (2001)
   PUBMED   11389198
REFERENCE   8  (bases 1 to 1225)
  AUTHORS   Ahern,C.A., Powers,P.A., Biddlecome,G.H., Roethe,L., Vallejo,P.,
            Mortenson,L., Strube,C., Campbell,K.P., Coronado,R. and Gregg,R.G.
  TITLE     Modulation of L-type Ca2+ current but not activation of Ca2+
            release by the gamma1 subunit of the dihydropyridine receptor of
            skeletal muscle
  JOURNAL   BMC Physiol 1, 8 (2001)
   PUBMED   11495636
  REMARK    GeneRIF: the L-type Ca2+ channel function, but not the sarcoplasmic
            reticulum Ca2+ release triggering function of the skeletal muscle
            dihydropyridine receptor, is modulated by the gamma1 subunit
REFERENCE   9  (bases 1 to 1225)
  AUTHORS   Freise,D., Held,B., Wissenbach,U., Pfeifer,A., Trost,C.,
            Himmerkus,N., Schweig,U., Freichel,M., Biel,M., Hofmann,F., Hoth,M.
            and Flockerzi,V.
  TITLE     Absence of the gamma subunit of the skeletal muscle dihydropyridine
            receptor increases L-type Ca2+ currents and alters channel
            inactivation properties
  JOURNAL   J Biol Chem 275 (19), 14476-14481 (2000)
   PUBMED   10799530
REFERENCE   10 (bases 1 to 1225)
  AUTHORS   Wissenbach,U., Bosse-Doenecke,E., Freise,D., Ludwig,A.,
            Murakami,M., Hofmann,F. and Flockerzi,V.
  TITLE     The structure of the murine calcium channel gamma-subunit gene and
            protein
  JOURNAL   Biol Chem 379 (1), 45-50 (1998)
   PUBMED   9504716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099482.1.
            
            On Jul 13, 2005 this sequence version replaced NM_007582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099482.1, AK132580.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.29 cM"
     gene            1..1225
                     /gene="Cacng1"
                     /note="calcium channel, voltage-dependent, gamma subunit
                     1"
                     /db_xref="GeneID:12299"
                     /db_xref="MGI:MGI:1206582"
     exon            1..317
                     /gene="Cacng1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..757
                     /gene="Cacng1"
                     /note="dihydropyridine receptor gamma 1;
                     dihydropyridine-sensitive L-type, skeletal muscle calcium
                     channel subunit gamma"
                     /codon_start=1
                     /product="voltage-dependent calcium channel gamma-1
                     subunit"
                     /protein_id="NP_031608.1"
                     /db_xref="CCDS:CCDS25570.1"
                     /db_xref="GeneID:12299"
                     /db_xref="MGI:MGI:1206582"
                     /translation="MSQTKTAKVRVTLFFILVGGVLAMVAVVTDHWAVLSPHLEHHNE
                     TCEAAHFGLWRICTARVAVHNKDKSCEHVTPSGEKNCSYFRHFNPGESSEIFEFTTQK
                     EYSISAAAIAIFSLGFIIVGSICAFLSFGNKRDYLLRPASMFYAFAGLCLIVSVEVMR
                     QSVKRMIDSEDTVWIEHYYSWSFACACAAFILLFLGGLFLLLFSLPRMPQNPWESCMD
                     AEPEH"
     exon            318..392
                     /gene="Cacng1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..530
                     /gene="Cacng1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..1203
                     /gene="Cacng1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1182..1187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacng1"
                     /note="hexamer: AATAAA"
     polyA_site      1203
                     /gene="Cacng1"
                     /note="major polyA site"
ORIGIN      
        1 cgtagccact gccaccatct agctagctgc ctgggagaca ctgctgctgc cccctgccca
       61 gagcacccac acctcaacga ccgccatgtc acagaccaaa acagcgaagg ttcgtgtgac
      121 cctcttcttc atcctggtgg gcggggtgct cgccatggtg gccgtggtga ctgaccactg
      181 ggccgtgctg agtccacacc tggagcacca caatgaaacg tgcgaggcag cccactttgg
      241 cctctggagg atctgcaccg ctcgggttgc cgtgcacaac aaagacaaga gttgtgagca
      301 cgtcacacca tcaggggaaa agaactgctc ctacttcagg cacttcaacc caggggagag
      361 ctcggaaatc tttgaattca ccactcaaaa ggagtacagc atctcagcag cggccattgc
      421 catcttcagc ctcggcttca tcattgtggg ttccatctgc gcatttctgt ccttcgggaa
      481 taagcgtgat tacctgctga ggccagcatc catgttttat gccttcgcag ggctctgcct
      541 catcgtctcc gtggaggtca tgaggcagtc ggtgaagcgt atgattgaca gcgaggacac
      601 ggtctggata gagcactact attcgtggtc tttcgcctgt gcatgtgccg cgttcatctt
      661 gctcttcctc ggtgggctgt tcctcctgct cttctccctg cctcggatgc ctcagaaccc
      721 ctgggaatcc tgcatggacg ctgagccaga gcactagatc aaaccagagt ctttcggagg
      781 tgaggaggga gtttcacctc tgccctgacc tcttgtctct cacgtgtctc tccctctgag
      841 ctcctctaca aacagtgcac atggacacaa acgcagacct gcccagggtc agaggaagca
      901 ggccagcagg tatatgaaag ggccctcctc cgtgcctgcc ccagctcagg cttgcccacc
      961 atgcctgacg gctgtgacga tctggtctgg tcatctttag aaagcttccg ggaacagcct
     1021 gttctcattc tgcagttctg agcatcgcgg gtgtcctgag tcagctcctc ccccactctt
     1081 ctccgccatg atacgaaccc ctcctctgtg aactgaacat ctctccttgg cttccaggat
     1141 tcccaagaga catttttggc tggataggat ctgtggtttg aaataaaaga tctcggaaat
     1201 gttaaaaaaa aaaaaaaaaa aaaaa
//
