LOCUS       NM_001410382            2530 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, beta 3 subunit
            (Cacnb3), transcript variant 5, mRNA.
ACCESSION   NM_001410382 XM_006520360
VERSION     NM_001410382.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Martus,D., Williams,S.K., Pichi,K., Mannebach-Gotz,S., Kaiser,N.,
            Wardas,B., Fecher-Trost,C., Meyer,M.R., Schmitz,F., Beck,A.,
            Fairless,R., Diem,R., Flockerzi,V. and Belkacemi,A.
  TITLE     Cavbeta3 Contributes to the Maintenance of the Blood-Brain Barrier
            and Alleviates Symptoms of Experimental Autoimmune
            Encephalomyelitis
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (8), 1833-1851 (2024)
   PUBMED   38957986
  REMARK    GeneRIF: Cavbeta3 Contributes to the Maintenance of the Blood-Brain
            Barrier and Alleviates Symptoms of Experimental Autoimmune
            Encephalomyelitis.
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Woo,M.S., Ufer,F., Sonner,J.K., Belkacemi,A., Tintelnot,J.,
            Saez,P.J., Krieg,P.F., Mayer,C., Binkle-Ladisch,L., Engler,J.B.,
            Bauer,S., Kursawe,N., Vieira,V., Mannebach,S., Freichel,M.,
            Flockerzi,V., Vargas,P. and Friese,M.A.
  TITLE     Calcium channel beta3 subunit regulates ATP-dependent migration of
            dendritic cells
  JOURNAL   Sci Adv 9 (38), eadh1653 (2023)
   PUBMED   37729408
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Burgess,D.L., Biddlecome,G.H., McDonough,S.I., Diaz,M.E.,
            Zilinski,C.A., Bean,B.P., Campbell,K.P. and Noebels,J.L.
  TITLE     beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel
            subunit compositions in lethargic mouse brain
  JOURNAL   Mol Cell Neurosci 13 (4), 293-311 (1999)
   PUBMED   10328888
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Namkung,Y., Smith,S.M., Lee,S.B., Skrypnyk,N.V., Kim,H.L., Chin,H.,
            Scheller,R.H., Tsien,R.W. and Shin,H.S.
  TITLE     Targeted disruption of the Ca2+ channel beta3 subunit reduces N-
            and L-type Ca2+ channel activity and alters the voltage-dependent
            activation of P/Q-type Ca2+ channels in neurons
  JOURNAL   Proc Natl Acad Sci U S A 95 (20), 12010-12015 (1998)
   PUBMED   9751781
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Jones,J.M., Ranscht,B., Berglund,E.O., Gruenheid,S., Gros,P. and
            Meisler,M.H.
  TITLE     Close linkage of three neuronal genes on distal mouse chromosome 15
  JOURNAL   Mamm Genome 7 (9), 696-697 (1996)
   PUBMED   8703126
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Murakami,M., Wissenbach,U. and Flockerzi,V.
  TITLE     Gene structure of the murine calcium channel beta3 subunit, cDNA
            and characterization of alternative splicing and transcription
            products
  JOURNAL   Eur J Biochem 236 (1), 138-143 (1996)
   PUBMED   8617257
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Chin,H., Kwon,O.J., Jung,H.H., Kim,D.S. and Kozak,C.A.
  TITLE     Genetic mapping of the mouse genes encoding the voltage-sensitive
            calcium channel subunits
  JOURNAL   Genomics 28 (3), 592-595 (1995)
   PUBMED   7490102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156543.10.
            
            On Aug 6, 2022 this sequence version replaced XM_006520360.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3531604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC156543.10        31647-31790
            145-267             AC156543.10        38758-38880
            268-390             AC156543.10        39084-39206
            391-506             AC156543.10        39609-39724
            507-571             AC156543.10        39956-40020
            572-591             AC156543.10        40229-40248
            592-672             AC156543.10        40447-40527
            673-731             AC156543.10        40670-40728
            732-841             AC156543.10        40886-40995
            842-993             AC156543.10        41209-41360
            994-1089            AC156543.10        41579-41674
            1090-1239           AC156543.10        41772-41921
            1240-2530           AC156543.10        42509-43799
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.64 cM"
     gene            1..2530
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="calcium channel, voltage-dependent, beta 3 subunit"
                     /db_xref="GeneID:12297"
                     /db_xref="MGI:MGI:103307"
     exon            1..144
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1572
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="isoform 5 is encoded by transcript variant 5;
                     voltage-dependent L-type calcium channel subunit beta-3;
                     calcium channel voltage-dependent subunit beta 3"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-3 isoform 5"
                     /protein_id="NP_001397311.1"
                     /db_xref="GeneID:12297"
                     /db_xref="MGI:MGI:103307"
                     /translation="MSFSDSSATFLLNEGSADSYTSRPSLDSDVSLEEDRESARREVE
                     SQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDW
                     WIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLGDIGNRRSPPPSLAKQK
                     QKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTA
                     DLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHP
                     AQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDV
                     ILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQILCGPQNQQLLGE
                     RVEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTS
                     GLPSANGHDPQDRLLAQDSEHDHNDRNWQRNRPWPKDSY"
     exon            145..267
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            268..390
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            391..506
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            507..571
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..591
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            592..672
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            673..731
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            732..841
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..993
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1089
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1239
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..2530
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2510..2515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="major polyA site"
ORIGIN      
        1 aggcgtgcag gctggagcgg tgtgcagaga gacgcggctg ggtcccgctc ccgcctcgga
       61 gcccctggcc cgggggaggg agagaggccg ctaacccggt ctatgtcttt ttctgactcc
      121 agtgcaacct tcctgctgaa cgagggttca gccgactcct acaccagccg cccctctctg
      181 gactcagacg tctccctgga ggaggaccgg gagagtgccc ggcgagaagt ggagagtcag
      241 gctcagcagc agctggaaag agccaagcac aaacctgtgg catttgctgt gaggaccaat
      301 gtcagctact gtggggttct ggatgaggag tgcccggtcc agggctctgg agtcaacttt
      361 gaggccaaag attttctgca cattaaagag aagtacagca atgactggtg gatcgggagg
      421 ctagtgaaag agggcggaga catcgccttc atccccagcc cccaacgcct ggagagcatc
      481 cggctcaaac aggaacagaa ggccaggaga tctgggaacc cttccagcct gggtgacatt
      541 ggcaaccgac gctctcctcc tccgtctcta gccaagcaga agcaaaagca ggcggaacat
      601 gttcccccgt atgatgtggt gccctccatg cggcctgtgg tgctggtggg accctctctg
      661 aaaggctatg aggtcacgga catgatgcag aaggcgctct tcgacttcct taaacacagg
      721 tttgatggca ggatctccat cacacgcgtc acggccgacc tctcgctggc caagcgctct
      781 gtgctcaaca atcctggcaa gaggaccatc attgagcgct cctccgcccg ctccagcatt
      841 gctgaagtgc agagtgagat tgagcgcata ttcgagctgg ccaaatccct gcagctagtg
      901 gtgttggatg ctgacaccat caaccaccca gcacaacttg ccaagacctc actggctccc
      961 atcatcgtct ttgtcaaagt gtcctcgcca aaggtactgc agcgactgat ccgctccagg
     1021 ggaaagtcac agatgaagca cctcactgta cagatgatgg cgtacgataa gctggttcag
     1081 tgcccacccg agtcattcga cgtgattctg gatgagaacc agctagaaga tgcctgtgag
     1141 cacctggctg aatacttaga ggtttactgg cgagcgaccc accacccagc accgggcccc
     1201 ggactgctgg gtccgcctag tgccatccct ggacttcaga tcttgtgtgg cccccagaac
     1261 cagcagctgc tgggggagcg agtggaggag cactcacccc tggagaggga cagcctgatg
     1321 ccctcagatg aggccagcga gagctcccgc caggcctgga ccggatcttc acagcgcagc
     1381 tctcgccatc tggaggagga ctatgcagat gcctaccagg acctgtacca gcctcaccgc
     1441 caacacacct cggggctgcc cagtgctaac gggcacgacc cccaagaccg gctcctagcc
     1501 caggactcgg agcatgacca caatgaccgg aactggcagc gtaaccggcc ttggcccaag
     1561 gacagctact gaccacctcc tgccccaccc tggcaggcgc aggcacagcg gctggggtgt
     1621 ccacctcagg caggttggag ttagattggc attaggctgc cgttaggttc agctcacaca
     1681 accctctgcc cagccccagg tccagggctg actgtggtcc caaggttctg ggagaagcaa
     1741 ggggcccctc acctcctggg cacagtgacc ccgtaggttc tcatccgggt actagccgtg
     1801 ttctgcatcc ttggcacctc cccctgcata agctgccgcc cccgtgggca acaatctcag
     1861 gccaggatca cttagcaggg gccttccagc cagaatggat gcccctctaa agagcaagag
     1921 ggtgtgagtg tgggcaacat agcctgagga agaagaaact cggttcctaa gcaggcgtag
     1981 atcctaagca aagggactcc attcacgcca ctgccacaca tcagaaatga agcaatcaga
     2041 gctcaacatg gcggcacttc tgtcccatca gctggggtgg gcacttacac ctaagacagg
     2101 agcagtgcgg gtgaggcagg acagacagac tcacagctgt agctctgcta gaaaacggcc
     2161 cactcaccaa accgggacgc ttagcatctg gtgagactag ggaactgggg catattcaag
     2221 ccaagagcca gcctggactg cgggggaggg tgggacagct tccggccccc cttgctcttc
     2281 tcattctttg cccttgcatc tgtcatttct gtcctttccc tccatggctc ctgcaagata
     2341 ggggcttcct gactcatagc agccacttca gttagggtta gatgagagga acaggacaca
     2401 gtgaacagtc cccgaggctg tccacctggc tacccttgcc ttatggctct agcgtgtgac
     2461 ctacagagca tgctccatta agaacccgcc ccacctcatt gtcatctcca ataaaacacc
     2521 acgcacagtc
//
