LOCUS       NM_001286226            2738 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Mus musculus calcium channel, voltage-dependent, beta 3 subunit
            (Cacnb3), transcript variant 3, mRNA.
ACCESSION   NM_001286226
VERSION     NM_001286226.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Martus,D., Williams,S.K., Pichi,K., Mannebach-Gotz,S., Kaiser,N.,
            Wardas,B., Fecher-Trost,C., Meyer,M.R., Schmitz,F., Beck,A.,
            Fairless,R., Diem,R., Flockerzi,V. and Belkacemi,A.
  TITLE     Cavbeta3 Contributes to the Maintenance of the Blood-Brain Barrier
            and Alleviates Symptoms of Experimental Autoimmune
            Encephalomyelitis
  JOURNAL   Arterioscler Thromb Vasc Biol 44 (8), 1833-1851 (2024)
   PUBMED   38957986
  REMARK    GeneRIF: Cavbeta3 Contributes to the Maintenance of the Blood-Brain
            Barrier and Alleviates Symptoms of Experimental Autoimmune
            Encephalomyelitis.
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Woo,M.S., Ufer,F., Sonner,J.K., Belkacemi,A., Tintelnot,J.,
            Saez,P.J., Krieg,P.F., Mayer,C., Binkle-Ladisch,L., Engler,J.B.,
            Bauer,S., Kursawe,N., Vieira,V., Mannebach,S., Freichel,M.,
            Flockerzi,V., Vargas,P. and Friese,M.A.
  TITLE     Calcium channel beta3 subunit regulates ATP-dependent migration of
            dendritic cells
  JOURNAL   Sci Adv 9 (38), eadh1653 (2023)
   PUBMED   37729408
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Fecher-Trost,C., Lux,F., Busch,K.M., Raza,A., Winter,M.,
            Hielscher,F., Belkacemi,T., van der Eerden,B., Boehm,U.,
            Freichel,M. and Weissgerber,P.
  TITLE     Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is
            Involved In Offspring Bone Development
  JOURNAL   J Bone Miner Res 34 (4), 699-710 (2019)
   PUBMED   30786075
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Burgess,D.L., Biddlecome,G.H., McDonough,S.I., Diaz,M.E.,
            Zilinski,C.A., Bean,B.P., Campbell,K.P. and Noebels,J.L.
  TITLE     beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel
            subunit compositions in lethargic mouse brain
  JOURNAL   Mol Cell Neurosci 13 (4), 293-311 (1999)
   PUBMED   10328888
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Namkung,Y., Smith,S.M., Lee,S.B., Skrypnyk,N.V., Kim,H.L., Chin,H.,
            Scheller,R.H., Tsien,R.W. and Shin,H.S.
  TITLE     Targeted disruption of the Ca2+ channel beta3 subunit reduces N-
            and L-type Ca2+ channel activity and alters the voltage-dependent
            activation of P/Q-type Ca2+ channels in neurons
  JOURNAL   Proc Natl Acad Sci U S A 95 (20), 12010-12015 (1998)
   PUBMED   9751781
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Jones,J.M., Ranscht,B., Berglund,E.O., Gruenheid,S., Gros,P. and
            Meisler,M.H.
  TITLE     Close linkage of three neuronal genes on distal mouse chromosome 15
  JOURNAL   Mamm Genome 7 (9), 696-697 (1996)
   PUBMED   8703126
REFERENCE   9  (bases 1 to 2738)
  AUTHORS   Murakami,M., Wissenbach,U. and Flockerzi,V.
  TITLE     Gene structure of the murine calcium channel beta3 subunit, cDNA
            and characterization of alternative splicing and transcription
            products
  JOURNAL   Eur J Biochem 236 (1), 138-143 (1996)
   PUBMED   8617257
REFERENCE   10 (bases 1 to 2738)
  AUTHORS   Chin,H., Kwon,O.J., Jung,H.H., Kim,D.S. and Kozak,C.A.
  TITLE     Genetic mapping of the mouse genes encoding the voltage-sensitive
            calcium channel subunits
  JOURNAL   Genomics 28 (3), 592-595 (1995)
   PUBMED   7490102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156543.10.
            
            On Aug 6, 2022 this sequence version replaced NM_001286226.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148088.1, SRR7345562.1142512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-451               AC156543.10        34033-34483
            452-574             AC156543.10        38758-38880
            575-697             AC156543.10        39084-39206
            698-813             AC156543.10        39609-39724
            814-878             AC156543.10        39956-40020
            879-898             AC156543.10        40229-40248
            899-957             AC156543.10        40670-40728
            958-1067            AC156543.10        40886-40995
            1068-1219           AC156543.10        41209-41360
            1220-1315           AC156543.10        41579-41674
            1316-1465           AC156543.10        41772-41921
            1466-2738           AC156543.10        42527-43799
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.64 cM"
     gene            1..2738
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="calcium channel, voltage-dependent, beta 3 subunit"
                     /db_xref="GeneID:12297"
                     /db_xref="MGI:MGI:103307"
     exon            1..451
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..1780
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="isoform 3 is encoded by transcript variant 3;
                     voltage-dependent L-type calcium channel subunit beta-3;
                     calcium channel voltage-dependent subunit beta 3"
                     /codon_start=1
                     /product="voltage-dependent L-type calcium channel subunit
                     beta-3 isoform 3"
                     /protein_id="NP_001273155.1"
                     /db_xref="CCDS:CCDS88834.1"
                     /db_xref="GeneID:12297"
                     /db_xref="MGI:MGI:103307"
                     /translation="MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREV
                     ESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSND
                     WWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLGDIGNRRSPPPSLAKQ
                     KQKQVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARS
                     SIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRL
                     IRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATH
                     HPAPGPGLLGPPSAIPGLQNQQLLGERVEEHSPLERDSLMPSDEASESSRQAWTGSSQ
                     RSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHDHNDRNWQRNR
                     PWPKDSY"
     exon            452..574
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..697
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..813
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            814..878
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            879..898
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            899..957
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1067
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1219
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1315
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1465
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..2738
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="hexamer: AATAAA"
     polyA_site      2738
                     /gene="Cacnb3"
                     /gene_synonym="Beta3; Ca(v)beta3; CAB3; Cchb3"
                     /note="major polyA site"
ORIGIN      
        1 cttcttcccc gccgccccgg ccccggaggt gccggggacc caccttcccg actcgcgtgc
       61 gcccggttcc gcggccccgg cgggtccccc ctggctgccg cgcccccgcc gcccgcgtct
      121 tcccgggagg gggtcaggtg ggcgggcact attgttgtgg gagccggcgg cagattcctc
      181 agccgcgctg gcgcgctcgg ggtgggaccg gctgggctgg ggggtgggga ggggagcggt
      241 gatctgagct gcgagcagct ggtcttcgcg gctcgctcct tccttcgcgc tcgcgctctc
      301 cgccgccgcc gcccgcaggg ctgcgcggct cggtggcatc tcgggcgcgg cccgccgtcc
      361 tcgcccccgg cgccgctcgc tccccccacc caccccggac tcccccatgt atgacgactc
      421 ctacgtgccc gggtttgagg actcggaggc gggttcagcc gactcctaca ccagccgccc
      481 ctctctggac tcagacgtct ccctggagga ggaccgggag agtgcccggc gagaagtgga
      541 gagtcaggct cagcagcagc tggaaagagc caagcacaaa cctgtggcat ttgctgtgag
      601 gaccaatgtc agctactgtg gggttctgga tgaggagtgc ccggtccagg gctctggagt
      661 caactttgag gccaaagatt ttctgcacat taaagagaag tacagcaatg actggtggat
      721 cgggaggcta gtgaaagagg gcggagacat cgccttcatc cccagccccc aacgcctgga
      781 gagcatccgg ctcaaacagg aacagaaggc caggagatct gggaaccctt ccagcctggg
      841 tgacattggc aaccgacgct ctcctcctcc gtctctagcc aagcagaagc aaaagcaggt
      901 cacggacatg atgcagaagg cgctcttcga cttccttaaa cacaggtttg atggcaggat
      961 ctccatcaca cgcgtcacgg ccgacctctc gctggccaag cgctctgtgc tcaacaatcc
     1021 tggcaagagg accatcattg agcgctcctc cgcccgctcc agcattgctg aagtgcagag
     1081 tgagattgag cgcatattcg agctggccaa atccctgcag ctagtggtgt tggatgctga
     1141 caccatcaac cacccagcac aacttgccaa gacctcactg gctcccatca tcgtctttgt
     1201 caaagtgtcc tcgccaaagg tactgcagcg actgatccgc tccaggggaa agtcacagat
     1261 gaagcacctc actgtacaga tgatggcgta cgataagctg gttcagtgcc cacccgagtc
     1321 attcgacgtg attctggatg agaaccagct agaagatgcc tgtgagcacc tggctgaata
     1381 cttagaggtt tactggcgag cgacccacca cccagcaccg ggccccggac tgctgggtcc
     1441 gcctagtgcc atccctggac ttcagaacca gcagctgctg ggggagcgag tggaggagca
     1501 ctcacccctg gagagggaca gcctgatgcc ctcagatgag gccagcgaga gctcccgcca
     1561 ggcctggacc ggatcttcac agcgcagctc tcgccatctg gaggaggact atgcagatgc
     1621 ctaccaggac ctgtaccagc ctcaccgcca acacacctcg gggctgccca gtgctaacgg
     1681 gcacgacccc caagaccggc tcctagccca ggactcggag catgaccaca atgaccggaa
     1741 ctggcagcgt aaccggcctt ggcccaagga cagctactga ccacctcctg ccccaccctg
     1801 gcaggcgcag gcacagcggc tggggtgtcc acctcaggca ggttggagtt agattggcat
     1861 taggctgccg ttaggttcag ctcacacaac cctctgccca gccccaggtc cagggctgac
     1921 tgtggtccca aggttctggg agaagcaagg ggcccctcac ctcctgggca cagtgacccc
     1981 gtaggttctc atccgggtac tagccgtgtt ctgcatcctt ggcacctccc cctgcataag
     2041 ctgccgcccc cgtgggcaac aatctcaggc caggatcact tagcaggggc cttccagcca
     2101 gaatggatgc ccctctaaag agcaagaggg tgtgagtgtg ggcaacatag cctgaggaag
     2161 aagaaactcg gttcctaagc aggcgtagat cctaagcaaa gggactccat tcacgccact
     2221 gccacacatc agaaatgaag caatcagagc tcaacatggc ggcacttctg tcccatcagc
     2281 tggggtgggc acttacacct aagacaggag cagtgcgggt gaggcaggac agacagactc
     2341 acagctgtag ctctgctaga aaacggccca ctcaccaaac cgggacgctt agcatctggt
     2401 gagactaggg aactggggca tattcaagcc aagagccagc ctggactgcg ggggagggtg
     2461 ggacagcttc cggcccccct tgctcttctc attctttgcc cttgcatctg tcatttctgt
     2521 cctttccctc catggctcct gcaagatagg ggcttcctga ctcatagcag ccacttcagt
     2581 tagggttaga tgagaggaac aggacacagt gaacagtccc cgaggctgtc cacctggcta
     2641 cccttgcctt atggctctag cgtgtgacct acagagcatg ctccattaag aacccgcccc
     2701 acctcattgt catctccaat aaaacaccac gcacagtc
//
