LOCUS       NM_001037099            7974 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, beta 4 subunit
            (Cacnb4), transcript variant 1, mRNA.
ACCESSION   NM_001037099
VERSION     NM_001037099.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7974)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7974)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7974)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 7974)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   5  (bases 1 to 7974)
  AUTHORS   Benedetti,B., Benedetti,A. and Flucher,B.E.
  TITLE     Loss of the calcium channel beta4 subunit impairs parallel fibre
            volley and Purkinje cell firing in cerebellum of adult ataxic mice
  JOURNAL   Eur J Neurosci 43 (11), 1486-1498 (2016)
   PUBMED   27003325
  REMARK    GeneRIF: Study demonstrates that the lack of the voltage-gated
            calcium channel beta4 subunit causes a decreased late development
            in cerebellar cortical networks, characterized by reduced parallel
            fibre-purkinje cell input, shorter purkinje cell dendrites and
            depressed purkinje cell output.
REFERENCE   6  (bases 1 to 7974)
  AUTHORS   Hosford,D.A., Clark,S., Cao,Z., Wilson,W.A. Jr., Lin,F.H.,
            Morrisett,R.A. and Huin,A.
  TITLE     The role of GABAB receptor activation in absence seizures of
            lethargic (lh/lh) mice
  JOURNAL   Science 257 (5068), 398-401 (1992)
   PUBMED   1321503
REFERENCE   7  (bases 1 to 7974)
  AUTHORS   Guillaume,D., Grisar,T. and Vergniolle-Burette,M.
  TITLE     Glial contribution to seizure: carbonic anhydrase activity in
            epileptic mammalian brain
  JOURNAL   Epilepsia 32 (1), 10-15 (1991)
   PUBMED   1898718
REFERENCE   8  (bases 1 to 7974)
  AUTHORS   Dung,H.C., Lawson,R.L. and Stevens,M.
  TITLE     A study of the increased serum level of IgG1 in 'lethargic' mice
            combined with a depressed thymus-dependent lymphoid system
  JOURNAL   J Immunogenet 4 (4), 287-293 (1977)
   PUBMED   410895
REFERENCE   9  (bases 1 to 7974)
  AUTHORS   Dung,H.C.
  TITLE     Deficiency in the thymus-dependent immunity in 'lethargic' mutant
            mice
  JOURNAL   Transplantation 23 (1), 39-43 (1977)
   PUBMED   13525
REFERENCE   10 (bases 1 to 7974)
  AUTHORS   Dung,H.C. and Swigart,R.H.
  TITLE     Histo-pathologic observations of the nervous and lymphoid tissues
            of 'lethargic' mutant mice
  JOURNAL   Tex Rep Biol Med 30 (1), 23-39 (1972)
   PUBMED   5037658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928960.25 and AL845467.3.
            
            On Jan 4, 2022 this sequence version replaced NM_001037099.2.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147338.1, SRR7974084.9616.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-310               AL928960.25        124028-124337       c
            311-394             AL928960.25        123485-123568       c
            395-514             AL845467.3         76433-76552
            515-637             AL845467.3         79259-79381
            638-768             AL845467.3         84637-84767
            769-845             AL845467.3         86924-87000
            846-865             AL845467.3         88331-88350
            866-946             AL845467.3         88566-88646
            947-1005            AL845467.3         89576-89634
            1006-1115           AL845467.3         98535-98644
            1116-1267           AL845467.3         102224-102375
            1268-1363           AL845467.3         104199-104294
            1364-1549           AL845467.3         117173-117358
            1550-7974           AL845467.3         119495-125919
FEATURES             Location/Qualifiers
     source          1..7974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 29.98 cM"
     gene            1..7974
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /note="calcium channel, voltage-dependent, beta 4 subunit"
                     /db_xref="GeneID:12298"
                     /db_xref="MGI:MGI:103301"
     exon            1..310
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1810
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /note="isoform a is encoded by transcript variant 1;
                     voltage-dependent L-type calcium channel subunit beta-4;
                     CAB4; calcium channel voltage-dependent subunit beta 4"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-4 isoform a"
                     /protein_id="NP_001032176.1"
                     /db_xref="CCDS:CCDS16034.1"
                     /db_xref="GeneID:12298"
                     /db_xref="MGI:MGI:103301"
                     /translation="MSSSYGKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSF
                     ILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSY
                     CGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIR
                     IQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTTTAKQKQKVTEHIPPYDVVPSM
                     RPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKR
                     AIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVK
                     VSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGE
                     YLEAYWRATHTSSSTPMTPLLGRNVGSTALSPYPTAISGLQSQRMRHSNHSTENSPIE
                     RRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSP
                     GGCSHDSRHRL"
     exon            311..394
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            395..514
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            515..637
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            638..768
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            769..845
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            846..865
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            866..946
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1005
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1115
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1267
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1363
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1549
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..7974
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4412..4417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /note="hexamer: AATAAA"
     polyA_site      4438
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /note="major polyA site"
     regulatory      7204..7209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /note="hexamer: CATAAA"
     polyA_site      7223
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /note="major polyA site"
     regulatory      7953..7958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
                     /note="hexamer: AATGAA"
     polyA_site      7974
                     /gene="Cacnb4"
                     /gene_synonym="3110038O15Rik; Cchb4; lh"
ORIGIN      
        1 acttctcccc gaggctcggg aaggcgacaa ccgagaagcc ccctctcctg gacctccagg
       61 agggcgcggg gggggggagg gaagcgcttc ggccccttta aggtgcggcg ctcggcgaag
      121 tgcgggcagg cggcccgcga gccggcgcgg ggccaggagc cgggtaggga agtcctgcct
      181 ccccctccac ccgcaccggc ccgcgccctc cgcccaccgc gctgcgaggg ccatgcggcg
      241 cctctgaacc atgtcgtcct cgtacggcaa gaacggggcg gcggacgggc cgcactcccc
      301 cagctcacag gtggcccgag gcaccacgac ccggaggagc aggttgaaaa gatcggatgg
      361 cagcaccact tctaccagct tcatcctcag acaggggtca gcagattcct atacaagcag
      421 gccatcggac tccgatgtct ccttggaaga ggaccgggaa gcgatccggc aagagcgaga
      481 acagcaagca gctatccagc ttgagagagc gaagtccaaa cctgtagctt ttgcggtgaa
      541 aacgaacgtg agctactgtg gtgccctgga cgaagatgtg cccgttccca gcacagccat
      601 ctcctttgac gccaaggact ttcttcacat taaagagaaa tataacaatg attggtggat
      661 aggaagactg gtaaaagagg gctgtgagat tggcttcatc ccaagtccac tgcgcttgga
      721 gaatattcgg attcaacagg aacagaaaag aggccgtttt catggcggga aatcgagtgg
      781 aaactcttcc tccagtctgg gagaaatggt atcaggaaca ttccgagcaa ctcccacaac
      841 aacagcaaaa cagaagcaga aagtgacgga gcacattcct ccgtatgacg tcgtgccgtc
      901 aatgcgtcct gtggtgttag tggggccatc actgaaaggt tatgaggtaa cagacatgat
      961 gcagaaagcc ctctttgatt tcctgaagca caggtttgat gggaggatat caataacaag
     1021 agtgacagct gacatttctc ttgctaagag atctgtcctc aacaatccta gcaagagagc
     1081 aataattgaa cgttccaaca ccagatccag cttagcggaa gtacaaagtg aaattgaaag
     1141 aatttttgag ttggcaagat ctttgcaatt ggttgttctt gatgcagaca ccatcaacca
     1201 cccagcacag ctgataaaga catccttagc acccatcatc gtccacgtga aggtctcgtc
     1261 cccaaaggtt ttacagcggc tgattaagtc cagaggaaag tcccaaagca aacacttgaa
     1321 tgttcaactg gtggcggccg ataaactggc ccagtgcccg cctgaaatgt ttgatgttat
     1381 attagatgag aatcaacttg aggatgcctg tgaacatctg ggagagtacc tggaggcata
     1441 ctggcgtgcc acccacacga gcagtagcac ccctatgacc ccattactgg ggcggaacgt
     1501 gggctccaca gccctctcac catatcccac agcaatctct ggattacaga gtcagcgaat
     1561 gagacacagc aaccattcta cagagaattc tccaattgaa agacgaagcc taatgacctc
     1621 ggatgaaaat taccacaatg agagggcccg caagagtagg aaccgcttgt cttccagctc
     1681 ccagcacagc cgagaccact accctctggt ggaagaagat tacccggact cgtaccagga
     1741 cacttataag ccccatagga accgaggatc gcccgggggg tgcagccatg actcccgaca
     1801 taggctttga ggctgccgaa acaaacaaac aaacaaacaa acaaacatca tctgttgaca
     1861 atttgccata gtactgctat taaccagtca tcttaatttg gcaagcacag cacagtatct
     1921 gctgtgtggg tgggctgctg tcatttgatc ctaggggcaa gaattaaata gaagtacatt
     1981 atgcccttga gtctagatgg gtattagatg cccgatcata taggtatttt taagtgctac
     2041 atttacatga taacagtacc ttttgttttc ttcatagatt ttagacacat caatttgtaa
     2101 tttagggtac ttatcaaggc acatataaaa taatttcccg tgtaggaaat tccaaatgac
     2161 cagttccagt tggaaccaat ttataaacca attcctgttg gaatttgggt gaattgactg
     2221 gaaagtctac tagagcatgt tgaaatcaat tgaaaaatca gaaaaagaaa atatccaata
     2281 aagaaatcaa aatattaatt gaaaccaaac ccagctgtgg aatttatttg ctggaagcta
     2341 aatttacact tcaagttgga atgtataaac attttaataa tatgttaatg ctgccagaat
     2401 ggcttttcaa acttaccaaa tatattgata gtgccaaaaa aaatctcaga aatcttaatg
     2461 cagaaattat ataatcgcct cagattttaa tattcttatt tttcctgata cagctgttgt
     2521 attcaaagtg tttttgcctt ctgttcagtc agtactgtta gtcagtttga agttgacaaa
     2581 atccggggga tatttgagag tagtaaagtg aagcccaagc acgcccagtt ccggggaatg
     2641 gagaacgagg tgttgtttct tctgtagtcg gtctgcatac aactacacac atctggagct
     2701 ctgcagtcag ccagcagaga tgtggccaga gctcccggga tactgctgtg attggctctg
     2761 gatgggaagc tgtccttcct gctgcaccct gacacggctt agcagctcag ccagctgagg
     2821 atctatccct cagtccagcc agtctctgac tttggataga ataaatgtct tggccctaca
     2881 tcacacttct tttatttttc atgggcataa tcaaattagg tactgaaagt tatgttttta
     2941 caaaacaatt aggaaacgtt aaaacactga attaaaatct tgaaggaaaa aaaaaaccct
     3001 cacagattca aaatatattt attcactaaa agcagggcag ttttaatgca tgccattaga
     3061 gagagtttag agactgctcg gtttcattgc tagtgaacag cctttagatt tccaatgagt
     3121 gtatttatgg aattggtgac ctatgtccta tattgttaaa gaaggcttta atccaagaaa
     3181 ttattgaaat tgaccctttg aaacagatgt ctttatgaaa gggcttgcct ctgaaatgac
     3241 acatgcatgt gttttctaaa gacccaattt gagctagaca taaagtgtct ttctactaat
     3301 gccttgaagt caatttttaa aacaagtata attaatttta tgttaatttt ctccaaaaat
     3361 ttcaagacat gggcccctaa aactatgtac cagttcatta gttttcctga tcaagagtcc
     3421 aagtttcata ttcttaatca gttattcata tcttgaatcc caccaaacca ctgtcttgac
     3481 tgtatgtgca acccgttatg aacctgctta tctgataatg aggctgcctg aaattttgta
     3541 agtaatctca aacatttgat acatttaaac acgggctcag taaaattgac aagctaccat
     3601 ctgatacagg cttgtgaagc ccgagtgtca tccatcgagg cgtacagaat tttctgttaa
     3661 gacatttaac agagctgtat tcattgggct ctttaataag catataatct tccattactg
     3721 aagacttcgt tagaacacag aagagcattt tccagcaaac aaactatatt tattacatgt
     3781 atagcacata cttgcatgag aaagaaaaca ttagccaaac attttcctgt atgctttact
     3841 ggtttcttgt ttgtgcgcat taaagcattt aattgcagag agtgcacttg ggtgtataaa
     3901 tttagaatag attgctgttc agctttttct gcagtagcat tagcaatttg gtcatttaac
     3961 tactttaaga tatttctatt ttatggcggg tagctgtaac agcatttaca tatatttcct
     4021 agtcaacaag gctacctttc ctttcaactt tgaggggtca cttggttgtg aagcctctcc
     4081 agccttttcc tccctccccc ctcttttgct cttccatgtc atgctggaag acggaggccc
     4141 atgtaatttg tgcacaacac tcatccatca tctgccatca aaagtccata cctattttgc
     4201 tttgcagttc tattaaaaag ctagcaatgc tgggaaaggg taagatatat attcttgatg
     4261 aatatattca ccgtttcact tcaattttgc atatctttca tcttccttct gtaagcttct
     4321 ctccttcaaa tgacgaagag ataagattcc tcctctcttt gtaaaggctc agagttgctt
     4381 gtataaatga ctaaaatcca gatatatact aaataaaatg ttttattttt gccaagcata
     4441 ccaagaacct ctaggaaatg cctattccac aagtactttg cttcaattca ttttactcaa
     4501 aatggcaaat gatgacaagc aagagaaata tttctatatc atttgaggct attttcactt
     4561 atagaataga ccatgttaga attctatgag tttttatgat atataataat gcagactcat
     4621 gcaaacaatg tggaaatatg ttcctggaaa aagaagatat gctacttatg gtcttttggc
     4681 ttatttccaa gactataata tgactacaat atcataatca acactgttac cttgtttatg
     4741 ctaacactta acaacacata gtagtattta taaataactg tgattctctc ccatctttat
     4801 atggctctac tgggtagaag attggaatag ttagcaatta gactcatggt ctttcctaaa
     4861 gagtctcaac tgtgttacta tacaaatcac tacatcattt catccttgaa gggaaggaat
     4921 tttaaagtct gaaacgaatt gagacaatta tttgttccac tttgaatact ctgtgatttg
     4981 ctccaattat aattgctgtc tgcaaaaaaa aatgtatttt tagaatgtta acgtcttttc
     5041 atacctgcat acttgaactt gtcttttgtg tggggggcct taaatttcat agtagagaat
     5101 gggggcgtgg aaagggaatg aagacaaagg agctgtggta aaagacagtg cacactcttc
     5161 tactttcaat gaccatatcc caaaatgctg aggcacagtg tgtcagtgaa gaacgtttct
     5221 aggcaacctt gatttgcaag ctagtatatt ttcttacata attttatttt ggtatttgct
     5281 aaaaaaaaaa aaaaaaaaaa gaacacacaa taccaccata caaattgccc tctgtaatga
     5341 tagatatact acctcttttc tagagaaaac agtctatgtt tggaggggaa agtcctggtg
     5401 agagtgtcca ttctgccagc cgtgtgcggg gttggaagtg ttcagacacg cctgcccttt
     5461 agaggtcaca ctgttctcaa atgctcccag catgttctca tttcttcaac gtcagctagg
     5521 ttttcttgaa atcgatccac agcttctcat ggcgtgagtt taacaagaag ccatcctagg
     5581 gaacaaagca aagcgaaagg aactacctct gtgccaaatg tagcctctag ctcaggtcta
     5641 aggaagagaa atccagagac tagatgttta aaggcagagt tggttgatcc ttgacttcta
     5701 ggggtactaa gggcatgctg tggccactgg gtaaggatct gcattgtatg caactcccat
     5761 gtaattgcac caaacctcat atcaacattt caaatacatg attacatcac ctttactcct
     5821 ttatatttgc ctttgtctct catgacagtg ttacattttt aatgatatac atctaatcct
     5881 tgaatgactt gtatgagtaa aaactgcagg aaatcatgta ataaaatgtt tatcagttcc
     5941 ttacatcttt aaatattgtc aacactgtaa ctgttaagtt acttactcca gctgtgtcta
     6001 cctggcaaac aacagtcctt ttctttgaaa tgataatgat gatagaatca ggtaacttaa
     6061 gagctgctgg acagacatta agaataactt cttgttgagt taagcaatct ggtttatcaa
     6121 aatcgtaaaa ctggcttata tgggcagaca gctacagcat tcagaaatta ctctttaagg
     6181 tttcttcttt tgttaaaagg acctttctcc aatgaaataa tcctctgata gcaatgtctt
     6241 tacttgtgga taacttaaga caaaatgctg catgtaatga aggtgtatca tgagaaggtt
     6301 aggacgtatc tcatcagata atcttaatta agggctgtaa ctcctatttg ccataaatac
     6361 atatacataa gaggggatag tgctaactaa gacttgggga atcataactt ttcatgaaac
     6421 tttctttttg gtggatgtaa aatattcaca ggaagatgga agaaaatgtt accaatgaac
     6481 ttataatagc ttagggaatt cactgattct tcctcatttg aaagttataa agagttaaaa
     6541 tgagaactga gaagagtagc agatcgttag cgtttcaaga gtcttgggtt atattttaaa
     6601 tatttaaatc tcccaacaaa cagctcgatc tgtgtttacg caggggcctt tcttgccctg
     6661 cctgcatact actacataca cttcatggaa atcagtgtgg attccataca cacagggcat
     6721 cccggatgcg gggaaatcgc tgtgagttct gttcgcacag gggtgtcaca caggtggggg
     6781 tcattaacgc tatattgttg catactattt ttcatatgcc ttacaatatt ttctggaacg
     6841 ttattaaaac gaaagcattt tattgccaaa ataaatctat gttgttactt ctgcattagc
     6901 agtagaaaaa taatgtagca aaaatatata ttgtacagta caaaattata gtatatatat
     6961 atattttgcc aataaatgaa aatagattga ggagaaagaa gcacatttgt tatagcacaa
     7021 acttacaaca aaacccactg ttaaatttgg cagtcctgtt ttttagactt atgtagattt
     7081 ggttctctgt cttaccaatt tatttcatct ctcatatttg taattctgct gcttgatatt
     7141 ttccagcaat ttatttcata gccttgcaat ctgtgagtgt aatttactta ttttattcct
     7201 ttacataaaa catatgaact ttattttgtg ttacgactca tactatatta ttctattttc
     7261 tgttcctgtt tcttctcctt tggtaacaga tggcacagct ggtgagctcg cagggctcct
     7321 ctggcctttg gatgttcgaa agtttatgtt tttcccagcc tcaagttaga gatcagtaaa
     7381 atgtccccat ggaaaaatat taagtaggga ttatttttgt tttgttttgt tttgtacttg
     7441 atactatttg aagcataaat taaagctatt agctgtattt ttaagaggtg ggagggatta
     7501 aaaataatgt tattaatagg acacatacta aaaataacta tggcaaaatg atattaaaag
     7561 atacccccat tctgagggct gttgatatcc caggctattc ctgtgtctct gctgatgtgg
     7621 tgggggaaat gcctttgtca aataacttat tttcctttgc ttatttattt caataatttg
     7681 accctttcat ttttgttaca tagatatgcg tagcgttcta caaggcatgc tggggaaaat
     7741 acactatgca aatgtactgc atgctttgtt ctccctccgc ttagtggctt taaagaaaaa
     7801 aaatgtggtg ttatttttgt gaacaaagac atttaacaac aacaacaaca aaaaatgcag
     7861 agtgcatgaa tacagtatcc taatttctat gggttgtttt atggaattta aatgtgtaca
     7921 aaaactgcat taattttttc ttttatataa taaatgaaaa aaaaaacaca gaaa
//
